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CHAPTER 17 Nervous System
Nervous System ,[object Object],[object Object],[object Object],[object Object]
Organization of Nervous Systems ,[object Object],[object Object],[object Object],[object Object],[object Object],A  nerve  is a communication line made from cable-like  bundles of neuron fibers .
Central Nervous System Brain Spinal Cord Peripheral Nervous System Peripheral Nerve
The 3 interconnected functions of the nervous system are carried out by 3 types of neurons: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
You hit the ball
Why are athletes so good at what they are doing? Researchers found that the brain of athletes is  “quieter”  than non-athletes when asked to perform a task.  This suggests that their brain would be  more efficient , and need less neurons to perform a task. Some neurons strenghten their connections to other neurons and weakens connections to others. (ex: soccer players and screen) Practice also changes the brain Athletes can analyze a situation and make a decision in a split second.
NEURONS The Functional units of the Nervous System
Neurons ,[object Object],[object Object],[object Object],[object Object],[object Object]
5  AXON :  Transmits the action potential. 2 DENDRITES:  Receive signals  from other neurons. 4 Action potential starts here. 1  Synaptic terminals:   Bring signals from other neurons. 3 CELL BODY Integrates signals; coordinates metabolic activities. 6 Myelin:  Insulates axon, speeds conduction. 8 DENDRITES (of other neurons) 7 Synaptic terminals:  Transmit signals to other neurons.
How Do Neurons Communicate? ,[object Object],[object Object],[object Object]
Neuron 1 Neuron 2 1. Action Potential 2. Synapse 3. Neurotransmitters 4. Action Potential
1. The Action Potential
How Is Neural Activity Produced and Transmitted? ,[object Object],[object Object],[object Object]
The Action Potential ,[object Object],[object Object]
 
Propagation ,[object Object],[object Object],[object Object]
 
2. SYNAPSES
Neurons Communicate at Synapses Synapses a re the relay points between 2 neurons or between a neuron and an effector cell
Based on  Harvard Medical School Family Health Guide SYNAPSES Synapses rely on  neurotransmitters   to carry information from one nerve cell to another kind of cell that will react.
So, how is the message carried from one neuron to the other? Or  What happens in the Synapse?
Synaptic cleft Neuron 2 Neuron 1 Synapse Vesicles containing  neurotransmitters Receptors The neurotransmitters binds there
Synaptic cleft ,[object Object]
[object Object]
3.  Neurotransmitter  released into the synaptic cleft
4.  Neurotransmitter  binds to the  receptor  and opens up the ion Channel
a new  action potential starts Na + 5.  Na+ enters ,
A neuron may receive input from hundreds of other neurons via thousands of synaptic terminals.
3. Neurotransmitters
50 Known Neurotransmitters ,[object Object],[object Object],[object Object],[object Object],[object Object]
Example of Neurotransmitter DOPAMINE
DOPAMINE ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Synapses must be cleaned up
[object Object],[object Object],[object Object],[object Object]
HOW DRUG ADDICTION WORKS?
[object Object],[object Object],[object Object],DRUG ADDICTION
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. enzyme Axon terminal neurotransmitter synaptic vesicle Synaptic cleft Postsynaptic neuron 2 1 3 6 4 5 receptor
According to scientists: DOPAMINE . It is thought to  be the master molecule of addiction. ,[object Object],[object Object]
It is made in the brain and affects  primitive parts of the brain Based on  Time , May 5, 1997
[object Object],[object Object]
[object Object],MAO ,[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Nicotine stimulates the release of dopamine, while another substance in cigarette smoke blocks the action of MAO. How Drug Affect Dopamine Levels Based on  Time , May 5, 1997
When a cell has been exposed to a chemical signal for a long time, it tends to get used to it and looses its sensibility to the stimulus. (ex: sitting on a chair).  Drug Addiction:  If a cell is exposed to high levels of neurotransmitter, it will adapt by having less receptors (homeostasis)
Physiology of Addiction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Do you know a good addiction? ,[object Object],[object Object],[object Object],Runner’s high
The Human Nervous System  ,[object Object],[object Object],[object Object]
The Central Nervous System:  CNS is made up of the   spinal cord   and the  brain ,[object Object],[object Object]
The Central Nervous System ,[object Object],[object Object],[object Object],Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. a. spinal cord spinal nerve vertebra Intervertebral disk
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
A Somatic Reflex Arc Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. pin Dorsal sensory receptor (in skin) cell body of  sensory neuron cell body of interneuron axon of motor neuron cell body of motor neuron effector (muscle) Ventral side Dorsal side
