ΑΝΟΣΙΑ - ΤΟΜΟΣ 3, ΤΕΥΧΟΣ 01-02, 2007

1. E§§HNIKH HELLENIC
ETAIPEIA SOCIETY OF
ANO™O§O°IA™ IMMUNOLOGY
′
ανοσια
TPIMHNIAIA EK¢O™H TH™ E§§HNIKH™ ETAIPEIA™ ANO™O§O°IA™
TOMO™ 3, TEYXO™ 1-2 ñ 2007
ISSN 1790-6490
anosia
QUARTERLY EDITION OF THE HELLENIC SOCIETY OF IMMUNOLOGY
VOLUME 3, NUMBER 1-2 ñ 2007

2. E§§HNIKH
ETAIPEIA
ANO™O§O°IA™
TPIMHNIAIA EK¢O™H
TH™ E§§HNIKH™ ETAIPEIA™ ANO™O§O°IA™
ISSN 1790-6490 TOMO™ 3 ñ TEYXO™ 1-2
ª·È¿Ó‰ÚÔ˘ 23, 115 28 ∞ı‹Ó· |
ΔËÏ. +30 210 7211845 | F·¯: +30 210 7215082 |
E-mail: helsocimmun@yahoo.com |
περιεχόμενα
http: //mednet.gr/hsi
¢IOIKHTIKO ™YMBOY§IO E.E.A.
¶Úfi‰ÚÔ˜ : ¶. MÔ‡Ú·
AÓÙÈÚfi‰ÚÔ˜ : X. NÈÎÔÏ¿Ô˘ ∞ÈÙÈÔ·ıÔÁÂÓÂÙÈÎÔ› Ì˯·ÓÈÛÌÔ› ÛÙË ÓfiÛÔ A‰·Ì·ÓÙÈ¿‰Ë-Behçet
°ÂÓ. °Ú·ÌÌ·Ù¤·˜ : º. ¶·ÏËÔÁÈ¿ÓÓË
Eȉ. °Ú·ÌÌ·Ù¤·˜ : A. TÛÈÚÔÁÈ¿ÓÓË
º. ∫·ÎÏ·Ì¿Ó˘, ∂. ∫·ÎÏ·Ì¿ÓË ............................................................................................ 7
T·Ì›·˜ : O. MˆÚ·ÏfiÁÏÔ˘-MÂÓ¤ÙÔ˘
M¤ÏË : X. ÕÓÙ˙Ô˘-AÁÁÔ˘Úȉ¿ÎË
ÃÚfiÓȘ ∏·Ù›Ùȉ˜ ππ – ÃÚfiÓÈ· ∏·Ù›Ùȉ· C
£. KÂÚ·ÌÈÙÛfiÁÏÔ˘ E. °ÈÁ‹, ª. ƒ·ÙÔÔ‡ÏÔ˘-°ÈÁ‹ ............................................................................................. 17
™YNTAKTIKH E¶ITPO¶H
¶Úfi‰ÚÔ˜ : ¶. MÔ‡Ú· TÔ Û˘Ìϋڈ̷ ÛÙȘ ·ÁÁÂȷΤ˜ ÓÂÊÚÈΤ˜ ·ı‹ÛÂȘ
Y‡ı˘ÓÔÈ Û‡ÓÙ·Í˘ ∫. ¶·Ï¤Ù·˜ ............................................................................................................................... 35
X. NÈÎÔÏ¿Ô˘
º. ¶·ÏËÔÁÈ¿ÓÓË ∞ÓÔÛÈ·Îfi Û‡ÛÙËÌ· Î·È Á‹Ú·ÓÛË
A. TÛÈÚÔÁÈ¿ÓÓË ¶. ™Î¤Ó‰ÚÔ˜ ............................................................................................................................ 40
O. MˆÚ·ÏfiÁÏÔ˘-MÂÓ¤ÙÔ˘
X. ÕÓÙ˙Ô˘-AÁÁÔ˘Úȉ¿ÎË °ÂÓˆÌÈ΋: ªÈ· ηıÔÚÈÛÙÈ΋ ÚfiÎÏËÛË ÁÈ· ÙÔ Ì¤ÏÏÔÓ Ù˘ ·ÓÔÛÔÏÔÁ›·˜
£. KÂÚ·ÌÈÙÛfiÁÏÔ˘
™YMBOY§EYTIKH E¶ITPO¶H
∞.£. ∫·ÏÔÁÂÚ›‰Ë˜ ................................................................................................................... 44
EÈÙÚÔ‹ ¶ÚÔ¤‰ÚˆÓ EEA
† M. ¶·˘Ï¿ÙÔ˘
ªÂϤÙË Î·È ·ÓÔÛÔÊ·ÈÓfiÙ˘Ô˜ ÙˆÓ Î˘„ÂÏȉÈÎÒÓ Î˘ÙÙ¿ÚˆÓ Û ·ÛıÂÓ›˜
I. OÈÎÔÓÔÌ›‰Ô˘ Ì Ó¢ÌÔÓÈ΋ ÚÔÛ‚ÔÏ‹ ·fi ÓÔÛ‹Ì·Ù· ÙÔ˘ Û˘Ó‰ÂÙÈÎÔ‡ ÈÛÙÔ‡
E. K·ÎÏ·Ì¿ÓË ¢. ¶··ÎÒÛÙ·, ∫. ª·Ó›Î·, °. ∫˘ÚÈ·˙‹˜, ∞. °·Ú‡Ê·ÏÏÔ˜, £. ∫ÔÓÙ·ÎÈÒÙ˘,
AÈÎ. ™Ù·˘ÚÔÔ‡ÏÔ˘-°ÎÈfiη
M. B¿ÚÏ·-§Â˘ıÂÚÈÒÙË £. ¶ÔÏ˘˙ÒÓË, ¶. ∞ÚÁ˘ÚÔÔ‡ÏÔ˘, ¢. °ÎÈÔ˘Ï¤Î·˜, ¢. ªÔ‡ÚÔ˜, ¢. ¶·Ù¿Î·˜ ....... 65
Z. ¶ÔÏ˘ÌÂÓ›‰Ë˜
X. ¶··ÛÙÂÚÈ¿‰Ë ∏ Û˘ÌÌÂÙÔ¯‹ ÙˆÓ ÚÂÙÚÔ˚ÒÓ ÛÙËÓ ·ÓÔÛÔ·ıÔÁ¤ÓÂÈ· Ù˘ ÓfiÛÔ˘ Graves
M. ¢·ÓÈËÏ›‰Ë˜ °. ΔÛÈڷΛ‰Ë˜, ª. ¢·ÓÈËÏ›‰Ë˜, °. ∫ÔηڿÎË, ∑. ¶ÔÏ˘ÌÂÓ›‰Ë˜, ¡. ∫·Ú·ÓÙ¿ÓË,
°. K˘ÚÈ·˙‹˜ º. ÷ÚÛÔ‡Ï˘ ........................................................................................................................ 73
K·ıËÁËÙ¤˜ AÓÔÛÔÏÔÁ›·˜
M. P·ÙÔÔ‡ÏÔ˘-°ÈÁ‹ ∏ ¤ÎÊÚ·ÛË ÙÔ˘ ˘Ô‰Ô¯¤· Ù˘ IL-2 ÛÙ· Δ-ÏÂÌÊÔ·ÙÙ·Ú· ·ÛıÂÓÒÓ
º. K·Ó·ÎÔ‡‰Ë-T۷ηϛ‰Ô˘
¶. ªÔ‡Ú·
Ì ȉÈÔ·ı‹ ‰È·Ù·ÙÈ΋ Ì˘ÔηډÈÔ¿ıÂÈ·. ∏ Â›‰Ú·ÛË Ù˘ ·ÓıÚÒÈÓ˘
EΉfiÙ˜ ηډȷ΋˜ Ì˘ÔÛ›Ó˘
A. M¿ÓıÔ˜ π. ∂˘ı˘ÌÈ¿‰Ë˜, ¶. ™Î¤Ó‰ÚÔ˜, ∞. ™·Ú·ÓÙfiÔ˘ÏÔ˜, ¶. ªÔ‡Ú· .................................. 81
A. °ÂÚÌÂÓ‹˜
°. B¤ÚÁÔ˘Ï·˜ ªÂϤÙË Ù˘ Â›‰Ú·Û˘ ÙˆÓ Gram ·ÚÓËÙÈÎÒÓ Î·È Gram ıÂÙÈÎÒÓ
E¶ITPO¶H E¶IME§EIA™ ™YNTA•H™ ÙÔÍÈÓÒÓ ÛÙ· ÌÔÓÔ·ÙÙ·Ú·-ÂÓ‰ÔıËÏȷο ·ÙÙ·Ú·
A. ™·Ú·ÓÙfiÔ˘ÏÔ˜
¶. ™Î¤Ó‰ÚÔ˜ π. ∫˘ÚÈ·ÎÔÔ‡ÏÔ˘, L. Reynolds, ∂. πˆ·ÓÓ›‰Ô˘, ™. ÷ڷϷÌ›‰Ô˘,
∫. ΔÛ¤ÏÈÔ˜ π. ∫ψÓÈ˙¿Î˘ .......................................................................................................................... 89
Y¶OBO§H AP£PøN-™YN¢POME™
°È· ÙÔ ÂÚÈÔ‰ÈÎfi √ ˘Ô‰Ô¯¤·˜ ÙˆÓ ÔÈÛÙÚÔÁfiÓˆÓ ER· Ú˘ıÌ›˙ÂÈ ÙËÓ ¤ÎÊÚ·ÛË ÙÔ˘
¶. ªÔ‡Ú· ∏·ÙÈÎÔ‡ ¶˘ÚËÓÈÎÔ‡ ¶·Ú¿ÁÔÓÙ· HNF3· ÛÙÔÓ Î·ÚΛÓÔ ÙÔ˘ Ì·ÛÙÔ‡
ΔÌ‹Ì· ∫ÏÈÓÈ΋˜ ∞ÓÔÛÔÏÔÁ›·˜ μ′ ¶·ıÔÏÔÁÈ΋˜ ∫ÏÈÓÈ΋˜ ∞¶£
πÔÎÚ¿ÙÂÈÔ °.¶.N.£. | ∫ˆÓÛÙ·ÓÙÈÓÔ˘fiψ˜ 49 Ã.£. ∫·Ú·‰¤‰Ô˘, ª. ¢·ÓÈËÏ›‰Ë˜, ∫. °È·ÓÓÔ‡Ï˘, ∂. °È·ÓÓÔ‡Ï˘ .............................. 97
546 42 £ÂÛÛ·ÏÔÓ›ÎË | TËÏ. 2310 892239 & 2310 992810
e-mail: anosia@universitystudiopress.gr
EÙ‹ÛÈ· Û˘Ó‰ÚÔÌ‹ € 30,00
ºˆÙÔÁÚ·Ê›· Â͈ʇÏÏÔ˘: ∞ÂÈÎfiÓÈÛË ÙÔ˘ ÂÓ‰Ô΢ÙÙ¿ÚÈÔ˘ ÂÈÎÔÈÓˆÓÈ·ÎÔ‡ ‰ÈÎÙ‡Ô˘, ̤ۈ ÙÔ˘ ÔÔ›Ô˘, ÙÔ
Y¶EY£YNO™ TY¶O°PAºEIOY-¢IAºHMI™EøN ›‰ÈÔ ÂÓÈ·›Ô ÁÂÁÔÓfi˜ ÂÓÂÚÁÔÔÈ› ‰È·ÊÔÚÂÙÈο ‚ÈÔÏÔÁÈο ÚÔÁÚ¿ÌÌ·Ù·, ‰›ÓÔÓÙ·˜ ÙÔ ÁÂÓÂÙÈÎfi ÏÂÔÓ¤ÎÙË-
UNIVERSITY STUDIO PRESS
Ì· Û ¿ÙÔÌ· ÙÔ˘ ÂÓfi˜ ÏËı˘ÛÌÔ‡. ¶·Ú¤Ì‚·ÛË ÛÙ· ÛËÌ›· ÂϤÁ¯Ô˘ (check points) ÙˆÓ ‚ÈÔÏÔÁÈÎÒÓ ÚÔ-
§ÂˆÓ›‰·˜ A. Mȯ¿Ï˘
AÚÌÂÓÔÔ‡ÏÔ˘ 32, 546 35 £ÂÛÛ·ÏÔÓ›ÎË ÁÚ·ÌÌ¿ÙˆÓ ·ÔÙÂÏ› ‰˘ÓËÙÈÎfi ıÂÚ·¢ÙÈÎfi ÛÙfi¯Ô.
TËÏ. 2310 209637, 2310 209837, Fax 2310 216647 ∞.£. ∫·ÏÔÁÂÚ›‰Ë˜. °ÂÓˆÌÈ΋ – ¶ÚˆÙˆÌÈ΋ – ∫˘ÙÙ·ÚˆÌÈ΋: ∂Ê·ÚÌÔÁ¤˜ Ì Ӥ˜ ÚÔÔÙÈΤ˜ ÛÙËÓ ∞ÓÔ-
E-mail: info@universitystudiopress.gr ÛÔÏÔÁ›·. ∞ÓÔÛ›· 2007; ™˘ÌÏËڈ̷ÙÈÎfi Ù‡¯Ô˜: 107-115.

3. anosia
TRIMESTRAL EDITION OF
THE HELLENIC SOCIETY OF IMMUNOLOGY
ISSN 1790-6490 VOLUME 3 ñ NUMBER 1-2
HELLENIC
SOCIETY OF
IMMUNOLOGY
Meandrou 23, 115 28 Athens |
Tel. + 30 210 7211845 | F·¯: + 30 210 7215082 |
E-mail: helsocimmun@yahoo.com |
contents
http: //mednet.gr/hsi
BOARD OF H.S.I.
President : P. Boura
Vice President : Ch. Nikolaou Etiopathogenetic mechanisms in Adamantiades-Behçet disease
General Secretary: F. Palioyianni
Specific Secretary : A. Tsiroyianni
Ph. Kaklamanis, E. Kaklamani .............................................................................................. 7
Treasurer : O. Moraloglou-Benetou
Members : Ch. Antzou-Agouridaki
Chronic hepatitis II – Chronic Hepatitis C
Th. Keramitsoglou E. Gigi, M. Raptopoulou-Gigi ............................................................................................... 17
EDITORIAL BOARD
Editor in Chief : P. Boura The complement in renal vascular diseases
Co-editors K. Paletas .................................................................................................................................. 35
Ch. Nikolaou
F. Palioyianni Ageing and the immune system
A. Tsiroyianni P. Skendros .............................................................................................................................. 40
O. Moraloglou-Benetou
Ch. Antzou-Agouridaki Genomics: a major challenge for the future of immunology
Th. Keramitsoglou
ADVISORY COMMITTEE
A. Kalogeridis ........................................................................................................................... 44
Board of Presidents of H.S.I.
† M. Pavlatou
Immunophenotyping study of alveolar cells in patients with
I. Ekonomidou connective tissue diseases and lung involvement
E. Kaklamani D. Papakosta, K. Manika, G. Kiriazis, A. Garifallos, Th. Kontakiotis,
A. Stavropoulou-Gioka
M. Varla-Leftherioti Th. Polizoni, P. Argiropoulou, D. Gioulekas, D. Bouros, D. Patakas ........................ 65
Z. Polymenidis
Ch. Papasteriadi Retroviruses in immunopathogenesis of Graves’ disease
M. Daniilidis G. Tsirakidis, M. Daniilidis, G. Kokaraki, Z. Polimenidis, N. Karadani,
G. Kiriazis Ph. Harsoulis ............................................................................................................................ 73
Professors of Immunology
M. Raptopoulou-Gigi T lymphocyte interleukin-2 receptor expression in patients with
F. Kanakoudi-Tsakalidou
P. Boura
idiopathic dilated cardiomyopathy: the effect of human cardiac
Editors myosin
A. Manthos J. Efthimiadis, P. Skendros, A. Sarantopoulos, P. Boura .............................................. 81
A. Germenis
G. Vergoulas The effect of Gram (–) and Gram (+) toxins on monocytes
EDITORIAL ASSISTANT COMMITTEE and endothelial cells
A. Sarantopoulos
P. Skendros J. Kiriakopoulou, L. Reynolds, E. Ioannidou, S. Haralambidou, J. Klonizakis ......... 89
K. Tselios
Estrogen receptor · (ER·) regulates the expression of Hepatic
SUBMISSION OF ARTICLES-SUBSCRIPTIONS
anosia Nuclear Factor 3· (HNF3·) in breast cancer
P. Boura, editor-in-chief C. Karadedou, M. Daniilidis, K. Giannoulis, E. Giannoulis .......................................... 97
Clinical Immunology Unit, 2nd Medical Clinic, Hippokratio
Gen. Hospital of Thessaloniki. |49 Konstantinoupoleos Str.
