1. Stimulates Inhibits Ca+ Stimulates Inhibits

2. inhibits inhibits

3. inhibits Stimulates Stimulates

4. Insulin Glucagon Stimulates Stimulates

5. Factor Inhibits Stimulates Explain why do your answer(s) in the previous columns “make sense?” ADP PFK If ADP is being used or is building up, it means that the body is in need of energy (ATP –> ADP+P). ADP will stimulate or “tell” PFK to act on G-^P, thus beginning non-oxidative metabolism (glycolysis) G-6-P Hexokinase and Phosphorlase If there is an excessive amount of G-6-P it does not need to make more so it must stop the enzyme making it. Ca + Phosphorlase Calcium contract muscle and in order to do so you need ATP. The enzyme that makes ATP is Phosphorlase thus stimulating it in order to function. ATP-CP Atpase If there is enough ATP-CP it inhabits Atpase because that is the enzyme that breaks it down in ADP+ P+ energy. Citric Acid PFK If citric acid is building up it inhibits PFK because acetyl-coA comes from parovic acid, which is made by the enzyme PFK. O 2 PFK If there is too much O2 it will back up the citric cycle, which will back up the parovic acid, which is stimulated by PFK so PFK is inhibited by O2. Epinephrine Synthase PFK Hexokinase Phosphorlase If adrenaline is building up it gets it energy from G-6-P so it will stimulates hexokinase and phosphorlase, which make G-6-P and PFK which is the enzyme that makes the energy. It inhabits sythetase when it there is an excessive amount because sythetase stimulates glycogen. Insulin Synthase Insulin is trying to stimulate synthase to synthesize glycogen in muscle and liver. Glucagon Phosphorlase Glucagon wants to get glycogen out of the liver and muscles so it stimulates phosphorlase making more G-6-P