for Neuro CPC 091808

1. The tau of PSP Neurofibrillary tangles Tufted astrocytes (Oligodendroglial) Coiled bodies

2. Basal ganglia

3. Subthalamic nucleus

4. Globus pallidus

5. Atrophy of superior colliculus

6. Superior colliculus

7. Substantia nigra

8. Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.

10. Grade 3

11. Grade 3

12. Dentate nucleus: Grumose degeneration

13. PSP-tau scores Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.

14. Distribution of tau pathology in PSP-tau score >7 Pink = Grade 1 Purple = Grade 2 Red = Grade 3 Brown = Grade 4 Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.

15. Mid-Frontal Hippocampus