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A Review of the Pharmanex Biophotonic Scanner, Supplementation and the “Cady White Paper”  An  Educational Presentation for Health Care Practitioners  September 24, 2011 – Los Angeles, CA Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute  Adjunct Professor – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana Disclaimer: Pharmanex/NuSkin products are not FDA approved for the diagnosis or treatment of ANY disease or  “medical condition.”
“ There are two objects of medical education: to heal the sick and to advance the science. ” - Dr. Charles H. Mayo, MD “ The glory of medicine is that it is always moving forward, that there is always more to learn.” - Dr. William J. Mayo
Is this any way to take care of the health of a nation? 3.4  Billion   Prescriptions 307  million   People ,[object Object],[object Object],[object Object],[object Object],1. Ukens C. How mail order pharmacy gained in market share in 2003.  Drug Topics  Mar 22, 2004; 148. 2.  U.S. Census Bureau, Jul 2009  3.  CNN Money, May 3, 2010;  http://money.cnn.com/magazines/fortune/ ortune500/2010/industries/21/index.html   accessed August 17, 2011 3.4 * 10  9  Rx 3.1 * 10  8  Peeps
CURRENT PRACTICE OF MEDICINE:  What a patient had to say about her “specialists”: ,[object Object]
 
Cady Wellness Institute – July 2005 The Reasons: ,[object Object],[object Object],[object Object],[object Object]
 
Evansville Courier & Press : May 29, 2006
“ Real doctoring”: The Chance to Change Patient’s BRAINS
“ But my patients don’t know about this and aren’t asking for it….” ,[object Object],[object Object]
How not to get overwhelmed in this presentation:
What causes oxidative stress? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Why is the brain so  susceptible to oxidative stress?
Why is the brain so  susceptible to oxidative stress? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What are some consequences of oxidative stress? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
Where to read more…
The fastest, cheapest, most painless way to measure antioxidants…. ,[object Object],[object Object]
Psst.  Hey buddy.  Wanna buy a portable Raman spectrometer?
“ The Complete Idiot’s Guide to the “Cady White Paper” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Carotenoid correlation with other antioxidants (pp 4-6) ,[object Object],[object Object],[object Object],[object Object],*Peng YM et al.  Concentrations and plasma-tissue-diet relationships of carotenoids, retinoids, and tocopherols in humans. Nutr Cancer. 1995;23(3):233-46. ** Packet, Lester. The Antioxidant Miracle. John Wiley & Sons, Inc. © 1999 ***Yeum et al. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma.  Arch Biochem Biophys. 2004 Oct 1; 430(1):97-103.
Relationships of carotenoids to other more conventionally measured antioxidants (p 6 -7) ,[object Object],[object Object],[object Object],* Svilaas A, et al.  Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans.  J Nutr. 2004 Mar;134(3):562-7.
Missing point: Vitamin E as antioxidant predictor Jaques PF, et al.  Antioxidant status in persons with and without senile cataract. Arch Opthalmol. 1988;106(3):337-340. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Higher Vitamin E lowers oxidative stress in Alzheimer’s disease ,[object Object],[object Object],[object Object],[object Object],[object Object],Guan, JZ et al.  Effect of Vitamin E Adminsitration on the Elevated Oxygen Stress and the Telomeric and Subtelomeric status in Alzheimer’s Disease.  Gerontology. 2011, Sept 7 (epub ahead of print)
Vitamin E as antioxidant – a molecular biology assessment ,[object Object],[object Object],[object Object],Calo LA et al.  Molecular biology-based assessment of vitamin E-coated dialyzer effects on oxidative stress, inflammation, and vascular remodeling.  Artif Organs. 2011 Feb;35(2):E33-9. doi:10.1111/j. 1525-1594.2010.01125.x
Convenience of carotenoids as antioxidant measurement: from the eye to the skin (pp7-11) ,[object Object],[object Object],[object Object],[object Object],*Bernstein P et al.  Raman detection of macular carotenoids pigments in intact human retina.  Invest Opthalmol Vis Sc. 1998 Oct;39(11):2003-11.  **Hata et al. Non-invasive Raman spectroscopic detection of carotenoids in human skin.  J Invest Dermatol. 2000 Sep; 115(3):441-8.
Dissolved carotenoids in  stratum corneum 27 days
The Svilaas/Hata Syllogism: ,[object Object],[object Object],[object Object]
Time warp – News Flash!
High oxidative stress = low skin carotenoids (p 11) ,[object Object],[object Object],[object Object],Ermakov IV, et al.  Resonance Raman detection of carotenoids antioxidants in living human tissue.  J Biomed Opt. 2005 Nov-Dec;10(6):064028
Pharmanex research (pp 12-13), or, “Taking the Scanner Out to Play” ,[object Object],[object Object],[object Object],[object Object],[object Object],Smidt, C.  Clinical screening study: use of the Pharmanex ® BioPhotonic scanner to assess skin carotenoids as a marker of antioxidant status.  Pharmanex, LCC, 75 West Center Street, Provo, UT. 2002
Biophotonic Scan scores as function of # of servings of fruits and vegetables (p 12) Smidt, C.  Clinical screening study: use of the Pharmanex ® Biophotonic scanner to assess skin carotenoids as a marker of antioxidant status. 2002
Fun footnotes (p 13) ,[object Object],[object Object],[object Object],[object Object],Smidt, C. , 2002, loc cit.
More fun with LifePak supplementation, prescanner (1999) p. 14 ,[object Object],[object Object],[object Object],[object Object],[object Object],Smidt, CR et al.  The effects of a nutritionally complete dietary supplement (LifePak®) on antioxidant status and LDL-oxidation in healthy non-smokers. Federation of American Society for Experimental Biology. 1999;13(4).  Pharmanex Clinical Study Report published February 23, 2000.
More fun with LifePak supplementation, prescanner (1999) p. 14 RESULTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Smidt, CR et al.  (1999, 2000 loc cit)
How are we doing? 2006 Data Histogram:  N =2,591,667  Mean SCS  =  26,673 Skin Carotenoid Score Frequency THE LIFE PAKERS! Source: data reported by Pharmanex 5-9 Fruits & Vegetables Smokers Average (2-3 Fruits & Vegetables) Obesity LifePak LifePak + 5-9 Fruits & Vegetables
Clinical opportunities – p. 16 ,[object Object],[object Object],[object Object],[object Object],[object Object],*   http://www.ars.usda.gov /Services/docs.htm?docid=7716
Final aspects of Cady White Paper  ,[object Object],[object Object]
What’s new since the 2006 “Cady Report”? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Harvesting more data: Akbaraly and dysglycemia ,[object Object],[object Object],[object Object],Akbaraly TN et al. Plasma carotenoids and onset of dysglycemia in an elderly population: results of the Epidemiology of Vascular Ageing Study.  Diabetes Care. 2008 Jul;31(7):1355-9.
More data: a mad dash through the literature ,[object Object],One more time… no supplement, under the DSHEA act, may be represented to treat, cure, mitigate or prevent any disease.  No such “health claims” are being advanced for any Pharmanex/NuSkin supplement or product.  The following slides represents a LITERATURE REVIEW.  Louis B. Cady, MD
 
