Classification Of Parenterals, Small Volume Parenterals: Defn & Components, Large Volume Parenterals: Defn & Introduction, Types of LVP, Examples Of IV fluids, Difference Between SVP & LVP,

1. Types of Parentrals By : Mr. Mahesh Wamanrao Thube, Govt. College Of Pharmacy, A’Bad.

2. Content: At A Glance 7 October 2009 Govt. College Of Pharmacy, Aurangabad 2 Classification Of Parenterals, Small Volume Parenterals: Defn & Components, Large Volume Parenterals: Defn & Introduction, Types of LVP, Examples Of IV fluids, Difference Between SVP & LVP, References

3. Classification Of Parenterals 7 October 2009 Govt. College Of Pharmacy, Aurangabad 3

5. 7 October 2009 Govt. College Of Pharmacy, Aurangabad 5

6. Large Volume Parenterals Defn: LVP are Parenterals designed to provide -Fluid(water), -Calories(Dextrose soln), -Electrolytes(Saline soln), or -Combination of these. Volume 101-1000mL IV infusion technique is “Venoclysis”. 7 October 2009 Govt. College Of Pharmacy, Aurangabad 6

7. Requirements for LVP Sterile, Non Pyrogenic, Free from Particulate matter Volume 101-1000mL, Single dose unit, No Preservative, Clear solution except Fat Emulsion, Isotonic, but Hypertonic also administered in TPN. 7 October 2009 Govt. College Of Pharmacy, Aurangabad 7

8. 7 October 2009 Govt. College Of Pharmacy, Aurangabad 8 Types of Large Volume Parenterals

9. 1.Hyperalimentation Solution Adm. Of large amt. of nutrients to patients who unable to take food orally, at caloric intake of 4000 kCal/day. Subclavian vein cannulation : Infusion of Hypertonic soln. Formulation : mix. Of Dextrose, Amino acids, Lipids, Electrolytes, & Vitamins. Use: 1.Adm. of Life saving/sustaining drug to Comatose patient. 2.Patient undergoing t/t of GI disease 7 October 2009 Govt. College Of Pharmacy, Aurangabad 9

10. Total Parenterals Nutrition Modified term for Hyperalimentation Defn: IV adm. Of Caloric, Nitrogen, & other nutrients in sufficient qt. to achieve tissue synthesis & anabolism 7 October 2009 Govt. College Of Pharmacy, Aurangabad 10

11. Indication For Use of TPN GI disease, Major trauma, Septicemia, Major Abdominal Surgery, Malignancy of Small Bowel, Radiation Enteritis, Chemotherapy & Radiotherapy, Bone Marrow Transplantation, Prolonged Coma. 7 October 2009 Govt. College Of Pharmacy, Aurangabad 11

12. 2. Cardioplegic Solutions Are LVP used in Heart surgery to prevent injury to myocardium during reperfusion, as well as to maintain bloodless operating field. Maintains the Diastolic arrest. Adm. In cold form. Slightly alkaline to compensate Metabolic acidosis, Hypertonic Use: To minimize reperfusion injury resulting from tissue edema 7 October 2009 Govt. College Of Pharmacy, Aurangabad 12

13. 3. Peritoneal Dialysis Solution Infused continuously into abdominal cavity, bathing peritoneum & are then continuously withdrawn. Formulation:- Glucose , - Antibiotics as Prophylactic Use: Removal of toxic substances from body. To aid & accelerate excretion normal. To treat acute renal insufficiency 7 October 2009 Govt. College Of Pharmacy, Aurangabad 13

14. 4.Irrigating solutions To irrigate, flush & aid in cleansing body cavities & wounds. Certain IV soln(Normal Saline) may be used as irrigating soln, but soln designed as Irrigating soln should not be used Paretentrally. Use: treatment of serious wounds infused into blood stream. 7 October 2009 Govt. College Of Pharmacy, Aurangabad 14

15. Examples Of LVP fluids 7 October 2009 Govt. College Of Pharmacy, Aurangabad 15

16. Difference Between SVP & LVP 7 October 2009 16

17. Continued.. 7 October 2009 Govt. College Of Pharmacy, Aurangabad 17

18. References Modern Pharmaceutics Fourth Edition, Revised and Expanded, Edited By G.S.Banker & C.T.Rhodes, Marcel Dekker pg387-389. The Science & practice of Pharmacy, By Remington, Vol-01, Edi.21st, Lippincott Publication, pg-838-840. Pharmaceutical Dosage Forms. Vol. 3 : Parenteral Medications, Pub Informa Healthcare, Edi. Avis, Kenneth E, Vol I, pg173-180 http://melindo.co.id/images/respiratory.jpg www.weiler-bfs.com 7 October 2009 Govt. College Of Pharmacy, Aurangabad 18

19. Thank You……….. 7 October 2009 Govt. College Of Pharmacy, Aurangabad 19