CONGENITAL RENAL ABNORMALITIES By Dr. Enobong Runcie(0).pptx
Renal Development Dysplasia 2
1. Renal Development & Dysplasia Part I Hsiao Lai, MD Feb 19, 2010 ECU, Brody School of Medicine Nephrology and Hypertension Pediatric Nephrology Core Curriculum
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4. Causes of Pediatric ESRD % 23 Other 3 PKD 3 Cystinosis 5 Nephronophthises 8 Congenital Nephrotic Syndrome 18 Acquired GN 40 CAKUT
Intermediate mesoderm on either side of the dorsal body wall/notochord gives rise to 3 successive nephric structures of increasingly advanced design
Pronephroi- nonfunctional segmental nephrotomes which develop in cervical region-represent a vestige of primitive kidneys seen in lower vertebrates, begin to appear at 24 days and regress in the fourth week Mesonephros – initial appearance of mesonephros and mesonephric duct at 25 days. Metanephric blastema and metanephric ducts appear at 28 days or end of week 4 Mesonephros develop in thoracic and lumbar regions during 4 th week, functional with complete but simple nephrons drained by the mesonephric (Wolffian Ducts) Nephric ducts grow caudally to open into the posterior wall of the primitive urogenital sinus by week 5 Metanephroi-definitive kidneys begin to form during 5 th week by induction of sacral intermediate mesoderm by UBs
UBs sprout from the distal end of the mesonephric duct by week 5