546 42 Thessaloniki, Greece
TËÏ. +30 2310 892239 & +30 2310 992810
e-mail: anosia@universitystudiopress.gr
Annual subscription € 30,00 Cover Figure: The intracellular transduction pathway. The same extracellular stimuli activate different
biological programs, offering the genetic advantage in certain members of a population. Manipulation of the
PUBLISHER
check points represents a potent therapeutic target.
UNIVERSITY STUDIO PRESS
A. Kalogeridis. Genomics – Proteomics – Cytomics: Prospective applications in Immunology: Anosia 2002;
Leonidas A. Michalis
Armenopoulou 32, 546 35 Thessaloniki Suppl: 107-115.
Tel. 2310 209637, 2310 209837, Fax 2310 216647
E-mail: info@universitystudiopress.gr

4. ∞Ó·ÛÎfiËÛË
∞ÈÙÈÔ·ıÔÁÂÓÂÙÈÎÔ› Ì˯·ÓÈÛÌÔ› ÛÙË ÓfiÛÔ
A‰·Ì·ÓÙÈ¿‰Ë-Behçet
º. ∫·ÎÏ·Ì¿Ó˘1, ∂. ∫·ÎÏ·Ì¿ÓË2
1 K·ıËÁËÙ‹˜ ƒÂ˘Ì·ÙÔÏÔÁ›·˜
2 ∫·ıËÁ‹ÙÚÈ· ÀÁÈÂÈÓ‹˜ Î·È ∂ȉËÌÈÔÏÔÁ›·˜, ∂ıÓÈÎfi Î·È ∫·Ô‰ÈÛÙÚÈ·Îfi ¶·ÓÂÈÛÙ‹ÌÈÔ ∞ıËÓÒÓ
2007; 3, 1-2: 7 – 16
¶∂ƒI§∏æ∏
∏ ÓfiÛÔ˜ ∞‰·Ì·ÓÙÈ¿‰Ë-Behçet Â›Ó·È ¯ÚfiÓÈ· ÔÏ˘Û˘ÛÙËÌ·ÙÈ΋ ·ÁÁÂÈ›Ùȉ· Ì ·ÚȘ ÎÏÈÓÈΤ˜ ÂΉËÏÒÛÂȘ ÙȘ ˘ÔÙÚÔÈ¿˙Ô˘Û˜
·ÊıÒ‰ÂȘ ÂÍÂÏÎÒÛÂȘ ÙÔ˘ ÛÙfiÌ·ÙÔ˜ Î·È ÙˆÓ ÁÂÓÓËÙÈÎÒÓ ÔÚÁ¿ÓˆÓ, ηıÒ˜ Î·È ‚Ï¿‚˜ ÙÔ˘ ‰¤ÚÌ·ÙÔ˜ Î·È ÙˆÓ ÔÊı·ÏÌÒÓ. ∏ ·ÈÙÈÔ-
ÏÔÁ›· Ù˘ ÓfiÛÔ˘ ·Ú·Ì¤ÓÂÈ ÂÓ ÔÏÏÔ›˜ ¿ÁÓˆÛÙË, ˆÛÙfiÛÔ Î·Ù·‰ÂÈÎÓ‡ÂÙ·È Ù· ÙÂÏÂ˘Ù·›· ¤ÙË fiÙÈ ÁÂÓÂÙÈÎÔ› Î·È ÂÚÈ‚·ÏÏÔÓÙÈÎÔ› ·-
Ú¿ÁÔÓÙ˜ ¤¯Ô˘Ó ȉȷ›ÙÂÚË ı¤ÛË ÛÙËÓ ·ıÔÁ¤ÓÂÛ‹ Ù˘. ∏ ·ÚÔ˘Û›· ÙÔ˘ ·ÏÏËÏ›Ô˘ HLA-B51 Û¯ÂÙ›˙ÂÙ·È Ì ·˘ÍË̤ÓË ÂȉÂÎÙÈÎfiÙË-
Ù· Î·È ‚·Ú‡ÙÂÚË ÓfiÛÔ. ∂˘Ú‡ Ê¿ÛÌ· ·ıÔÁfiÓˆÓ ÌÈÎÚÔÔÚÁ·ÓÈÛÌÒÓ ¤¯Ô˘Ó ÂÓÔ¯ÔÔÈËı› ÁÈ· ÂΉËÏÒÛÂȘ ·˘ÙÔ·ÓfiÛÔ˘ Ù‡Ô˘ ̤-
Ûˆ Ì˯·ÓÈÛÌÒÓ ÌÔÚÈ·ÎÔ‡ ÌÈÌËÙÈÛÌÔ‡. ¶·Ú¿ÏÏËÏ·, ¤¯Ô˘Ó ‰È·ÈÛÙˆı› ‰È·Ù·Ú·¯¤˜ Û ‰È¿ÊÔÚ· Â›‰· Ù˘ ·ÓÔÛȷ΋˜ ·fiÎÚÈ-
Û˘, Ô˘ ÂÌϤÎÔ˘Ó ÙfiÛÔ ÙË Ê˘ÛÈ΋ fiÛÔ Î·È ÙËÓ ÂȉÈ΋ ·ÓÔÛ›·, ¯ˆÚ›˜ ˆÛÙfiÛÔ Ó· ¤¯ÂÈ Î·Ù·‰Âȯı› ÂȉÈ΋ ÁÈ· ÙË ÓfiÛÔ ‚Ï¿‚Ë. ™ÎÔ-
fi˜ Ù˘ ·ÚÔ‡Û·˜ ÌÂϤÙ˘ Â›Ó·È Ë ·Ó·ÛÎfiËÛË Ù˘ Û‡Á¯ÚÔÓ˘ ‚È‚ÏÈÔÁÚ·Ê›·˜, fiÛÔÓ ·ÊÔÚ¿ ÛÙËÓ ·ÈÙÈÔ·ıÔÁ¤ÓÂÈ· Ù˘ ÓfiÛÔ˘, ÌÂ
ȉȷ›ÙÂÚË ¤ÌÊ·ÛË ÛÙȘ ÂÈ̤ÚÔ˘˜ ‰È·Ù·Ú·¯¤˜ ÙÔ˘ ·ÓÔÛÈ·ÎÔ‡ Û˘ÛÙ‹Ì·ÙÔ˜.
§¤ÍÂȘ-ÎÏÂȉȿ: NfiÛÔ˜ ∞‰·Ì·ÓÙÈ¿‰Ë-μehçet, ·ÓÔÛÔ·ıÔÁ¤ÓÂÈ·, ÁÂÓÂÙÈ΋ ÚԉȿıÂÛË.
H ÓfiÛÔ˜ A‰·Ì·ÓÙÈ¿‰Ë-Behçet (∞μ) Â›Ó·È ÔÏ˘Û˘- ıÔÁ¤ÓÂÈ· Ù˘ ÓfiÛÔ˘ Â›Ó·È ÔÏ˘·Ú·ÁÔÓÙÈ΋ Î·È Û˘Ì-
ÛÙËÌ·ÙÈ΋, ¯ÚfiÓÈ·, ÊÏÂÁÌÔÓ҉˘, ˘ÔÙÚÔÈ¿˙Ô˘Û· ÌÂÙ¤¯Ô˘Ó ÁÂÓÂÙÈÎÔ› Î·È ÂÚÈ‚·ÏÏÔÓÙÈÎÔ› ·Ú¿ÁÔÓÙ˜,
Ì ·ÚȘ ÎÏÈÓÈΤ˜ ÂΉËÏÒÛÂȘ ÙȘ ¿Êı˜ ÛÙfiÌ·ÙÔ˜, Ù· ÂÓÒ ‰È·ÈÛÙÒÓÔÓÙ·È ‰È·Ù·Ú·¯¤˜ ÙÔ˘ ·ÓÔÛÈ·ÎÔ‡ Û˘-
¤ÏÎË ÙˆÓ ÁÂÓÓËÙÈÎÒÓ ÔÚÁ¿ÓˆÓ, ÙËÓ ÚÔÛ‚ÔÏ‹ ÙÔ˘ ÛÙ‹Ì·ÙÔ˜4,6,7. √È ·ÓÔÛȷΤ˜ ‰È·Ù·Ú·¯¤˜ ‰ÂÓ ÏËÚÔ‡Ó
ÔÊı·ÏÌÔ‡, ÙÔ˘ ‰¤ÚÌ·ÙÔ˜, ÙÔ˘ Ì˘ÔÛÎÂÏÂÙÈÎÔ‡ Û˘ÛÙ‹- Ù· ÎÚÈÙ‹ÚÈ· Ù˘ ·ÌÈÁÔ‡˜ ·˘ÙÔ·ÓÔÛ›·˜8, ÒÛÙÂ Ë ÓfiÛÔ˜
Ì·ÙÔ˜ Î·È ÙȘ ‚Ï¿‚˜ ÙÔ˘ ÎÂÓÙÚÈÎÔ‡ Ó¢ÚÈÎÔ‡ Û˘ÛÙ‹- Ó· ıˆÚËı› ·˘ÙÔ¿ÓÔÛÔ˜. √È ‚Ï¿‚˜ ÙˆÓ ·ÁÁ›ˆÓ ›-
Ì·ÙÔ˜1,2. ∫‡ÚÈ· ÁÓˆÚ›ÛÌ·Ù· Ù˘ ÓfiÛÔ˘ Â›Ó·È Ë ÂÚÈÔ- Ó·È ÛËÌ·ÓÙÈÎfi ÎÏÈÓÈÎÔÂÚÁ·ÛÙËÚÈ·Îfi ‡ÚËÌ· Î·È ı·
‰È΋ Î·È Ë Î·Ù¿ Ì·ÎÚ¤˜ ÂÚÈfi‰Ô˘˜ ÂÌÊ¿ÓÈÛË ÙˆÓ ÎÏÈ- ÌÔÚÔ‡ÛÂ Ë ÓfiÛÔ˜ Ó· ηٷٷÁ› ÛÙËÓ Â˘Ú›· ÔÈÎÔÁ¤-
ÓÈÎÒÓ Â˘ÚËÌ¿ÙˆÓ Î·È Ë ¤ÏÏÂÈ„Ë ·ıÔÁÓˆÌÔÓÈ΋˜ ÎÏÈ- ÓÂÈ· ÙˆÓ Û˘ÛÙËÌ·ÙÈÎÒÓ ·ÁÁÂÈÈÙ›‰ˆÓ9. ¶ÚfiÛÊ·Ù· ·Îfi-
ÓÈ΋˜ ÂΉ‹ÏˆÛ˘ ‹ ÂÚÁ·ÛÙËÚÈ·ÎÔ‡ Â˘Ú‹Ì·ÙÔ˜1-3. Ì· Û˘˙ËÙÂ›Ù·È Ë Û¯¤ÛË Ù˘ Ì ٷ ηÏÔ‡ÌÂÓ· ÎÏËÚÔ-
∏ ÌÂÁ·Ï‡ÙÂÚË Û˘¯ÓfiÙËÙ· Ù˘ ÓfiÛÔ˘ ‰È·ÈÛÙÒ- ÓÔÌÈο ·˘ÙÔÊÏÂÁÌÔÓÒ‰Ë ÓÔÛ‹Ì·Ù·10. ¶Ú¤ÂÈ fï˜
ÓÂÙ·È ÛÙËÓ Õˆ ∞Ó·ÙÔÏ‹, ÛÙË ª¤ÛË ∞Ó·ÙÔÏ‹ Î·È ÛÙȘ Ó· ÛËÌÂȈı› fiÙÈ ÌÂÙ¿ ·fi Û‡ÁÎÚÈÛË ÙˆÓ ÎÏÈÓÈÎÔÂÚ-
¯ÒÚ˜ Ù˘ ªÂÛÔÁ›Ԣ1,3,4. ¶ÚÔÛ‚¿ÏÏÔÓÙ·È Î·È Ù· ‰‡Ô Á·ÛÙËÚÈ·ÎÒÓ Â˘ÚËÌ¿ÙˆÓ ÚÔ·ÙÔ˘Ó ÛËÌ·ÓÙÈΤ˜
ʇϷ Û fiϘ ÙȘ ËÏÈ˘, Ì ‰È·ÊÔÚ¤˜ Û˘¯ÓfiÙËÙ·˜ ‰È·ÊÔÚ¤˜ ÌÂٷ͇ Ù˘ ÓfiÛÔ˘ ∞μ Î·È ÙˆÓ ·˘ÙÔÊÏÂÁ-
·Ó¿ÏÔÁ· Ì ÙȘ ÁˆÁÚ·ÊÈΤ˜ ÂÚÈÔ¯¤˜4,5. ∏ ·ÈÙÈÔ·- ÌÔÓˆ‰ÒÓ ÓÔÛËÌ¿ÙˆÓ, fiˆ˜ Ë ÔÏ˘ÁÔÓÈÎfiÙËÙ·, Ë

5. 8 ∞ÈÙÈÔ·ıÔÁÂÓÂÙÈÎÔ› Ì˯·ÓÈÛÌÔ› ÛÙË ÓfiÛÔ ∞‰·Ì·ÓÙÈ¿‰Ë-Behçet
Û¯¤ÛË Ì ÙÔ ∏LA Û‡ÛÙËÌ·, Ë ÎÏÈÓÈ΋ ÔÚ›· Î·È Ë ıÂ- ̤ÏË ÔÈÎÔÁÂÓÂÈÒÓ ·ÛıÂÓÒÓ. √È ÂÚ¢ÓËÙ¤˜ ·˘ÙÔ› ˘Ô-
Ú·¢ÙÈ΋ ·ÓÙ·fiÎÚÈÛË11. ÛÙËÚ›˙Ô˘Ó ÙË Û˘ÌÌÂÙÔ¯‹ ÁÂÓÂÙÈÎÒÓ Î·È ÂÚÈ‚·ÏÏÔÓÙÈ-
ÎÒÓ ·Ú·ÁfiÓÙˆÓ ÛÙËÓ ·ÈÙÈÔ·ıÔÁ¤ÓÂÈ· Ù˘ ÓfiÛÔ˘22.
1. ¶ÂÚÈ‚·ÏÏÔÓÙÈÎÔ› ·Ú¿ÁÔÓÙ˜ ∞ӷʤÚıËΠÂ›Û˘ ÚfiÛÊ·Ù· Û¯¤ÛË Ù˘ ÓfiÛÔ˘ ÌÂ
ÙÔ ÃϷ̇‰ÈÔ Ù˘ Ó¢ÌÔÓ›·˜23 Î·È ÙÔ ª˘ÎfiÏ·ÛÌ·
∏ Û˘¯ÓfiÙËÙ· Ù˘ ÓfiÛÔ˘ ∞μ ÛÙÔÓ ÁÂÚÌ·ÓÈÎfi ÏËı˘- fermentans24.
ÛÌfi Â›Ó·È 0,30 ·Ó¿ 100.000 ηÙÔ›ÎÔ˘˜. ∏ ÌÂÁ·Ï‡ÙÂÚË T· ‰È¿ÊÔÚ· ›‰Ë ÛÙÚÂÙfiÎÔÎÎÔ˘ (S. sanguis, S.
