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Airborne Pathogens Can  Induce Mad Cow Disease, New Findings Suggest   AND   Unfolding Pathogenesis in Parkinson’s: Breakthrough  Suggests Damaged Proteins Travel Between Cells   Mateo Zuluaga Gómez Medicine Student UPB Medellín-Colombia
FOLDING
FOLDING
INTRODUCTION PRION  PROTEIN  DNA REPLICATION Parkinson Disease affects the Central Neural System
Airborne Pathogens Can Induce Mad Cow Disease, New Findings  Suggest Science Daily  January 14,2011
Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily  January 14,2011 PRION IS AN INFECTIOUS AGENT THAT COULD AFFECT THE HUMAN BODY ON DIFFERENT SITES PRION COULD REPLICATE HIS DNA INFORMATION
Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily  January 14,2011 PRION COULD BE TRANSPORTED BY THE FOOD INGESTINS AND SURGICAL ELEMENTS PRION COULD BE TRANSPORTED BY THE AIR NEW INVESTIGATION
Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily  January 14,2011 The investigators made tests with immunosupresed and immunocompetents mices to determine if they would be vulnerable to the air  transmission prions Prions can induce mad cow disease
OBSERVATION
  Unfolding Pathogenesis in   Parkinson’s:  Break through Suggests  Damaged Proteins  Travel Between Cells    Science Daily  January 26,2011
  Unfolding Pathogenesis in Parkinson’s:  Break through Suggests Damaged Proteins  Travel Between Cells    Science Daily  January 26,2011 Parkinson is a degenerative disease that affects the neurons of the Substancia Nigra. It produces cognitive alteration , emotional alteration and loss of the autonomous functionality
  Unfolding Pathogenesis in Parkinson’s:  Break through Suggests Damaged Proteins  Travel Between Cells    Science Daily  January 26,2011 The investigation found a misfolding of the protein alpha-synuclein (Implicated in Parkinson´s disease) Alpha-synuclein
  Unfolding Pathogenesis in Parkinson’s:  Break through Suggests Damaged Proteins  Travel Between Cells    Science Daily  January 26,2011 Protein Alpha-synuclein could be transfered from one cell to other one, and also it can aggregate in cell receptors Cell Receptor
OBSERVATION
MEDICAL UTILITY The investigations about prions must be principal topics in health care and also it may has a real value, to find enigmatic solutions to problems that this pathogenic agent can develop as the BSE
MEDICAL UTILITY The parkinson´s disease  is a great topic of world interest that must go  stopping due to the advance in the investigations, it could have gone away distinguishing information that has not been reported about the disease and the manner for helping the patients who suffer it
MEDICAL UTILITY When the science knows the mechanism of the alpha sinucleina protein the world could work in different topics, for example the physiopatology of parkinson and the treatment indicated to diminish the symptoms of the patient
MEDICAL UTILITY The investigation is an important field  in the medicine because it allows to quantify and to qualify variables and also it allows other actions for reaching  the medicine
BIBLIOGRAPHY ·  MARTINEZ S, Lina María. Biología  molecular. 3. ed. Medellín: UPB. Fac. de Medicina.       ·  Unfolding Pathogenesis in Parkinson’s: Breakthrough Suggests Damaged  Proteins Travel Between Cells. Science Daily. January 26, 2011       Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest. Science Daily. January 14, 2011    
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Molecular Biology

  • 1. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest AND Unfolding Pathogenesis in Parkinson’s: Breakthrough Suggests Damaged Proteins Travel Between Cells   Mateo Zuluaga Gómez Medicine Student UPB Medellín-Colombia
  • 4. INTRODUCTION PRION PROTEIN DNA REPLICATION Parkinson Disease affects the Central Neural System
  • 5. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily January 14,2011
  • 6. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily January 14,2011 PRION IS AN INFECTIOUS AGENT THAT COULD AFFECT THE HUMAN BODY ON DIFFERENT SITES PRION COULD REPLICATE HIS DNA INFORMATION
  • 7. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily January 14,2011 PRION COULD BE TRANSPORTED BY THE FOOD INGESTINS AND SURGICAL ELEMENTS PRION COULD BE TRANSPORTED BY THE AIR NEW INVESTIGATION
  • 8. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily January 14,2011 The investigators made tests with immunosupresed and immunocompetents mices to determine if they would be vulnerable to the air transmission prions Prions can induce mad cow disease
  • 10. Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged Proteins Travel Between Cells Science Daily January 26,2011
  • 11. Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged Proteins Travel Between Cells Science Daily January 26,2011 Parkinson is a degenerative disease that affects the neurons of the Substancia Nigra. It produces cognitive alteration , emotional alteration and loss of the autonomous functionality
  • 12. Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged Proteins Travel Between Cells Science Daily January 26,2011 The investigation found a misfolding of the protein alpha-synuclein (Implicated in Parkinson´s disease) Alpha-synuclein
  • 13. Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged Proteins Travel Between Cells Science Daily January 26,2011 Protein Alpha-synuclein could be transfered from one cell to other one, and also it can aggregate in cell receptors Cell Receptor
  • 15. MEDICAL UTILITY The investigations about prions must be principal topics in health care and also it may has a real value, to find enigmatic solutions to problems that this pathogenic agent can develop as the BSE
  • 16. MEDICAL UTILITY The parkinson´s disease is a great topic of world interest that must go stopping due to the advance in the investigations, it could have gone away distinguishing information that has not been reported about the disease and the manner for helping the patients who suffer it
  • 17. MEDICAL UTILITY When the science knows the mechanism of the alpha sinucleina protein the world could work in different topics, for example the physiopatology of parkinson and the treatment indicated to diminish the symptoms of the patient
  • 18. MEDICAL UTILITY The investigation is an important field in the medicine because it allows to quantify and to qualify variables and also it allows other actions for reaching the medicine
  • 19. BIBLIOGRAPHY ·  MARTINEZ S, Lina María. Biología molecular. 3. ed. Medellín: UPB. Fac. de Medicina.       ·  Unfolding Pathogenesis in Parkinson’s: Breakthrough Suggests Damaged Proteins Travel Between Cells. Science Daily. January 26, 2011       Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest. Science Daily. January 14, 2011