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9/2/2012




                                      By- Jitendra Bhangale
                                    Assistant Professor & Head,
                                   Department of Pharmacology,
                                Smt N. M. Padalia Pharmacy College,
                                            Ahmedabad
                                                                                     1
                               © 2010 Delmar, Cengage Learning




 Cells are specialized for particular functions

 Tissues

    Groups of cells with similar structure and function

    Four primary types

        Epithelium

        Connective tissue

        Nervous tissue

        Muscle                                                                      2
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                 1
9/2/2012




 Found in different areas
    Body coverings
    Body linings
    Glandular tissue
 Functions
    Protection
    Absorption
    Filtration
    Secretion
                                                                                     3
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Cells fit closely together


 Tissue layer always has one free surface


 The lower surface is bound by a basement membrane


 Avascular (have no blood supply)


 Regenerate easily if well nourished

                                                                                     4
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                 2
9/2/2012




 Number of cell layers


    Simple – one layer


    Stratified – more than

       one layer



                                                                                     5
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Shape of cells


    Squamous – flattened

    Cuboidal – cube-

       shaped


    Columnar – column-

       like
                                                                                     6
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                 3
9/2/2012




 Simple squamous

    Single layer of flat
       cells

    Usually forms
       membranes

        Lines body cavities

        Lines lungs and
          capillaries
                                                                                     7
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Simple cuboidal

    Single layer of cube-
       like cells

    Common in glands
       and their ducts

    Forms walls
       of kidney tubules

    Covers the ovaries
                                                                                     8
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                 4
9/2/2012




 Simple columnar

    Single layer of tall
       cells

    Often includes goblet
       cells, which produce
       mucus

    Lines digestive tract

                                                                                     9
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Pseudostratified
    Single   layer,   but
     some cells are shorter
     than others
    Often looks like                  a
     double cell layer
    Sometimes      ciliated,
     such    as    in     the
     respiratory tract
    May     function                 in
     absorption                       or
     secretion
                                                                                    10
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                 5
9/2/2012




 Stratified squamous
    Cells at the free edge
     are flattened
    Found as a protective
     covering where
     friction is common
    Locations
        Skin
        Mouth
        Esophagus
                                                                                    11
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Stratified cuboidal

    Two layers of cuboidal cells

 Stratified columnar

    Surface cells are columnar, cells underneath vary in
       size and shape

 Stratified cuboidal and columnar

    Rare in human body

    Found mainly in ducts of large glands                                          12
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                 6
9/2/2012




 Transitional epithelium


    Shape              of        cells

       depends          upon        the

       amount of stretching


    Lines organs of the

       urinary system
                                                                                    13
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Gland – one or more cells that secretes a particular
  product
 Two major gland types
    Endocrine gland
        Ductless
        Secretions are hormones
    Exocrine gland
        Empty through ducts to the epithelial surface
        Include sweat and oil glands
                                                                                    14
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                 7
9/2/2012




 Found everywhere in the body

 Includes the most abundant and widely distributed
   tissues

 Functions

    Binds body tissues together

    Supports the body

    Provides protection
                                                                                    15
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Variations in blood supply


    Some tissue types are well vascularized


    Some have poor blood supply or are avascular


 Extracellular matrix


    Non-living material that surrounds living cells

                                                                                    16
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                 8
9/2/2012




 Two main elements

    Ground substance – mostly water along with
     adhesion proteins and polysaccharide molecules

    Fibers

        Produced by the cells

        Three types

             Collagen fibers

             Elastic fibers

             Reticular fibers                                                      17
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Bone (osseous tissue)
    Composed of:
        Bone     cells     in
         lacunae (cavities)
        Hard    matrix               of
         calcium salts
        Large numbers of
         collagen fibers
    Used to protect and
     support the body
                                                                                    18
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                 9
9/2/2012




 Hyaline cartilage

    Most                   common
     cartilage

    Composed of:

        Abundant collagen
         fibers

        Rubbery matrix

    Entire fetal skeleton
     is hyaline cartilage
                                                                                    19
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Elastic cartilage


    Provides elasticity


    Example: supports the external ear



                                                                                    20
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                10
9/2/2012




 Fibrocartilage


    Highly compressible


    Example:                   forms

       cushion-like              discs

       between vertebrae

                                                                                    21
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Dense connective tissue

    Main matrix element
       is collagen fibers

    Cells are fibroblasts

    Examples

        Tendon – attach
          muscle to bone

        Ligaments – attach
          bone to bone           © 2010 Delmar, Cengage Learning
                                                                                    22
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                11
9/2/2012




 Areolar connective
  tissue
    Most widely
     distributed
     connective tissue
    Soft, pliable tissue
    Contains all fiber
     types
    Can soak up excess
     fluid


