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Synthetic Drugs of Abuse:  ‘Spice,’ ‘K2’ and ‘Bath Salts’ Erik Gunderson, MD Assistant Professor  Department of Psychiatry and Neurobehavioral Sciences and Department of Medicine Director, Clinical Pharmacological Research Unit University of Virginia April 14, 2011
Synthetic Cannabinoids (SCs) ,[object Object],[object Object],[object Object],[object Object],Psychonaut Web Mapping Research Group (2009.) Spice Report. Institute of Psychiatry, King’s College London: London UK.
 
Spice and K2 ,[object Object],[object Object],[object Object],[object Object],http://buyherbalspice.com/spice_reviews/category/news/
Pharmacology ,[object Object],[object Object],[object Object],[object Object],JWH-018 ∆ 9 -THC
Psychoactive Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://buyk2spice.net/
Side Effects of SC Products ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://investigationmiami.blogspot.com/2011/01/be-afraid-really-afraid.html
Legal Timeline for SCs ,[object Object],[object Object],[object Object],[object Object],[object Object]
Current and Future Epidemiology? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Synthetic Stimulants ,[object Object],[object Object],[object Object],[object Object]
MDPV and Mephedrone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://www.herbalextracts.net/library/supplements/khat_uses.html
Product Marketing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://www.helphopehealing.org/
MDPV ,[object Object],[object Object],[object Object],[object Object],http://www.stompin-gardeners.com/index. MDMA
Pharmacology of MDPV ,[object Object],[object Object],[object Object],[object Object]
Effects of MDPV ,[object Object],[object Object],[object Object],[object Object],http://www.tradevv.com/chinasuppliers/chwhtltd_p_198b58/china-Mdpv-by-pevukka.html
Other Sequelae of MDPV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MDPV’s Legal Status ,[object Object],[object Object],[object Object],http://addiction-dirkh.blogspot.com/2010/11/dea-slaps-temporary-ban-on-spice-and.html
Mephedrone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://www.synchronium.net/2010/01/05/mephedrone-cat/
Pharmacology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mephedrone Amphetamine
Routes of Administration ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://www.guardian.co.uk/society/mephedrone
Effects of Mephedrone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://www.drugs.org.im/campaigns.htm
Mephedrone Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://theblackheartofgrahamquirk.blogspot.com/
Mephedrone’s Legal Status ,[object Object],[object Object],[object Object],[object Object],[object Object]
Current and Future Epidemiology? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Questions?
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acknowledgement   Laura Willing, BS Contact Information Erik Gunderson, MD 434-924-8013 office [email_address]

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Va calc spice bath salts 2011 04-14 final

  • 1. Synthetic Drugs of Abuse: ‘Spice,’ ‘K2’ and ‘Bath Salts’ Erik Gunderson, MD Assistant Professor Department of Psychiatry and Neurobehavioral Sciences and Department of Medicine Director, Clinical Pharmacological Research Unit University of Virginia April 14, 2011
  • 2.
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  • 27. Acknowledgement Laura Willing, BS Contact Information Erik Gunderson, MD 434-924-8013 office [email_address]

Editor's Notes

  1. No disclosure
  2. Potpouri, other brands
  3. Also vaporization, many mix due to the poor taste, ads such as above look more like MJ than in reality Poorly labeled contents John Huffman compounds, Pfizer CP compound, 100s of others
  4. Potency: tigher binding, full agonism: potentially greater harm?
  5. Virtually nothing known about clinical effects (e.g., from human lab studies), few non-structured studies describe Also, MJ cas >60 cannabinoids may modulate delta-9 effects (e.g., cannabidiod) Survey data
  6. Acute anxiety reactions, psychosis in biol vulnerable
  7. Available in UK 2006-7 first mention Off the shelves 12/2010 before xmas still available INTERNET REG? CHANGE NAME? COMPOUND?
  8. Anecdotally teen/young adult National Poison Data System (NPDS
  9. Limited data on clinical effects, mostly non-scientific anecdote
  10. MDMA comparison anecdotal, non-scietific data hence slang terminology
  11. Also, few scientific data
  12. Anecdotally teen/young adult National Poison Data System (NPDS