 
 
 
 
 
 
 
But what about other  things besides carotenoids  and “Antioxidants”?? B12, Magnesium, Zinc, fish oil…
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Symptoms of B 12  Deficiency ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mental Physical
[object Object],[object Object],B12
[object Object],[object Object],[object Object],[object Object],B 12  Deficiency ,[object Object],[object Object],[object Object],[object Object]
Magnesium mementos ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Symptoms of Magnesium Deficiency ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Health Conditions Associated with Magnesium Deficiency
November 2009  “Alpha Male” issue ,[object Object],[object Object],[object Object],[object Object],[object Object]
Fast food (low Zn) is bad for you. ,[object Object],[object Object],[object Object]
Special needs - Zinc ,[object Object],[object Object],[object Object],[object Object]
Essential Fatty Acids – relevant for: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Do YOU Need Fish Oil?
c. 15-20X Omega 6:3
 
How to lie about vitamins and antioxidants…
How to Lie about Vitamins & Antioxidants
 
 
 
 
 
 
 
 
 
 
“ If you’re going to be thinking anyway, you might as well thing big.”  -  Donald  Trump
“ For me, the practice of medicine has opened the door to the greatest adventure in life.  Medicine is like a hallway lined with doors,  each door opening into a different room, and each room opening into another hallway,  again lined with doors.   Medicine is always wonderful and never will be finished. ” -  Charles H. Mayo, M.D.

