Monarsh

1. 1

2. Prepared for Monash University
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3. Presentation of my companies
28.05.2012
Prepared for Monash University
Presented by Dr. MT Madakbas
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4. 2

5. Biophotek Pty/Ltd, Melbourne , Australia
2

6. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
2

7. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
2

8. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
Photek Ltd St Leonard on Sea, UK
2

9. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
Photek Ltd St Leonard on Sea, UK
Founder,Chairman Major share Holder 1991-Present
2

10. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
Photek Ltd St Leonard on Sea, UK
Founder,Chairman Major share Holder 1991-Present
Image intensifiers, Fast PMT’s, Cameras, Streak tubes,
2

11. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
Photek Ltd St Leonard on Sea, UK
Founder,Chairman Major share Holder 1991-Present
Image intensifiers, Fast PMT’s, Cameras, Streak tubes,
Bioptics.inc Tucson AZ USA
2

12. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
Photek Ltd St Leonard on Sea, UK
Founder,Chairman Major share Holder 1991-Present
Image intensifiers, Fast PMT’s, Cameras, Streak tubes,
Bioptics.inc Tucson AZ USA
Founder, Director 2001-Present
2

13. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
Photek Ltd St Leonard on Sea, UK
Founder,Chairman Major share Holder 1991-Present
Image intensifiers, Fast PMT’s, Cameras, Streak tubes,
Bioptics.inc Tucson AZ USA
Founder, Director 2001-Present
Specimen radiography, CMOS large Area FFDM cameras
2

14. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
Photek Ltd St Leonard on Sea, UK
Founder,Chairman Major share Holder 1991-Present
Image intensifiers, Fast PMT’s, Cameras, Streak tubes,
Bioptics.inc Tucson AZ USA
Founder, Director 2001-Present
Specimen radiography, CMOS large Area FFDM cameras
Faxitron Chicago USA
2

15. Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
Photek Ltd St Leonard on Sea, UK
Founder,Chairman Major share Holder 1991-Present
Image intensifiers, Fast PMT’s, Cameras, Streak tubes,
Bioptics.inc Tucson AZ USA
Founder, Director 2001-Present
Specimen radiography, CMOS large Area FFDM cameras
Faxitron Chicago USA
Share holder, 2011-Present
2

16. My present Companies
Biophotek Pty/Ltd, Melbourne , Australia
Founder ,Chairman, 2002-Present
Molecular Imaging, ELSS
Photek Ltd St Leonard on Sea, UK
Founder,Chairman Major share Holder 1991-Present
Image intensifiers, Fast PMT’s, Cameras, Streak tubes,
Bioptics.inc Tucson AZ USA
Founder, Director 2001-Present
Specimen radiography, CMOS large Area FFDM cameras
Faxitron Chicago USA
Share holder, 2011-Present
Cabinet X-Ray radiographic systems, Irrediators
2

17. 3

18. Hi-Light Opto Electronics BV Tolbert, NL
3

19. Hi-Light Opto Electronics BV Tolbert, NL
( Night vision HVPS, and test systems)
3

20. Hi-Light Opto Electronics BV Tolbert, NL
( Night vision HVPS, and test systems)
1985-2000 sold to Photonis SA in France
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21. Hi-Light Opto Electronics BV Tolbert, NL
( Night vision HVPS, and test systems)
1985-2000 sold to Photonis SA in France
Medoptics-Inc Tucson, AZ ,USA
3

22. My Former Companies
Hi-Light Opto Electronics BV Tolbert, NL
( Night vision HVPS, and test systems)
1985-2000 sold to Photonis SA in France
Medoptics-Inc Tucson, AZ ,USA
1994-2000 sold to DALSA in Canada (CCD large area cameras)
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23. Company Profile
• Specialist manufacturers of vacuum based detectors and
camera systems for photon detection.
• Photek manufacture Image Intensifiers, PMT’s, Streak
Tubes, open faced detectors and a range of associated
electronics and camera systems
• Located in St Leonards-on-Sea – South East England
• Established September 1991
4 www.photek.co.uk

24. Applications
• Early warning missile systems
• Wafer silicon inspection
• Astronomy including orbital space science experiments
• Ultra-high speed cameras
• Nuclear & high energy physics research
• Life-science research
• Industrial processing
• Security
5 www.photek.co.uk

25. Track Record
• CERN • University of Oxford
• AWE • University of Cambridge
• LANL • Imperial College London
• LLNL • Julich
• Caltech • Rutherford Appleton Labs
• CEA • Daresbury Lab
• Fermilab • NASA
• Rochester LLE • Indian Institute of Astrophysics
6 www.photek.co.uk

26. 7 www.photek.co.uk

27. MCP240 MCP340
8 Way Cathode Built in Taper PMT240 - 96
Quadrant PMT PMT206
8 page
www.photek.co.uk

28. Gated ICCD125
80mm X-ray
ICCD125 Solar Blind ICCD235
ICCD112 ICCD225
150mm
Photon Counting
9 www.photek.co.uk

29. • 25mm and 40mm Versions • Chemi Luminescence
• Single Photon Counting • Bio Luminescence
• Resistive Anode • Thermo Luminescence
• X, Y, Time Output • Missile Detection

30. Image Photon Detector
• 25mm and 40mm Versions • Chemi Luminescence
• Single Photon Counting • Bio Luminescence
• Resistive Anode • Thermo Luminescence
• X, Y, Time Output • Missile Detection

