The document discusses the conceptual framework for a proposed Malaria Virtual Research Environment (VRE) in South Africa. Interviews were conducted with 20 malaria researchers to understand their current research tools and workflows. The interviews identified priorities for the VRE including further investigating experimental workflows, the wider research context, and collaboration needs. The next step proposed is to build a prototype Malaria VRE using elements from other international VRE projects and with support from South African stakeholders.