ÂıÓÈ΋ Û˘¯ÓfiÙËÙ· Â›Ó·È ÙÔ˘ÚÎÈ΋˜ ÚÔ¤Ï¢Û˘ (ÂıÓÈ- pyogenes, S. salivarius) ‰ÈηÈÔÏÔÁË̤ӷ ¤¯Ô˘Ó ÂÓÔ¯Ô-
΋ 15,13: 100.000 Î·È μÂÚÔÏ›ÓÔ˘ 77,37: 100.000)12. ÔÈËı› ˆ˜ ·ÈÙÈÔÏÔÁÈÎÔ› ·Ú¿ÁÔÓÙ˜ Ù˘ ÓfiÛÔ˘. √È
™ÙËÓ ∞Ó·ÙÔÏÈ΋ ΔÔ˘ÚΛ· Ë Û˘¯ÓfiÙËÙ· Î˘Ì·›ÓÂÙ·È ·fi ·ÛıÂÓ›˜ Ì ÓfiÛÔ ∞μ ¤¯Ô˘Ó Û ÌÂÁ¿ÏË Û˘¯ÓfiÙËÙ·
20-80: 100.000 ηÙÔ›ÎÔ˘˜13. Δ· ‰Â‰Ô̤ӷ ·˘Ù¿ ÛÙË- (70%) ÛÙÔÌ·ÙÔÊ·Ú˘ÁÁÈο Û˘ÌÙÒÌ·Ù·, fiˆ˜ ¿Êı˜,
Ú›˙Ô˘Ó ÙËÓ ¿Ô„Ë Ù˘ ·ÚÈ·˜ Â›‰Ú·Û˘ ÙˆÓ ÁÂÓÂÙÈ- ÏÔÈÌÒÍÂȘ ÚÈÓÔÊ¿Ú˘ÁÁ· Î·È ÙÂÚˉÔÓÈṲ̂ÓÔ˘˜ Ô‰fi-
ÎÒÓ ·Ú·ÁfiÓÙˆÓ14 Î·È ·ÓÙ›ÎÂÈÓÙ·È Û ÚÔËÁÔ‡ÌÂÓ˜ ÓÙ˜. ∞ӷʤÚÂÙ·È Â›Û˘ ˘ÂÚ¢·ÈÛıËÛ›· ÌÂÙ¿ ·fi
·Ú·‰Ô¯¤˜ Ù˘ Û˘ÌÌÂÙÔ¯‹˜ ÙˆÓ ÂÚÈ‚·ÏÏÔÓÙÈÎÒÓ ÂÓ‰Ô‰ÂÚÌÈ΋ ¤Á¯˘ÛË ÛÙÚÂÙÔÎÔÎÎÈÎÔ‡ ·ÓÙÈÁfiÓÔ˘,
·Ú·ÁfiÓÙˆÓ. ∞ÓÙ›ıÂÙ·, Ë ÓfiÛÔ˜ Â›Ó·È Û¯Â‰fiÓ ¿ÁÓˆ- ÂÓÒ ‚ÂÏÙÈÒÓÔÓÙ·È ÙfiÛÔ ÔÈ ·ÚıÚÈΤ˜ fiÛÔ Î·È ÔÈ ‚ÏÂÓ-
ÛÙË Û π¿ˆÓ˜ Ô˘ ¤¯Ô˘Ó ÌÂÙ·Ó·ÛÙ‡ÛÂÈ ÛÙËÓ Ã·- ÓÔÁÔÓÈΤ˜ ÂΉËÏÒÛÂȘ Ù˘ ÓfiÛÔ˘ ÌÂÙ¿ ·fi ıÂÚ·›·
‚¿Ë Î·È ÛÙËÓ ∞ÌÂÚÈηÓÈ΋ ◊ÂÈÚÔ15, ·Ú¿ ÙË ÌÂÁ¿ÏË Ì ÂÓÈÎÈÏÏ›ÓË Î·È ÎÔϯÈΛÓË7,25,26. Œ¯ÂÈ ‰È·ÈÛÙˆı› fiÙÈ
Û˘¯ÓfiÙËÙ· Ù˘ ÓfiÛÔ˘ ÛÙËÓ π·ˆÓ›·. Δ· ·ÓˆÙ¤Úˆ Ù· ÛÙÚÂÙÔÎÔÎÎÈο ·ÓÙÈÁfiÓ· ¢ԉÒÓÔ˘Ó ÙËÓ ·Ú·-
˘Ô‰ËÏÒÓÔ˘Ó fiÙÈ ÂÎÙfi˜ ÙˆÓ ÁÂÓÂÙÈÎÒÓ ·Ú·ÁfiÓÙˆÓ ÁˆÁ‹ Ù˘ ÈÓÙÂÚÊÂÚfiÓ˘-Á (IFN-Á) ·fi Ù· Δ ÏÂÌÊÔ-
Î·È ÔÈ ÂÚÈ‚·ÏÏÔÓÙÈΤ˜ ÂȉڿÛÂȘ ÌÂÙ¤¯Ô˘Ó ÛÙËÓ ÂÎ- ·ÙÙ·Ú· ·ÛıÂÓÒÓ Ì ÓfiÛÔ ∞μ27 Î·È ·˘Ùfi ·ÔÙÂÏ›
‰‹ÏˆÛË Ù˘ ÓfiÛÔ˘. ¤Ó‰ÂÈÍË Ù˘ Δ Î˘ÙÙ·ÚÈ΋˜ ˘ÂÚ¢·ÈÛıËÛ›·˜ Û ‰È¿-
ªÂ ÙË ÓfiÛÔ ∞μ ¤¯ÂÈ Î·Ù¿ ηÈÚÔ‡˜ Û˘Û¯ÂÙÈÛı› ¢- ÊÔÚ· ‚·ÎÙËÚȉȷο ·ÓÙÈÁfiÓ·, ÁÂÁÔÓfi˜ Ô˘ ›Ûˆ˜ Û¯Â-
Ú‡ Ê¿ÛÌ· ÏÔÈ̈‰ÒÓ ·Ú·ÁfiÓÙˆÓ, ¯ˆÚ›˜ fï˜ Ó· Ù›˙ÂÙ·È Ì ÙËÓ ·ıÔÁ¤ÓÂÈ· Ù˘ ÓfiÛÔ˘. ™˘ÌÂÚ·ÛÌ·ÙÈ-
¤¯Ô˘Ó ‰È·ÈÛÙˆı› ÛÙ·ıÂÚ¿ Î·È ÙÂÎÌËÚȈ̤ӷ Â˘Ú‹Ì·Ù·. ο, Ô ÛÙÚÂÙfiÎÔÎÎÔ˜ Â›Ó·È Èı·ÓfiÓ Ó· ÚÔηÏ› ÙÔ
√È ÈÔ› Ù˘ Ë·Ù›Ùȉ·˜ ∞, μ, C Î·È ∂ ¤¯Ô˘Ó ÂÓÔ- ¤Ó·˘ÛÌ· Ù˘ ÓfiÛÔ˘ Ì ÙË Û˘Ó¤ÚÁÂÈ· Î·È ¿ÏÏˆÓ ·-
¯ÔÔÈËı› ¯ˆÚ›˜ fï˜ Ó· ˘¿Ú¯Ô˘Ó ·ԉ›ÍÂȘ16,17. Ú·ÁfiÓÙˆÓ28.
ΔÔ Á¤ÓˆÌ· ÙÔ˘ ÈÔ‡ ∏SV ·ÔÌÔÓÒıËΠ·fi ÙÔÓ
˘Ú‹Ó· ÙˆÓ ÏÂÌÊÔ΢ÙÙ¿ÚˆÓ Î·È ·fi ‚ÈÔÏÔÁÈο ˘ÁÚ¿
¶ÚˆÙ½Ó˜ ÙÔ˘ ıÂÚÌÈÎÔ‡ shock (HSP)
·ÛıÂÓÒÓ Ì ÓfiÛÔ ∞μ, ÂÓÒ ‰È·ÈÛÙÒıËÎÂ Î·È ·˘ÍË̤-
ÓË Û˘¯ÓfiÙËÙ· ΢ÎÏÔÊÔÚÔ‡ÓÙˆÓ ·ÓÙÈÛˆÌ¿ÙˆÓ ¤Ó·ÓÙÈ √È ÚˆÙ½Ó˜ ·˘Ù¤˜ ·Ú¿ÁÔÓÙ·È ·fi Ù· ¢ηڢˆÙÈο
ÙÔ˘ ∏SV. ŸÙ·Ó fï˜ ÂÊ·ÚÌfiÛıËÎÂ Ë Ì¤ıÔ‰Ô˜ Ù˘ ·ÙÙ·Ú· ÌÂÙ¿ ·fi Â›‰Ú·ÛË ÔÏÏÒÓ ÂÚÂıÈÛÌ¿ÙˆÓ,
·Ï˘ÛȉˆÙ‹˜ ·ÓÙ›‰Ú·Û˘ ÔÏ˘ÌÂÚ¿Û˘ (PCR) ÛÙÔ fiˆ˜ Ë Ïԛ̈ÍË ·fi ‰È¿ÊÔÚÔ˘˜ ÌÈÎÚÔ‚È·ÎÔ‡˜ ·-
Û›ÂÏÔ, ÛÙ· ÂÚÈÊÂÚÈο Ï¢ÎÔ·ÙÙ·Ú· Î·È Û Âȯڛ- Ú¿ÁÔÓÙ˜, Ô ÙÚ·˘Ì·ÙÈÛÌfi˜, Ë ıÂÚÌfiÙËÙ·, ÙÔ „‡¯Ô˜
ÛÌ·Ù· ÛÙfiÌ·ÙÔ˜ ÁÈ· HSV-DNA ‰ÂÓ ·Ú·ÙËÚ‹ıËÎÂ Î·È ¿ÏÏ·. √È ÚˆÙ½Ó˜ ÙÔ˘ ıÂÚÌÈÎÔ‡ shock, ÂȉÈο Ë
‰È·ÊÔÚ¿ ÌÂٷ͇ ·ÛıÂÓÒÓ Î·È ˘ÁÈÒÓ Ì·ÚÙ‡ÚˆÓ7. ∏ ıÂ- 60/65 ∫D· (∏SP 65), Â›Ó·È Èı·ÓÔ› ·ÓÙÈÁÔÓÈÎÔ› ·Ú¿-
Ú·›· ÂÍ¿ÏÏÔ˘ Ì ·ÓÙÈÈο Ê¿Ú̷η (acyclovir) ‰ÂÓ ÁÔÓÙ˜ Ù˘ ÓfiÛÔ˘.
ÂËÚ¿˙ÂÈ Ù· ÛÙÔÌ·ÙÔÁÂÓÓËÙÈο ¤ÏÎË Ù˘ ÓfiÛÔ˘18, ·Ó ∞Ó¿ÏÔÁ˜ ÚˆÙ½Ó˜ ·Ú¿ÁÔÓÙ·È Î·È ·fi ÚÔ-
Î·È ÙÔ famciclovir ÙÚÔÔÔÈ› Ù· Û˘ÌÙÒÌ·Ù· Ù˘ Ófi- ηڢˆÙÈο ·ÙÙ·Ú·. ∏ ÚÔηڢˆÙÈ΋ 65∫D· ∏SP
ÛÔ˘ Û ÔÓÙ›ÎÈ·18. ÕÏÏÔ˜ Èfi˜ Ô˘ ˘ÔÙ›ıÂÙ·È fiÙÈ Û¯Â- ¤¯ÂÈ Ôχ ÛËÌ·ÓÙÈ΋ ·ÏÏËÏÔ˘¯›· Ì ÙËÓ ·ÓıÚÒÈÓË
Ù›˙ÂÙ·È Ì ÙË ÓfiÛÔ Â›Ó·È Ô ·Ú‚Ô˚fi˜19. ¶Ú¤ÂÈ Ó· ÛË- ÌÈÙÔ¯ÔӉȷ΋ 60 ∫D· ∏SP26. H 65 KD· ∏SP ·Ó¢ڛ-
ÌÂȈı› fiÙÈ Ì¤¯ÚÈ ÙÒÚ· ‰ÂÓ ¤¯ÂÈ ·Ó·ÊÂÚı› ÌÂÙ¿‰ÔÛË ÛÎÂÙ·È ÛÙ· ·Ó·ÊÂÚı¤ÓÙ· ›‰Ë ÛÙÚÂÙfiÎÔÎÎÔ˘ Ô˘
Ù˘ ÓfiÛÔ˘ ·fi ¿ÙÔÌÔ Û ¿ÙÔÌÔ7. ¤¯Ô˘Ó ÂÓÔ¯ÔÔÈËı› ÁÈ· ÙËÓ ·ÈÙÈÔÏÔÁ›· Ù˘ ÓfiÛÔ˘
ÕÏÏÔÈ ÌÈÎÚÔ‚È·ÎÔ› ·Ú¿ÁÔÓÙ˜ Ô˘ ÂÓÔ¯ÔÔÈ‹- ∞μ26. Δ· ÂÙ›‰È· Ô˘ ÚÔ¤Ú¯ÔÓÙ·È ·fi ÙË ÌÈÎÚÔ-
ıËηÓ, ¯ˆÚ›˜ fï˜ ·ԉ›ÍÂȘ ›ӷÈ: Ë μorrelia burg- ‚ȷ΋ 65KD· HSP Î·È Ù· ·ÓÙ›ÛÙÔȯ¿ Ù˘ 60 KD· HSP
dorferi, ÙÔ ÂÏÈÎÔ‚·ÎÙËÚ›‰ÈÔ ÙÔ˘ ˘ÏˆÚÔ‡20 Î·È Ô ™·Î- ÙˆÓ ıËÏ·ÛÙÈÎÒÓ, ÚÔηÏÔ‡Ó ·ÌÊfiÙÂÚ· ·˘ÙÔ·ÓÔÛ›·
¯·ÚÔ̇ÎËÙ·˜ cerevisiae. ∞ÓÙÈÛÒÌ·Ù· ¤Ó·ÓÙÈ ÙÔ˘ ™·Î- Ì ÔÌÔÏÔÁ›· ·ÏÏËÏÔ˘¯›·˜ 60%. ∞‰›¯ıË ÚfiÛÊ·-
¯·ÚÔ̇ÎËÙ· cerevisiae ‰È·ÈÛÙÒıËÎ·Ó Û ·ÛıÂÓ›˜ Ù· fiÙÈ ‰ÈÂÁ›ÚÔ˘Ó ÙË ÏÂÌÊÔ¸ÂÚÏ·ÛÙÈ΋ ·¿ÓÙËÛË
Ì ÓfiÛÔ ∞μ Î·È ÚÔÙ›ÓÔÓÙ·È Ù· ·ÓÙÈÛÒÌ·Ù· ·˘Ù¿ Û ·ÛıÂÓ›˜ Ì ÓfiÛÔ ∞μ7. Δ· ÂÙ›‰È· Ù˘ Ì˘ÎÔ‚·-
Û·Ó ‰Â›ÎÙ˘ ÂÓÂÚÁfiÙËÙ·˜ ÓfiÛÔ˘21. ™Â ÚfiÛÊ·ÙË ÌÂ- ÎÙËÚȷ΋˜ 65KDa HSP Î·È Ù˘ ·ÓıÚÒÈÓ˘ 60 KD·
ϤÙË ·fi ÙÔ˘˜ ›‰ÈÔ˘˜ Û˘ÁÁÚ·Ê›˜ ‰È·ÈÛÙÒıËΠfiÙÈ HSP Â›Ó·È ·˘ÍË̤ӷ Û ΔÔ‡ÚÎÔ˘˜ ·ÛıÂÓ›˜ Ì ÓfiÛÔ
Ù· ·ÓÙÈÛÒÌ·Ù· ·˘Ù¿ ‹Ù·Ó ·˘ÍË̤ӷ Â›Û˘ Û ˘ÁÈ‹ ∞μ Û˘ÁÎÚÈÙÈο Ì ̿ÚÙ˘Ú˜29. ™ÙË ÓfiÛÔ ∞μ ‰È·È-

