Ohio has a large and growing bioscience industry sector. It ranks highly nationally in areas like biotechnology industry strength, university research funding, and clinical trials activity. The bioscience sector in Ohio includes subsectors like pharmaceuticals, medical devices, agriculture, and research laboratories. BioOhio is a non-profit organization that works to build and accelerate the bioscience industry, research, and education in Ohio through initiatives like company attraction and expansion, workforce development, and advocacy.

1. BioOhio Update Name or Date An Ohio Thomas Edison Center

4. The Original Biotechnologies

10. Be Proud…Be Strategic “ Ohio is one of the best places in the world to optimize the growth of your bioscience company because we can imbed you in an asset base, 1141 companies and growing; We are a partner that allows you to maximize any or all phases of your business strategy”

11. * Total Ohio bioscience establishments are 1141 (March 1, 2009)

15. 3 cities in the top 40 Biotech locations in USA #4 in biotechnology industry strength 2008 All three cities rank higher than the 100 city average in Research grant awards in Bio- Sciences $630 Million in NIH Awards in 2008! State City Rank OH Cleveland-Akron 20 Columbus 22 Cincinnati 28

22. Direct Commercial Bioscience Economic Impact Summary

23. Central Ohio Regional Impact

24. Northeast Ohio Regional Impact

25. Southwest Ohio Regional Impact

26. West Central Ohio Regional Impact

27. Southeast Ohio Regional Impact

28. Northwest Ohio Regional Impact

31. Total Bioscience Funding 2004-2007

33. Top Employers

34. Top Employers

35. Top Employers

36. NAICS

37. NAICS

38. Ohio is ranked 8 th nationally in total patents issued and has more than every country in the world except for Japan, Germany, and the UK

41. 16% of all clinical trials in the US are conducted in Ohio

42. Distribution of Active Clinical Trials by Disease As of November 4, 2008

45. Tax Reform

47. Ohio Ranks 4 th in the Nation in Biotech Strength in the latest report

48. Ohio – National Top 10 AdvaMed

49. Ohio claims its third Governor's Cup in a row, 06-08, for the most new or expanded capital projects, thanks to the Strickland Administration's focus on taking steps necessary to be competitive, even in a challenging economic environment.

50. BioOhio’s Balanced Strategy industry growth, resource optimization, community building Company & Capital Formation Company Attraction & Expansion Member / Trade Association Industry Function Bioscience Workforce & Education

53. By-The Numbers, then & now Year 1991 2001 2008/2009 Number of bio entities in Ohio 170 352 1141 (3.2X) 2009 University R&D expenditures $285 million $481 million $1.1 billion (2.3X) New Company starts ≈ 12 12 65 per year (5.4X) 2004-08 Private capital raised for new starts Unknown $14 million $189 million (13.5X) $473 million IPO/Acquisitions 2008 Bioscience Capital sources (in State) 4 8 63 (7.9) 2009 BioOhio (EBTC) membership 52 86 280 (3.3X) 2009

55. Ohio Bioscience Growth Report & Magazines

64. Ohio’s Agricultural Output $79.6 Billion Ohio’s Chemicals, Plastics, Rubber Materials Output $49 Billion Ohio BioProducts Innovation Center

66. Impact of the Human Genome Project

72. Third Frontier Network (OSCnet) The most advanced IT research network in USA

73. Technology Innovation Cycle ADVANCED RESEARCH (8-15 years) PRODUCT CYCLE (1-3 years) BREAKTHROUGH (5-8 years) v: Discovery Development Application Product Development Involves the “Application” of Technology t e r C r o s s I n d u s t r y S o u r c e s F e d e r a l R e s e a r c h C o l l a b o r a t i v e R e s e a r c h R e s e a r c h U n i v e r s i t i e s G l o b a l S o u r c i n g C o r p o r a t e L a b s I n t e r n a t i o n a l S o u r c e s I n t e g r a t i o n S e n s e & L o c a t e G a p A s s e s s m e n t A s s e s s P r o d u c t P l a t f o r m P r o d u c C u s t o m D r i v e s U n m e t N e e d s Develop

74. Medical Device Commercialization Pathway Concept Development and Initial Research Company Formation / Project Team Secure IP Portfolio Product Engineering and Prototype Development Pre-Clinical and Clinical Studies Manufacturing Development/ expansion for clinical trials Clinical Trials/Outcomes FDA Approval and Market Launch Expansion/ Investment in Working Capital $ A B

75. Typical Product Development Process Source: PTRM

79. Medical Product Development each step has defined Work Processes

80. Let me know how we can help you! John F. Lewis Jr. Vice President [email_address] 614-675-3686 x7 An Ohio Thomas Edison Center