The Human Brain ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cerebrum
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. skull meninges Diencephalon pons spinal cord Cerebellum fourth ventricle pineal gland hypothalamus thalamus (surrounds the third ventricle) third ventricle lateral ventricle Cerebrum corpus callosum pituitary gland Brain stem midbrain medulla oblongata a. Parts of  brain
1. The Cerebrum
The cerebrum is involved in several functions of the body including:  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THE CEREBRUM largest portion of human brain ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Gray Matter White Matter ,[object Object]
Cerebrum ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Size of the body part reflects the amount of cerebral cortex devoted to that body part Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Toes Ankle Knee Hip Trunk Shoulder A r m Ring finger Index finger Thumb Neck Eyelid and eyeball Lips and jaw Face Tongue Genitals Hip Trunk Neck Shoulder Little finger Ring finger Middle finger Index finger Face Lips, teeth, gums, and jaw Tongue Pharynx a. Prima ry motor area b . Primary somatosensory area Intra-abdominal Nose Eye Thump Leg Foot Toes Elbow Arm Forearm wrist Hand Pharynx Middle finger Little finger Hand Wrist Foreman Elbow
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Cerebrum
Language and Speech Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. motor speech (Broca ’ s area) Ability to speech primary motor area primary visual area primary auditory area sensory speech (Wernicke ’ s area) Ability to comprehend speech Example : writer who, one morning, couldn ’t read/recognizes words anymore, but it could write flawlessly.
2. The diencephalon
DIENCEPHALON
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Diencephalon hypothalamus thalamus pituitary gland ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
3. The cerebellum
CEREBELLUM
The Cerebellum ,[object Object],[object Object],[object Object],[object Object]
4. The Brain Stem The most ancient,  sometimes called  the Reptilian Brain
BRAIN STEM
The Brain Stem ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
DISORDERS OF THE BRAIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
1. The case of Phineas Gage
Phineas Gage was the 1st patient from whom we learned about the link between  personality and decision making  and the function of the  front parts of the brain (frontal lobes) . In 1848, a 3 foot steel rod was blown through his head by an explosion. He survived but his personality changed. He became rude, impatient, fitful. He died at 37 after experiencing severe seizures.
2. Recent findings More recently, doctors were able to communicate with a brain-injured patient. They could read is thoughts using a scanner.
3. Alzheimer Disease (AD) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Alzheimer Disease Presence of plaques in different regions of the brain from an Alzheimer patient.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],4. Parkinson Disease (PD)
[object Object],[object Object],[object Object],5. Multiple Sclerosis (MS) ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],6. Stroke
[object Object],[object Object],[object Object],[object Object],[object Object],7. Meningitis
[object Object],[object Object],[object Object],[object Object],8. Mad Cow Disease
The Peripheral Nervous System The vertebrate peripheral nervous system is divided into 2 components:
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Disorders of the Spinal Cord ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Disorders of the Peripheral Nerves ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Chapter 17

  • 2.
  • 3.
  • 4. Central Nervous System Brain Spinal Cord Peripheral Nervous System Peripheral Nerve
  • 5.
  • 6. You hit the ball
  • 7. Why are athletes so good at what they are doing? Researchers found that the brain of athletes is “quieter” than non-athletes when asked to perform a task. This suggests that their brain would be more efficient , and need less neurons to perform a task. Some neurons strenghten their connections to other neurons and weakens connections to others. (ex: soccer players and screen) Practice also changes the brain Athletes can analyze a situation and make a decision in a split second.
  • 8. NEURONS The Functional units of the Nervous System
  • 9.
  • 10. 5 AXON : Transmits the action potential. 2 DENDRITES: Receive signals from other neurons. 4 Action potential starts here. 1 Synaptic terminals: Bring signals from other neurons. 3 CELL BODY Integrates signals; coordinates metabolic activities. 6 Myelin: Insulates axon, speeds conduction. 8 DENDRITES (of other neurons) 7 Synaptic terminals: Transmit signals to other neurons.
  • 11.
  • 12. Neuron 1 Neuron 2 1. Action Potential 2. Synapse 3. Neurotransmitters 4. Action Potential
  • 13. 1. The Action Potential
  • 14.
