Hemolytic Uremic Syndrome: A Dangerous Complication of E. coli
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In this presentation provided by the nation's foremost food poison law firm - Marler Clark, Hemolytic Uremic Syndrome (HUS) is explained. HUS is a rare and highly dangerous result of an E. coli infection and can result in acute kidney failure
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Hemolytic Uremic Syndrome: A Dangerous Complication of E. coli
- 1. Long-Term Health Implications Hemolytic Uremic Syndrome (HUS)
- 2. Normal Kidney Structure and Function
- 6. Normal Kidney Courtesy of JC Jennette, MD, UNC-Chapel Hill The Human Body, Dorling Kindersly Limited, London 1995
- 9. Structure: Kidney Biopsy Normal Glomerulus Acute HUS Glomerulus Courtesy of JC Jennette, MD, UNC-Chapel Hill
- 15. HUS Pathogenesis Adapted from Stewart CL, Pediatr Rev, 1993 A: Normal Glomerular blood vessel B: (-) charged endothelial cell (+) charged Platelet ( ) C: Loss of (-) charge and PGI 2 due to endothelial damage D: Fibrin/platelet thrombi formation A B C D
- 16. The Kidney in HUS Courtesy of P Tarr MD, Univ of Washington Normal Capillary TMA Capillary Thrombus Expanded subendothelial zone Narrowed lumen Toxin causing injury to endothelial cells
- 17. Micrograph of TMA in Glomerulus Courtesy of JC Jennette, MD, UNC-Chapel Hill Glomerular Light Microscopy Normal Capillary TMA Capillary Lumen Subendothelial Expansion
- 18. Micrograph of TMA in Renal Artery Courtesy of JC Jennette, MD, UNC-Chapel Hill Normal Artery TMA Artery Arterial Intimal Thickening Lumen Intimal Expansion Obliterating Lumen
- 19. Electron Micrograph of Fibrin Clot and Red Blood Cells Fibrin Strands Red Blood Cells Courtesy of P Tarr MD, Univ of Washington
- 25. Other Organs Involved in Acute HUS Siegler RL, Spectrum of involvement in post-diarrheal hemolytic-uremic syndrome. J Pediatrics, 125(4): 511-518, 1994 Intestine Liver Brain Pancreas Heart / Lung / Other 100 % 40 % 20 % 20 % < 1 % Frequency
- 29. Six months after HUS 0.5 - Areas of scar formation 115 ml/min/1.73m2 100/60 10 mg/dl 0.2 NL NL NL NL NL Serum Cr GFR BP Urine Protein Urine Prot/Cr
- 30. 5 Years After HUS: Possible Outcomes III. Significant Hyperfiltration I. None/Minimal Hyperfiltration II. Moderate Hyperfiltration
- 31. 10-30 Years After HUS Chronic Renal Failure 4.0 NO Maybe? Probable Serum Cr 28 GFR U Prot Elevated BP High