This document discusses analyzing exome sequencing data using KNIME. It describes analyzing two exomes: 1) for a given mutation in one sample, expecting the mutation to not be present in the other sample, and 2) for composite heterozygous mutations present in both samples within the same gene. The workflow details include reading the data files, filtering and processing the variants, merging data from the two samples, and visualizing the results. Commands for implementing similar analyses via UNIX bash scripts are also provided.
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Analyzing Exome Data with KNIME
1. Pierre Lindenbaum PhD UMR915 – Institut du thorax Nantes, France @yokofakun http://plindenbaum.blogspot.com [email_address] Analysing Exome Data with KNIME