                                                                                    23
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Adipose tissue
    Matrix is an areolar
     tissue in which fat
     globules predominate
    Many cells contain
     large lipid deposits
    Functions
        Insulates the body
        Protects some
         organs
        Serves as a site of
         fuel storage
                                                                                    24
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                12
9/2/2012




 Reticular connective
  tissue
    Delicate network of
     interwoven fibers
    Forms stroma
     (internal supporting
     network) of
     lymphoid organs
        Lymph nodes
        Spleen
        Bone marrow
                                                                                    25
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Blood

    Blood cells
       surrounded by fluid
       matrix

    Fibers are visible
       during clotting

    Functions as the
       transport vehicle for
       materials                                                                    26
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                13
9/2/2012




     Function is to produce movement


     Three types


         Skeletal muscle


         Cardiac muscle


         Smooth muscle

                                                                                    27
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Skeletal muscle

    Can          be     controlled
       voluntarily

    Cells             attach         to
       connective tissue

    Cells are striated

    Cells have more than
       one nucleus
                                                                                    28
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                14
9/2/2012




 Cardiac muscle
    Found only in the
     heart
    Function is to pump
     blood (involuntary)
    Cells attached to
     other cardiac muscle
     cells at intercalated
     disks
    Cells are striated
    One nucleus per cell
                                                                                    29
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Smooth muscle

    Involuntary muscle

    Surrounds hollow
       organs

    Attached to other
       smooth muscle cells

    No visible striations

    One nucleus per cell
                                                                                    30
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                15
9/2/2012




 Neurons and nerve
   support cells

 Function is to send
   impulses to other areas
   of the body

    Irritability

    Conductivity

                                                                                    31
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Regeneration

    Replacement of destroyed tissue by the same kind
     of cells

 Fibrosis

    Repair by dense fibrous connective tissue (scar
     tissue)

 Determination of method

    Type of tissue damaged

    Severity of the injury
                                                                                    32
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                16
9/2/2012




 Capillaries become very permeable


    Introduce clotting proteins


    Wall off injured area


 Formation of granulation tissue


 Regeneration of surface epithelium

                                                                                    33
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




 Tissues that regenerate easily

    Epithelial tissue

    Fibrous connective tissue and bone

 Tissues that regenerate poorly

    Skeletal muscle

 Tissues that are replaced largely with scar tissue

    Cardiac muscle

    Nervous tissue within the brain and spinal cord                                34
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                                                                                17
9/2/2012




 Epithelial tissue arises from all three primary germ

   layers


 Muscle and connective tissue arise from the mesoderm


 Nervous tissue arises from the ectoderm


 With old age there is a decrease in mass and viabililty

   in most tissues
                                                                                       35
                                 © 2010 Delmar, Cengage Learning
By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad




                                  By Jitendra Bhangale
                                                                                        36
   Asst. Prof. Dept of Pharmacology, Delmar, Cengage Learning Pharmacy College, Ahmedabad
                               © 2010 Smt N. M. Padalia




                                                                                                  18

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Tissues by JITENDRA BHANGALE