  • 15.
  • 16.  
  • 17.
  • 18.  
  • 20. Neurons Communicate at Synapses Synapses a re the relay points between 2 neurons or between a neuron and an effector cell
  • 21. Based on Harvard Medical School Family Health Guide SYNAPSES Synapses rely on neurotransmitters to carry information from one nerve cell to another kind of cell that will react.
  • 22. So, how is the message carried from one neuron to the other? Or What happens in the Synapse?
  • 23. Synaptic cleft Neuron 2 Neuron 1 Synapse Vesicles containing neurotransmitters Receptors The neurotransmitters binds there
  • 24.
  • 25.
  • 26. 3. Neurotransmitter released into the synaptic cleft
  • 27. 4. Neurotransmitter binds to the receptor and opens up the ion Channel
  • 28. a new action potential starts Na + 5. Na+ enters ,
  • 29. A neuron may receive input from hundreds of other neurons via thousands of synaptic terminals.
  • 31.
  • 33.
  • 34.
  • 35.
  • 37.
  • 38.
  • 39.
  • 40.
  • 41. It is made in the brain and affects primitive parts of the brain Based on Time , May 5, 1997
  • 42.
  • 43.
  • 44.
  • 45. When a cell has been exposed to a chemical signal for a long time, it tends to get used to it and looses its sensibility to the stimulus. (ex: sitting on a chair). Drug Addiction: If a cell is exposed to high levels of neurotransmitter, it will adapt by having less receptors (homeostasis)
  • 46.
  • 47.
  • 48.
  • 49.
  • 50.
  • 51.
  • 52. A Somatic Reflex Arc Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. pin Dorsal sensory receptor (in skin) cell body of sensory neuron cell body of interneuron axon of motor neuron cell body of motor neuron effector (muscle) Ventral side Dorsal side
  • 53.
  • 55. Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. skull meninges Diencephalon pons spinal cord Cerebellum fourth ventricle pineal gland hypothalamus thalamus (surrounds the third ventricle) third ventricle lateral ventricle Cerebrum corpus callosum pituitary gland Brain stem midbrain medulla oblongata a. Parts of brain
  • 57.
  • 58.
  • 59.
  • 60.
  • 61. Size of the body part reflects the amount of cerebral cortex devoted to that body part Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Toes Ankle Knee Hip Trunk Shoulder A r m Ring finger Index finger Thumb Neck Eyelid and eyeball Lips and jaw Face Tongue Genitals Hip Trunk Neck Shoulder Little finger Ring finger Middle finger Index finger Face Lips, teeth, gums, and jaw Tongue Pharynx a. Prima ry motor area b . Primary somatosensory area Intra-abdominal Nose Eye Thump Leg Foot Toes Elbow Arm Forearm wrist Hand Pharynx Middle finger Little finger Hand Wrist Foreman Elbow
  • 62.
  • 63. Language and Speech Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. motor speech (Broca ’ s area) Ability to speech primary motor area primary visual area primary auditory area sensory speech (Wernicke ’ s area) Ability to comprehend speech Example : writer who, one morning, couldn ’t read/recognizes words anymore, but it could write flawlessly.
  • 66.
  • 69.
  • 70. 4. The Brain Stem The most ancient, sometimes called the Reptilian Brain
  • 72.
  • 73.
  • 74. 1. The case of Phineas Gage
  • 75. Phineas Gage was the 1st patient from whom we learned about the link between personality and decision making and the function of the front parts of the brain (frontal lobes) . In 1848, a 3 foot steel rod was blown through his head by an explosion. He survived but his personality changed. He became rude, impatient, fitful. He died at 37 after experiencing severe seizures.
  • 76. 2. Recent findings More recently, doctors were able to communicate with a brain-injured patient. They could read is thoughts using a scanner.
  • 77.
  • 78. Alzheimer Disease Presence of plaques in different regions of the brain from an Alzheimer patient.
  • 79.
  • 80.
  • 81.
  • 82.
  • 83.
  • 84. The Peripheral Nervous System The vertebrate peripheral nervous system is divided into 2 components:
  • 85.
  • 86.  
  • 87.
  • 88.

