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Email: enquiry@medicyatra.com



Infertility facts
 affects 1 in 6 married couples of
  childbearing age
 definition: have engaged in unprotected
  coitus for 1 year and haven’t become
  pregnant




            Copyright @ Forever
Email: enquiry@medicyatra.com


Infertility Facts
   can be due to:
     – failure to conceive, loss of conceptus
   origin of problem:
     – 35% female
     – 35% male
     – 20% both partners
     – 10% unexplained




                 Copyright @ Forever
Email: enquiry@medicyatra.com



Failure to ovulate
 often caused by low body fat or stress
 GnRH surge may be inadequate




            Copyright @ Forever
Email: enquiry@medicyatra.com


Tubal blockage
   Due to:
    – Endometriosis, scar tissue from STD,
      previous surgery
 Treatment: surgery
 If surgery unsuccessful, IVF, GIFT and
  ZIFT are best options




               Copyright @ Forever
Email: enquiry@medicyatra.com


Causes of male infertility
 low sperm count (oligospermia) or
  absence of sperm (azoospermia)
 male may produce antibodies to his
  own sperm
 accessory glands / ducts may
  malfunction




             Copyright @ Forever
Email: enquiry@medicyatra.com


Intracervical or intrauterine
insemination (ICI / IUI)
 Artificial insemination
 definition: sperm introduced into female
  reproductive tract by means other than
  coitus (near cervix or in uterus)
 sperm can come from donor / sperm
  bank or from husband
 Example of a sperm bank:
    – http://www.spermbankcalifornia.com/buy-sperm
               Copyright @ Forever
Email: enquiry@medicyatra.com



ICI / IUI, cont’d.
 usually, several ejaculations are pooled
 60,000 babies / year born in US. as
  result of artificial insemination
 often used when male has low sperm
  count or antibodies present in ejaculate




            Copyright @ Forever
Email: enquiry@medicyatra.com


In vitro fertilization

 “test - tube babies”
 1st performed in 1978 (Louise Joy
  Brown)
 often performed on infertile women with
  tubal blockage



            Copyright @ Forever
Email: enquiry@medicyatra.com


 IVF Protocol
 GnRH agonist (e.g. Lupron) for 7 days
 FSH agonist (follistim, Gonal-F,
  Repronex) until follicles measure 17-20
  mm in diameter (8-14 days)
 hCG given to induce egg maturation
 Egg retrieval (transvaginally) 34-35 h
  later



             Copyright @ Forever
Email: enquiry@medicyatra.com


IVF protocol
 sperm and ova added to dish;
  fertilization occurs 12-14hrs.
 eggs transferred to new dish and cell
  division occurs
 embryos squirted into uterus (optimal
  stage: blastocyst)
 Preimplantation genetic diagnosis
  (PGD)

             Copyright @ Forever
Email: enquiry@medicyatra.com



IVF Protocol, cont’d.
 3 to 5 embryos are injected to increase
  chances of pregnancy
 woman given progestagen to prevent
  miscarriage
 Example of prices:
    – http://www.advancedfertility.com/ivfprice.htm



                Copyright @ Forever
Email: enquiry@medicyatra.com


IVF Protocol, cont’d.
   new variations / improvements:
     – Intracytoplasmic sperm injection (ICSI)
     – use of frozen embryos
   27,000 attempts made per year; 18.6%
    successful (success rates are increasing)
   http://www.advancedfertility.com/sampleivfcal
    endar.htm




                Copyright @ Forever
Email: enquiry@medicyatra.com


IVF, cont’d.

   Ethical questions:
    – will it lead to selective breeding?
    – up to what stage can research be done?
    – if embryo dies in vitro, is it abortion,
      murder?
    – what should be done w/ unwanted
      embryos?
    – should government regulate research?

                Copyright @ Forever
Email: enquiry@medicyatra.com
GIFT and ZIFT
 GIFT = gamete intrafallopian transfer
 useful for tubal blockage
 ova are collected and inserted into
  oviducts below point of blockage
 husband’s sperm are placed in oviduct




            Copyright @ Forever
Email: enquiry@medicyatra.com


GIFT and ZIFT
   woman is treated with hormones to prevent
    miscarriage
   28% successful
   ZIFT = zygote intrafallopian transfer
   ZIFT is like IVF, only zygotes (1 cell stage)
    are inserted below blockage in oviduct (24%
    success rate)




