This case study is the result of semi-structured interviews with teaching faculty, other staff and students involved in health Open Educational Resources (OER) activities at University of Ghana (UG). The interviewees (listed at the end of this study), gave their consent for the author to use their names and direct quotations, and their words are included here verbatim. This case study explores CHS’s experience with OER, highlighting strategic priorities, perceived benefits, achievements, challenges, production process, lessons learned, future plans and participants’ advice for others interested in creating their own institutional OER initiatives. This case study was provided as a handout at ICTD2012 at this workshop: http://ictd2012.org/opensessions/306. This case study is licensed under a Creative Commons Attribution 3.0 license http://creativecommons.org/licenses/by/3.0/.