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Leukemia (blood cancer)

stress, viral infection, drug intake


             healthy

          flu, poisoning
What would aid them to move toward cancer tumor?
Automatic
Detection


 100
   clicks




 Incorrectly     Undetected   Correctly
 detected cell   cell         detected cell
Automatic
Detection


  10
   clicks




 Incorrectly     Undetected   Correctly
 detected cell   cell         detected cell
Our
Method


 10
  clicks




Incorrectly     Undetected   Correctly
detected cell   cell         detected cell
1. many types       2. first-timer   3. label effort




 Construct cell      Learn from
size distribution   previous types         ?
Training Image
                                  Cell

                                  Non-
                                  cell

                                Training Samples

  User
                                                        Size Distribution



                                                   GATLAB
label effort
                     random
                   interactive
                                                            Previous types
               Select most important
               samples for user to label.
Training Image
                             Cell

                             Non-
                             cell

                           Training Samples

User
                                                   Size Distribution

                  Detection Confidence
                                              GATLAB


                                                       Previous types
White Blood Cells   HT29 Cancer   Natural Killer T   Drosophila   Red Blood Cells
AdaBoost        uses Adaptive Boosting
   TaskTrAdaBoost            learns from previous cell types

GlobalTrAdaBoost             obtains cell size distribution
              GATLAB         selects most important samples



Freund and Schapire (2000)
Yao and Doretto (2010)
Nguyen et al. (2011)
Training samples were selected from 1 to 10.
Execute training and testing 30 times.
Training samples were selected up to 100 samples.
Natural Killer T-cells
AdaBoost
GATLAB
HT29 Colon Cancer
AdaBoost
GATLAB
Natural Killer T-cells



                         *presented in the 11th GRF (2011)
An accurate cell detection algorithm.

Require minimal training effort.

Help biologists to study various cell types.
N. Nguyen, E. Norris, M. Clemens, M. Shin. “Rapidly Adaptive Cell Detection.”
   Machine Vision and Applications (MVA), Special Issue: Machine Learning in
   Medical Imaging [in review].

N. Nguyen and M. Shin. “Active Transfer Boosting to Reduce Training Effort in
   Multi-class Data classification." IEEE International Conference on Computer
   Vision and Pattern Recognition (CVPR), Providence, Rhode Island, June 18-20, 2012
   [in review].

N. Nguyen, E. Norris, M. Clemens, M. Shin. “Rapidly Adaptive Cell Detection using
   Transfer Learning with a Global Parameter.” The Second International
   Workshop on Machine Learning in Medical Imaging (MLMI), Toronto, Canada.
   September 18-22, 2011.

N. Nguyen, S. Keller, E. Norris, T. Huynh, M. Clemens, M. Shin. “Tracking Colliding
   Cells in vivo Microscopy Video.” IEEE Transactions on Biomedical Engineering
   (TBE), 58(8):2391-2400, August 2011.

N. Nguyen, S. Keller, T. Huynh, M. Shin. “Tracking Colliding Cells”. IEEE Workshop
   on Applications of Computer Vision (WACV), Snowbird, UT December 07-09,
   2009.
Min Shin, PhD   Mark Clemens, PhD   Eric Norris, MS   Toan Huynh, MD Steve Keller, MS
An Accurate Cell Detection with Minimal Training Effort

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An Accurate Cell Detection with Minimal Training Effort

  • 1.
  • 2.
  • 3. Leukemia (blood cancer) stress, viral infection, drug intake healthy flu, poisoning
  • 4. What would aid them to move toward cancer tumor?
  • 5.
  • 6. Automatic Detection 100 clicks Incorrectly Undetected Correctly detected cell cell detected cell
  • 7. Automatic Detection 10 clicks Incorrectly Undetected Correctly detected cell cell detected cell
  • 8. Our Method 10 clicks Incorrectly Undetected Correctly detected cell cell detected cell
  • 9.
  • 10. 1. many types 2. first-timer 3. label effort Construct cell Learn from size distribution previous types ?
  • 11. Training Image Cell Non- cell Training Samples User Size Distribution GATLAB label effort random interactive Previous types Select most important samples for user to label.
  • 12. Training Image Cell Non- cell Training Samples User Size Distribution Detection Confidence GATLAB Previous types
  • 13.
  • 14. White Blood Cells HT29 Cancer Natural Killer T Drosophila Red Blood Cells
  • 15. AdaBoost uses Adaptive Boosting TaskTrAdaBoost learns from previous cell types GlobalTrAdaBoost obtains cell size distribution GATLAB selects most important samples Freund and Schapire (2000) Yao and Doretto (2010) Nguyen et al. (2011)
  • 16. Training samples were selected from 1 to 10. Execute training and testing 30 times.
  • 17. Training samples were selected up to 100 samples.
  • 24. Natural Killer T-cells *presented in the 11th GRF (2011)
  • 25. An accurate cell detection algorithm. Require minimal training effort. Help biologists to study various cell types.
  • 26. N. Nguyen, E. Norris, M. Clemens, M. Shin. “Rapidly Adaptive Cell Detection.” Machine Vision and Applications (MVA), Special Issue: Machine Learning in Medical Imaging [in review]. N. Nguyen and M. Shin. “Active Transfer Boosting to Reduce Training Effort in Multi-class Data classification." IEEE International Conference on Computer Vision and Pattern Recognition (CVPR), Providence, Rhode Island, June 18-20, 2012 [in review]. N. Nguyen, E. Norris, M. Clemens, M. Shin. “Rapidly Adaptive Cell Detection using Transfer Learning with a Global Parameter.” The Second International Workshop on Machine Learning in Medical Imaging (MLMI), Toronto, Canada. September 18-22, 2011. N. Nguyen, S. Keller, E. Norris, T. Huynh, M. Clemens, M. Shin. “Tracking Colliding Cells in vivo Microscopy Video.” IEEE Transactions on Biomedical Engineering (TBE), 58(8):2391-2400, August 2011. N. Nguyen, S. Keller, T. Huynh, M. Shin. “Tracking Colliding Cells”. IEEE Workshop on Applications of Computer Vision (WACV), Snowbird, UT December 07-09, 2009.
  • 27. Min Shin, PhD Mark Clemens, PhD Eric Norris, MS Toan Huynh, MD Steve Keller, MS

Notes de l'éditeur

  1. A special type of white blood cells, call natural killer t-cells, has a potential of killing cancer tumor.
  2. 10 training samples, which is only 10% of the training effort as
  3. Our previous research has solved the first 2 of these challenges.
  4. Elaborate much more in this one.
  5. Elaborate much more in this one.
  6. Need to have all four methods. 1 figure that said it all. Zoom in on the 1 to 10 number of training samples.
  7. Need to have all four methods. 1 figure that said it all. Zoom in on the 1 to 10 number of training samples.
  8. And finally, thank you for listening.