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ANTIMICROBIAL RESISTANCE -
CHALLENGES AND SOLUTIONS
The strength of trillions upon trillions of

micro-organism , combined with ancient

     force of evolution will inevitably

         over power our drugs
The evolution of
microorganism is
Darwinian : in the face
of change , THE
FITTEST SURVIVES
It is the ability of micro-organism to survive
concentration of antibiotic that is sensitive to
cells of same strain.

When a sensitive strain gain the ability to
withstand an antibiotic, its an antibiotic
resistant
anti microbial resistances challenges and solutions
anti microbial resistances challenges and solutions
   MDR-TB & XDR –TB

   MRSA

   Vancomycin resistant Enterococci

   Beta lactamase NDM-I

   Antibiotic resistant E.coli
anti microbial resistances challenges and solutions
anti microbial resistances challenges and solutions
anti microbial resistances challenges and solutions
anti microbial resistances challenges and solutions
Causes of development of
 antimicrobial resistance
INAPPROPRIATE AND IRRATIONAL USE OF
            ANTIBIOTICS
anti microbial resistances challenges and solutions
Inappropriate use
of antibiotics in
livestock as
growth promoters
Diagnostics




Vaccines
 Failure of response   to standard treatment

 Hampers the control of infectious diseases

 Increase in   cost of health care

 Threatens a return    to pre- antibiotic era

 Jeopardizes health    care gains to society
   QUORUM SENSING- confers
    virulence, conjugation,sporulation & biofilm
    formation. Q.S. can acts as potential target for
    antimicrobial resistance bacteria

   Vaccination
   Use of narrow spectrum antibiotics
   Rapid diagnostic tests
   Antibiotic susceptibility test
   Rational usage of antibiotics
There is a need to extend
the capabilities of
antimicrobial
therapies, to develop
drugs that destroy
pathogens and also
undermine resistance
mechanism in more
effective way.
Thank you

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anti microbial resistances challenges and solutions

  • 2. The strength of trillions upon trillions of micro-organism , combined with ancient force of evolution will inevitably over power our drugs
  • 3. The evolution of microorganism is Darwinian : in the face of change , THE FITTEST SURVIVES
  • 4. It is the ability of micro-organism to survive concentration of antibiotic that is sensitive to cells of same strain. When a sensitive strain gain the ability to withstand an antibiotic, its an antibiotic resistant
  • 7. MDR-TB & XDR –TB  MRSA  Vancomycin resistant Enterococci  Beta lactamase NDM-I  Antibiotic resistant E.coli
  • 12. Causes of development of antimicrobial resistance
  • 13. INAPPROPRIATE AND IRRATIONAL USE OF ANTIBIOTICS
  • 15. Inappropriate use of antibiotics in livestock as growth promoters
  • 17.  Failure of response to standard treatment  Hampers the control of infectious diseases  Increase in cost of health care  Threatens a return to pre- antibiotic era  Jeopardizes health care gains to society
  • 18. QUORUM SENSING- confers virulence, conjugation,sporulation & biofilm formation. Q.S. can acts as potential target for antimicrobial resistance bacteria  Vaccination  Use of narrow spectrum antibiotics  Rapid diagnostic tests  Antibiotic susceptibility test  Rational usage of antibiotics
  • 19. There is a need to extend the capabilities of antimicrobial therapies, to develop drugs that destroy pathogens and also undermine resistance mechanism in more effective way.