31. Input Window
Photocathode
MCP Stack
Anode
11 www.photek.co.uk

32. Tube Production - Rig
12 www.photek.co.uk

33. • Create a single image from a defined time domain
• Create a time sequence of images
Total Integral 10 Second Integral per Image
Aequorin Ca signals in a tobacco leaf in response to cold
shock Campbell, University of Wales College of Medicine and Dr Marc Knight, University Oxford.
Courtesy Prof.AK

34. Time Resolved Imaging
This is shown in BBC 12 May1995
1/2 h-Tomorrows world
• Create a single image from a defined time domain
• Create a time sequence of images
Total Integral 10 Second Integral per Image
Aequorin Ca signals in a tobacco leaf in response to cold
shock Campbell, University of Wales College of Medicine and Dr Marc Knight, University Oxford.
Courtesy Prof.AK

35. Time Resolved Imaging
This is shown in BBC 12 May1995
1/2 h-Tomorrows world
• Create a single image from a defined time domain
• Create a time sequence of images
Total Integral 10 Second Integral per Image
Aequorin Ca signals in a tobacco leaf in response to cold
shock Campbell, University of Wales College of Medicine and Dr Marc Knight, University Oxford.
Courtesy Prof.AK

36. • Create a single image from a defined time domain
• Create a time sequence of images
Total Integral 10 Second Integral per Image
Aequorin Ca signals in a tobacco leaf in response to cold shock
Courtesy Prof.AK Campbell, University of Wales College of Medicine and Dr Marc Knight, University Oxford.
14 www.photek.co.uk

37. • 93,384,1536 Well Versions
• Used by Pharmaceutical
Research Laboratories
• Drug Development
• High Throughput Screening
1,000,000 Samples / Day
• Drive for Higher Density Plates
• Less Light Output
• More Sensitive Cameras Required
15 www.photek.co.uk

38. ACE Advanced Composition Explorer
XMM UV Optical Monitor
MSX UVISI Detector
GUVI Global Ultraviolet Imager
16 www.photek.co.uk

39. 17 page
www.photek.co.uk

40. 18 page
www.photek.co.uk

41. 19 www.photek.co.uk

42. MSX
• Johns Hopkins University
• Launched 24 April 96
• Part of the spectrograph on the UVISI Instrument
• Diffuse and Discrete Aurora
• Low Earth Atmosphere Phenomena
20 www.photek.co.uk

43. GUVI
• Johns Hopkins University Applied Physics Laboratory
• Launched on the TIMED Spacecraft during 2001
• TIMED is used to study the energetics and dynamics
of the Mesosphere and lower Thermosphere between an
altitude of approximately 60 to 180 kilometers.
• GUVI is a far-ultraviolet (115 to 180 nm), scanning
imaging spectrograph that provides horizon-to-horizon
images in five selectable wavelength intervals
21 www.photek.co.uk

44. UVIT
• Indian Space Research Organisation (ISRO)
• Due to launch on the ASTROSAT spacecraft
• ASTROSAT aims are to investigate the origin and
mechanism of radiation emissions in active galactic nuclei.
• UVIT aims to provide flux calibrated images of the sky in
the far-UV, near-UV and visible spectral regions
22 www.photek.co.uk

45. The Leader in Digital Specimen

46. Overview
• Pioneer in Digital Mammography
• Founded in 2001
• Fastest growing company in this space
• Have proprietary digital imaging technology
• High resolution >10 lp /mm or 50 microns
• High sensitivity
• Robust
• Durable

47. Products
BioVISION CoreVISION
X-ray specimen system for the OR Biopsy system for stereotactic
core biopsies

48. Stereotactic Specimen Imaging

51. CMOS Digital Mammography
Modular, tiled CMOS sensor approach to
digital mammography

52. The Standard in Cabinet X-
ray
Partnering for Leadership in Medical Specimen
Radiography
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53. Breadth of Product Offering
Combined Cabinet X-Ray Solutions for Multiple Applications
The Standard in Cabinet X-ray
BioVision CoreVisio DX5 MX2 Irradiator
n 0 0 s
CONFIDENTIAL 4

54. Target Markets
Scale Business Can Successfully Address Multiple
Core Focus - Medical
 Surgical specimen radiography
 Stereotactic specimen radiography
 Pathology specimen radiography
Adjacent Applications - Scientific
 Animal imaging & irradiation
 Agriculture imaging & irradiation
 Forensic imaging
Industrial
 Non-destructive testing
CONFIDENTIAL 5

55. Spectrapath Technolgy
Dr MT Madakbas
President
BioPhotek P/L

56. Simple system
Fiber cable
Spectrometer
Labtop
Light source

57. What are the
differences between
Normal Cells and
Cancerous Cells?
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Confidential and Proprietary
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58. Diagnosing Cancer Cells
CancerScanner™ has a great potential of
differentiating different cancer grades of
cells, including dysplasia. Extensive
microscopic examinations have shown that
the mean nuclear areas vary significantly
depending on whether the tissue examined is
normal, low-grade, or high-grade cancer .
Some of these studies have also shown that
nucleus size varies considerably even
between cells of benign and slightly atypical
samples.

59. What differs ELSS from X-Rays
It should be stressed that detection of
dysplasia is crucial because dysplasia cannot
be detected by visual examinations or
diagnostic radiology methods, such as X-ray
and ultrasound. In addition, many cancers
can be cured if detected early. However,
cancerous tissue is often detected only after
it becomes visible. Therefore, SpectraPath is
planning to utilize the CancerScanner™
technology on human subjects to verify
specificity and sensitivity of the technology.

61. developing new device to detect
cancer cells
• Pathological image currently used

63. • diagnostic with Elastic Light Scattering
Spectrometers (ELSS)

64. How to differentiate
Experiments on Balb/c mice with
EMT-6 breast cancer cells

65. Kidney

66. Mice Liver