6. º. ∫·ÎÏ·Ì¿Ó˘ Î·È Û˘Ó. 9
ÛÙÒıËΠÛÙ·ÙÈÛÙÈο ÛËÌ·ÓÙÈ΋ ¤ÎÊÚ·ÛË Ù˘ 60/65 ¶·ÚfiÌÔȘ ΢ÙÙ·ÚÈΤ˜ ‰ÈËı‹ÛÂȘ ·Ó¢ڛÛÎÔÓÙ·È
∫Da HSP Û ‚ÏÂÓÓÔÁÔÓÔ‰ÂÚÌ·ÙÈΤ˜ ‚Ï¿‚˜ Ù˘ Ófi- Î·È Û ¿ÏϘ ÈÛÙÈΤ˜ ‚Ï¿‚˜ Ù˘ ÓfiÛÔ˘. ªÂϤÙ˜ ÔÈ
ÛÔ˘30. Δ¤ÛÛÂÚ· ÂÙ›‰È· ÚÔÂÚ¯fiÌÂÓ· ·fi ÙËÓ 65 K Ôԛ˜ ·ÎÔÏÔ‡ıËÛ·Ó ·¤‰ÂÈÍ·Ó ·˘ÍË̤ÓË ÌÂÙ·Ó¿-
Da HSP Ì˘ÎÔ‚·ÎÙËÚȉ›Ô˘ Î·È Ù· ÔÌfiÏÔÁ· ÂÙ›‰È· ÛÙ¢ÛË ÔÏ˘ÌÔÚÊÔ‡ÚËÓˆÓ in vivo Û ·ÛıÂÓ›˜ ÌÂ
Ù˘ ·ÓıÚÒÈÓ˘ 60 K Da HSP ‰È·ÈÛÙÒıËÎ·Ó Î·Ù¿ ÙË ÂÓÂÚÁfi ÛÙ¿‰ÈÔ ÓfiÛÔ˘ ∞μ Ë ÔÔ›· Û ·ÓÂÓÂÚÁfi ÛÙ¿-
¯·ÚÙÔÁÚ¿ÊËÛË ÂÈÙfiˆÓ Δ Î˘ÙÙ¿ÚˆÓ Î·È ıˆڋıË- ‰ÈÔ ÔÌ·ÏÔÔÈ‹ıËΠ·ÓÂÍ¿ÚÙËÙ· Ù˘ ·Ô˘Û›·˜ ‹ Û˘-
Î·Ó ˘‡ı˘Ó· ÁÈ· ÙËÓ ·ÈÙÈÔ·ıÔÁ¤ÓÂÈ· Ù˘ ÓfiÛÔ˘31. Ó¯È˙fiÌÂÓ˘ ıÂÚ·›·˜38. ∂ÓÂÚÁÔÔÈË̤ÓË Ì˘ÂÏÔÂ-
∞fi ÚfiÛÊ·Ù˜ ÌÂϤÙ˜ ‰È·ÈÛÙÒıËΠfiÙÈ Ù· Δ ÚÔÍÂȉ¿ÛË Ï¿ÛÌ·ÙÔ˜, Ë ÔÔ›· ·ÓÙÈÚÔÛˆ‡ÂÈ ÙËÓ
Î·È μ ÏÂÌÊÔ·ÙÙ·Ú·, fiˆ˜ Î·È ÔÈ ÚˆÙ½Ó˜ ÙÔ˘ ıÂÚ- ÂÓÂÚÁÔÔ›ËÛË ÙˆÓ Ô˘‰ÂÙÂÚfiÊÈψÓ, ‚Ú¤ıËΠ·˘ÍË̤-
ÌÈÎÔ‡ shock, ÂËÚ¿˙Ô˘Ó ÙËÓ ÔÚ›· ÙˆÓ ÔÊı·ÏÌÈÎÒÓ ÓË ÂȉÈο Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘7. ∞˘Ùfi ˘Ô-
Î·È ‚ÏÂÓÓÔÁÔÓÔ‰ÂÚÌ·ÙÈÎÒÓ ‚Ï·‚ÒÓ Ù˘ ÓfiÛÔ˘ ∞μ Û˘- ‰ËÏÒÓÂÈ ÙË Û˘ÌÌÂÙÔ¯‹ ÙˆÓ ÂÓÂÚÁÔÔÈËÌ¤ÓˆÓ ÔÏ˘-
ÓÂ›· ÙˆÓ ·ÎfiÏÔ˘ıˆÓ ‰Â‰ÔÌ¤ÓˆÓ Î·È ·Ú·ÙËÚ‹ÛˆÓ: ÌÔÚÊÔ‡ÚËÓˆÓ ÛÙËÓ ·ÈÙÈÔ·ıÔÁ¤ÓÂÈ· Ù˘ ÓfiÛÔ˘
1) ·ÓÙÈÛÒÌ·Ù· ¤Ó·ÓÙÈ ‚·ÎÙËÚȉȷ΋˜ Î·È ·ÓıÚÒÈÓ˘ ∞μ7. ΔfiÛÔ Ë ¯ËÌÂÈÔÙ·Í›· ÙˆÓ Ô˘‰ÂÙÂÚfiÊÈÏˆÓ fiÛÔ
60/65 KD· HSP ¤¯Ô˘Ó ‰È·ÛÙ·˘ÚÔ‡ÌÂÓË ·ÓÙ›‰Ú·ÛË ÌÂ Î·È Ë Ê·ÁÔ΢ÙÙ¿ÚˆÛË Â›Ó·È ·˘ÍË̤ӷ Û ‰ÂÚÌ·ÙÈΤ˜
·ÓÙÈÁfiÓ· ÙÔ˘ ·ÌÊÈ‚ÏËÛÙÚÔÂȉԇ˜, 2) Ë ¤ÎıÂÛË Û ·ÏÏÔÈÒÛÂȘ Ù˘ ÓfiÛÔ˘39. Δ· Â›‰· Ù˘ ·Ú·ÁˆÁ‹˜
Â͈ÁÂÓ›˜ ‹ ÂÓ‰ÔÁÂÓ›˜ HSPs ÚÔηÏ› ÔÏÏ·Ï·ÛÈ·- ÙÔ˘ ˘ÂÚÔÍÂȉ›Ô˘ ·fi Ù· ÔÏ˘ÌÔÚÊÔ‡ÚËÓ· ·ÛıÂ-
ÛÌfi ÙˆÓ ÂÚÈÊÂÚÈÎÒÓ Δ ÏÂÌÊÔ΢ÙÙ¿ÚˆÓ ·ÛıÂÓÒÓ Ì ÓÒÓ, fiˆ˜ Î·È Ë ¯ËÌÂÈÔÙ·Í›· ÙÔ˘˜, ‹Ù·Ó ÛËÌ·ÓÙÈο
ÔÊı·ÏÌÈ΋ ÚÔÛ‚ÔÏ‹ Ù˘ ÓfiÛÔ˘ ∞μ ηÙ¢ı˘ÓfiÌÂÓÔ ˘„ËÏfiÙÂÚ· ·fi ·˘Ù¿ ÙˆÓ Ì·ÚÙ‡ÚˆÓ Î·È Û¯ÂÙ›˙ÔÓÙ·Ó
¤Ó·ÓÙÈ ·ÓÙÈÁfiÓˆÓ ·ÌÊÈ‚ÏËÛÙÚÔÂȉԇ˜ ̤ۈ Ì˯·ÓÈ- Ì ÙËÓ ‡·ÚÍË ÙÔ˘ HLA-B5139,40. ∏ ·˘ÍË̤ÓË ¯ËÌÂÈ-
ÛÌÔ‡ ÌÔÚÈ·ÎÔ‡ ÌÈÌËÙÈÛÌÔ‡, 3) ÙÔÈΤ˜ ‰ÂÚÌ·ÙÈΤ˜ ÔÙ·Í›· ÙˆÓ Ô˘‰ÂÙÂÚfiÊÈÏˆÓ Î·È Ë ·˘ÍË̤ÓË ·Ú·Áˆ-
‚Ï¿‚˜ Ù˘ ÓfiÛÔ˘ ÂÚȤ¯Ô˘Ó ·˘ÍË̤ÓÔ ·ÚÈıÌfi ·ÌÊÔ- Á‹ ˘ÂÚÔÍÂȉ›Ô˘ Î·È Ï˘ÛÔۈ̷ÙÈÎÒÓ ÂÓ˙‡ÌˆÓ ·Ó·Ì-
Ù¤ÚˆÓ 60 KD· HSP Î·È TCR Á‰+ T ÏÂÌÊÔ΢ÙÙ¿ÚˆÓ, ÊÈÛ‚‹ÙËÙ· ÚÔηÏÔ‡Ó ÈÛÙÈΤ˜ ‚Ï¿‚˜41.
4) Á‰+ Δ ÏÂÌÊÔ·ÙÙ·Ú· ·Ó¢ڛÛÎÔÓÙ·È Û ÛËÌ›· ∞ÎfiÌ·, Ù· ÌfiÚÈ· ÚÔÛÎfiÏÏËÛ˘ ÙˆÓ Ï¢ÎÔ΢Ù-
fiÔ˘ Ë ¤ÎÊÚ·ÛË Ù˘ 65 KD· HSP Â›Ó·È ¿ÊıÔÓË ÂȉÈ- Ù¿ÚˆÓ (P Î·È L Selectins, mac-1 Î·È CD44) ÂÎÊÚ¿˙Ô-
ο Û ÂȉÂÚÌÈΤ˜ ÂÚÈÔ¯¤˜ ÂÓÂÚÁÒÓ ‰ÂÚÌ·ÙÈÎÒÓ ÓÙ·È ÛÙ· ÂÚÈÊÂÚÈο Ï¢ÎÔ·ÙÙ·Ú· Î·È Ï·Ì‚¿ÓÔ˘Ó
‚Ï·‚ÒÓ, fiˆ˜ ÙÔ Ô˙҉˜ ÂÚ‡ıËÌ· Î·È ¿ÏϘ ‚ÏÂÓÓÔ- ̤ÚÔ˜ ÛÙÔÓ Î·Ù·ÚÚ¿ÎÙË Ù˘ ¯ËÌÂÈÔÙ·Í›·˜ Î·È ÚÔ-
ÁÔÓÔ‰ÂÚÌ·ÙÈΤ˜ ‚Ï¿‚˜ ·ÛıÂÓÒÓ Ì ÓfiÛÔ ∞μ Î·È Ù¤- ÛÎfiÏÏËÛ˘, ÂÓ‰ÂÈÎÙÈο ÙÔ˘ ÂÓÂÚÁÔÔÈË̤ÓÔ˘ ·ÓÔÛÈ·-
ÏÔ˜ 5) ÔÈ ·˘ÍË̤Ó˜ ∏SPs ¢ÓÔÔ‡Ó ÙË Ú‡ıÌÈÛË Ù˘ ÎÔ‡ Û˘ÛÙ‹Ì·ÙÔ˜ ÛÙË ÓfiÛÔ ∞μ7,42, 43.
¤ÎÊÚ·Û˘ ÙÔ˘ ÙfiÔ˘ ªπCA Û ·ÛıÂÓ›˜ Ì ÓfiÛÔ ∞μ
ÎÔÓÙ¿ ÛÙË ı¤ÛË HLA-B51017,30,32. 2‚. ªÔÓÔ‡ÚËÓ·
Œ¯ÂÈ Â›Û˘ ·Ó·ÊÂÚı› fiÙÈ Ù· ÂÙ›‰È· 336-351
Δ· ÌÔÓÔ·ÙÙ·Ú· ÛÙË ÓfiÛÔ ∞μ Â›Ó·È ÂÓÂÚÁÔÔÈ-
∏SP Â¿ÁÔ˘Ó ÔÏÏ·Ï·ÛÈ·ÛÌfi ÙˆÓ Δ Î˘ÙÙ¿ÚˆÓ ÛÙË
Ë̤ӷ in vivo Î·È ·Ú¿ÁÔ˘Ó ÊÏÂÁÌÔÓÒ‰ÂȘ ΢ÙÙ·ÚÔ-
ÓfiÛÔ ∞μ33. Δ· ÂÙ›‰È· ·˘Ù¿ (336-351) ¤¯Ô˘Ó ÌÂÁ¿-
ÏÔ ‚·ıÌfi ·ÓÙÈÁÔÓÈÎfiÙËÙ·˜ Î·È ÚÔηÏÔ‡Ó ÚfiÛıÈ· ΛÓ˜, ÔÈ Ôԛ˜ ·ÛÎÔ‡Ó ÛËÌ·ÓÙÈÎfi ÚfiÏÔ ÛÙË ¯ÚfiÓÈ·
Ú·ÁÔÂȉ›Ùȉ· fiÙ·Ó ¯ÔÚËÁÔ‡ÓÙ·È ·fi ÙÔ ÛÙfiÌ· ‹ ̤- ÊÏÂÁÌÔÓ‹ Ù˘ ÓfiÛÔ˘44. ∂›Û˘, ÛÙÔÓ ÔÚfi ·˘ÙÒÓ ÙˆÓ
Ûˆ ÙÔ˘ ÚÈÓÈÎÔ‡ ‚ÏÂÓÓÔÁfiÓÔ˘ Û ÔÓÙ›ÎÈ· Lewis Ô˘ ·ÛıÂÓÒÓ ‰È·ÈÛÙÒıËΠ·˘ÍË̤ÓÔ˜ Ô ‰È·Ï˘Ùfi˜ CD14,
·ÓÔÛÔÔÈ‹ıËÎ·Ó ˘Ô‰fiÚÈ· Ì ÂÓ‰ÔÂÚÈÙÔÓ·˚Îfi μ. Ô˘ ·ÔÙÂÏ› ‰Â›ÎÙË ÂÓÂÚÁÔÔ›ËÛ˘ ÙˆÓ ÌÔÓÔ΢ÙÙ¿-
pertusis Î·È ÂÓÈÛ¯˘ÙÈÎfi Freund34. ÚˆÓ. ∂ÈϤÔÓ, ‰Â›ÎÙ˜ ÂÓÂÚÁÔÔ›ËÛ˘/‰È·ÊÔÚÔÔ›Ë-
Û˘, fiˆ˜ ÂÎÊÚ¿˙ÔÓÙ·È Ì ÙÔ CD14 Î·È Ù· ÂÈÊ·ÓÂÈ-
·Î¿ ·ÓÙÈÁfiÓ·, Ô˘ ·ÓÙȉÚÔ‡Ó Ì ٷ ÌÔÓÔÎψÓÈο
2. AÓÔÛÈ·ÎÔ› Ì˯·ÓÈÛÌÔ› ·ÓÙÈÛÒÌ·Ù· 25F9 Î·È G-16/1, ·Ó¢ڛÛÎÔÓÙ·È Û ·˘-
2·. ¶ÔÏ˘ÌÔÚÊÔ‡ÚËÓ· Ï¢ÎÔ·ÙÙ·Ú· ÍË̤ÓÔ ·ÚÈıÌfi ÌÔÓÔ΢ÙÙ¿ÚˆÓ ÛÙË ÓfiÛÔ44. ∏ ·˘Ùfi-
Ì·ÙË Â›Û˘ ˘ÂÚ·Ú·ÁˆÁ‹ ÙÔ˘ Δ¡F·, IL-6 Î·È πL-8
∞˘ÍË̤ÓË ¯ËÌÂÈÔÙ·ÎÙÈ΋ ‰Ú·ÛÙËÚÈfiÙËÙ· ÙˆÓ ÔÏ˘-
·fi Ù· ÌÔÓÔ·ÙÙ·Ú· ÙˆÓ ·ÛıÂÓÒÓ Û¯ÂÙ›˙ÂÙ·È Ì ÙËÓ
ÌÔÚÊÔ‡ÚËÓˆÓ Ï¢ÎÔ΢ÙÙ¿ÚˆÓ ·Ó·Ê¤ÚıËΠÌÂÙ¿
ÂÓÂÚÁfiÙËÙ· Ù˘ ÓfiÛÔ˘45.
