Dr Ciro Liberato - Epidemiologia Cancer Infantil

EPIDEMIOLOGIA DEL CANCER INFANTIL Dr. CIRO LIBERATO RAMON ONCOLOGO PEDIATRA FELLOW VISITING PEDIATRIC BONE MARROW TRANSPLANTATION UNIVERSITY OF COLORADO USA IOP PEDIATRIC LEUKEMIA ST JUDE CHILDRENS UNIV. TENNESSEE USA

EPIDEMIOLOGIA DEL CANCER INFANTIL

EPIDEMIOLOGIA DEL CANCER INFANTIL ,[object Object],[object Object],[object Object]

EL NIÑO NO ES UN ADULTO PEQUEÑO

Brain Tumors Childhood Cancers Other Lymphoma Neuroblastoma Soft tissue sarcomas Kidney tumors Bone tumors Retino- blastoma Leukemia

EPIDEMIOLOGIA DEL CANCER INFANTIL Neuroblastoma Retinoblastoma Wilms tumor Age ( yrs) at diagnosis Average annual rate per million SEER data, 2002

EPIDEMIOLOGIA DEL CANCER INFANTIL Registro de Cáncer de Lima Metropolitana (1990-1993) FRECUENCIA DE CÁNCER EN NIÑOS* AMBOS SEXOS (0-14 años) % 1. Leucemias 2. Linfomas 3. Cáncer Cerebro-Médula espinal 4. Sarcomas de Tejidos Blandos 5. Retinoblastoma 6. Sarcomas óseos 7. Gonodal y de células germinales 8. Riñón 9. Epiteliales 10. Hepáticos 11. S. Nervioso simpático (neuroblastoma) 12. Otros 37,35 16,14 13,49 5,78 5,18 4,46 4,34 4,10 3,13 2,65 2,17 1,20

Peripheral smear show lymphoBLASTS

LEUCEMIA INFANTIL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

LEUCEMIA INFANTIL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],• Fever of malignancy

TUMORES CEREBRALES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TUMORES CEREBRALES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Medulloblastoma Can grow very large before detection

LINFOMAS ,[object Object],[object Object],[object Object],[object Object],[object Object]

LINFOMAS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],95%

[object Object],[object Object],[object Object],HD in 9 y/o boy cough, fever, night sweats Pruritus shins, + orthopnea Superior Mediastinal Syndrome (SMS) = Oncologic Emergency

Superior Vena Cava (SVC) Syndrome in 10 y/o with Lymphoblastic Lymphoma Facial swelling, plethora, cyanosis,  neck veins Mediastinal mass: tracheal and SVC compression

Burkitt ’ s Lymphoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],= Oncologic Emergency

NEUROBLASTOMA Origen ,[object Object],[object Object],[object Object],[object Object],[object Object]

Localización anatómica esquemática del sistema nervioso simpátetico

Neuroblastoma Localización por Edad

More Periorbital Ecchymoses of Neuroblastoma 13 months old at diagnosis 1 month into therapy

NEUROBLASTOMA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Wilms Tumor ,[object Object],[object Object],[object Object],[object Object],[object Object]

Tumor de wilms Presentación Clinica ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Sarcoma de Tejido Blandos ,[object Object],[object Object],[object Object],[object Object],[object Object]

Rhabdomiosarcoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],35%

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],RABDOMIOSARCOMA Botryoid: grape-like

Rhabdomiosarcoma Presentación Clinica

Rhabdomiosarcoma Tratamiento ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Riesgo-bajo Riesgo-intermedio Riesgo-alto

TUMORES OSEOS ,[object Object],[object Object],[object Object],[object Object],[object Object],Ewing Sarcoma All bones: Long: diaphyses Flat Pelvis Skull Ribs Osteogenic Sarcoma Metaphyses of long bones: Distal femur Proximal tibia Proximal humerus Pelvis

Tratamiento De los Tumores Del Hueso ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Dr Ciro Liberato - Epidemiologia Cancer Infantil

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Dr Ciro Liberato - Epidemiologia Cancer Infantil