Radiation Therapy

Radiobiology A Preview By: Katherine Walz Callie Widmayer

Ionizing Radiation ,[object Object],http://www.paradigmlink.com/ionrad.shtml

Linear Energy Transfer (LET) ,[object Object],[object Object]

Low LET / High LET ,[object Object],[object Object],[object Object],[object Object],http://staff.jccc.net/PDECELL/biochemistry/dna.gif e -

Low LET / High LET ,[object Object],[object Object],[object Object],http://staff.jccc.net/PDECELL/biochemistry/dna.gif α ++

Ionizing Radiation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The following are the most common types of ionizing radiation: http://www.paradigmlink.com/ionrad.shtml

Ionizing Radiation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],http://www.paradigmlink.com/ionrad.shtml

Ionizing Radiation ,[object Object],[object Object]

H 2 O HOH + e - water electron Positively charged water molecule Radiation reacts with water to produce an electron and a positively charged water molecule.

H 2 O HOH + e - + H 2 O HOH - water negatively charged water molecule electron water Positively charged water molecule The electron reacts with another water molecule to produce a negatively charged water molecule

H 2 O HOH + H + OH * e - + H 2 O HOH - water negatively charged water molecule Hydrogen ion Hydroxyl radical electron water Positively charged water molecule The positively charged water molecule dissociates into a hydrogen ion and a hydroxyl radical.

H 2 O HOH + H + OH * H * OH - e - + H 2 O HOH - water negatively charged water molecule Hydrogen ion Hydroxyl radical electron water Positively charged water molecule hydrogen radical Hydroxyl ion The negatively charged water molecule dissociates into a hydrogen radical and a hydroxyl ion.

Reactions ,[object Object],[object Object]

HOH + + e - H 2 O The positively charged water molecule and the electron recombine to form water. H 2 O HOH + H + OH * H * OH - e - + H 2 O HOH -

H + + OH - H 2 O The ions combine to form water. H 2 O HOH + H + OH * H * OH - e - + H 2 O HOH -

H * + OH * H 2 O The radicals combine to form water. H 2 O HOH + H + OH * H * OH - e - + H 2 O HOH -

H 2 O HOH + H + OH * H * OH - e - + H 2 O HOH - OH* OH* + OH* H 2 O 2 The hydroxyl radical reacts with another hydroxyl radical to form hydrogen peroxide.

Free Radicals ,[object Object],[object Object]

Direct Action / Indirect Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DNA Damage ,[object Object],[object Object],[object Object],[object Object]

http://www.greenfacts.org/glossary/def/dna.htm

Chromosome Aberrations ,[object Object],[object Object],[object Object],Translocation Inversion Deletion

Radiosensitivity ,[object Object],[object Object],[object Object]

Fractionation ,[object Object],[object Object],[object Object],http://www.usoncology.com/CompanyInfo/PhotoLibrary.asp

References ,[object Object],[object Object],[object Object],[object Object],[object Object]

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