·fi Â›‰Ú·ÛË ¯ËÌÂÈÔÙ·ÎÙÈÎÒÓ ·Ú·ÁfiÓÙˆÓ35, Ë ÔÔ›·
‰ÂÓ ÂȂ‚·ÈÒıËΠ·fi ¿ÏÏÔ˘˜ ÂÚ¢ÓËÙ¤˜36. ∂›Ó·È fi-
̈˜ ·ԉ‰ÂÈÁ̤ÓÔ fiÙÈ ÛÙÔ ÛËÌÂ›Ô Ù˘ ·ÓÙ›‰Ú·Û˘ 2Á. μ-ÏÂÌÊÔ·ÙÙ·Ú·
·ı¤ÚÁÂÈ·˜ (Pathergy test), Ë ÔÔ›· ·ÓÙÈÚÔÛˆ‡ÂÈ ∞Ó Î·È Ë ·Ó·ÏÔÁ›· ÙˆÓ Î˘ÎÏÔÊÔÚÔ‡ÓÙˆÓ μ-ÏÂÌÊÔ-
ÌË ÂȉÈ΋ ˘ÂÚ·ÓÙȉڷÛÙÈÎfiÙËÙ· ÙˆÓ Ô˘‰ÂÙÂÚfiÊÈÏˆÓ Î˘ÙÙ¿ÚˆÓ ‰ÂÓ ‹Ù·Ó ·˘ÍË̤ÓË ÛÙË ÓfiÛÔ ∞μ, ‰È·È-
Û ÙÔÈÎfi ÂÚ¤ıÈÛÌ·, ·ıÚÔ›˙ÔÓÙ·È Ô˘‰ÂÙÂÚfiÊÈÏ·, Δ ÛÙÒıËΠÂÓÙÔ‡ÙÔȘ ÛÙ· μ ·ÙÙ·Ú· ÛËÌ·ÓÙÈ΋ ·‡ÍËÛË
ÏÂÌÊÔ·ÙÙ·Ú· Î·È ÌÔÓÔ·ÙÙ·Ú·/Ì·ÎÚÔÊ¿Á·37. Ù˘ ÌÂÌ‚Ú·ÓÈ΋˜ Û˘Ó‰Â‰Â̤Ó˘ πgA46. º˘ÛÈÔÏÔÁÈÎfi

7. 10 ∞ÈÙÈÔ·ıÔÁÂÓÂÙÈÎÔ› Ì˯·ÓÈÛÌÔ› ÛÙË ÓfiÛÔ ∞‰·Ì·ÓÙÈ¿‰Ë-Behçet
·ÚÈıÌfi μ-ÏÂÌÊÔ΢ÙÙ¿ÚˆÓ ‰È·›ÛÙˆÛ·Ó Î·È ¿ÏÏÔÈ ˘ÔÏÔÁÈṲ̂ÓË Ì ÙËÓ ∫562 ΢ÙÙ·ÚÔÙÔÍÈÎfiÙËÙ· ‰È·È-
ÂÚ¢ÓËÙ¤˜45. Δ· ·˘ÍË̤ӷ Â›‰· ÂÓÂÚÁÔÔÈËÌ¤ÓˆÓ ÛÙÒıËΠfiÙÈ ‹Ù·Ó ¯·ÌËÏ‹ ÏfiÁˆ ·ÓÒÚÈÌˆÓ Î˘ÙÙ¿ÚˆÓ
Î·È ˘ÔÙ‡ˆÓ ÌÓËÌÔÓÈÎÒÓ μ ΢ÙÙ¿ÚˆÓ ·Ô‰ÂÈÎÓ‡Ô˘Ó Ê˘ÛÈÎÒÓ ÊÔÓ¤ˆÓ Û ÂÓÂÚÁfi ÓfiÛÔ56. ∞˘ÍË̤ӷ Â›-
ÙÚÔÔÔÈË̤ÓË ÏÂÈÙÔ˘ÚÁ›· ÙˆÓ μ ΢ÙÙ¿ÚˆÓ, Ë ÔÔ›· ‰· ÙˆÓ Î˘ÙÙ¿ÚˆÓ ·˘ÙÒÓ ‚Ú¤ıËÎ·Ó ÌÂÙ¿ ·fi ‚·-
ÌÔÚ› Ó· Û¯ÂÙ›˙ÂÙ·È Ì ÂÚ¤ıÈÛÌ· ·fi ¿ÁÓˆÛÙÔ Â͈- ÎÙËÚȉȷ΋ ‰È¤ÁÂÚÛË Ì ‰‡Ô ‰È·ÊÔÚÂÙÈÎÔ‡˜ ÌÈÎÚÔÔÚ-
ÙÂÚÈÎfi ·ÓÙÈÁfiÓÔ46. √ ‰Â›ÎÙ˘ Ù˘ ΢ÙÙ·ÚÈ΋˜ ÂÈÊ¿- Á·ÓÈÛÌÔ‡˜57. ™Â ÚÔËÁÔ‡ÌÂÓË ÌÂϤÙË ·Ó¢ڤıËÎÂ
ÓÂÈ·˜, Ô˘ ·Ó¢ڛÛÎÂÙ·È Û ÂÓÂÚÁÔÔÈË̤ӷ ·ÙÙ·Ú· ·˘ÍË̤ÓÔ˜ ·ÚÈıÌfi˜ ΢ÎÏÔÊÔÚÔ‡ÓÙˆÓ Î˘ÙÙ¿ÚˆÓ Ê˘-
Î·È Î‡ÙÙ·Ú· ÌÓ‹Ì˘ (CD45R√), ηٷ‰Â›¯ıËΠÛËÌ·- ÛÈÎÒÓ ÊÔÓ¤ˆÓ Î·È ıˆڋıËΠfiÙÈ ¤¯ÂÈ ·ıÔÁÂÓÂÙÈ΋
ÓÙÈο ˘„ËÏfiÙÂÚÔ˜ Û ·ÛıÂÓ›˜ Ì ÓfiÛÔ ∞μ Î·È ¿ÏÏ· Û¯¤ÛË Ì ÙË ÓfiÛÔ.
ÓÔÛ‹Ì·Ù· Û˘ÁÎÚÈÙÈο Ì ˘ÁÈ›˜ Ì¿ÚÙ˘Ú˜47. ∂ÈϤÔÓ,
Ô ‰Â›ÎÙ˘ ÂÓÂÚÁfiÙËÙ·˜ CD80 ‹Ù·Ó ·˘ÍË̤ÓÔ˜ ÌfiÓÔ 3. πÓÙÂÚÏ¢ΛÓ˜
ÛÙË ÓfiÛÔ ∞μ.
3·. πÓÙÂÚÏ¢ΛÓË 1 (πL-1)
2‰. Δ-ÏÂÌÊÔ·ÙÙ·Ú· H ÈÓÙÂÚÏ¢ΛÓË 1‚ (πL -1‚) ‚Ú¤ıËÎÂ Ê˘ÛÈÔÏÔÁÈ΋ ‹
∞fi ÔÏϤ˜ ÌÂϤÙ˜ ·‰›¯ıË ÛÙË ÓfiÛÔ ∞μ ·˘ÍË- ·˘ÍË̤ÓË ÛÙË ÓfiÛÔ ∞μ. ∏ πL-1‚ ‰È·ÈÛÙÒıËΠfiÙÈ
̤ÓÔ˜ ·ÚÈıÌfi˜ Á‰ Δ Î˘ÙÙ¿ÚˆÓ Û˘ÁÎÚÈÙÈο Ì ̿ÚÙ˘- ‹Ù·Ó Ê˘ÛÈÔÏÔÁÈ΋ ÛÙÔÓ ÔÚfi ·ÛıÂÓÒÓ Ì ÓfiÛÔ ∞μ,
Ú˜46,48-50. Δ· ÂÓÂÚÁÔÔÈË̤ӷ Á‰ Δ Î‡ÙÙ·Ú·, Ô˘ fiˆ˜ Î·È ÛÙÔ˘˜ Ì¿ÚÙ˘Ú˜58. ÕÏÏÔÈ ÂÚ¢ÓËÙ¤˜ ‰È·›-
·Ú¿ÁÔ˘Ó πFN-Á Î·È Δ¡F-·, ·Ó¢ڛÛÎÔÓÙ·È ÛÙÔ ÂÚÈ- ÛÙˆÛ·Ó Ê˘ÛÈÔÏÔÁÈΤ˜ ÙÈ̤˜ Ù˘ πL-1 Û ·Û˘Ìو̷-
ÊÂÚÈÎfi ·›Ì·, ˘Ô‰ÂÈÎÓ‡ÔÓÙ·˜ fiÙÈ Ù· Á‰ Δ Î‡ÙÙ·Ú· ÙÈÎÔ‡˜ ·ÛıÂÓ›˜, ÌÂÙ¿ fï˜ ·fi ‰È¤ÁÂÚÛË ÂÚÈÊÂÚÈ-
Ú˘ıÌ›˙Ô˘Ó ‰˘Ó·ÌÈο ÙÔ˘˜ ·ÓÔÛÔ·ıÔÁÂÓÂÙÈÎÔ‡˜ ÌË- ÎÒÓ Ï¢ÎÔ΢ÙÙ¿ÚˆÓ Ì ÏÈÔÔÏ˘Û·Î¯·Ú›Ù˜ ÔÈ ÙÈ̤˜
¯·ÓÈÛÌÔ‡˜48. º·ÈÓÔÙ˘ÈÎÔ› ˘ÔÏËı˘ÛÌÔ› ÙˆÓ Á‰Δ Ù˘ ·˘Í‹ıËηÓ, ¯ˆÚ›˜ fï˜ Ó· Û¯ÂÙ›˙ÔÓÙ·È Ì ÙËÓ
΢ÙÙ¿ÚˆÓ CD45RA+CD45RO-VÁ9+V‰2+ ÚÔÊ·ÓÒ˜ ÂÓÂÚÁfiÙËÙ· Ù˘ ÓfiÛÔ˘59. ™Â ¿ÏÏË ÌÂϤÙË Â›Û˘ ‰È·-
Û˘ÌÌÂÙ¤¯Ô˘Ó Û ·ÓÔÛȷΤ˜ ‰È·Ù·Ú·¯¤˜, ÔÈ Ôԛ˜ ÈÛÙÒıËΠfiÙÈ ÔÈ Î˘ÙÙ·ÚÔΛÓ˜ πL-1· Î·È πL-1‚ ‰ÂÓ
Û¯ÂÙ›˙ÔÓÙ·È Ì ÙËÓ ·ıÔÊ˘ÛÈÔÏÔÁ›· Ù˘ ÓfiÛÔ˘51. ™Â ‹Ù·Ó ·˘ÍË̤Ó˜ ÛÙÔÓ ÔÚfi ÙˆÓ ·ÛıÂÓÒÓ60.
¿ÏÏË ÌÂϤÙË ‰È·ÈÛÙÒıËΠÈÛ¯˘Ú‹ ÛÙÚÔÊ‹ ÚÔ˜ Ù·
Δh1 ·ÙÙ·Ú·. Δ· ·ÙÙ·Ú· ·˘Ù¿ Û¯ÂÙ›˙ÔÓÙ·È Ì ÙËÓ 3‚. πÓÙÂÚÏ¢ΛÓË 2 (πL-2)
ÔÚ›· Ù˘ ÓfiÛÔ˘, ‰ÈfiÙÈ ·Ó¢ڛÛÎÔÓÙ·È ·˘ÍË̤ӷ Ù·
CD3+/IFNÁ+ Î·È CD3+/IL-2+ Û ·ÛıÂÓ›˜ Ì ÂÓÂÚÁfi ¢È·ÈÛÙÒıËΠfiÙÈ Ô ˘fiÙ˘Ô˜ ÙˆÓ Á‰ Δ Î˘ÙÙ¿ÚˆÓ
ÓfiÛÔ Û˘ÁÎÚÈÙÈο Ì ·ÛıÂÓ›˜ Ì Ï‹ÚË ‡ÊÂÛË Î·È CD45RA ÂͤÊÚ·˙ πL-2R‚ Î·È ∏LA-DR ÌfiÓÔ ÛÂ
˘ÁÈ‹ ¿ÙÔÌ·52. Δ· Á‰+ Δ Î‡ÙÙ·Ú· ·Ó¢ڛÛÎÔÓÙ·È Û ÂÓ- ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘, ˘Ô‰ÂÈÎÓ‡ÔÓÙ·˜ ÙËÓ ÂÓÂÚ-
‰ÔıËÏȷΤ˜ ÂÈÊ¿ÓÂȘ Î·È ÂÍ·ÛÎÔ‡Ó Ú˘ıÌÈÛÙÈÎfi Úfi- ÁÔÔ›ËÛË in vivo ÛÙÔ ÛÙ¿‰ÈÔ ·˘Ùfi Ù˘ ÓfiÛÔ˘51. √
ÏÔ Û ‰È¿ÊÔÚ˜ ·ÓÔÛȷΤ˜ ·ÔÎÚ›ÛÂȘ. ∏ ·Ó‡ÚÂÛ‹ ‰È·Ï˘Ùfi˜ ˘Ô‰Ô¯¤·˜ Ù˘ πL-2 (sIL2-R) ·Ó¢ڤıËÎÂ
ÙÔ˘˜ ÂÍ¿ÏÏÔ˘ Û ÛËÌ›· ÊÏÂÁÌÔÓ‹˜ ˘Ô‰ËÏÒÓÂÈ ÙË ·˘ÍË̤ÓÔ˜ ÛÙÔÓ ÔÚfi ·ÛıÂÓÒÓ Ì ÙË ÓfiÛÔ ∞μ59,61.
Û˘ÌÌÂÙÔ¯‹ ÙÔ˘˜ ÛÙËÓ ÙÔÈ΋ ÈÛÙÈ΋ ‚Ï¿‚Ë. ™Â Úfi- ™Â ÚfiÛÊ·ÙË ÌÂϤÙË ·Ó·Ê¤ÚıËÎ·Ó ·˘ÍË̤ӷ Â›Â-
ÛÊ·ÙË ÂÍ¿ÏÏÔ˘ ÌÂϤÙË ‰È·ÈÛÙÒıËΠfiÙÈ Ù· ‰· ÛÙÔÓ ÔÚfi ÙÔ˘ ‰È·Ï˘ÙÔ‡ ˘Ô‰Ô¯¤· Ù˘ πL-2 Î·È Ù·
CD4+CD25+ Ú˘ıÌÈÛÙÈο Δ Î‡ÙÙ·Ú· Â›Ó·È ·˘ÍË̤ӷ Â›‰· ·˘Ù¿ ‹Ù·Ó ÈÔ ·˘ÍË̤ӷ Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ
Û ÂÓÂÚÁfi ÓfiÛÔ Û˘ÁÎÚÈÙÈο Ì ·ÓÂÓÂÚÁfi ÓfiÛÔ Î·È Ù˘ ÓfiÛÔ˘62. ÕÏÏÔÈ ÂÚ¢ÓËÙ¤˜ ‚Ú‹Î·Ó Ê˘ÛÈÔÏÔÁÈΤ˜
˘ÁÈ›˜ Ì¿ÚÙ˘Ú˜53. Δ· Δh-1 ÏÂÌÊÔ·ÙÙ·Ú· ·Ú¿ÁÔ˘Ó ÙÈ̤˜ Ù˘ πL-2 ÛÙË ÓfiÛÔ ∞μ63. ∞ÓÙ›ıÂÙ·, Û ¿ÏÏË ÌÂ-
ÚÔÊÏÂÁÌÔÓÒ‰ÂȘ ΢ÙÙ·ÚÔΛÓ˜ (πL-2, IL-6, IL-8, IL- ϤÙË ‰È·ÈÛÙÒıËÎ·Ó Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘ ηÈ
12, IL-18, TNF-· Î·È πFN-Á) ÔÈ Ôԛ˜ Â›Ó·È ·˘ÍË̤Ó˜ Û ·ÛıÂÓ›˜ Ô˘ ‰ÂÓ ˘Ô‚¿ÏÏÔÓÙ·Ó Û ıÂÚ·›· ·˘-
ÛÙË ÓfiÛÔ ∞μ7. ÍË̤ӷ Â›‰· Ù˘ πL-2 Û˘ÁÎÚÈÙÈο Ì ·ÛıÂÓ›˜ ÛÂ
Δ· Δh-2 ÏÂÌÊÔ·ÙÙ·Ú· ·ÛÎÔ‡Ó ·ÓÙ›ıÂÙ˜ ‰Ú¿- ·ÓÂÓÂÚÁfi ÛÙ¿‰Èfi Ù˘64.
ÛÂȘ ·fi ·˘Ù¤˜ ÙˆÓ Δh-1 ΢ÙÙ¿ÚˆÓ ·ÎfiÌ· Î·È Û fiÙÈ
·ÊÔÚ¿ ÙËÓ ·Ú·ÁˆÁ‹ ÈÓÙÂÚÏ¢ÎÈÓÒÓ. 3Á. πÓÙÂÚÏ¢ΛÓË 4 (πL-4)
T· ÔÏ˘ÌÔÚÊÔ‡ÚËÓ· ·ÛıÂÓÒÓ Ì ÓfiÛÔ ∞μ ·Ú¿-
2Â. ∫‡ÙÙ·Ú· Ê˘ÛÈÎÔ› ÊÔÓ›˜ (¡∫) ÁÔ˘Ó ·˘ÍË̤ӷ Â›‰· πL-463 Î·È È‰È·›ÙÂÚ· Û ÂÓÂÚ-
√ ÚfiÏÔ˜ ÙˆÓ Î˘ÙÙ¿ÚˆÓ Ê˘ÛÈÎÒÓ ÊÔÓ¤ˆÓ ÛÙË ÓfiÛÔ Áfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘65. ∞ÓÙ›ıÂÙ·, ¿ÏÏÔÈ ÂÚ¢ÓËÙ¤˜
∞μ Â›Ó·È ·ÌÊÈÛ‚ËÙÔ‡ÌÂÓÔ˜. ™Â ‰È¿ÊÔÚ˜ ÌÂϤÙ˜ Ù· ‰ÂÓ ‰È·›ÛÙˆÛ·Ó ‰È·ÊÔÚ¿ ÙˆÓ ÂÈ¤‰ˆÓ Ù˘ πL-4 ÛÂ
·ÙÙ·Ú· ·˘Ù¿ Â›Ó·È Ê˘ÛÈÔÏÔÁÈο, Û ¿ÏϘ ÌÂȈ̤ӷ ‹ ·ÛıÂÓ›˜ Ì ÂÓÂÚÁfi, ·ÓÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘ ηÈ
·˘ÍË̤ӷ54-56. ∏ ÂÓÂÚÁfiÙËÙ· ÙˆÓ Î˘ÙÙ¿ÚˆÓ ·˘ÙÒÓ Û ÔÌ¿‰· ÂϤÁ¯Ô˘64,66.

