Welcome Remarks and Overview of CTSI Resources Steven Dubinett, MD Director, UCLA Clinical and Translational Science Institute President/CEO, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center

1. Steven Dubinett, MD
Director, Clinical and Translational Science Institute
Associate Vice Chancellor and Senior Associate Dean, Translational Research
NIH/ Career Development Award
Workshop
July 25, 2013
1
UCLA CTSI
Clinical and Translational Science Institute
www.ctsi.ucla.edu

2. Create an academic home for translational science
Advance team science
Train the next generation of translational scientists
Build bi-directional community partnerships
Promote inter-institutional collaborations
UCLA CTSI Goals
2

3. NIH CTSA Consortium

4. 4
UCLA translational investigation extends
from molecules to society
Translating knowledge gained from laboratory
science into clinical practice to improve health.
The aim of translational research is to produce new:
• therapeutics
• medical devices
• tools for diagnosing disease
• avenues for community engagement research
What is translational research?

5. 5
1) Clinical and Community Research Resources (CCRR)
2) Biomedical Informatics Program (BIP)
3) Community Engagement in Research Program (CERP)
4) Pilot and Collaborative Translational and Clinical Studies
Programs (Pilot)
5) Research Education, Training and Career Development
Program (CTSI-ED)
Program Areas (1-5)

6. 6
6) Biostatistics and Computational Biology Program
7) Center for Translational Technologies (CTT)
8) Maternal, Child and Adolescent Health (MCAH)
9) Regulatory Knowledge, Industry Relations and Research
Ethics Program (Regulatory)
10) Evaluation & Tracking
Program Areas (6-10)

7. 7
Opportunity Funds Grant Amount Duration of
Award (Years)
Award Cycle Application
Due Date
KL2 Awards:
to pursue interdisciplinary, mentored
research with training
Up to $125,000
in salary and
research support
1 year at 75%
effort
(renewable for
up to 3 years)
July 1 RFA to be
released in
Jan 2014
Full application:
late Feb 2014
TL1 Translational Science Fellowship:
PhD candidates in the Department of
Health Policy and Management in the
UCLA Fielding School of Public Health
receive mentored training to ensure
the translational nature of their
dissertation projects
Annual stipend
plus funding for
health
insurance,
tuition/fees, and
training-related
travel
Renewable for
up to 4 years
Annual UCLA School of
Public Health
application
deadline is
Dec 1, 2014
TL1 Summer Program for
Professional Students:
provides professional students
(medical, nursing and dental) early
exposure to interdisciplinary,
community-partnered translational
or health services research
Summer stipend
plus funding for
training-related
expenses
The summer
between
student’s first
and second
year (8 weeks)
June 1 March 28, 2014
Early Career Awards

8. Assistant Professor, CDU
“ Effects of Varenicline on Alcohol and Nicotine Consumption and
changes in Dopamine D2-like Receptor Availability in High-Alcohol
Preferring Mice”
Amira Brown, MS, PhDAmira Brown, MS, PhD
Assistant Professor, Pediatric Nephrology, UCLA
“ Hepcidin and the Anemia of Chronic Kidney Disease”
Joshua Zaritsky, MD, PhDJoshua Zaritsky, MD, PhD
Assistant Professor of Medicine, UCLA/VA
“ Patterns and Predictors of Poor Outcomes Following Emergency
Department Discharge in Older Adults”
Gelareh Gabayan, MD, MSHSGelareh Gabayan, MD, MSHS
KL2 Y1 Awardees

9. 9
Assistant Professor, UCLA-Harbor / LA-BioMed
“Using Research in Vancomycin-Resistant Enterococcus to Validate an
Efficient System of Quantifying Antibiotic Utilization”
James McKinnell, MDJames McKinnell, MD
Assistant Professor, UCLA
“Modeling of EMT/MET transitions in breast cancer stem cells”
Mary Sehl, MD, PhDMary Sehl, MD, PhD
Assistant Professor, UCLA
“Development of novel therapeutic strategies to target LKB1/STK11
deficient non-small cell lung cancer”
David Shackelford, PhDDavid Shackelford, PhD
KL2 Y2 Awardees

