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Clinical Pearls in Cardiology

       Examination skills
       Clinical scenarios
Physical examination of a patient's
cardiovascular system
1.Introduce yourself. position pt.optimal exposure
2.cyanosis/clubbing
splinter hemorrhages
pallor
3.Pulse rate/rhythm, respiratory rate
4.BP lying and standing
5. JVP: height and waveform
carotid pulse:quality, bruits
6. central cyanosis
dental caries
conjunctival pallor
7.Precordial inspection: shape of chest, abnormal pulsation
8.Palpation: site/quality of apex beat, heaves/thrills
Physical examination continued

9. Listen to apex, axilla, LSE, LLSE
10. Sit patient forward- feel for parasternal thrill
Listen during inspiration and expiration
11. Palpate thyroid
sacral edema/basal lung dullness
auscultate lungfields for rales
12. Lie patient flat
Pulsatile hepatomegaly
splenomegaly; ascites
Bruits: renal, femoral
13. calf tenderness
ankle edema, tendon xanthomas, peripheral pulses
Heart Failure
HTN
CAD
Arrhthymia- A Fib, V fib, SVT
Valvular Heart Disease
Infective endocarditis
Cardiac clearance/Risk
assessment
The heart in other diseases
Case1
• 51yo man w dilated cardiomyopathy
  whom you have been treating for the past
  3 years has class II NYHA heart failure.
  Cor angio showed normal coronary
  arteries. He would like to be more active
  and asks if anything else can be tried.
  Takes metop 100mg/d, resting HR
  58bpm. Never been able to tolerate ACEI
  or ARB developing a severe cough in
  multiple previous trials of these agents.
  Denies peripheral edema, orthopnea, or
Meds and Findings
• Metop 100mg/d
• Furosemide 20mg/d
• Eplerenone 50mg/d
• Digoxin 0.125mg/d
• ECG- nsr w PR interval 147ms and QRS interval
  of 98ms
• Echo-LVEF 42%, no sig valve dz, dilated LV w
  global hypokinesis
• Exam- JVP 8cm, BP 137/76, HR 58, lungs clear,
  no peripheral edema
• Cardiac exam-+s3,1/6 systolic murmur at LLSB
  that decreases w Valsalva, enlarged & sustained
  point of maximal impulse
Which one of the following is the most reasonable
          next step in management?

• Prescribe a statin- rosuvastatin 5mg/d
• Refer him to a cardiologist for evaluation
  for an AICD
• Refer him to a cardiologist to be evaluated
  for cardiac resynchronization therapy
• Initiate treatment w hydralazine and long
  acting nitrates
• Increase furosemide to 80mg/d
Case 2
• 76 yo man presents w SOB on exertion
  that began 6mo ago and has gradually
  worsened. Can no longer perform normal
  activities wo developing sym and that
  climbing one flight of stairs causes him to
  be profoundly SOB. Walking on level
  ground, he does well, but any hill causes
  dyspnea. H/O HTN but no h/o HL, T2D,
  tobacco abuse or F/H/O early CAD. On no
  meds
Findings
• ECG- NSR w normal intervals
• CXR -normal cardiac silhouette w clear
  lung fields
• Echo- LVEF 64% w normal valves, N LV,
  RV size and function, no regional wall
  motion abnormality, normal wall thickness
• Stress test- ability to walk for 4.8 min on
  Bruce Protocol (78% of predicted
  functional aerobic capacity), HR incr to
  146, BP 200/98, stopped test due to SOB,
  neg ECG for ischemia
• Exam- lungs clear, JVP 12cm, peripheral
  edema 1+, BMI 32
Which one of the following actions is
the least appropriate to this patient?
• Initiate treatment w ACEI for BP
• Initiate treatment w diuretic to resolve
  congestion and peripheral edema
• Recommend a regular exercise program,
  telling him to start slow and increase
  gradually
• Encourage him to lose weight
• Refer him for cor angiography
Case 3
• 66 yo woman w known CAD has had 2
  previous MIs, the first 7 years ago & the
  second 11mos ago. After her last MI, her
  EF was 28%. Currently has class II NYHA
  heart failure
• Meds- lisinopril 40mg/d; carvidelol 12.5mg
  BID; spironolactone 25mg/d; ASA 81mg/d;
  pravastatin 20mg/d
Findings
• Labs- Na 138, K4.4, creat 1.2
• Echo- EF 32% w mild MR, markedly enlarged LV
  w anterior wall hypokinesis
• ECG- HR 60 w SR, PR interval 168 ms, QRS
  interval 111 ms, corrected QT interval 402 ms,
  prior ant MI
• Exam- BP 116/72, HR 60 reg, JVP flat, no
  peripheral edema, lungs clear w good BS
• Cardiac exam- presence of S3 w enlarged point
  of maximal impulse that is bifid, no murmur or
  rub
Which one of the following would be the best
         therapy for this patient?
