The document outlines opportunities and challenges in e-Science. It discusses how e-Science relies on massive computing and large datasets to unify theory, experimentation, and simulation. This represents a major shift in research paradigms. However, challenges remain around organizing, mining, and understanding huge amounts of data. Scientists must also become experts in complex computing methods, taking away from their primary research. There is an opportunity for "here and now" business tools to help scientists focus on research instead of computing.