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Phosphorylation Motif Atlas for Signaling Networks

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Lars Juhl Jensen
Lars Juhl Jensen

Advances in Bioinformatics, Heidelberg, Germany, March 6-8, 2009

TechnologieSpirituel
1  sur  50
A linear motif atlas for phosphorylation-dependent signaling
location
 
 
 
signaling networks
phosphoproteomics
Linding, Jensen, Ostheimer et al., Cell , 2007
in vivo phosphosites
kinases are unknown
sequence motifs
Miller, Jensen et al., Science Signaling , 2008
sequence specificity
kinase-specific
in vitro
context
association networks
Linding, Jensen, Ostheimer et al., Cell , 2007
NetworKIN
Linding, Jensen, Ostheimer et al., Cell , 2007
sequence motifs
NetPhorest
Miller, Jensen et al., Science Signaling , 2008
data organization
Miller, Jensen et al., Science Signaling , 2008
automated pipeline
compilation of datasets
redundancy reduction
training and evaluation
classifier selection
motif atlas
 
179 kinases
93 SH2 domains
8 PTB domains
BRCT domains
WW domains
14-3-3 proteins
phosphatases
model organisms
biological applications
disease-related kinases
Miller, Jensen et al., Science Signaling , 2008
cell-cycle kinases
variation and signaling
augmented browsing
Reflect
 
Acknowledgments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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