Notes de l'éditeur

  1. Main Idea(s) of This Slide - This slide depicts the synapses between the axon of one neuron and the dendrite of another. Here is a close-up view of the synapse between two adjacent neurons. The axon of the neuron at the top of the slide terminates in what is called an axon bulb. Inside the axon bulb are synaptic vesicles that contain neurotransmitters. The neurotransmitters are responsible for exiting the axon bulb and entering into the synapse. Once inside the synapse (space between the neurons), the neurohormones bind to the adjacent neurons “postsynaptic membrane” and cause a new depolarization wave to begin. This image on the right depicts the neurotransmitter (neurohormone) being released from the synaptic vesicle into the synapse where it can then bind to receptors on the adjacent neuron.
  2. Main Idea(s) of This Slide - There are over 50 known neurotransmitters today. This slide lists three commonly discussed neurotransmitters; acetylcholine, dopamine, and serotonin. Acetylcholine is the neurotransmitter that is responsible for carrying a nerve impulse from a motor neuron, across a synapse, to a muscle cell (the effector) and causing the muscle to respond by contracting. Insufficient levels of acetylcholine or disruption in it ’s ability to work can cause neuromuscular problems. Seratonin is a neurotransmitter that is responsible for “filtering” sensory information coming into the brain. Some recreational drugs such as ecstasy create imbalances in the levels of serotonin resulting in hallucinations and mood changes. Other drugs called SSRI’s (selective serotonin re-uptake inhibitors) elevate serotonin levels in the brain resulting in mood elevation and are prescribed as anti-depressants. Dopamine is considered the “master molecule” of addiction. It is a neurotransmitter that is released by brain cells that causes a feeling of “well being” in response to pleasurable activities such as sex and eating. Elevated levels of dopamine cause a euphoric high and are associated with many recreational drugs.
  3. Main Idea(s) of This Slide - Neurotransmitters must be cleaned-up from the synapse to ensure that the response to them is short-lived and precise. Most neurotransmitters have enzymes which either break them down or cause them to be taken back into the neuron that released them. Acetylcholine, for example, the neurotransmitter that causes muscle contraction is broken down by an enzyme called acetylcholinesterase. The presence of this enzyme ensures that when a neuron stimulates a muscle cell, the stimulus only lasts a second which allows the muscle to then relax immediately after it was stimulated. This allows precise, coordinated movements. Other neurotransmitters have enzymes of their own that regulate their levels in the synaptic spaces.
  4. Main Idea(s) of This Slide - Again, use this opportunity to generate discussion in order to see if students are comprehending the impact that dopamine has on the central nervous system.
  5. Main Idea(s) of This Slide - Dopamine is believed to be the primary neurotransmitter responsible for chemical dependency based upon it ’s ability to reward behaviors with pleasurable feelings.
  6. Main Idea(s) of This Slide - Some recreational drugs interfere with the ability of the brain to regulate dopamine levels. Cocaine blocks the reabsorption of dopamine back into the neuron that released it. This results in a build-up of dopamine causing a prolonged sense of euphoria. Amphetamines stimulate excessive release of dopamine which overwhelms the ability of the neurons to reabsorb it quickly or MAO to break it down. The net result, again, is an elevated level of dopamine and a “high” feeling. Nicotine stimulates excessive release of dopamine and blocks the ability of MAO to break it down. This leaves the neurons ability to reabsorb the dopamine as the only way to return levels to normal. Again, this results in a short term “high”.
  7. Main Idea(s) of This Slide - Because these drugs elevate the levels of dopamine, they result in increased feelings of pleasure. This reinforces the behavior of taking the drug. In response to continued elevated dopamine levels, the brain begins to reduce the number of dopamine receptors on it ’s neurons (this is a kind of negative feedback mechanism where the brain is trying to keep things in balance). As a result of decreased numbers of dopamine receptors, the drug addict must take more and more of the drug and more often in order to maintain the same “high” feeling. This process continues, with number of receptors decreasing to the point that eventually, the drug addict must take high levels of the drug just to feel “O.K.” (in order to not feel bad).
  8. The 29 year old man was injured in a car accident. He was showing no signs of conciousness. The doctors were convinced he was in a vegetative stage, until now. To answer yes, he was told to think of playing tennis, a motor activity. To answer no, he was told to think of wandering from room to room in his home, visualising everything he would expect to see there, creating activity in the part of the brain governing spatial awareness. His doctors were amazed when the patient gave the correct answers to a series of questions about his family. The ­experiment will fuel the controversy of when a patient should have life support removed.