1. Technology Transfer from the Weizmann Institute of Science
from our pipeline to your bottom line
Amir Naiberg, CEO
Yeda Research & Development Co. Ltd.
Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om

2. The Weizmann Institute of Science
Discovering Basic Science
Yeda Research & Development Co. Ltd.
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from the Weizmann Institute of Science w w w.YedaRnD .c om
w w w .Yeda R n D .com

3. Weizmann Institute
of Science
Curiosity Driven
Research
Yeda Research & Development Co. Ltd.
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4. What will be Who will
the next make the
scientific next scientific
revolution? revolution?
Yeda Research & Development Co. Ltd.
Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om

5. The next scientific revolution
will be
• driven by scientists who
have a multidisciplinary
view of science
• the opportunity to take
risks
• the infrastructure to work
• the freedom to think
Yeda Research & Development Co. Ltd.
Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om

6. The Weizmann Institute of Science
The Pool of knowledge
Mathematics
Computer Chemistry Biology
Science
Physics Biochemistry
Yeda Research & Development Co. Ltd.
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7. The Weizmann Institute of Science
Quality Driven
Average number of citations per paper
Technion
TAU
HUJ
WIS
BGU “Best Place in Academia”
BIU ranked No.1 in 2011 among top
International academic
Haifa
Institutions”
TheScientist.com
Yeda Research & Development Co. Ltd.
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8. ERC Starter+Established 2007-2010
35
30
25
Success Rate (%)
20
15
10
5
0
Weizmann Technion Hebrew Tel Aviv Ben Gurion Bar Ilan Haifa
Yeda Research & Development Co. Ltd.
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9. The Need to Rethink Innovation
Company Total R&D Spending 1997-2011 R&D Spending Per Number of Drugs
($Mil) Drug ($Mil) Approved
AstraZeneca 58,955 11,790.93 5
GlaxoSmithKline 81,708 8,170.81 10
Sanofi 63,274 7,909.26 8
Roche Holding AG 85,841 7,803.77 11
Pfizer Inc. 108,178 7,727.03 14
Johnson & Johnson 88,285 5,885.65 15
Eli Lilly & Co. 50,347 4,577.04 11
Abbott Laboratories 35,970 4,496.21 8
Merck & Co Inc 67,360 4,209.99 16
Bristol-Myers Squibb Co. 45,675 4,152.26 11
Novartis AG 83,646 3,983.13 21
Amgen Inc. 33,229 3,692.14 9
Total 802,468 5,773 139
Sources: InnoThink Center For Research In Biomedical Innovation; Thomson Reuters Fundamentals via FactSet Research Systems
The Truly Staggering Cost Of Inventing New Drugs, Matthew Herper (Forbes, 10.2.2012)
Yeda Research & Development Co. Ltd.
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10. The Israel National Center
for Personalized Medicine
BENCH TO
BEDSIDE
Enhancing medical
treatment efficacy
using the most
advanced research
tools
Yeda Research & Development Co. Ltd.
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11. Personalized Medicine – What is it?
Yeda Research & Development Co. Ltd.
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12. The Israel National Center for Personalized Medicine
Infrastructure
Sequencing Unit Proteomics Unit
Building on the Weizmann Crown Arising from the Weizmann Advanced
Human Genome Center, the unit will Mass Spectrometry Lab, the unit will
provide High Throughput DNA/RNA provide quantitative proteomics
sequencing and affiliated analyses to study differential
bioinformatics to analyse genomic expression and post-translational
variations, transcriptomes, non-coding modifications of proteins.
RNAs, and editomes.
Bioinformatics Unit Small Molecules Screening Unit
Build on the Bioinformatics and Incorporating the Weizmann Structural
Biological Computing Group at Proteomics Unit for protein production
Weizmann, the unit will use advanced and structure determination
tools to identify promising gene capacities, the unit will screen small
targets, key proteins and molecule and siRNA libraries for
critical pathways. desired biological effects.
Yeda Research & Development Co. Ltd.
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13. Yeda Research & Development Co. Ltd.
Bridging Research & Development
Yeda Research & Development Co. Ltd.
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14. Yeda = Knowledge
Applied Basic
Top Down Bottom up
Demand driven Curiosity driven
Secrecy Publish or Perish
Short term Long term
Risk taking Avoid commercial risks
Yeda Research & Development Co. Ltd.
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15. Yeda Research & Development Co. Ltd.
A World Leader in Technology Transfer
 Dozens of “Weizmann-Inside” products on the market.
 Total annual royalty-generating sales in 2011:
Over $15 Billion.
 Over 50 new companies were established around Yeda’s
technologies.
 Yeda owns the largest portfolio of patents in Israel:
560 live patent families, with more than 1,700 patent
families filed since 1971.
Yeda Research & Development Co. Ltd.
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16. Israeli Patents in the USA
(Accumulated for the Years 2006-2010)
450
403
400
350 325
300
250
200 164
144 141
150
95 90 87
100 77 77 63 62 61 61 57 57
50
0
Yeda Research & Development Co. Ltd. Source: BDI
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17. Governmental Support
Yeda Research & Development Co. Ltd.
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18. Innovation Capacity Score
Enterprise Support
encourages growth of
domestic biotechnology
startups and lures foreign
companies to establish
facilities domestically.
Source: SCEINTIFIC
AMERICAN/WORLDVIEW 2010
Yeda Research & Development Co. Ltd.
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19. Intervention Programs
KAMIN
60%
85%
60%
90%
Yeda Research & Development Co. Ltd.
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20. The Role of Governments
 Financial support for academic, basic research. Public
support is essential for academic freedom.
 Intervention programs for “bridging the gap”.
 Legal infrastructure: intellectual property rights (IPR)
laws, Taxations, corporate law, etc.
 Fixing market failures.
Yeda Research & Development Co. Ltd.
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21. Global vs. Local
 Science is inherently global: it is like parachute, it
only functions when open; Scientists look for the
international collaborators which most fit their
research needs.
 Industry aims at global markets; it looks for the best
international deals.
 Governments act Locally – for national growth, for
the local industry, for jobs creation, etc.
=> Government involvement is against
internationalization of R&D.
Yeda Research & Development Co. Ltd.
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22. Government’s involvement in university-
industry relations
 Under the responsibility of the office of the Chief Scientist at
the ministry of Industry, Trade and Labor (OCS).
 Different intervention programs for university-LOCAL
industry collaboration.
 Restrictions on exporting of knowledge created under these
programs.
Yeda Research & Development Co. Ltd.
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23. Summary
 Israel’s example has shown that successful global TT can
go together with excellent science and bring products to the
marketplace.
 Acting globally scientifically and the freedom of operation
of the TTOs’ were essential for this success and brought
investments to Israel.
 Lately, government’s policy is more dominant, trying to
encourage LOCAL TT.
 EU, as a superstructure, should support cross border
technology transfer.
Yeda Research & Development Co. Ltd.
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24. www.YedaRnD.com
Thank you
Yeda Research & Development Co. Ltd.
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