Joseph P. Jackson III Enlightenment 2.0: Unleashing the Open Science and Open Source Innovation Revolutions The 21st century is off to a rocky start, and as economic and ecological crises converge, there is no shortage of dire predictions. On the other hand, politicians and pundits point to the expectation that Science and Technology will let humanity invent its way out of the problems we’ve created. This rosy outlook ignores a deep crisis that has been brewing and could hamstring our innovative capacity when we most urgently need it. Despite nostalgic myths that Science is the realm of open inquiry, reasoned debate, and the pursuit of objective truth, it has always been politicized, though never to the dangerous degree attained just in the past decade. The viciousness of the fight over embryonic stem cell research, the conflict over creationism, and the politics of climate change are unprecedented new lows. In the last ten years, a collection of burgeoning movements has begun the herculean task of overhauling the outmoded institutions and worldviews that make up our global scientific governance system. Imagine a vastly accelerated research, development, and commercialization cycle using an entire Open Innovation process from start to finish. In the best case scenario, a virtuous circle of mutually reinforcing shifts toward transparency and collaboration could unleash hitherto untapped reserves of human ingenuity. Joseph P. Jackson III is a philosopher, entrepreneur, activist, and organizer in the Open Science Movement. His goal is to assist the emergence of a new political-economic paradigm that enables sustainable prosperity for all based on distributed, decentralized, appropriate technologies, fully hackable and modifiable to suit the needs of users.

1. Biomedical Innovation today
Biotech 2.0

2. A Tale of 2 Technologies, Computing Vs Biology
The Futurist's Bias: Accidents of History, Economics, Culture
STEMI (J Smart) compression not inevitable.
Transistor, anti-trust forced to be licensed broadly, Shockley
alienated co-workers, ARPA Net, open standards = Web
explosion
No Guarantee we're going to make it for biomedicine!
Optimism, G Church Like the 50s for sny bio parts (transistors
+capacitors) Even with Electronics because we can use CAD.
Unique advantage of directed evolution, trillions of
combinations to throw at problem. Hard take off, sequenced/
synthesis... will it be enough?

3. Show me the Money ?$$
Show me the Innovation!
Cure Entrepreneurs! Biotech has destroyed more capital
than any sector in history (-90 biliion until 2008 when it finally
showed a profit). PHARMA doesn't create improved health
outcomes.
Myth of Patents: Penicillin, Polio Vaccine, Defeat of Smallpox
Recombinant DNA
Salk: Can we Patent the Sun? (Polio Vaccine)
Are we being good ancestors? NO!

4. Open Science/Biology/Innovation Paradigm IS
1) Collective Intelligence: semantic web for biology, BioTorrents,
massive open data sets, OA Publishing, Slashdot for Science Karma
systems to supplant static peereview, Mendley (Last FM for research
papers) Don't wait for AI, build Epistemology 2.0 NOW
2) Interoperable technology stacks: Stem Cells, Gene therapy vectors,
Biobricks
Biology fundamentally distributed, cheap (sunlight + sugar), self
replicating, cell cultures--share and share alike Biobanking for these
components should be DEFAULT. No one click shopping?
3) Radically better business models, financing mechanisms/prizes/
instruments, incentivize sharing, require it, demand to get what your
taxes pay for. Monopolies are Obsolete, Progress/Evolution depends
on Copying...whether in Biology or Culture. Perversity of Patent as
"incentive" for progress. Greenxchange, Innocentive, etc

6. Modern University... Obsolete? Open
Courseware, Fab Lab Network
Schizophrenic, Public vs Private?
Harvard Horror Story

7. How to Blow a Billion
40 Billion $ endowment 8 billion evaporated over night. Tech
Transfer
Where Innovation goes to Die. Wanna bet your future on them?

8. Desperate Times = Garage Biotech

9. Tired of Doing it all Yourself DIY?
Come Do it With US
Community Lab Hackerspace for Citizen Science

10. She's BioCurious!

11. Straining Towards the Singularity
Innovation Constipation
20 yr patent monopolies
Singularity is not NEAR!

12. P2P Shall set us Free
DIY or DIE
opensciencesummit.com