• Given that she has NYHA class II HF,
  continue current therapy
• Add in a diuretic agent such as
  furosemide 20mg/d
• Add in digoxin 0.125mg every 6hours for 4
  times, 0.125 mg /d orally
• Refer for cardiac resynchronization
  therapy
• Refer for evaluation for an AICD
Case 4
• 68 yo man follows up w you after a
  hospitalization 2 weeks previously for an
  episode of acute decompensated HF.
  During his hospitalization, he underwent
  diuresis w IV lasix to lose 10lbs of fluid, he
  has decreased LV function thought to be
  secy to chronic MR. His MV had been
  repaired 2 years ago, but his EF of 42%
  has not improved significantly since then.
  He has a dilated LV and has sym c/w
  NYHA class II HF
Meds and Findings
• Meds- lasix 20 mg/d; metop 25mg/d;
  lisiopril 10mg qhs
• Labs- creat 1.4, e GFR 46, K 4.5, clear
  lung fields w enlarged cardiac shadow on
  CXR
• Exam- height 177cm, weight 99kg, BP
  118/76, HR 62, both lung bases clear, no
  leg edema
• Cardiac exam- enlarged bifid; lateral point
  of maximal impulse, 1/6 holosystolic
  murmur at apex, pos S3, no S4, JVP 8cm
Which one of the following is the next best
  step in the treatment of this patient?

• Increase lisinopril to 20mg/d
• Add 30 mg of ISMN in am and increase to 60
  mg as tolerated
• Refer to a dietitian for a low-sodium, fluid
  restricted (1500mL) diet
• Request that he weigh himself each morning,
  provide a schedule for increasing lasix if he
  gains weight
• Refer him to an electrophysiologist for
  possible AICD implantation
Case 5
• A 73 yo woman w LV systolic dysfunction
  whom you have been treating for several
  years presents to the ED. She is having
  palpitations and is diagnosed as having A
  fib HR 130 in the ED. She denies chest
  pain but is mildly SOB w RVR. She is not
  sure how long she has had palpitations-
  thinks they have been intermittent during
  past few months but have always resolved
  after a few minutes. This episode lasted
  more that 2 h, prompting her to seek
  treatment.
Medical History
• HTN well controlled w HCTZ
• Hypothyroidism treated medically with normal
  TSH
• No h/o bleeding problems, strokes or TIAs
• No syncope or presyncope
• Known CAD w 3-vessel CABG graft performed
  11y ago
• Meds- HCTZ 25mg/d; lisinopril 20mg/d; metop
  12.5mg/d, ASA 81 mg/d
• Social history- not physically active, lives in a
  high rise retirement complex
Findings
• Labs- TSH normal, electrolytes normal,
  cbc normal, troponin normal
• ECG- A fib, old inferolateral MI, no acute
  ST-T changes
• Echo- bilateral atrial enlargement w
  enlarged LV and decreased function, EF
  34%, evidence of inferolateral MI
• Exam- height 167cm, weight 63 kg, lungs
  clear, rhythm irreg irreg, 1/6 systolic
  ejection murmur at LLSB, no edema
Which one of the following is the best therapy for
this woman w systolic LV dysfunction presenting
                    w A Fib?
• Control HR w beta-blockers and/or dig &
  provide anticoagulation w warfarin to INR
  2-3
• Administer antiarrhythmic propofenone &
  perform DC cardioversion
• Administer propofenone, perform TEE to
  r/o LA thrombus & perform DC
  cardioversion
• Refer to EP for consideration of AV node
  ablation w pacemaker implantation & long
  term anticoagulation
• Refer to EP for pulmonary vein isolation
Case 6
• A 78 yo woman who you have been treating for the
  past 10 y for ch functional NYHA classIII HF, EF
  28%, was admitted to the hospital 3 days ago for
  HF. A year earlier she had an AICD/ CRD
  implanted. Since being admitted, she has
  undergone diuresis, lost 8lbs and feels much
  better. You are ready to dismiss her today, w
  instructions to continue on her usual home
  regimen- lasix 20, carvedilol 25mg BID, lisinopril
  20mg qhs. She weighs herself daily & takes extra
  lasix & K when her weight increases. She has
  been adhering to a low NA diet w 1500ml fluid
  restriction. Her BNP is 2186. the cause of her HF
  is CAD, but her last stress test 4mos ago showed
  a fixed anterior defect but no evidence of ischemia.
Which one of the following would be the best
treatment option for this patient at this point in her
                       care?
