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1. Timing of Angiography and Patient Considerations
A ngiography for SAH should be performed promptly, considering the patient’s overall medical and
neurologic condition to establish the diagnosis and facilitate timely treatment . In cases of aneurysmal
SAH, the peak incidence of rebleeding occurs within the first 24 hours (4.1%), then drops to
approximately 1.5% per day for a cumulative rebleed rate of 26.5% for the first 2 weeks in patients not
receiving antifibrinolytics . For selected patients, early therapeutic intervention prevents acute aneurysmal
rehemorrhage and allows for effective medical or endovascular treatment for delayed ischemic neurologic
complications (vasospasm). Patients considered good candidates for early surgical or endovascular treatment
require early angiography. Angiography for very ill or unstable patients may be deferred.
When surgery has been significantly delayed after initial angiography has been performed, it may be
necessary to repeat the study. The development of vasospasm and cerebral ischemia may influence surgical
planning, whereas the resolution of vasospasm may allow the visualization of additional vascular pathology
missed on the initial study.
There are several reports of spontaneous thrombosis of cerebral aneurysms occurring 2 weeks to 2 years
following initial angiography Conversely, recanalization of previously thrombosed aneurysms or de novo
aneurysm development has also been reported.
Acute SAH patients may be gravely ill and special attention to their clinical condition is mandatory. In the
angiography suite, the patient should be adequately monitored, minimally requiring frequent vital signs and
electrocardiographic monitoring. An automated sphygmomanometer and a pulse oximeter are desirable. A
nurse may help to assess the patient’s neurologic and hemodynamic status, as well as administer oxygen,
intravenous fluids, and medications. It is safest and most efficient for the neuroradiologist to be able to
concentrate on the performance and interpretation of the study; however, it must be remembered that during the
procedure, care for the patient is the operator’s responsibility and should remain the highest priority. For
stuporous, comatose, or hemodynamically unstable patients, proper medical care, intubation before the
procedure, and use of intravenous sedation or general anesthesia by anesthesia personnel is recommended. A
moving, uncooperative, or unstable patient is subject to higher risk during the procedure and increased
likelihood of poor quality or nondiagnostic images. If adequate clinical care cannot be given to a seriously ill
patient during angiography, the study should be deferred until the necessary arrangements can be made.
Cerebral angiography is an invasive procedure and carries inherent risks. A study reviewing 1000 consecutive
transfemoral cerebral angiograms disclosed a 1% transient and a 0.5% permanent neurologic deficit within 24
hours secondary to the procedure. Complications correlated with age, length of procedure, and contrast burden
2. and occurred more frequently in patients presenting with a history of stroke, transient ischemic attack, and
carotid bruit. Referring to the annual risk of aneurysmal rupture, and the morbidity and mortality of SAH, the
benefit derived from the angiographic information outweighs the potential risks.
Postangiography headache, possibly due to catheter or contrast-induced release of vasoactive substances,
occurs in up to 33% of patients, may be accompanied by nausea, vomiting, photophobia, and phonophobia, and
should be differentiated from rehemorrhage.
One recent study reported a 4.8% incidence of angiography-induced rerupture when performed within 6 hours
of the initial SAH. This incidence is lower than previously reported and is not much different than the natural
incidence of rehemorrhage; thus, early angiography should not be discouraged.
Pan Cerebral Angiography Versus Limited Study
As discussed earlier, patients with intracranial aneurysms often harbor multiple lesions. The possibility of
associated unruptured aneurysms in the setting of aneurysmal SAH mandates the performance of pan cerebral
angiography to assess the entire cerebral circulation..
Although incomplete angiography is not encouraged, it has been suggested that in cases of medically unstable
or neurologically deteriorating patients, or when inexperienced angiographers are performing emergent studies,
limited angiography may be performed. The estimated risk of erroneous surgical exploration given a suggestive
CT and a limited angiogram is less than 0.4%. Conversely, demonstration of multiple aneurysms by pan
cerebral angiography allows the surgeon the opportunity to perform a single-stage approach to clip all
accessible unruptured aneurysms while attending to the ruptured one, obviating the need for additional surgery.
Additionally, it may significantly affect patient management with regard to hypertensive or hypervolemic
therapy, as well as influence decisions regarding endovascular therapy for these aneurysms.
Unless prohibited by special anatomic considerations, four vessel is routinely performed angiography. If
bilateral internal carotid and vertebral artery injections do not reveal intracranial lesions, external carotid artery
angiography should be done specifically to evaluate the potential presence of dual vascular pathology.
Follow-up for an Initial Negative Angiogram
In patients with acute spontaneous SAH, pan cerebral angiography will not reveal a finding in approximately
10% to 20% of cases .Several factors may account for this negative evaluation.
Focal vasospasm may prevent adequate opacification of an aneurysm and reduces the certainty of a negative
angiogram. The presence of vasospasm influences the decision regarding the timing and number of follow-up
3. angiograms and is discussed later in this article.