10. 10
Assistant Professor, UCLA
“Understanding the relationship between adolescent identity and
substance use”
Rebecca Dudovitz, MD, MSHSRebecca Dudovitz, MD, MSHS
Assistant Clinical Professor, Cedars-Sinai Medical Center
“Role of IL1-ß and the NLRP3 inflammasome in the development of
hypoxemia in acute lung injury”
Heather Jones, MDHeather Jones, MD
Assistant Professor, UCLA
“Single fraction vs. multiple fraction radiation for patients with
advanced cancer and painful bone metastases”
Anne Walling, MD, PhDAnne Walling, MD, PhD
KL2 Y3 Awardees
Clinical Instructor, UCLA
“Mechanisms Of Allograft Injury And The Development Of
Bronchiolitis Obliterans Syndrome After Lung Transplantation”
Michael Shino, MDMichael Shino, MD

11. 11
Assistant Clinical Professor, UCLA
“Relationship of physical activity to hippocampal structure and
memory in MCI”
David Merrill, MD, PhDDavid Merrill, MD, PhD
Assistant Professor, UCLA
“Gene expression profiles of ECT response in major depressive
disorder”
Eliza Congdon, PhDEliza Congdon, PhD
Assistant Professor, Cedars-Sinai Medical Center
“Minimizing errors in medication histories obtained at hospital
admission”
Joshua Pevnick, MD, MSHSJoshua Pevnick, MD, MSHS
KL2 Y3 Awardees
Assistant Professor, Charles Drew University of Medicine and Science
“Sensitization of castration-resistant prostate tumors to docetaxel
treatment by green tea and quercetin”
Piwen Wang, MD, PhD, MSPiwen Wang, MD, PhD, MS

12. Ambulatory Clinical Research Facilities
at Westwood
•7 private rooms, infusion rooms, 2 procedure rooms
•>20,000 sq ft outpatient area
•Clinical and Research Sleep Center
•Interview and conference rooms
•Scatter Specialty Unit
•Service center with pharmacy and sample processing
•23 hour capacity
CTSI-Wide Accomplishments
•Clinical support for existing research projects
•119 new protocols
•8,137 out-patient & 744 in-patient stays across the CTSI
•Implemented cost-sharing model with waivers or
reduced rates for new investigators
Clinical and Translational Research Center (CTRC)

13. Biostatistical Consults · Core Services · Pilot Funding · CTSI Activities
13banner “Cite It” card posters newsletters
Quarterly
publication
awards
Biostatistical Consults
•1267 projects for 611 investigators
Vouchers
•Awarded 230 proposals ($2.2 M)
Pilot funding
•Awarded 195 pilot grants for total of $6.45 M
($3.65 M in CTSI funds; $2.8 M institutional funds)
•Return of $26 M
CTSI Activities
• 20 proposals funded for total of $80 M ($88 M pending)
• Rapid Response Team: supported 23 collaborations
• Office of Investigator Services: 744 consults
More than 430 publications prior to January 2013

14. University of California,
Los Angeles
CTSA Regional Consortia

15. 15
• A committee of the CTSA PIs at UC Davis, San
Diego, San Francisco, Irvine and Los Angeles
• Initial focus on contracting, informatics and IRBs
• Drug discovery and development
• Biobanking and global consent
• Future inclusion of UCLA CTSI partner
institutions including LA county health system
UC Biomedical Research Acceleration Integration and Development (UC-BRAID)

16. 16banner “Cite It” card newsletters
UCLA
UC Davis
UC San Francisco
UC Irvine
UC San Diego
Los Angeles
UCLA xData Repository
· Los Angeles Data Repository · UC Research Exchange
UC Research Exchange (UC-ReX)
Los Angeles Data Repository (LADR)
UCLA xData Repository (xDR)

17. 17
UC Research Exchange (UC-ReX)
UC Biomedical Research Acceleration Integration and Development (UC-BRAID)

18. factsperdecision
5
Adapted from W. Stead et al, Academic Medicine, Vol. 84, No. 4 / April 2011
1990 2000 2010 2020
Clinical data
Human cognitive capacity
Genetics and proteomics
10
100
1000
Augmenting human cognitive capacity in translational research

19. imagingimaging
pathologypathology
activities of daily livingactivities of daily living
clinical outcomesclinical outcomes
DNADNA
RNARNA
epigeneticsepigenetics
proteinsproteins
computationalcomputational
medicinemedicine
universe ofuniverse of
clinical dataclinical data
computationalcomputational
biologybiology
symptomssymptoms
clinical laboratoryclinical laboratory
monitored datamonitored data
A model of computational medicine
behaviorsbehaviors

20. time
prediction
medicine
data
Investigations in Prediction Medicine
population
based
evaluations
Katzan and Rudick. Time to integrate clinical and research informatics. Science Transl Med 2012

21. UC Research Exchange (UC-ReX)UC Research Exchange (UC-ReX)