Immunoglobulins 2001

Immunoglobulins: Structure and Function

Immunoglobulins:Structure and Function ,[object Object],Immune serum Ag adsorbed serum  1  2   + - albumin globulins Mobility Amount of protein

General Functions of Immunoglobulins ,[object Object],[object Object],[object Object],(Usually require Ag binding) ,[object Object],[object Object],[object Object]

Basic Immunoglobulin Structure ,[object Object],[object Object]

Immunoglobulin Structure ,[object Object],[object Object],[object Object],[object Object],C H1 V L C L V H C H2 C H3 Hinge Region Carbohydrate Disulfide bond

IgG molecule Used with permission from: Dr. Mike Clark, Immunology Division, Department of Pathology Cambridge University, Cambridge, England

Structure of the Variable Region ,[object Object],[object Object],HVR3 FR1 FR2 FR3 FR4 HVR1 HVR2 Variability Index 25 75 50 100 Amino acid residue 150 100 50 0

Immunoglobulin Fragments: Structure/Function Relationships ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Papain Fc Fab

Immunoglobulin Fragments: Structure/Function Relationships Ag Binding Complement Binding Site Placental Transfer Binding to Fc Receptors

Immunoglobulin Fragments: Structure/Function Relationships ,[object Object],[object Object],[object Object],[object Object],[object Object],Pepsin Fc Peptides F(ab’) 2

Human Immunoglobulin Classes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Human Immunoglobulin Subclasses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Human Immunoglobulin Light Chain Types ,[object Object],[object Object]

Human Immunoglobulin Light Chain Subtypes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Immunoglobulins ,[object Object],[object Object],[object Object],[object Object],[object Object]

IgG ,[object Object],[object Object],IgG1, IgG2 and IgG4 IgG3

IgG ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IgM ,[object Object],[object Object],[object Object],[object Object],C  4 J Chain

IgM ,[object Object],[object Object],[object Object],[object Object],[object Object]

Fixation of C1 by IgG and IgM Abs No activation Activation C1r C1s C1q C1r C1s C1q

IgM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Tail Piece

B Cell Antigen Receptor (BcR) Ig-  Ig-  Ig-  Ig- 

IgA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],J Chain Secretory Piece

Origin of Secretory Component of sIgA Y Y Y Y Y Y

IgA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IgD ,[object Object],[object Object],[object Object],Tail Piece

IgD ,[object Object],[object Object],[object Object],[object Object],[object Object]

IgE ,[object Object],[object Object],[object Object],C  4

IgE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Immunoglobulins 2001

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Immunoglobulins 2001