• Continuation of current therapy
• Addition of an aldosterone inhibitor, such
  as spironolactone or eplerenone
• Augmentation of current therapy to reduce
  her BNP levels to normal and her
  functional status to NYHA classII or less
• Switch from carvedilol to metoprolol
• Follow up stress test

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Clinical Pearls in Cardiology

  • 1. Clinical Pearls in Cardiology Examination skills Clinical scenarios
  • 2. Physical examination of a patient's cardiovascular system 1.Introduce yourself. position pt.optimal exposure 2.cyanosis/clubbing splinter hemorrhages pallor 3.Pulse rate/rhythm, respiratory rate 4.BP lying and standing 5. JVP: height and waveform carotid pulse:quality, bruits 6. central cyanosis dental caries conjunctival pallor 7.Precordial inspection: shape of chest, abnormal pulsation 8.Palpation: site/quality of apex beat, heaves/thrills
  • 3. Physical examination continued 9. Listen to apex, axilla, LSE, LLSE 10. Sit patient forward- feel for parasternal thrill Listen during inspiration and expiration 11. Palpate thyroid sacral edema/basal lung dullness auscultate lungfields for rales 12. Lie patient flat Pulsatile hepatomegaly splenomegaly; ascites Bruits: renal, femoral 13. calf tenderness ankle edema, tendon xanthomas, peripheral pulses
  • 4. Heart Failure HTN CAD Arrhthymia- A Fib, V fib, SVT Valvular Heart Disease Infective endocarditis Cardiac clearance/Risk assessment The heart in other diseases
  • 5. Case1 • 51yo man w dilated cardiomyopathy whom you have been treating for the past 3 years has class II NYHA heart failure. Cor angio showed normal coronary arteries. He would like to be more active and asks if anything else can be tried. Takes metop 100mg/d, resting HR 58bpm. Never been able to tolerate ACEI or ARB developing a severe cough in multiple previous trials of these agents. Denies peripheral edema, orthopnea, or
  • 6. Meds and Findings • Metop 100mg/d • Furosemide 20mg/d • Eplerenone 50mg/d • Digoxin 0.125mg/d • ECG- nsr w PR interval 147ms and QRS interval of 98ms • Echo-LVEF 42%, no sig valve dz, dilated LV w global hypokinesis • Exam- JVP 8cm, BP 137/76, HR 58, lungs clear, no peripheral edema • Cardiac exam-+s3,1/6 systolic murmur at LLSB that decreases w Valsalva, enlarged & sustained point of maximal impulse
  • 7. Which one of the following is the most reasonable next step in management? • Prescribe a statin- rosuvastatin 5mg/d • Refer him to a cardiologist for evaluation for an AICD • Refer him to a cardiologist to be evaluated for cardiac resynchronization therapy • Initiate treatment w hydralazine and long acting nitrates • Increase furosemide to 80mg/d
  • 8. Case 2 • 76 yo man presents w SOB on exertion that began 6mo ago and has gradually worsened. Can no longer perform normal activities wo developing sym and that climbing one flight of stairs causes him to be profoundly SOB. Walking on level ground, he does well, but any hill causes dyspnea. H/O HTN but no h/o HL, T2D, tobacco abuse or F/H/O early CAD. On no meds
  • 9. Findings • ECG- NSR w normal intervals • CXR -normal cardiac silhouette w clear lung fields • Echo- LVEF 64% w normal valves, N LV, RV size and function, no regional wall motion abnormality, normal wall thickness • Stress test- ability to walk for 4.8 min on Bruce Protocol (78% of predicted functional aerobic capacity), HR incr to 146, BP 200/98, stopped test due to SOB, neg ECG for ischemia • Exam- lungs clear, JVP 12cm, peripheral edema 1+, BMI 32
  • 10. Which one of the following actions is the least appropriate to this patient? • Initiate treatment w ACEI for BP • Initiate treatment w diuretic to resolve congestion and peripheral edema • Recommend a regular exercise program, telling him to start slow and increase gradually • Encourage him to lose weight • Refer him for cor angiography
  • 11. Case 3 • 66 yo woman w known CAD has had 2 previous MIs, the first 7 years ago & the second 11mos ago. After her last MI, her EF was 28%. Currently has class II NYHA heart failure • Meds- lisinopril 40mg/d; carvidelol 12.5mg BID; spironolactone 25mg/d; ASA 81mg/d; pravastatin 20mg/d
  • 12. Findings • Labs- Na 138, K4.4, creat 1.2 • Echo- EF 32% w mild MR, markedly enlarged LV w anterior wall hypokinesis • ECG- HR 60 w SR, PR interval 168 ms, QRS interval 111 ms, corrected QT interval 402 ms, prior ant MI • Exam- BP 116/72, HR 60 reg, JVP flat, no peripheral edema, lungs clear w good BS • Cardiac exam- presence of S3 w enlarged point of maximal impulse that is bifid, no murmur or rub
