T3, or triiodothyronine, shows promise as an augmentation strategy for treatment-resistant major depressive disorder. Several studies and meta-analyses have found T3 improves outcomes when added to tricyclic antidepressants or SSRIs. T3's mechanism of action involves stimulating gene expression and metabolism in the brain and body. However, high doses of T3 can cause hyperthyroidism in euthyroid patients, so monitoring of thyroid levels is recommended when using T3 for psychiatric conditions.

1. By Mohamed Abdelghani

8. Recommended safety guidelines for T3 Augmentation