8. º. ∫·ÎÏ·Ì¿Ó˘ Î·È Û˘Ó. 11
3‰. πÓÙÂÚÏ¢ΛÓË 6 (πL-6) ÓÔ˘Ó IL-2, IL-4, πL-10, IL-13 Û ·ÛıÂÓ›˜ Ì ÓfiÛÔ
∞μ63. ∞‡ÍËÛË ÂÓÙÔ‡ÙÔȘ Ù˘ πL-10 ·Ó·Ê¤ÚıËΠÌfiÓÔ
∏ ·˘ÙfiÌ·ÙË ·Ú·ÁˆÁ‹ Ù˘ IL-6 ·fi Ù· ÌÔÓÔ·ÙÙ·Ú·
Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘ ·fi ¿ÏÏÔ˘˜ ÂÚ¢ÓË-
‚Ú¤ıËΠ·˘ÍË̤ÓË È‰È·›ÙÂÚ· ÛÙÔ ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘
Ù¤˜65.
ÓfiÛÔ˘60. ∏ ‰È¤ÁÂÚÛË Ì ÏÈÔÔÏ˘Û·Î¯·Ú›Ù˜ Û˘ÓÂ-
¿ÁÔÓÙ·Ó ÛËÌ·ÓÙÈο ·˘ÍË̤ÓË ÈÓÙÂÚÏ¢ΛÓË 659. ∞ÓÙ›-
ıÂÙ·, ¿ÏÏÔÈ ÂÚ¢ÓËÙ¤˜ ‰ÂÓ ‰È·›ÛÙˆÛ·Ó ·‡ÍËÛË ·˘- 3˙. πÓÙÂÚÏ¢ΛÓË 12 (πL-12)
Ù‹˜ Ù˘ ÈÓÙÂÚÏ¢ΛÓ˘ ÛÙË ÓfiÛÔ58,67. ∏ ÔÏ˘ÏÂÈÙÔ˘Ú- H IL-12 Â›Ó·È ÈÛ¯˘Ú¿ ·ÓÔÛÔÚÚ˘ıÌÈÛÙÈ΋ Î·È Â˘ÓÔ› ÙË
ÁÈ΋ ÚÔÊÏÂÁÌÔÓ҉˘ ·˘Ù‹ ΢ÙÙ·ÚÔΛÓË ‚Ú¤ıËΠ‰È·ÊÔÚÔÔ›ËÛË Î·È ÙËÓ ˘ÂÚÏ·Û›· ÙˆÓ Δh1 ΢ÙÙ¿-
·˘ÍË̤ÓË ÛÙÔ ·ÓÂÓÂÚÁfi, ·ÏÏ¿ ΢ڛˆ˜ ÛÙÔ ÂÓÂÚÁfi ÚˆÓ52. ∏ IL-12 ·Ú¿ÁÂÙ·È ·fi Ù· ·ÓÙÈÁÔÓÔ·ÚÔ˘ÛÈ·-
ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘ Û˘ÁÎÚÈÙÈο Ì ̿ÚÙ˘Ú˜62. ∂›Û˘, ÛÙÈο ·ÙÙ·Ú· (Ì·ÎÚÔÊ¿Á· Î·È ‰ÂÓ‰ÚÈÙÈο ·ÙÙ·-
Û ÂÓÂÚÁfi Ó¢ÚÔÂÁÎÂÊ·ÏÈÎfi Û‡Ó‰ÚÔÌÔ Ù˘ ÓfiÛÔ˘ Ë Ú·)52. ∏ ΢ÙÙÙ·ÚÔΛÓË ·˘Ù‹ ‚Ú¤ıËΠ¿Óˆ ·fi Ù·
πL-6 ‹Ù·Ó ·˘ÍË̤ÓË ÛÙÔ ÂÁÎÂÊ·ÏÔÓˆÙÈ·›Ô ˘ÁÚfi68. Ê˘ÛÈÔÏÔÁÈο Â›‰· ÛÙÔ Ï¿ÛÌ· Û ÔÛÔÛÙfi 64%
ÙˆÓ ·ÛıÂÓÒÓ Î·È Ù· Â›‰¿ Ù˘ ‰ÂÓ Û¯ÂÙ›˙ÔÓÙ·Ó ÌÂ
3Â. πÓÙÂÚÏ¢ΛÓË 8 (πL-8) ÙËÓ ÂÓÂÚÁfiÙËÙ· Ù˘ ÓfiÛÔ˘72. ∞˘ÍË̤ӷ Â›‰· Ù˘
πL-12 ‰È·ÈÛÙÒıËÎ·Ó Û ·ÛıÂÓ›˜ Ì ÂÓÂÚÁfi ÓfiÛÔ65.
∏ ‰ÈÂÚ‡ÓËÛË Ù˘ Û¯¤Û˘ Ù˘ πL-8 Ì ÙË ÓfiÛÔ ∞μ
ÚÔÛ‹Ï΢Û ÌÂÁ·Ï‡ÙÂÚÔ ÂӉȷʤÚÔÓ ÛÙÔ˘˜ ÂÚ¢ÓË-
Ù¤˜, ÏfiÁˆ Ù˘ Û˘ÌÌÂÙÔ¯‹˜ Ù˘ ÛÙË ÊÏÂÁÌÔÓ‹. Δ·
3Ë. πÓÙÂÚÏ¢ΛÓË 13 (πL-13)
CD45RA+Á‰ Δ Î‡ÙÙ·Ú· Î·È Ù· CD45+R√+ ·Ú¿- ∞˘ÍË̤ÓË ¤ÎÎÚÈÛË ·˘Ù‹˜ Ù˘ ÈÓÙÂÚÏ¢ΛÓ˘ ‰È·ÈÛÙÒ-
ÁÔ˘Ó ›Û· ÔÛ¿ πL-851. ∏ ÈÓÙÂÚÏ¢ΛÓË ·˘Ù‹ ·Ú¿ÁÂÙ·È ıËΠÛÙË ÓfiÛÔ ∞μ Û˘ÁÎÚÈÙÈο Ì ÂÏÂÁ¯fiÌÂÓË ÔÌ¿‰·63.
·fi Ù· ÌÔÓÔ·ÙÙ·Ú·, ÙÔ˘˜ ÈÓÔ‚Ï¿ÛÙ˜ Î·È Ù· ÂÓ‰Ô- Δ· ›‰È· ·Ó·Ê¤ÚÔÓÙ·È Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘65.
ıËÏȷο ·ÙÙ·Ú·, fiÙ·Ó ‰ÈÂÁ›ÚÔÓÙ·È Ì ÔÏ˘Û·Î¯·Ú›-
Ù˜, Ì πL-1 ‹ Ì ·Ú¿ÁÔÓÙ· ÓÂÎÚÒÛˆ˜ ÙÔ˘ fiÁÎÔ˘ 3ı. πÓÙÂÚÏ¢ΛÓË 18 (πL-18)
(Δ¡F). ªÂ ÈÛÙÔ¯ËÌÈ΋ ÌÂϤÙË ·ԉ›¯ıËÎÂ Ë ‡·ÚÍË
∏ ΢ÙÙ·ÚÔΛÓË ·˘Ù‹ Â›Ó·È Â›Û˘ ·˘ÍË̤ÓË ÛÙË ÓfiÛÔ
Ù˘ πL-8 Û ·ÙÙ·Ú· ‰ÂÚÌ·ÙÈÎÒÓ ‚Ï·‚ÒÓ Ù˘ ÓfiÛÔ˘69.
∞μ ÌfiÓÔ Û ·ÛıÂÓ›˜ Ì ÂÓÂÚÁfi ÓfiÛÔ73.
∏ πL-8 ‰È·ÈÛÙÒıËΠ·˘ÍË̤ÓË Û ·ÛıÂÓ›˜ Ì ÂÓÂÚ-
Áfi ÓfiÛÔ, ÏÈÁfiÙÂÚÔ Û ·ÛıÂÓ›˜ Ì ·ÓÂÓÂÚÁfi ÓfiÛÔ ‹
ÛÂ Ê˘ÛÈÔÏÔÁÈÎÔ‡˜ Ì¿ÚÙ˘Ú˜70. ∞fi ÔÏÏÔ‡˜ ÂÚ¢ÓË- 3È. ¶·Ú¿ÁÔÓÙ˜ ÓÂÎÚÒÛˆ˜ ÙÔ˘ fiÁÎÔ˘
Ù¤˜59,61,62,70 ‰È·ÈÛÙÒıËÎ·Ó ·˘ÍË̤ӷ Â›‰· Ù˘ πL- (TNF)
8 ÛÙÔÓ ÔÚfi ·ÛıÂÓÒÓ È‰È·›ÙÂÚ· Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ. T· ·Ó·ÊÂÚfiÌÂÓ· ·ÔÙÂϤÛÌ·Ù· ÁÈ’ ·˘Ù‹ ÙËÓ Î˘ÙÙ·-
∞ӷʤÚıËΠÂ›Û˘ ·˘ÙfiÌ·ÙË ·Ú·ÁˆÁ‹ ÙÔ˘ RNA ÚÔΛÓË Â›Ó·È ·ÓÙÈÎÚÔ˘fiÌÂÓ·. ∞ÓȯÓ‡ÛÈ̘ ÙÈ̤˜
πL-8 ·fi Ù· ÏÂÌÊÔ·ÙÙ·Ú· ·ÛıÂÓÒÓ Î·È Èı·ÓÒ˜ ·˘- ·Ó¢ڤıËÛ·Ó Û 10 Î·È ÛËÌ·ÓÙÈο ·˘ÍË̤Ó˜ Û 4
Ù‹ Ó· Û¯ÂÙ›˙ÂÙ·È Ì ÙËÓ ¿ÓÔÛÔ ÂÓÂÚÁÔÔ›ËÛË Î·È ‰È¤- ·fi ÙÔ˘˜ 32 ÂÍÂÙ·Ûı¤ÓÙ˜ ·ÛıÂÓ›˜61. ∞˘ÍË̤ӷ Â›-
ÁÂÚÛË ÚÔÊÏÂÁÌÔÓˆ‰ÒÓ Î˘ÙÙ·ÚÔÎÈÓÒÓ ÚÔηÏÒ- ‰· ‰È·ÈÛÙÒıËÎ·Ó Û ·ÓÂÓÂÚÁfi ΢ڛˆ˜, fï˜ ηÈ
ÓÙ·˜ ÊÏÂÁÌÔÓ‹ Î·È ÈÛÙÈ΋ ‚Ï¿‚Ë. π‰È·›ÙÂÚÔ ÂӉȷʤ- Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘, Û˘ÁÎÚÈÙÈο Ì ̿ÚÙ˘-
ÚÔÓ ¤¯Ô˘Ó ÔÈ ÌÂϤÙ˜ ¿ÏÏˆÓ ÂÚ¢ÓËÙÒÓ ÔÈ Ôԛ˜ Ú˜59. ªÂÙ¿ ‰Â ·fi ‰È¤ÁÂÚÛË Ì ÏÈÔÔÏ˘Û·Î¯·Ú›Ù˜
¤‰ÂÈÍ·Ó fiÙÈ Ë πL-8 ‹Ù·Ó ·˘ÍË̤ÓË Û ÂÓÂÚÁ¤˜ ‚Ï¿‚˜ Ù· Â›‰· ÙÔ˘ Δ¡F ·˘Í¿ÓÔÓÙ·Ó ÛËÌ·ÓÙÈο59. √ ‰È·-
ÛÙfiÌ·ÙÔ˜ Î·È Ó¢ÚÈÎÔ‡ Û˘ÛÙ‹Ì·ÙÔ˜ Î·È fiÙÈ Ù· ÂÓ‰Ô- Ï˘Ùfi˜ ˘Ô‰Ô¯¤·˜ 75 ÙÔ˘ Δ¡F (soluble TNFR75)
ıËÏȷο ·ÙÙ·Ú· Â›Ó·È Î˘Ú›ˆ˜ ˘‡ı˘Ó· ÁÈ· ÙËÓ ¤Î- ÂÍ¿ÏÏÔ˘ ‚Ú¤ıËΠ·˘ÍË̤ÓÔ˜ Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Î·È
ÎÚÈÛ‹ Ù˘ Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘60. ¶ÚfiÛÊ·Ù· ÚÔÙ›ÓÂÙ·È Ó· ¯ÚËÛÈ̇ÛÂÈ Û·Ó ‚ÈÔÏÔÁÈÎfi˜ ‰Â›ÎÙ˘
ÂȂ‚·ÈÒıËÎÂ Ë ·‡ÍËÛË Ù˘ πL-8 ÛÙË ÓfiÛÔ ∞μ, fiˆ˜ ÂÓÂÚÁfiÙËÙ·˜ Ù˘ ÓfiÛÔ˘72.
Î·È Ë Û¯¤ÛË Ù˘ ˆ˜ ‰Â›ÎÙË ÂÓÂÚÁÔ‡ ÓfiÛÔ˘ ηχÙÂÚÔ˘
Ì¿ÏÈÛÙ· ·’ fi,ÙÈ Ë Δ∫∂ Î·È Ë C-·ÓÙȉÚÒÛ· ÚˆÙ½ÓË71. 3Î. πÓÙÂÚÊÂÚfiÓË Á (IFN-Á)
¶ÚÈÓ ·fi ‰ÂηÂٛ˜ ·Ó·Ê¤ÚıËΠ·˘ÙfiÌ·ÙË ·Ú·Áˆ-
3ÛÙ. πÓÙÂÚÏ¢ΛÓË 10 (πL-10) Á‹ Ù˘ πFN-Á Û ·ÛıÂÓ›˜ Ì ÓfiÛÔ ∞μ74. ∂›Û˘, ÛÂ
∏ πL-10 ‰ÂÓ ‚Ú¤ıËΠ·˘ÍË̤ÓË Û ·ÛıÂÓ›˜ Ì ÓfiÛÔ ÌË ıÂÚ·¢fiÌÂÓÔ˘˜ ·ÛıÂÓ›˜ Î·È Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ
∞μ Û˘ÁÎÚÈÙÈο Ì ¿ÏϘ ÔÌ¿‰Â˜66. ∞fi ¿ÏÏÔ˘˜ ÂÚ¢- Ù· Â›‰· Ù˘ πFN-Á ‹Ù·Ó ÛËÌ·ÓÙÈο ˘„ËÏfiÙÂÚ· ·’
ÓËÙ¤˜ ‰È·ÈÛÙÒıËΠfiÙÈ Ù· ·ÓÙÈ-CD3/ ·ÓÙÈ-CD40 ‰ÈÂ- fi,ÙÈ Û ·ÓÂÓÂÚÁfi ÛÙ¿‰ÈÔ64.
