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The impact of new drug launches on longevity: evidence from longitudinal, disease-level data from 52 countries, 1982-2001 Frank R. Lichtenberg Columbia University and   National Bureau of Economic Research
United Nations  Human Development Index   ,[object Object],[object Object],[object Object],[object Object]
U.S. economic growth, 20 th  C. Nordhaus: “to a first approximation, the economic value of increases in longevity over the twentieth century is about as large as the value of measured growth in non-health goods and services”
Life expectancy at birth, world, 1950-2000
Life expectancy at birth, by region Unlike GDP, longevity is converging
Sources of longevity increase? ,[object Object],[object Object]
Conventional wisdom ,[object Object],[object Object]
Conventional wisdom ,[object Object],[object Object]
Paul Romer’s Model of  Endogenous Technical Progress ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Health production function ,[object Object],[object Object],[object Object],[object Object],[object Object]
Specification ,[object Object],[object Object]
Controlling for “other factors” ,[object Object],[object Object],[object Object],[object Object]
Controlling for “other factors” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Reduced form ,[object Object],[object Object],[object Object]
IMS Health Drug Launches database ,[object Object],[object Object],[object Object]
Example: tenecteplase ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug launch probability profiles:  U.S. vs. Canada
Censoring of drug launches ,[object Object],[object Object]
Censoring of drug launches ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
WHO Mortality database ,[object Object],[object Object]
Relationship between life expectancy and probability of survival to age 65, U.S., 1900-2000
Linkage of drug launches to diseases ,[object Object],[object Object],[object Object]
11 broad disease categories
Countries with most and fewest drug launches
Findings ,[object Object],[object Object],[object Object],[object Object]
Estimates of   NCE  for different lags between stock of NCEs launched and longevity
Estimates of   NCE  and   expend   at different lag values
Contribution of NCE launches to  longevity increase ,[object Object],[object Object],[object Object],[object Object]
Contribution of NCE launches to increase in average  life expectancy of the population since 1986
Cost per life-year gained from the launch of NCEs   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Micro evidence from  a Medicaid program
Probability  of death by  end of 2002 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],540,000 people 12.2 million claims
Data ,[object Object],[object Object],[object Object],[object Object]
Mortality rate declines as  drug vintage increases
Actual vs. hypothetical  mortality rates
Analysis by disease group
The Economics of Invention Incentives: Patents, Prizes, and Research Contracts Brian D. Wright American Economic Review  73,  1983, pp. 691-707.
How  should the government support biomedical research? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Simple model of research ,[object Object],[object Object],[object Object]
Optimal number of firms
Optimal number of firms
Research contracts ,[object Object]
Government prizes ,[object Object],[object Object],[object Object],[object Object]
Government uncertainty ,[object Object],[object Object]
Patents ,[object Object],[object Object],[object Object]
Patents ,[object Object],[object Object],[object Object]
Public policy towards innovation ,[object Object],[object Object],[object Object]
Patents: benefits and risks ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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