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The "Cady White Paper" Review & Rationale for Antioxidant and Nutrient supplementation

  • 1. A Review of the Pharmanex Biophotonic Scanner, Supplementation and the “Cady White Paper” An Educational Presentation for Health Care Practitioners September 24, 2011 – Los Angeles, CA Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Professor – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana Disclaimer: Pharmanex/NuSkin products are not FDA approved for the diagnosis or treatment of ANY disease or “medical condition.”
  • 2. “ There are two objects of medical education: to heal the sick and to advance the science. ” - Dr. Charles H. Mayo, MD “ The glory of medicine is that it is always moving forward, that there is always more to learn.” - Dr. William J. Mayo
  • 3.
  • 4.
  • 5.  
  • 6.
  • 7.  
  • 8. Evansville Courier & Press : May 29, 2006
  • 9. “ Real doctoring”: The Chance to Change Patient’s BRAINS
  • 10.
  • 11. How not to get overwhelmed in this presentation:
  • 12.
  • 13. Why is the brain so susceptible to oxidative stress?
  • 14.
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  • 18.  
  • 19.  
  • 20.  
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  • 22.  
  • 23.  
  • 24.  
  • 25.  
  • 26. Where to read more…
  • 27.
  • 28. Psst. Hey buddy. Wanna buy a portable Raman spectrometer?
  • 29.
  • 30.
  • 31.
  • 32.
  • 33.
  • 34.
  • 35.
  • 36. Dissolved carotenoids in stratum corneum 27 days
  • 37.
  • 38. Time warp – News Flash!
  • 39.
  • 40.
  • 41. Biophotonic Scan scores as function of # of servings of fruits and vegetables (p 12) Smidt, C. Clinical screening study: use of the Pharmanex ® Biophotonic scanner to assess skin carotenoids as a marker of antioxidant status. 2002
  • 42.
  • 43.
  • 44.
  • 45. How are we doing? 2006 Data Histogram: N =2,591,667 Mean SCS = 26,673 Skin Carotenoid Score Frequency THE LIFE PAKERS! Source: data reported by Pharmanex 5-9 Fruits & Vegetables Smokers Average (2-3 Fruits & Vegetables) Obesity LifePak LifePak + 5-9 Fruits & Vegetables
  • 46.
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  • 51.  
  • 52.  
  • 53.  
  • 54.  
  • 55.  
  • 56.  
  • 57.  
  • 58.  
  • 59. But what about other things besides carotenoids and “Antioxidants”?? B12, Magnesium, Zinc, fish oil…
  • 60.
  • 61.
  • 62.
  • 63.
  • 64.
  • 65.
  • 66.
  • 67.
  • 68.
  • 69. Do YOU Need Fish Oil?
  • 71.  
  • 72. How to lie about vitamins and antioxidants…
  • 73. How to Lie about Vitamins & Antioxidants
  • 74.  
  • 75.  
  • 76.  
  • 77.  
  • 78.  
  • 79.  
  • 80.  
  • 81.  
  • 82.  
  • 83.  
  • 84. “ If you’re going to be thinking anyway, you might as well thing big.” - Donald Trump
  • 85. “ For me, the practice of medicine has opened the door to the greatest adventure in life. Medicine is like a hallway lined with doors, each door opening into a different room, and each room opening into another hallway, again lined with doors. Medicine is always wonderful and never will be finished. ” - Charles H. Mayo, M.D.

Notes de l'éditeur

  1. FROM WIKIPEDIA - Epidermis Epidermis , "epi" coming from the Greek meaning "over" or "upon", is the outermost layer of the skin. It forms the waterproof, protective wrap over the body's surface and is made up of stratified squamous epithelium with an underlying basal lamina. The epidermis contains no blood vessels, and cells in the deepest layers are nourished by diffusion from blood capillaries extending to the upper layers of the dermis. The main type of cells which make up the epidermis are Merkel cells, keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum (only in palms of hands and bottoms of feet), granulosum, spinosum, basale. Cells are formed through mitosis at the basale layer. The daughter cells (see cell division) move up the strata changing shape and composition as they die due to isolation from their blood source. The cytoplasm is released and the protein keratin is inserted. They eventually reach the corneum and slough off (desquamation). This process is called keratinization and takes place within about 27 days. This keratinized layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out, making skin a natural barrier to infection. From WIKIpedia
  2. Based on clinical studies with the biophotonic scanner, we have identified a number of factors that may influence your score. The average skin carotenoid score for Europeans is 26,673, those who eat the recommended 5-9 fruits and vegetables or take lifepak regularly have even higher scores. What is really exciting is that people with the best lifestyles - eat the recommended 5-9 fruits and vegetables, take LifePak regularly, avoid cigarettes, and so on, have the very highest scores, in the 40,000 range. Therefore, the effects of a good lifestyle are cumulative when it comes to Antioxidant protection. The other point I would like to make is that people with known oxidative stress such as smokers, have lower scanner scores, just as we would predict, but people who are overweight or obese tend to have even lower scores than smokers! Thus it appears that obesity depletes antioxidant levels even more than smoking.
  3. Dr. Greenblatt treats anyone at less than 600. “Serum levels don’t accurately reflect what’s in the CSF.”
  4. When repleted - results pretty quickly. “If if spasms, think magnesium” – bowel, bronchial.