  • 1. 9/2/2012 By- Jitendra Bhangale Assistant Professor & Head, Department of Pharmacology, Smt N. M. Padalia Pharmacy College, Ahmedabad 1 © 2010 Delmar, Cengage Learning  Cells are specialized for particular functions  Tissues Groups of cells with similar structure and function Four primary types Epithelium Connective tissue Nervous tissue Muscle 2 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 1
  • 2. 9/2/2012  Found in different areas Body coverings Body linings Glandular tissue  Functions Protection Absorption Filtration Secretion 3 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Cells fit closely together  Tissue layer always has one free surface  The lower surface is bound by a basement membrane  Avascular (have no blood supply)  Regenerate easily if well nourished 4 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 2
  • 3. 9/2/2012  Number of cell layers Simple – one layer Stratified – more than one layer 5 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Shape of cells Squamous – flattened Cuboidal – cube- shaped Columnar – column- like 6 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 3
  • 4. 9/2/2012  Simple squamous Single layer of flat cells Usually forms membranes Lines body cavities Lines lungs and capillaries 7 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Simple cuboidal Single layer of cube- like cells Common in glands and their ducts Forms walls of kidney tubules Covers the ovaries 8 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 4
  • 5. 9/2/2012  Simple columnar Single layer of tall cells Often includes goblet cells, which produce mucus Lines digestive tract 9 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Pseudostratified Single layer, but some cells are shorter than others Often looks like a double cell layer Sometimes ciliated, such as in the respiratory tract May function in absorption or secretion 10 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 5
  • 6. 9/2/2012  Stratified squamous Cells at the free edge are flattened Found as a protective covering where friction is common Locations Skin Mouth Esophagus 11 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Stratified cuboidal Two layers of cuboidal cells  Stratified columnar Surface cells are columnar, cells underneath vary in size and shape  Stratified cuboidal and columnar Rare in human body Found mainly in ducts of large glands 12 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 6
  • 7. 9/2/2012  Transitional epithelium Shape of cells depends upon the amount of stretching Lines organs of the urinary system 13 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Gland – one or more cells that secretes a particular product  Two major gland types Endocrine gland Ductless Secretions are hormones Exocrine gland Empty through ducts to the epithelial surface Include sweat and oil glands 14 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 7
  • 8. 9/2/2012  Found everywhere in the body  Includes the most abundant and widely distributed tissues  Functions Binds body tissues together Supports the body Provides protection 15 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Variations in blood supply Some tissue types are well vascularized Some have poor blood supply or are avascular  Extracellular matrix Non-living material that surrounds living cells 16 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 8
  • 9. 9/2/2012  Two main elements Ground substance – mostly water along with adhesion proteins and polysaccharide molecules Fibers Produced by the cells Three types Collagen fibers Elastic fibers Reticular fibers 17 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Bone (osseous tissue) Composed of: Bone cells in lacunae (cavities) Hard matrix of calcium salts Large numbers of collagen fibers Used to protect and support the body 18 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 9
  • 10. 9/2/2012  Hyaline cartilage Most common cartilage Composed of: Abundant collagen fibers Rubbery matrix Entire fetal skeleton is hyaline cartilage 19 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Elastic cartilage Provides elasticity Example: supports the external ear 20 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 10
  • 11. 9/2/2012  Fibrocartilage Highly compressible Example: forms cushion-like discs between vertebrae 21 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Dense connective tissue Main matrix element is collagen fibers Cells are fibroblasts Examples Tendon – attach muscle to bone Ligaments – attach bone to bone © 2010 Delmar, Cengage Learning 22 By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 11
  • 12. 9/2/2012  Areolar connective tissue Most widely distributed connective tissue Soft, pliable tissue Contains all fiber types Can soak up excess fluid 23 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Adipose tissue Matrix is an areolar tissue in which fat globules predominate Many cells contain large lipid deposits Functions Insulates the body Protects some organs Serves as a site of fuel storage 24 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 12
  • 13. 9/2/2012  Reticular connective tissue Delicate network of interwoven fibers Forms stroma (internal supporting network) of lymphoid organs Lymph nodes Spleen Bone marrow 25 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Blood Blood cells surrounded by fluid matrix Fibers are visible during clotting Functions as the transport vehicle for materials 26 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 13
  • 14. 9/2/2012  Function is to produce movement  Three types Skeletal muscle Cardiac muscle Smooth muscle 27 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Skeletal muscle Can be controlled voluntarily Cells attach to connective tissue Cells are striated Cells have more than one nucleus 28 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 14
  • 15. 9/2/2012  Cardiac muscle Found only in the heart Function is to pump blood (involuntary) Cells attached to other cardiac muscle cells at intercalated disks Cells are striated One nucleus per cell 29 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Smooth muscle Involuntary muscle Surrounds hollow organs Attached to other smooth muscle cells No visible striations One nucleus per cell 30 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 15
  • 16. 9/2/2012  Neurons and nerve support cells  Function is to send impulses to other areas of the body Irritability Conductivity 31 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Regeneration Replacement of destroyed tissue by the same kind of cells  Fibrosis Repair by dense fibrous connective tissue (scar tissue)  Determination of method Type of tissue damaged Severity of the injury 32 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 16
  • 17. 9/2/2012  Capillaries become very permeable Introduce clotting proteins Wall off injured area  Formation of granulation tissue  Regeneration of surface epithelium 33 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad  Tissues that regenerate easily Epithelial tissue Fibrous connective tissue and bone  Tissues that regenerate poorly Skeletal muscle  Tissues that are replaced largely with scar tissue Cardiac muscle Nervous tissue within the brain and spinal cord 34 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad 17
  • 18. 9/2/2012  Epithelial tissue arises from all three primary germ layers  Muscle and connective tissue arise from the mesoderm  Nervous tissue arises from the ectoderm  With old age there is a decrease in mass and viabililty in most tissues 35 © 2010 Delmar, Cengage Learning By J. O. Bhangale, Head, Dept of Pharmacology, Smt N. M. Padalia Pharmacy College, A’bad By Jitendra Bhangale 36 Asst. Prof. Dept of Pharmacology, Delmar, Cengage Learning Pharmacy College, Ahmedabad © 2010 Smt N. M. Padalia 18