ÁÂṲ́ӷ ÂÚÈÊÂÚÈο ÌÔÓÔ·ÙÙ·Ú· Ô˘ ˘Ô‰ËÏÒÓÔ˘Ó ™˘ÌÂÚ·ÛÌ·ÙÈο, Ù· ·ÓÙÈÎÚÔ˘fiÌÂÓ· ·ÔÙÂϤ-
ÙËÓ ÂÓÂÚÁÔÔ›ËÛË ÙˆÓ Th1 Î·È Δh2 ΢ÙÙ¿ÚˆÓ ÂÎÎÚ›- ÛÌ·Ù· Û’ fi,ÙÈ ·ÊÔÚ¿ ÙȘ ΢ÙÙ·ÚÔΛÓ˜ ÌÔÚÔ‡Ó Ó·

9. 12 ∞ÈÙÈÔ·ıÔÁÂÓÂÙÈÎÔ› Ì˯·ÓÈÛÌÔ› ÛÙË ÓfiÛÔ ∞‰·Ì·ÓÙÈ¿‰Ë-Behçet
·Ô‰ÔıÔ‡Ó ÛÙË ÌÂıÔ‰ÔÏÔÁ›·, ÛÙÔÓ ·ÚÈıÌfi ÙˆÓ ·ÛıÂ- ·ÓÙÈÛÒÌ·Ù· ·˘Ù¿ (πgG Î·È πgM) Û ÔÛÔÛÙfi ÌfiÓÔ
ÓÒÓ Û οı ÌÂϤÙË, ÛÙÔ ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘ Î·È ÛÙË ıÂ- 2,4%80. ™Â ¿ÏϘ ÌÂϤÙ˜ ·fi ÙËÓ ΔÔ˘ÚΛ· Ë Û˘¯Ófi-
Ú·¢ÙÈ΋ ·ÁˆÁ‹ Ô˘ ˘Ô‚¿ÏÏÔÓÙ·Ó ÔÈ ·ÛıÂÓ›˜. ÙËÙ· ‹Ù·Ó 9,5%80.
4. ∂Ó‰ÔıËÏȷ΋ ÂÓÂÚÁÔÔ›ËÛË/‚Ï¿‚Ë 5Á. ∞ÓÙÈÂÓ‰ÔıËÏȷο ·ÓÙÈÛÒÌ·Ù·
ŒÓ· ·fi Ù· ·ÚÈ· ¯·Ú·ÎÙËÚÈÛÙÈο Ù˘ ÓfiÛÔ˘ ∞μ ›- ∞ÓÙÈÛÒÌ·Ù· ¤Ó·ÓÙÈ ÙˆÓ ÂÓ‰ÔıËÏÈ·ÎÒÓ Î˘ÙÙ¿ÚˆÓ ·-
Ó·È Ë ÚÔÛ‚ÔÏ‹ fiÏˆÓ ÙˆÓ ·ÁÁ›ˆÓ (·ÚÙËÚÈÒÓ Î·È Ó¢ڤıËÎ·Ó Û ·ÛıÂÓ›˜ (πgG Î·È IgM 18.1%) fi¯È
ÊÏ‚ÒÓ)1. ∏ Ù¿ÛË ÁÈ· ıÚÔÌ‚ˆÙÈο ÂÂÈÛfi‰È·, ÂȉÈο fï˜ Û ˘ÁÈ‹ ¿ÙÔÌ·81. ÕÏÏÔÈ ÂÚ¢ÓËÙ¤˜ ·Ó¤ÊÂÚ·Ó
ÛÙÔ ÊÏ‚ÈÎfi ÛΤÏÔ˜ ÙˆÓ ·ÁÁ›ˆÓ, Â›Ó·È Â›Û˘ Û˘Ó‹- Û˘¯ÓfiÙËÙ· ·˘ÙÒÓ ÙˆÓ ·ÓÙÈÛˆÌ¿ÙˆÓ Û ÔÛÔÛÙfi
ı˘. ∏ ÂÓÂÚÁÔÔ›ËÛË ÙÔ˘ Û˘ÛÙ‹Ì·ÙÔ˜ ‹Íˆ˜ Î·È Ë 29%82. ™Â ÚfiÛÊ·ÙË ÌÂϤÙË ÙÔ ÔÛÔÛÙfi ıÂÙÈÎfiÙËÙ·˜
ÈÓˆ‰ÔÏ˘ÙÈ΋ ‰Ú·ÛÙËÚÈfiÙËÙ·, Ô˘ ·ÓÙ·Ó·ÎÏÔ‡Ó ÙËÓ ‹Ù·Ó 13,1% ÁÈ· Ù· Ù¿Í˘ IgG Î·È 6,8% ÁÈ· Ù· Ù¿Í˘
ÂÓ‰ÔıËÏȷ΋ ÂÓÂÚÁÔÔ›ËÛË Î·È ‚Ï¿‚Ë, Â›Ó·È ÁÓˆÛÙ¿ πgM Û ·ÛıÂÓ›˜ Ì ÓfiÛÔ ∞μ, ÂÓÒ ‹Ù·Ó ÛÂ Ê˘ÛÈÔÏÔ-
ÛÙË ÓfiÛÔ75. ∏ ‡·ÚÍË ÌÂÙ¿ÏÏ·Í˘ ÙÔ˘ ÚÔËÎÙÈÎÔ‡ ÁÈÎÔ‡˜ Ì¿ÚÙ˘Ú˜ 4% ÁÈ· Ù· Ù¿Í˘ πgG Î·È 8,0 % ÁÈ·
·Ú¿ÁÔÓÙ·, fiˆ˜ ÙÔ˘ ·Ú¿ÁÔÓÙ· V Leiden Î·È Ë ÌÂ- Ù· Ù¿Í˘ πgM, ¯ˆÚ›˜ Ó· ˘¿Ú¯ÂÈ ÛÙ·ÙÈÛÙÈο ÛËÌ·ÓÙÈ-
Ù¿ÏÏ·ÍË ÙÔ˘ ÁÔÓȉ›Ô˘ Ù˘ ÚÔıÚÔÌ‚›Ó˘ ·˘Í¿ÓÔ˘Ó Î‹ ‰È·ÊÔÚ¿83.
ÙÔÓ Î›Ó‰˘ÓÔ ıÚfiÌ‚ˆÛ˘75 ˆ˜ ·ÓÂÍ¿ÚÙËÙÔÈ ·Ú¿ÁÔ- Δ· ·ÔÙÂϤÛÌ·Ù· ·˘Ù¿ ·Ô‰ÂÈÎÓ‡Ô˘Ó ÙȘ ÌÂıÔ-
‰ÔÏÔÁÈΤ˜ ‰È·ÊÔÚ¤˜ Î·È Ë Û¯¤ÛË ÙÔ˘˜ Ì ÙË ‚Ï¿‚Ë
ÓÙ˜ ÎÈÓ‰‡ÓÔ˘. ∞ÎfiÌ·, Ë ıÚÔÌ‚ÔÌÔÓÙÔ˘Ï›ÓË, ÁÏ˘ÎÔ-
ÙÔ˘ ·ÁÁ›Ԣ ·Ú·Ì¤ÓÂÈ ˘ÔıÂÙÈ΋ Î·È Èı·ÓfiÓ ·ÓÙ·-
ÚˆÙ½ÓË Ù˘ ΢ÙÙ·ÚÈ΋˜ ÂÈÊ¿ÓÂÈ·˜ ÙÔ˘ ÂÓ‰ÔıËÏ›Ô˘,
Ó·ÎÏ¿ ÂÓÂÚÁfiÙËÙ· Ù˘ ÓfiÛÔ˘ Î·È ‰Â˘ÙÂÚÔ·ıÒ˜
Ë ÔÔ›· Â›Ó·È ·˘ÍË̤ÓË Û ÂÓÂÚÁfi ÛÙ¿‰ÈÔ Ù˘ ÓfiÛÔ˘,
ÚfiÎÏËÛË Ù˘ ·ÁÁÂȷ΋˜ ‚Ï¿‚˘75.
ÚÔηÏ› ‚Ï¿‚Ë ÛÙ· ÂÓ‰ÔıËÏȷο ·ÙÙ·Ú·5. ∏ ·ÚÔ˘-
Û›· ·ÓÙÈÂÓ‰ÔıËÏÈ·ÎÒÓ ·ÓÙÈÛˆÌ¿ÙˆÓ Û¯ÂÙ›˙ÂÙ·È Â›Û˘
Ì ÙȘ ·ÁÁÂȷΤ˜ ‚Ï¿‚˜. 6. ∞˘ÙÔ·ÓÙÈÁfiÓ·
6·. ∞ÓÙÈÁfiÓÔ S
5. ∞ÓÙÈÛÒÌ·Ù·
E›Ó·È ÙÔ ÈÔ ÈÛ¯˘Úfi ÚˆÙÂ˚ÓÈÎfi ·˘ÙÔ·ÓÙÈÁfiÓÔ Ù˘ Ú·-
5·. ∞ÓÙÈÛÒÌ·Ù· ¤Ó·ÓÙÈ ÙÔ˘ ΢ÙÙ·ÚÔÏ¿- ÁÔÂȉ›Ùȉ·˜ Î·È ÂÓÙÔ›˙ÂÙ·È ÛÙÔÓ ·ÌÊÈ‚ÏËÛÙÚÔÂȉ‹.
ÛÌ·ÙÔ˜ ÙˆÓ Ô˘‰ÂÙÂÚfiÊÈÏˆÓ ΔÔ ·ÓÙÈÁfiÓÔ ·˘Ùfi ÚÔηÏ› ÂÈÚ·Ì·ÙÈ΋ ·˘ÙÔ¿ÓÔÛË
Ú·ÁÔÂȉ›Ùȉ· Î·È ·ÓȯÓ‡ÂÙ·È ÛÙÔÓ ÔÚfi ·ÛıÂÓÒÓ ÌÂ
◊‰Ë ·fi ÙÔ 199359 ·Ó·˙ËÙ‹ıËÎ·Ó Ù· ·ÓÙÈÛÒÌ·Ù· ÓfiÛÔ ∞μ34. ∞˘ÍË̤ÓË ·¿ÓÙËÛË ÙˆÓ Δ Î˘ÙÙ¿ÚˆÓ ÛÂ
ANCA Û ·ÛıÂÓ›˜ Ì ÂÓÂÚÁfi Î·È ·ÓÂÓÂÚÁfi ÓfiÛÔ Ì ηÏÏȤÚÁÂȘ ¤Ó·ÓÙÈ ÙÔ˘ S ·ÓÙÈÁfiÓÔ˘ ·Ú·ÙËÚ‹ıËÎÂ
¤ÌÌÂÛÔ ·ÓÔÛÔÊıÔÚÈÛÌfi ¯ˆÚ›˜ fï˜ Ó· ·Ó¢ÚÂ- Û ·ÛıÂÓ›˜ Ì ÔÊı·ÏÌÈ΋ ÓfiÛÔ ∞μ ·Ú¿ Û’ ·˘ÙÔ‡˜
ıÔ‡Ó. ∏ ·Ó·˙‹ÙËÛË ·˘ÙÒÓ ÙˆÓ ·ÓÙÈÛˆÌ¿ÙˆÓ ÛÙË Ófi- ¯ˆÚ›˜ ÔÊı·ÏÌÈ΋ ÚÔÛ‚ÔÏ‹. √È ‰Â‡ÙÂÚÔÈ Â›¯·Ó
ÛÔ ∞μ ÌÔÚÔ‡Û ӷ ‰ÈηÈÔÏÔÁËı› ·fi ÙËÓ ·ÁÁÂÈ›ÙÈ- fiÌÔÈ· ·¿ÓÙËÛË Ì ÙÔ˘˜ Ì¿ÚÙ˘Ú˜34. ∂›Ó·È ÂӉȷʤ-
‰· Ô˘ ¯·Ú·ÎÙËÚ›˙ÂÈ ÙË ÓfiÛÔ. ™Â ÌÂϤÙ˜ fï˜ Ô˘ ÚÔÓ fiÙÈ ÙÔ S ·ÓÙÈÁfiÓÔ ¤¯ÂÈ ¯ÚËÛÈÌÔÔÈËı› ÁÈ· ÙË ıÂ-
·ÎÔÏÔ‡ıËÛ·Ó Ù· ·ÓÙÈÛÒÌ·Ù· ·˘Ù¿ ·Ó¢ڤıËÛ·Ó Ìfi- Ú·›· ·˘ÙÔ¿ÓÔÛˆÓ Ú·ÁÔÂȉÈÙ›‰ˆÓ Û˘ÌÂÚÈÏ·Ì‚·ÓÔ-
ÓÔ Û ÌÈÎÚfi ·ÚÈıÌfi ·ÛıÂÓÒÓ ‹ ‰ÂÓ ·Ó¢ڤıËÛ·Ó Û ̤Ó˘ Ù˘ Ú·ÁÔÂȉ›Ùȉ·˜ Ù˘ ÓfiÛÔ˘ ∞μ34.
ηӤӷ ·ÛıÂÓ‹76,77.
6‚. ΔÚÔÔÌ˘ÔÛ›ÓË ∞
5‚. ∞ÓÙÈηډÈÔÏÈÈÓÈο ·ÓÙÈÛÒÌ·Ù·
∂›Ó·È ÌÈ· ÔÈÎÔÁ¤ÓÂÈ· ÚˆÙÂ˚ÓÒÓ Ô˘ ÂÎÊÚ¿˙ÔÓÙ·È
∂·ÓÂÈÏËÌ̤ӷ Ù· ·ÓÙÈÛÒÌ·Ù· ·˘Ù¿ ·ÔÙ¤ÏÂÛ·Ó ÛÙfi- ÛÙÔ˘˜ Ì˘˜ Î·È Û ¿ÏÏ· ·ÙÙ·Ú· (ÂÈıËÏȷο, ÈÓÔ‚Ï¿-
¯Ô ·Ó·˙ËÙ‹Ûˆ˜ ·fi ÙÔ˘˜ ÂÚ¢ÓËÙ¤˜. ∞˘ÍË̤ӷ ÛÙ˜ Î·È ·ÈÌÔÂÙ¿ÏÈ·)84. ™ÙÔÓ ÔÚfi ·ÛıÂÓÒÓ Ì ÓfiÛÔ
·ÓÙÈηډÈÔÏÈÈÓÈο ·ÓÙÈÛÒÌ·Ù· ·Ó·Ê¤ÚıËÎ·Ó Û Ô- ∞μ ·Ó¢ڤıËÛ·Ó ·ÓÙÈÛÒÌ·Ù· ¤Ó·ÓÙÈ ·˘ÙÔ‡ ÙÔ˘ ·ÓÙÈ-
ÛÔÛÙfi 35% ÙˆÓ ·ÛıÂÓÒÓ Ì ÓfiÛÔ ∞μ Î·È Û¯ÂÙ›ÛıË- ÁfiÓÔ˘ Î·È Ë ·ÓÔÛÔÔ›ËÛË Ì ÙÚÔÔÌ˘ÔÛ›ÓË ∞ ÚÔ-
Î·Ó Ì ‚·ÚÈ¿ ÓfiÛÔ78. ∞‡ÍËÛË ÙˆÓ ·ÓÙÈÛˆÌ¿ÙˆÓ ·˘- οÏÂÛ ڷÁÔÂȉ›Ùȉ· Î·È ‰ÂÚÌ·ÙÈΤ˜ ‚Ï¿‚˜ Û ÔÓÙ›-
ÙÒÓ ·Ó·Ê¤ÚıËΠ۠ÂÓÂÚÁfi ÓfiÛÔ ÛÙÔ 46,7%, ‰ÂÓ ıÂ- ÎÈ· Lewis85. ∂Í¿ÏÏÔ˘ Û ÔÛÔÛÙfi 26,6% ÙˆÓ ·ÛıÂ-
ˆÚ‹ıËΠfï˜ fiÙÈ Û¯ÂÙ›˙ÔÓÙ·È Ì ÙËÓ ·ıÔÁ¤ÓÂÈ· Ù˘ ÓÒÓ Ì ÓfiÛÔ ∞μ, ¯ˆÚ›˜ Ô›ÛıÈ· Ú·ÁÔÂȉ›Ùȉ·, ·Ó¢-
ÓfiÛÔ˘, ÂÓÒ ÌÔÚ› Ó· ·ÔÙÂÏÔ‡Ó ¤Ó‰ÂÈÍË ÁÈ· ÂÌÊ¿- Ú¤ıËÛ·Ó ·ÓÙÈÛÒÌ·Ù· ¤Ó·ÓÙÈ ÙÚÔÔÌ˘ÔÛ›Ó˘84. ∞Îfi-
ÓÈÛË ‰ÂÚÌ·ÙÈ΋˜ ·ÁÁÂÈ›Ùȉ·˜, fiˆ˜ ÙÔ Ô˙҉˜ ÂÚ‡ıË- Ì· Û ÔÛÔÛÙfi 33%, ·ÛıÂÓ›˜ Ì Ô›ÛıÈ· Ú·ÁÔÂȉ›-
Ì·79. ∂ÓÙÔ‡ÙÔȘ Û ÚfiÛÊ·ÙË ÌÂϤÙË ·fi ÙËÓ ΔÔ˘Ú- Ùȉ·, ·ÚÔ˘Û›·Û·Ó ÏÂÌÊÔ¸ÂÚÏ·ÛÙÈ΋ ·ÓÙ·fiÎÚÈÛË
Λ·, Û ÌÂÁ¿ÏÔ ·ÚÈıÌfi ·ÛıÂÓÒÓ, ‰È·ÈÛÙÒıËÎ·Ó Ù· ÛÙËÓ ÙÚÔÔÌ˘ÔÛ›ÓË ∞ in vitro ‹ ÛÙ· ·Ú¿ÁˆÁ· Â-

10. º. ∫·ÎÏ·Ì¿Ó˘ Î·È Û˘Ó. 13
Ù›‰È¿ Ù˘ fi¯È fï˜ Î·È ÔÈ Ì¿ÚÙ˘Ú˜84. ∏ ·ÚÔ˘Û›· ÛÙ‹Ì·ÙÔ˜97. ™Â ÚfiÛÊ·Ù˜ ÌÂϤÙ˜ ‰ÂÓ ‰È·ÈÛÙÒıËÎÂ
·˘ÙÒÓ ÙˆÓ ‰È·Ù·Ú·¯ÒÓ ·Ô‰ÂÈÎÓ‡ÂÈ ÙÔÓ Èı·Ófi ÚfiÏÔ ·˘Ù‹ Ë Û¯¤ÛË Î·È Ú¤ÂÈ Ë ·ÈÙÈÔ·ıÔÁ¤ÓÂÈ· Ù˘ ÓfiÛÔ˘,
Ù˘ ÙÚÔÔÌ˘ÔÛ›Ó˘ ∞, Û·Ó ·˘ÙÔ·ÓÙÈÁfiÓÔ, Û ÂȉÈ΋ fiˆ˜ ·Ó·Ê¤ÚıËΠ‹‰Ë, Ó· Û¯ÂÙ›˙ÂÙ·È Ì ÁÂÓÂÙÈÎÔ‡˜ ηÈ
ηÙËÁÔÚ›· ·ÛıÂÓÒÓ Ì ÓfiÛÔ ∞μ. ÂÚÈ‚·ÏÏÔÓÙÈÎÔ‡˜ ·Ú¿ÁÔÓÙ˜98. ™Â ÌÂϤÙË 62 ∂ÏÏ‹-
ÓˆÓ ·ÛıÂÓÒÓ ‰È·ÈÛÙÒıËΠ·ÛıÂÓ‹˜ Û¯¤ÛË ÌÂٷ͇
7. ÕÓÔÛ· Û˘ÌϤÁÌ·Ù· μ*5101, Ú·ÁÔÂȉ›Ùȉ·˜ Î·È Ô˙Ò‰Ô˘˜ ÂÚ˘ı‹Ì·ÙÔ˜. ΔÔ
·ÏÏ‹ÏÈÔ ·˘Ùfi ‚Ú¤ıËÎÂ ÛÂ ÔÛÔÛÙfi 80% ÙˆÓ ·ÛıÂÓÒÓ
∏ ‡·ÚÍË Î˘ÎÏÔÊÔÚÔ‡ÓÙˆÓ ·ÓfiÛˆÓ Û˘ÌÏÂÁÌ¿ÙˆÓ Î·È 26% ÙˆÓ ˘ÁÈÒÓ Ì·ÚÙ‡ÚˆÓ Î·È ıˆڋıËΠÚÔ-
Û ·ÛıÂÓ›˜ Ì ÓfiÛÔ ∞μ ¤¯ÂÈ ·Ó·ÊÂÚı› ·fi ÔÏ- ‰È·ıÂÛÈÎfi˜ ·Ú¿ÁÔÓÙ·˜ ÁÈ· ÙË ÓfiÛÔ ∞μ99. ™¯¤ÛË ÌÂ-
ÏÔ‡˜ ÂÚ¢ÓËÙ¤˜34. ÕÓÔÛÔÛ˘ÌϤÁÌ·Ù· ¤¯Ô˘Ó Â›Û˘ ٷ͇ ÙˆÓ μ5, Ú·ÁÔÂȉ›Ùȉ·˜ Î·È ·ÁÁÂÈ›Ùȉ·˜ ·Ó·Ê¤Ú-
ÂÓÙÔÈÛÙ› Û ÈÛÙÈΤ˜ ‚Ï¿‚˜ Î·È Î˘Ú›ˆ˜ ÛÙÔ ÙÔ›¯ˆÌ· ıËΠ·fi ¿ÏÏÔ˘˜ ÂÚ¢ÓËÙ¤˜100.
