Bioavailability studies ii

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Bioavailability II Adapted by: Sereta Campbell-Elliott B. Pharm; M Pharm. Sc

Determination of bioavailability parameters ,[object Object],[object Object],[object Object]

Determination of ka ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Determination of ka cont’d ,[object Object]

Determination of ka cont’d ,[object Object],[object Object],[object Object],[object Object]

Determination of ka cont’d ,[object Object],[object Object],[object Object]

Determination of ka cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object]

Determination of variables from curve ,[object Object],[object Object],[object Object],[object Object],[object Object]

$Determination of F (fraction of absorbed dose) ,[object Object],[object Object],[object Object],[object Object],[object Object]$

Determination of F cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object]

Determination of F cont’d ,[object Object],[object Object],[object Object]

Determination of F from Urine data cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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This paper deals with the application of Laplace Transform [L(f)(s) = F(s) = e-ts f(t)dt] to derive the formula [(Cp (t)= Ae-at+ Be-bt] and [Ct (t)= Te-bt-Te-at] to estimate the fate of a drug in the mammillary body with the prediction of the biological parameters [k, k12, and k21]. The numerical values of [k, k12, and k21] which is estimated through the determination of the mathematical hybrid constants (A, B, a, b, T) also predict the tissue concentration of the drug, biological half-life as well.

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