                Copyright @ Forever
Email: enquiry@medicyatra.com


Others

 Ovarian stimulation protocol
 Surrogate pregnancy
 Adoption




            Copyright @ Forever

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Infertility Treatment

  • 1. Email: enquiry@medicyatra.com Infertility facts  affects 1 in 6 married couples of childbearing age  definition: have engaged in unprotected coitus for 1 year and haven’t become pregnant Copyright @ Forever
  • 2. Email: enquiry@medicyatra.com Infertility Facts  can be due to: – failure to conceive, loss of conceptus  origin of problem: – 35% female – 35% male – 20% both partners – 10% unexplained Copyright @ Forever
  • 3. Email: enquiry@medicyatra.com Failure to ovulate  often caused by low body fat or stress  GnRH surge may be inadequate Copyright @ Forever
  • 4. Email: enquiry@medicyatra.com Tubal blockage  Due to: – Endometriosis, scar tissue from STD, previous surgery  Treatment: surgery  If surgery unsuccessful, IVF, GIFT and ZIFT are best options Copyright @ Forever
  • 5. Email: enquiry@medicyatra.com Causes of male infertility  low sperm count (oligospermia) or absence of sperm (azoospermia)  male may produce antibodies to his own sperm  accessory glands / ducts may malfunction Copyright @ Forever
  • 6. Email: enquiry@medicyatra.com Intracervical or intrauterine insemination (ICI / IUI)  Artificial insemination  definition: sperm introduced into female reproductive tract by means other than coitus (near cervix or in uterus)  sperm can come from donor / sperm bank or from husband  Example of a sperm bank: – http://www.spermbankcalifornia.com/buy-sperm Copyright @ Forever
  • 7. Email: enquiry@medicyatra.com ICI / IUI, cont’d.  usually, several ejaculations are pooled  60,000 babies / year born in US. as result of artificial insemination  often used when male has low sperm count or antibodies present in ejaculate Copyright @ Forever
  • 8. Email: enquiry@medicyatra.com In vitro fertilization  “test - tube babies”  1st performed in 1978 (Louise Joy Brown)  often performed on infertile women with tubal blockage Copyright @ Forever
  • 9. Email: enquiry@medicyatra.com IVF Protocol  GnRH agonist (e.g. Lupron) for 7 days  FSH agonist (follistim, Gonal-F, Repronex) until follicles measure 17-20 mm in diameter (8-14 days)  hCG given to induce egg maturation  Egg retrieval (transvaginally) 34-35 h later Copyright @ Forever
  • 10. Email: enquiry@medicyatra.com IVF protocol  sperm and ova added to dish; fertilization occurs 12-14hrs.  eggs transferred to new dish and cell division occurs  embryos squirted into uterus (optimal stage: blastocyst)  Preimplantation genetic diagnosis (PGD) Copyright @ Forever
  • 11. Email: enquiry@medicyatra.com IVF Protocol, cont’d.  3 to 5 embryos are injected to increase chances of pregnancy  woman given progestagen to prevent miscarriage  Example of prices: – http://www.advancedfertility.com/ivfprice.htm Copyright @ Forever
  • 12. Email: enquiry@medicyatra.com IVF Protocol, cont’d.  new variations / improvements: – Intracytoplasmic sperm injection (ICSI) – use of frozen embryos  27,000 attempts made per year; 18.6% successful (success rates are increasing)  http://www.advancedfertility.com/sampleivfcal endar.htm Copyright @ Forever
  • 13. Email: enquiry@medicyatra.com IVF, cont’d.  Ethical questions: – will it lead to selective breeding? – up to what stage can research be done? – if embryo dies in vitro, is it abortion, murder? – what should be done w/ unwanted embryos? – should government regulate research? Copyright @ Forever
  • 14. Email: enquiry@medicyatra.com GIFT and ZIFT  GIFT = gamete intrafallopian transfer  useful for tubal blockage  ova are collected and inserted into oviducts below point of blockage  husband’s sperm are placed in oviduct Copyright @ Forever
  • 15. Email: enquiry@medicyatra.com GIFT and ZIFT  woman is treated with hormones to prevent miscarriage  28% successful  ZIFT = zygote intrafallopian transfer  ZIFT is like IVF, only zygotes (1 cell stage) are inserted below blockage in oviduct (24% success rate) Copyright @ Forever
  • 16. Email: enquiry@medicyatra.com Others  Ovarian stimulation protocol  Surrogate pregnancy  Adoption Copyright @ Forever