Spontaneous thrombosis of a ruptured intracranial aneurysm has been described in 9% to 13% of various
autopsy series. Several theories have been proposed concerning the pathogenesis of spontaneous thrombosis,
relating it to stasis, hypercoagulability, or endothelial injury. Cerebral vasospasm, systemic hypotension, local
damage to the arterial wall due to aneurysmal rupture, and antifibrinolytic agents have also been implicated.
The relationship between the size of the aneurysmal neck and the volume of the aneurysmal sac has also been
suggested as a predisposing factor because a narrow neck may facilitate stasis and thrombosis. Conversely,
recanalization of acutely thrombosed aneurysmshas also been described
Traditionally, the interval between the initial study and repeat angiography has been 3 to 6 weeks to allow for
possible vasospasm to resolve. However, a change in clinical status or a significant finding by noninvasive
imaging may affect the decision to repeat angiography at an earlier time.
Angiographic Considerations
Cerebral angiography for the evaluation of saccular aneurysms should achieve more than simply
demonstrating the presence or absence of a lesion. Detailed anatomic information is required for optimal
planning of surgical or endovascular intervention. Using anatomic principles and radiographic techniques the
angiographer should try to demonstrate the following:
• The size, shape, and orientation of the aneurysm; the angiographic lumen should be compared with
axial imaging for correlation.
• The location, size, and extent of the aneurysm neck in relation to the aneurysm fundus and parent
vessel. The angiographic neck may differ from that demonstrated by axial imaging. Accurate
delineation of the neck is mandatory for endovascular treatment considerations. The parent vessel from
which the aneurysm arises, including size, configuration, and anatomic variations.
• The relationship of the aneurysm to the surrounding vasculature.
• Collateral blood flow patterns pertinent to the vascular territory at the level of the circle of Willis and
leptomeningeal pathways.
• Multiplicity of aneurysms. In patients with SAH, sufficient characterization is necessary to suggest
which aneurysm has hemorrhaged. Correlation with axial imaging is recommended.
• The presence of thrombus within the aneurysm and associated thromboembolic complications.
Evidence of vasospasm (localized or generalized) or cerebral ischemia. Mass effect or vascular
displacement secondary to intraparenchymal hemorrhage or by the aneurysm itself.
• Associated vascular anomalies and diseases (AVMS, fibromuscular dysplasia, vasculitis,
atherosclerosis, moyamoya).
4. • Growth or change in aneurysm morphology compared with prior studies.
• Demonstration of external carotid artery branches when bypass surgery is anticipated.
The anatomic information related to the aneurysm and the parent vessel, as well as information concerning the
“physiologic neck,” inflow and outflow sites and vortex flow may prove useful in designing strategies and
predicting longevity of endo- vascular treatment as well as deciding among therapeutic modalities. To acquire
this complex information, the angiographer needs to be aware of patient positioning, radiographic projection,
centering, and collimation. Because DSA systems are prevailing, most of these are performed with live
fluoroscopy by the operator. These tasks were previously performed and mastered in conventional film screen
angiography by the radiologic technologist with position change of the patient’s head according to projection
protocols. The fluoroscopic recognition of different projections, as described previously in the literature, is
mandatory to obtain them efficiently by rotating and moving the x-ray tube and image intensifier. It is helpful
to recognize the relationship between the orbital rim and the superior aspect of the petrous bone in the anterior-
posterior (AP) plane . Variations of oblique views are routinely used to evaluate different segments of the
intracranial circulation . Ongoing adaptation and modification are necessary because anatomic variants, vessel
tortuosity, structural changes, head position, and angiographic equipment may influence the projection of
vessels.
When faced with multiple aneurysms in,SAH, it is necessary to decide which aneurysm ruptured .CT
localization, angiographic signs, and aneurysmal size and shape.are important in determination of the beeding
anerysms ACommA had the highest probability of rupture (62%) followed by BA and PICA aneurysms (50%
each) and PCommA aneurysms (38%). Larger and more irregular aneurysms are more likely to have bled, with
irregular shape being the more consistent predictor. Angiographic signs suggesting hemorrhage include contrast
dye extravasation (pathognomonic), focal mass effect, focal vasospasm, and presence of a nipple. New focal
vasospasm or a change in aneurysm shape, determined by sequential angiograms, are highly suggestive.
Identifying the symptomatic aneurysm is important because studies suggest that the morbidity and mortality of
patients with multiple aneurysms and SAH is related to the ruptured aneurysm and not the asymptomatic
lesions.
Angiography of Unusual Aneurysms
Serpentine aneurysms arise most commonly from the MCA (51 %). The PCA, vertebrobasilar junction, and
supraclinoid ICA constitute most of the remaining locations. Angiography is pathognomic revealing an
irregular, serpiginous vascular channel with markedly slow flow and separate entrance and exit sites,
terminating in normal vessels supplying vital tissue. Angiographic evaluation should provide information
regarding collateral sources of blood supply to cerebral tissue in the distribution of the aneurysm, including the
relevant leptomeningeal circulation. The external carotid artery (ECA) should also be selectively studied
because therapy often will include consideration of a vascular bypass graft to support distal vascular territories.
