Journal Club: Daily Corticosteroids Reduce Infection-associated Relapses in Frequently Relapsing Nephrotic Syndrome: A Randomized Controlled Trial

Journal Club Dr Sidharth Kumar Sethi MD, Fellowship [IPNA, ISN, ISPN] https://www.pediatric-nephrology.com

Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Infections and Relapses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Short term daily steroids during infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Research Question ,[object Object]

Aim of the study ,[object Object],[object Object],[object Object],[object Object],[object Object]

Study Design ,[object Object],[object Object],[object Object],[object Object]

Inclusion criteria ,[object Object],[object Object],[object Object],[object Object]

Exclusion Criteria ,[object Object],[object Object],[object Object],[object Object]

Standard Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Randomisation ,[object Object],[object Object],[object Object],[object Object]

Intervention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Follow up ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Relapse definition and management ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Follow up ,[object Object],[object Object],[object Object],[object Object]

Serious Infections ,[object Object],[object Object],[object Object],[object Object]

Outcomes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Premature termination ,[object Object],[object Object],[object Object],[object Object]

Sample Size ,[object Object],[object Object],[object Object],[object Object]

Statistical Analysis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Incidence Density Rates ,[object Object],[object Object]

Example of Relapse Rates ,[object Object],[object Object],[object Object]

Rate Ratio ,[object Object],[object Object],[object Object]

Number needed to Treat ,[object Object],[object Object],[object Object]

NNT Example Prophylaxis RF No RF Total Risk Yes 15 285 300 0.05 No 49 251 300 0.16 ARR 0.11 NNT 9

68 patients alternate-day prednisolone alone (strata 1) 32 received alternate-day prednisolone and levamisole (strata 2)

Relapse rates @ 12 months ,[object Object],[object Object]

Infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Adjusted Analysis & Number Needed to Treat ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Treatment failures and Add on therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Discussion: Salient points of results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Previous studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Previous studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

More infections in intervention group! ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Critical Appraisal ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Limitations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Conclusions ,[object Object],[object Object]

Journal Club: Daily Corticosteroids Reduce Infection-associated Relapses in Frequently Relapsing Nephrotic Syndrome: A Randomized Controlled Trial

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Journal Club: Daily Corticosteroids Reduce Infection-associated Relapses in Frequently Relapsing Nephrotic Syndrome: A Randomized Controlled Trial