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MEDIASTINAL MASSES
Mediastinal Anatomy
Mediastinal Anatomy
Anterior

  thymus, aorta, great veins, lymphatics

Middle

  heart, pericardium, trachea

Posterior

  Esophagus, vagus nerves, thoracic duct,
  sympathetic chain, azygous venous system
Anterior Mediastinum
Thymoma
Thymoma
Hodgkin’s
Intrathoracic goiter
Anterior Mediastinum
Other thymic tumors - carcinomas, carcinoid
tumors, lipomas, cysts

Germ cell tumors

Thyroid tumors

Parathyroid adenoma

Connective tissue tumors - lipomas,
liposarcomas, lymphangiomas, hemangiomas
Middle Mediastinum
Pericardial cyst
Bronchogenic cyst
Middle Mediastinum
Thyroid tumor or goiter

Tracheal tumors

Lymphadenopathy 2/2

  infection

  malignancy

  idiopathic
Posterior Mediastinum
Posterior Mediastinum

 Most neurogenic tumors

 Esophageal tumors

 Hiatus hernia

 Neurenteric cysts

 Unusual: pancreatic pseudocyst, achalasia,
 extramedullary hematopoiesis
Paraspinal ganglioneuroma
Paraspinal neurilemmoma
Notes
Aortic aneurysms can be located in any compartment

Anterior masses more likely to be malignant

   59% vs. 29% vs. 16%, converse is true in children

   increased likelihood in 20-40 yo

Most common lesions:

   Children - neurogenic tumors, enterogenous cysts

   Adults - neurogenic tumors, thymomas, thymic
   cysts
Signs & Symptoms
Hemoptysis, recurrent pulmonary infection (airway
compression)

Dysphagia (esophageal compression)

Paralysis (spinal column involvement)

Elevated hemidiaphragm (phrenic nerve damage)

Hoarseness (recurrent laryngeal involvement)

Horner’s & SVC syndrome (sympathetic ganglion, SVC)
Signs & Symptoms

Associated systemic diseases

   Thymoma = myasthenia gravis, immune deficiency,
   red cell aplastic anemia

   Thymic carcinoid tumor = Cushing syndrome

   Goiter = thyrotoxicosis

   Parathyroid adenoma = hyperparathyroidism
Imaging
CXR -> CT with IV contrast

MRI only recommended if pt has contrast allergy or
renal failure

   useful for neurogenic tumors

Transesophageal US - posterior lymph nodes

Radionuclide scanning

   123-I for thyroid, sestamibi for parathyroid,
   gallium for lymphomas (replaced by FDG-PET)
Labs
Goiter -> TFTs

Parathyroid adenoma -> Ca, P, PTH

Paragangliomas -> urine metanephrines,
catecholamines

Neurogenic tumors -> homovanillic acid,
vanillylmandelic acid

Germ cell tumor -> AFP, B-HCG

   all male pts with anterior mass
Management
Excision

   if likely benign - teratoma, thymoma

   needle aspiration, VATS, sternotomy/thoracotomy

Biopsy

   lymphoma, germ cell, unresectable malignancy

   surgical biopsy preferred over needle aspiration

Chest wall tumor implantation is a rare complication
Complications

Surgical treatment has increased risk of morbidity
2/2 central airway obstruction, greatest in those with:

   Cardiorespiratory symptoms

   Evidence of tracheal obstruction

   Mixed obstructive & restrictive PFTs
The End

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Mediastinal Mass

  • 3. Mediastinal Anatomy Anterior thymus, aorta, great veins, lymphatics Middle heart, pericardium, trachea Posterior Esophagus, vagus nerves, thoracic duct, sympathetic chain, azygous venous system
  • 9. Anterior Mediastinum Other thymic tumors - carcinomas, carcinoid tumors, lipomas, cysts Germ cell tumors Thyroid tumors Parathyroid adenoma Connective tissue tumors - lipomas, liposarcomas, lymphangiomas, hemangiomas
  • 13. Middle Mediastinum Thyroid tumor or goiter Tracheal tumors Lymphadenopathy 2/2 infection malignancy idiopathic
  • 15. Posterior Mediastinum Most neurogenic tumors Esophageal tumors Hiatus hernia Neurenteric cysts Unusual: pancreatic pseudocyst, achalasia, extramedullary hematopoiesis
  • 18. Notes Aortic aneurysms can be located in any compartment Anterior masses more likely to be malignant 59% vs. 29% vs. 16%, converse is true in children increased likelihood in 20-40 yo Most common lesions: Children - neurogenic tumors, enterogenous cysts Adults - neurogenic tumors, thymomas, thymic cysts
  • 19. Signs & Symptoms Hemoptysis, recurrent pulmonary infection (airway compression) Dysphagia (esophageal compression) Paralysis (spinal column involvement) Elevated hemidiaphragm (phrenic nerve damage) Hoarseness (recurrent laryngeal involvement) Horner’s & SVC syndrome (sympathetic ganglion, SVC)
  • 20. Signs & Symptoms Associated systemic diseases Thymoma = myasthenia gravis, immune deficiency, red cell aplastic anemia Thymic carcinoid tumor = Cushing syndrome Goiter = thyrotoxicosis Parathyroid adenoma = hyperparathyroidism
  • 21. Imaging CXR -> CT with IV contrast MRI only recommended if pt has contrast allergy or renal failure useful for neurogenic tumors Transesophageal US - posterior lymph nodes Radionuclide scanning 123-I for thyroid, sestamibi for parathyroid, gallium for lymphomas (replaced by FDG-PET)
  • 22. Labs Goiter -> TFTs Parathyroid adenoma -> Ca, P, PTH Paragangliomas -> urine metanephrines, catecholamines Neurogenic tumors -> homovanillic acid, vanillylmandelic acid Germ cell tumor -> AFP, B-HCG all male pts with anterior mass
  • 23. Management Excision if likely benign - teratoma, thymoma needle aspiration, VATS, sternotomy/thoracotomy Biopsy lymphoma, germ cell, unresectable malignancy surgical biopsy preferred over needle aspiration Chest wall tumor implantation is a rare complication
  • 24. Complications Surgical treatment has increased risk of morbidity 2/2 central airway obstruction, greatest in those with: Cardiorespiratory symptoms Evidence of tracheal obstruction Mixed obstructive & restrictive PFTs