ÙˆÓ ·ÁÁ›ˆÓ86. Δ· Â›‰· ÙˆÓ Î˘ÎÏÔÊÔÚÔ‡ÓÙˆÓ ∞Ó¿Ï˘ÛË ÙÔ˘ Û˘ÛÙ‹Ì·ÙÔ˜ ÈÛÙÔÛ˘Ì‚·ÙfiÙËÙ·˜
·ÓfiÛÔÛ˘ÌÏÂÁÌ¿ÙˆÓ Û¯ÂÙ›˙ÔÓÙ·Ó Ì ÙËÓ ÂÓÂÚÁfiÙËÙ· ¤‰ÂÈÍ fiÙÈ 3 ·ÏÏ‹ÏÈ· (ªπCA-A6,MIμ-348, C1-4-1-
Ù˘ ÓfiÛÔ˘ fi¯È fï˜ Ì ÙË ‰È¿ÚÎÂÈ· ‹ ÙËÓ ÚÔÛÂ΂Ô- 217) Î·È ÙÔ HLA-B*551 Û¯ÂÙ›˙ÔÓÙ·È ¿ÌÂÛ· Ì ÙË Ófi-
Ï‹ Û˘ÁÎÂÎÚÈ̤ÓÔ˘ ÔÚÁ¿ÓÔ˘87. ÕÏÏÔÈ ÂÚ¢ÓËÙ¤˜ ‰È·›- ÛÔ95,96. ™Â ¿ÏÏË ÌÂϤÙË ·Ú·ÙËÚ‹ıËΠ·‡ÍËÛË ÙÔ˘
ÛÙˆÛ·Ó ˘„ËÏfiÙÂÚ· Â›‰· ΢ÎÏÔÊÔÚÔ‡ÓÙˆÓ ·ÓÙÈ- MICA 006 Î·È fi¯È ÙÔ˘ ªπCA 009 Û ·ÛıÂÓ›˜ Û˘-
ÛˆÌ¿ÙˆÓ Û ·ÛıÂÓ›˜ Ì ٷ˘Ùfi¯ÚÔÓË ÚÔÛ‚ÔÏ‹ ÁÎÚÈÙÈο Ì ̿ÚÙ˘Ú˜101. ÕÏÏË Û˘Û¯¤ÙÈÛË Ì ÙË ÓfiÛÔ
‰¤ÚÌ·ÙÔ˜ Î·È ·ÚıÚÒÛˆÓ88. ™Â ÔÛÔÛÙfi 44%-60% Â›Ó·È ·˘Ù‹ Ì ÙÔ ∏LA-CW 1602102. ™Â ÚfiÛÊ·ÙË ÌÂ-
ÙˆÓ ·ÛıÂÓÒÓ Ù· ΢ÎÏÔÊÔÚÔ‡ÓÙ· ¿ÓÔÛ· Û˘ÌϤÁÌ·- ϤÙË ·Ó·Ê¤ÚÔÓÙ·È ÂӉ›ÍÂȘ ÁÂÓÂÙÈ΋˜ ÂÙÂÚÔÁ¤ÓÂÈ·˜
Ù· Û¯ÂÙ›˙ÔÓÙ·Ó Ì ÙËÓ ÂÓÂÚÁfiÙËÙ· Ù˘ ÓfiÛÔ˘34. ™ÙÔ ÛÙË ÓfiÛÔ ∞μ Î·È Û ·È‰È·ÙÚÈ΋ ÔÌ¿‰· ·ÛıÂÓÒÓ ÌÂ
ÂÁÎÂÊ·ÏÔÓˆÙÈ·›Ô ˘ÁÚfi ·Ó¢Ú‡ıËÛ·Ó ¿ÓÔÛ· Û˘- ÓfiÛÔ ·Ú·ÙËÚ‹ıËΠ‡·ÚÍË ª·ÓÙÂÏÈ·ÓÔ‡ ÚÔÙ‡Ô˘
ÌϤÁÌ·Ù· ηٿ ÙË ‰È¿ÚÎÂÈ· Ù˘ ÂÁÎÂÊ·Ï›Ùȉ·˜, ÂÓÒ ÎÏËÚÔÓÔÌÈÎfiÙËÙ·˜ Ì ·˘ÙfiÛˆÌÔ ˘ÔÏÂÈfiÌÂÓÔ ¯·-
‰È·ÈÛÙÒıËÎ·Ó ÙfiÛÔ Ë ·Ú·ÁˆÁ‹ πgG, IgM, IgA fiÛÔ Ú·ÎÙ‹Ú·103.
Î·È ÔÈ ˘„ËϤ˜ Û˘ÁÎÂÓÙÚÒÛÂȘ ÙˆÓ C3, C4 Î·È CD8+
T ÏÂÌÊÔ΢ÙÙ¿ÚˆÓ7.
μÈ‚ÏÈÔÁÚ·Ê›·
1. Kaklamani VG, Vaiopoulos G, Kaklamanis Ph. Behcet’s di-
8. ∞ÓÔÛÔÁÂÓÂÙÈ΋ sease. Semin Arthritis Rheum 1998; 27: 197-217.
∏ Û¯¤ÛË Ù˘ ·ÓÔÛÔÁÂÓÂÙÈ΋˜ Ì ÙË ÓfiÛÔ ∞μ ÛÙËÚ›- 2. Sakane T, Takeno M, Suzuki N, Inaba G. Behcet’s disease. N
˙ÂÙ·È ÛÙË ÁˆÁÚ·ÊÈ΋ ηٷÓÔÌ‹ Ù˘ ÓfiÛÔ˘, ÛÙËÓ ÔÈ- Engl J Med 1999; 341: 1284-91.
ÎÔÁÂÓ‹ ÂÌÊ¿ÓÈÛ‹ Ù˘ Î·È ÛÙË Û¯¤ÛË Ù˘ Ì ÙÔ Û‡- 3. Direskeneli H. Behcet’s disease: Infectious aetiology, new
autoantigens and HLA-B52 Ann Rheum Dis 2001; 60:
ÛÙËÌ· ÈÛÙÔÛ˘Ì‚·ÙfiÙËÙ·˜ (∏LA). H Û¯¤ÛË Ù˘ ÓfiÛÔ˘ 996-1002.
Ì ÙÔ Û‡ÛÙËÌ· ÈÛÙÔÛ˘Ì‚·ÙfiÙËÙ·˜ Â›Ó·È ·ԉ‰ÂÈÁ̤- 4. Zouboulis CC. Epidemiology of Adamantiades – Behcet’s
ÓË Û ÌÂÁ¿ÏË ÛÂÈÚ¿ ÌÂÏÂÙÒÓ ‰ÈÂıÓÒ˜. ΔÔ ∏LA B*551 disease. Ann Med Intern 1999; 150: 448-98.
‰È·ÈÛÙÒıËΠ۠ÔÛÔÛÙfi Î˘Ì·ÈÓfiÌÂÓÔ ·fi 54,1% 5. Zouboulis CC, May T. Pathogenesis of Adamantiades-Beh-
ÛÙËÓ ΔÔ˘ÚΛ·89 ̤¯ÚÈ Î·È 76,2% ÛÙÔ πÛÚ·‹Ï90. ΔÔ cet’s disease. Med Microbiol Immunol 2003; 192: 149-55.
∏LA-B*551 ¤¯ÂÈ ÙÔ˘Ï¿¯ÈÛÙÔÓ 34 ÔÈÎÈϛ˜ ·ÏÏËÏ›ˆÓ 6. Krause I, Uziel Y, Guedj D, et al. Mode of presentation and
Î·È ÔÈ Û˘ÓËı¤ÛÙÂÚÔÈ ˘fiÙ˘ÔÈ Â›Ó·È ÔÈ HLA-B*5101 multisystemic involvement in Behcet’s disease. The influ-
ence of sex and age of disease onset. J Rheumatol 1998;
Î·È ÔÈ ∏LA-B*510891. O ÈÔ Û˘¯Ófi˜ ˘fiÙ˘Ô˜ ›ӷÈ
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Ô ∏LA-B*5101. ∏ ‡·ÚÍË Û¯¤Û˘ ÙÔ˘ HLA-B*551
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ÚË Û˘¯ÓfiÙËÙ· Û ·ÛıÂÓ›˜ ·fi ÙËÓ πÙ·Ï›· Î·È ÙË ™·- the autoimmune diseases. Intern Rev Immunol 1997; 14:
Ô˘‰È΋ ∞Ú·‚›·93. ∞ÎfiÌ· ·fi ÙÔ˘˜ ›‰ÈÔ˘˜ ÂÚ¢ÓËÙ¤˜ 1-10.
‰È·ÈÛÙÒıËΠÈÛ¯˘Ú‹ Û¯¤ÛË ÙÔ˘ HLA-B51 Û πÚ·ÓÔ‡˜ 9. Hamuryudan V, Yurdakul S. Moral F, et al. Pulmonary arte-
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·ÛıÂÓ›˜. ™ÙË ¯ÒÚ· Ì·˜ ¤¯ÂÈ ‰ÈÂÚ¢ÓËı› Ë Û¯¤ÛË ÙÔ˘ cases. Br J Rheumatol 1994; 33: 48-51.
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Â›Ó·È ÈÔ Û˘¯Ófi Û ·ÛıÂÓ›˜ Ì ÚfiÛıÈ· Ú·ÁÔÂȉ›Ùȉ· 81-3.
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457-62. virginia@hol.gr

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¯ÚfiÓÈ·˜ Ë·ÙÈ΋˜ ÓfiÛÔ˘ Î·È ÙËÓ ÈÔ Û˘¯Ó‹ ¤Ó‰ÂÈÍË ÙÔ˘ ∏∫∫ ·ÁÎfiÛÌÈ· ÛÙËÓ ·ıÔÁ¤ÓÂÛË ÙÔ˘ ÔÔ›Ô˘
ÌÂÙ·ÌfiÛ¯Â˘Û˘ ÙÔ˘ ‹·ÙÔ˜. ÀÔÏÔÁ›˙ÂÙ·È fiÙÈ ÂÚÈÛ- ÂÌϤÎÂÙ·È Ô HCV, Ë HCV Ïԛ̈ÍË ÛÙȘ ÂÚÈÛÛfiÙÂ-
ÛfiÙÂÚÔ ·fi 170.000.000 ¿ÓıÚˆÔÈ ¤¯Ô˘Ó ÌÔÏ˘Óı› Ú˜ ÂÚÈÙÒÛÂȘ ¤¯ÂÈ Â¤ÏıÂÈ ÚÈÓ ·fi ‰ÂηÂٛ˜1,2.
Ì ÙÔÓ Èfi Ù˘ Ë·Ù›Ùȉ·˜ C (HCV)1. H Ë·Ù›Ùȉ· C ÌÂÙ·‰›‰ÂÙ·È ÌÂÙ¿ ·fi Â·Ê‹ ÌÂ
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̈ÍË Ì ÙÔÓ HCV ¢ı‡ÓÂÙ·È ÁÈ· ÙË ¯ÚfiÓÈ· Ë·ÙÈ΋ ¯Ú‹ÛË Ó·ÚΈÙÈÎÒÓ Ô˘ÛÈÒÓ. ÕÏÏÔÈ ‰˘ÓËÙÈÎÔ› ÙÚfiÔÈ
ÓfiÛÔ, Ë ÔÔ›· Î˘Ì·›ÓÂÙ·È ·fi ÙË ¯ÚfiÓÈ· Ë·Ù›Ùȉ·, ÌÂÙ¿‰ÔÛ˘ ›ӷÈ: Ë Â·ÁÁÂÏÌ·ÙÈ΋ ¤ÎıÂÛË, Ë ÛÂÍÔ˘·-
ÙËÓ Î›ÚÚˆÛË ÙÔ˘ ‹·ÙÔ˜ ¤ˆ˜ ÙÔÓ Ë·ÙÔ΢ÙÙ·ÚÈÎfi ÏÈ΋ ÌÂÙ¿‰ÔÛË, Ë ÂÓ‰ÔÚÚÈÓÈ΋ ¯Ú‹ÛË ÎÔη˝Ó˘, ÙÔ Ù·-