Mass effect from the thrombosed portion of the aneurysm may be appreciated. Superselective angiography, test
occlusions, and functional amytal testing may be performed .
5. Dissecting aneurysms have a distinctly different distribution from that of saccular aneurysms. Reportedly, the
most frequent locations are MCA, 41 %; VB, 23%; ICA, 21%; and ACA, 13%.” Angiography remains the most
accurate study for the delineation of these lesions .four angiographic features are described: (1) retention of
contrast mediainside an aneurysm through the late arterial and venous phases; (2) double lumen with an
aneurysmally dilated false lumen; (3) irregular narrowmg proximal or distal to the aneurysm; and (4) rapid
changes with disappearance or emergence of fusiform-like aneurysms upon repeated studies. Additional
angiographic description refers to irregular “pearl and string” dilatations and narrowings of the vessel wall
without definite aneurysm. Treatment combines supportive measures for any ischemic sequela and aneurysm
exclusion, usually by parent vessel occlus
ion.
Erroneous Angiographic Diagnosis of Cerebral Aneurysms An erroneous angiogram is a false-negative study
in which an aneurysm is missed Or a false-positive study in which something is mistakenly identified as an
aneurysm. Superimposition of vessel loops projecting as an aneurysm is a cause for a false-positive study.
The true nature of the anatomy may be delineated by using different projections, increased magnification, and high-
frame rate acquisition. Typically, superimposed vascular loops may be suggested by the presence of a “double
density” without contour abnormality. The presence of an infundibular dilatation at a vessel origin, particularly
the PCommA, may occasionally be difficult to distinguish from a small aneurysm. Infundibula are identified by
the following criteria
1. size less than 3 mm
2. triangular (funnel) shape
3. vessel arises from the apex of the dilatation.
Because some authors caution that infundibular dilatations are not always “normal” and may on rare occasion
be the cause of SAH, these criteria should be strictly applied when excluding the possibility of an aneurysm.
Vertebral artery angiography to opacify the posterior communicating ICA junction in a retrograde fashion may
be helpful to delineate an infundibulum from an aneurysm.
Failure to identify a small-sized aneurysm may simply be due to the inability to project the lesion adequately.
Small aneurysms may be obscured by surrounding vasculature and additional projections are required to reveal
or exclude them. Conversely, several inherent physiologic and anatomic conditions may produce a false-
negative study including aneurysm thrombosis , parent vessel thrombosis, or vasospasm. Because these
conditions are potentially reversible, repeat angiography is mandatory. MR angiography may demonstrate a
thrombosed aneurysm that failed to opacify by angiography and may be complementary to a negative study. It
has been suggested that MR angiography may demonstrate an aneurysm not identified by conventional
angiography, although suboptimal angiographic technique may also play an important role .
Technical error, such as inadequate contrast injection, may prevent aneurysmal opacification especially in areas
where washout by collateral flow exists (ACommA and PCommA). The neuroangiographer should be mindful
of the pitfalls and thus avoid the erroneous study.
6. Angiography for Vasospasm
Clinically significant vasospasm develops in up to 30% of patients following aneurysmal SAH. The incidence
of this complication is highest 4 to 12 days following the initial bleed. Although the etiology is still obscure,
there is evidence to support the concept that vasospasm is induced by vasoconstrictive substances released by
lysed blood cells. A patient’s response to vasospasm correlates with several factors including the volume of
blood within the subarachnoid spaces, cerebral perfusion pressure, hematocrit, and collateral blood supply to
the cerebrovascular territory at risk .
Early exclusion of a ruptured aneurysm from the circulation in combination with calcium channel blockers,
cerebrospinal fluid drainage, intracranial pressure monitoring, and “triple H” therapy (hemodilution,
hypertension, hypervolemia) are used to improve the patient’s outcome.
Transcranial Doppler ultrasonography is used routinely as a noninvasive method for early diagnosis and
quantitative monitoring of the development and course of vasospasm. Changes in the Doppler wave form and
velocity, in conjunction with frequent neurologic examinations, serve to select patients for repeat angiography
and possible endovascular treatment because early detection and treatment improves outcome. Angiography
performed in delayed cerebral ischemia may show widespread vessel narrowing or localized caliber changes,
mainly involving vascular segments within the basal cisterns. Percutaneous angioplasty is directed toward
dilatation of arteries supplying the vascular territorie most likely accounting for a specific neurologic deficit .
s
Mechanical vessel dilatation is performed with a balloon or microcatheter, whereas “chemical angioplasty”
uses intra-arterial infusion of papavarine. experience indicates that the vasodilatory effect of mechanical
angioplasty is permanent whereas that following papavarine may be only transient and often is associated with
increases in intracranial pressure . Angiographic improvement is judged by vessel caliber and vascular filling
and usually correlates with immediate improvement in transcranial Doppler parameters. When performed early
in the clinical course, neurologic improvement ensues. ruptured aneurysm from the circulation is well
established, we may approach the time when diagnostic cerebral angiography can offer an early diagnosis in
combination with early endovascular therapy, allowing supportive treatment for the complications of SAH.