Old and new insights into multiresistant bacteria

2. 16.09.2011 - MRE - Düsseldorf Deaths (per 100 000 citizens) due to infection in the U.S.A., 1900-1996 Influenza Pandemic First use of penicillin

7. 16.09.2011 - MRE - Düsseldorf Rate of multiresistant bacteria per 1,000 patient days

11. 16.09.2011 - MRE - Düsseldorf Basic principle of MRB MRB are not different from bacterial infections apart from by their RESISTANCE TO ANTIBIOTICS This means: - They transfer from person to person easily - They are capable of surviving (epidemic MRSA strains)? - Disinfection treatments have limitations *Discussion: Is MRSA connected to increased virulence?

21. 16.09.2011 - MRE - Düsseldorf Reduction of nosocomial MRSA infections after the introduction of MRSA screening with the LightCycler MRSA advanced test in the Southwest clinical network, Germany (colours correspond with areas within the network), Number of ha-MRSA infections/colonisations New screening implemented

24. The microbiological screening rules include: - A swab of the nose, mouth and - A swab of wounds if necessary 16.09.2011 - MRE - Düsseldorf If the MRSA results are positive (ICD-10: U 80.0): Take hygiene measures (see text) Recommended measures include isolation If the MRSA results are negative: Standard hygiene practices Source: Epi. Bull. 46/2004

37. 16.09.2011 - MRE - Düsseldorf Development of the rate of 3 rd Generation Cephalosporin resistant E. coli Average ESBL strains make up a growing proportion of E. coli-isolates in German ICUs Month/Year y axis: percent of resistant bacteria

46. MBL 16.09.2011 - MRE - Düsseldorf Carbapenemase-producers discovered so far The phenomenon of Carbapenem resistance is not new; 4 different resistance mechanisms are currently known Italy Turkey India