  • 13. Which one of the following would be the best therapy for this patient? • Given that she has NYHA class II HF, continue current therapy • Add in a diuretic agent such as furosemide 20mg/d • Add in digoxin 0.125mg every 6hours for 4 times, 0.125 mg /d orally • Refer for cardiac resynchronization therapy • Refer for evaluation for an AICD
  • 14. Case 4 • 68 yo man follows up w you after a hospitalization 2 weeks previously for an episode of acute decompensated HF. During his hospitalization, he underwent diuresis w IV lasix to lose 10lbs of fluid, he has decreased LV function thought to be secy to chronic MR. His MV had been repaired 2 years ago, but his EF of 42% has not improved significantly since then. He has a dilated LV and has sym c/w NYHA class II HF
  • 15. Meds and Findings • Meds- lasix 20 mg/d; metop 25mg/d; lisiopril 10mg qhs • Labs- creat 1.4, e GFR 46, K 4.5, clear lung fields w enlarged cardiac shadow on CXR • Exam- height 177cm, weight 99kg, BP 118/76, HR 62, both lung bases clear, no leg edema • Cardiac exam- enlarged bifid; lateral point of maximal impulse, 1/6 holosystolic murmur at apex, pos S3, no S4, JVP 8cm
  • 16. Which one of the following is the next best step in the treatment of this patient? • Increase lisinopril to 20mg/d • Add 30 mg of ISMN in am and increase to 60 mg as tolerated • Refer to a dietitian for a low-sodium, fluid restricted (1500mL) diet • Request that he weigh himself each morning, provide a schedule for increasing lasix if he gains weight • Refer him to an electrophysiologist for possible AICD implantation
  • 17. Case 5 • A 73 yo woman w LV systolic dysfunction whom you have been treating for several years presents to the ED. She is having palpitations and is diagnosed as having A fib HR 130 in the ED. She denies chest pain but is mildly SOB w RVR. She is not sure how long she has had palpitations- thinks they have been intermittent during past few months but have always resolved after a few minutes. This episode lasted more that 2 h, prompting her to seek treatment.
  • 18. Medical History • HTN well controlled w HCTZ • Hypothyroidism treated medically with normal TSH • No h/o bleeding problems, strokes or TIAs • No syncope or presyncope • Known CAD w 3-vessel CABG graft performed 11y ago • Meds- HCTZ 25mg/d; lisinopril 20mg/d; metop 12.5mg/d, ASA 81 mg/d • Social history- not physically active, lives in a high rise retirement complex
  • 19. Findings • Labs- TSH normal, electrolytes normal, cbc normal, troponin normal • ECG- A fib, old inferolateral MI, no acute ST-T changes • Echo- bilateral atrial enlargement w enlarged LV and decreased function, EF 34%, evidence of inferolateral MI • Exam- height 167cm, weight 63 kg, lungs clear, rhythm irreg irreg, 1/6 systolic ejection murmur at LLSB, no edema
  • 20. Which one of the following is the best therapy for this woman w systolic LV dysfunction presenting w A Fib? • Control HR w beta-blockers and/or dig & provide anticoagulation w warfarin to INR 2-3 • Administer antiarrhythmic propofenone & perform DC cardioversion • Administer propofenone, perform TEE to r/o LA thrombus & perform DC cardioversion • Refer to EP for consideration of AV node ablation w pacemaker implantation & long term anticoagulation • Refer to EP for pulmonary vein isolation
  • 21. Case 6 • A 78 yo woman who you have been treating for the past 10 y for ch functional NYHA classIII HF, EF 28%, was admitted to the hospital 3 days ago for HF. A year earlier she had an AICD/ CRD implanted. Since being admitted, she has undergone diuresis, lost 8lbs and feels much better. You are ready to dismiss her today, w instructions to continue on her usual home regimen- lasix 20, carvedilol 25mg BID, lisinopril 20mg qhs. She weighs herself daily & takes extra lasix & K when her weight increases. She has been adhering to a low NA diet w 1500ml fluid restriction. Her BNP is 2186. the cause of her HF is CAD, but her last stress test 4mos ago showed a fixed anterior defect but no evidence of ischemia.
  • 22. Which one of the following would be the best treatment option for this patient at this point in her care? • Continuation of current therapy • Addition of an aldosterone inhibitor, such as spironolactone or eplerenone • Augmentation of current therapy to reduce her BNP levels to normal and her functional status to NYHA classII or less • Switch from carvedilol to metoprolol • Follow up stress test