Dr. Walter Crinnion, one of the leading experts on environmental medicine and toxicology, shares his observations on the toxic burden we bear in modern society.

1. Environmental Toxicityand the Effect on Health Walter J. Crinnion, ND

2. Outline What is our current toxic burden ? How does it affect our health? What do the patients and their doctors need to help with this huge problem? Metametrix is the “go-to lab” for environmental medical testing

3. What is Our Current Toxic Burden?Are you toxic?

4. Better Living Through Chemistry There are over 80,000 chemicals registered for use by the US EPA. Over 3,800 of those are “high-use” chemicals. Less than half of high-use chemicals have been assessed for toxic effect on humans. Less than 9% have been assessed for toxic effects on children.

5. Environmental Working Group (EWG)Neonatal Toxicity Study www.ewg.org/reports/bodyburden2/ 10 babies born in US hospitals 287 chemical compounds identified in their cord blood Average of 200 chemicals per infant

6. Toxins in the Cord Blood of US Newborns

7. EWG Adult Burden Study 9 persons Including several international environmental activists 210 different chemicals Average of 91 chemical toxins per person www.ewg.org/reports/bodyburden1/

8. Bill Moyers’s Burden

10. Phthalates (plasticizers)in Urine(289 persons from CDC NHANES) Two phthalates in all urine samples tested Two more were found in over 75% of the samples as well

11. Xenobiotics in Meconium(in utero exposures) Nicotine Lowest but still detectable even in non-smokers Two metabolites of organophosphate pesticides (DEP and DETP) were found in 19/20 and 20/20 samples Mercury In 6.4% of the maternal blood and 46.1% of the meconium

12. US Children’s Urine Studies 1,4-dichlorobenzene in 96% of Arkansas children Chlorpyrifos in the urine of 93%, carbaryl in 45%, malathion in 33% in Minnesota OP metabolites DMTP and DETP were found in 70-75%, at least one was present in 99% of samples in Seattle preschoolers Only one child whose parents fed them organic food was clear of pesticides in the urine

13. The Weight…What we are all carrying OCDD 9. Ethylphenol HpCDD 10. DDE/T HxCDD 11. PCBs PeCDD 12. Phthalates Styrene 13. Chlordanes Dichlorbenzene 14. OP pesticides Xylene 15. Pb, Hg, Cd, As, etc. Parabens 16. PAHs

14. ? The Question About Human Toxic Burden NOT — IF you are toxic BUT — IF toxins are a causative factor in your health care problem(s), and — IF toxins are an obstacle to cure

15. Why We Are Exposed Part of mom’s toxic burden passed to us New compounds added to body daily through our nasty habits: Eating, Drinking, Breathing Biggest Sources: Indoor air in our homes and workplaces Food

16. Why They Build Up Our bodies are designed to hold on to fat Needed for healthy bodies Historically hard to come by Fats cannot leave by urination or defecation Reabsorption of fats — recycling These fat-resorption mechanisms cannot differentiate between good fats (EFA, fat-soluble vitamins) and DDT!!! Photo by graham

17. Worse with Weight Loss Weight loss increases circulating levels of persistent fat-stored pollutants Same increase seen after bariatric surgery (increases of 24-52%) ChevrierJ, et al. Int J Obes Relat Metab Disord 2000;24:1272-8 Hue O, et al. Obes Surg 2006;16:1145-54 Imbeault P, et al. Int J Obes 2001;25:1585-91 Charlier C, et al. In J Obes2002;26:1465-8 Photo by slushpup

18. Do These Toxins Cause Health Problems? Photo by D Sharon Pruitt

19. In Total, the Nine EWG Subjects Carried: Ü 76 chemicals linked to cancer in humans or animals (average of 53) Ü 94 chemicals that are toxic to the brain and nervous system (average of 62) Ü 86 chemicals that interfere with the hormone system (average of 58) Ü 79 chemicals associated with birth defects or abnormal development (average of 55) Ü 77 chemicals toxic to the reproductive system (average of 55) Ü 77 chemicals toxic to the immune system (average of 53)

20. What are The Main Targets? These compounds clearly affect: Immune system Allergies/Asthma Chronic infections Autoimmunity Nervous system Endocrine/hormonal system Generational

21. How They Cause Damage Mitochondrial toxicity Reduce function of mitochondria Reduced function of cell/organs that contain mitochondria Oxidative damage Neurotoxicity Solvents diminish neural functioning Pesticides are neurotoxins by design Photo by get directly down

22. Associated Adverse Outcomes Cancer incidences are increasing “Boomers” have higher rates of cancer than any previous generation Childhood brain cancers are rising Asthma rates are rising worldwide Autism and ADD/ADHD rates are increasing Chemical Sensitivity Chronic Fatigue Immune Deficiency Syndrome Gulf War Syndrome

23. Presenting As: Fatigue Obesity Diabetes Fibromyalgia Cognitive difficulties Brain Fog Mood disorders Tremors Chronic neurological illnesses Asthma Allergies Chemical sensitivities Autoimmune conditions Chronic bacterial, fungal, and viral infections Certain cancers Infertility Hormonal imbalances Etc.

25. Nutrient deficiencies (Mg,Se,B6)

26. High sugar, low protein diet

27. Stress, emotional stuffing, trauma

28. Heavy metal presence (esp. Hg)

29. Increased exposurePhoto by get wili hybrid

30. The Dirty DozenEWG’s 12 most contaminated fruits/vegetables Peaches 7. Cherries Apples 8. Pears Bell Peppers 9. Grapes (imported) Celery 10. Spinach Nectarines 11. Lettuce Strawberries 12. Potatoes www.ewg.org

31. EWG’s 12 Least Contaminated Fruits and Vegetables Onion 7. Sweet peas Avocado 8. Kiwi fruit Sweet corn 9. Bananas Pineapple 10. Cabbage Mango 11. Broccoli Asparagus 12. Papaya

32. Notes: The levels shown on this figure represent the sum of the 12 PCB compounds that resemble dioxin, widely recognized as the most toxic of all industrial pollutants, and linked to cancer as well as to damage of the nervous, reproductive, and immune systems. PCB concentrations are shown as toxic equivalents (TEQs) of 2,3.7,8-Tetrachlorodibenzo-p-dioxin, the benchmark of dioxin chemical. Source: EWG analysis of data from Axys (2003), Easton et al. (2002), EPA (2000a and 2000b), Fiedler et al. (2000), Jacobs et al. (2002), NMFS (2002), NAS (2003), Schecter et al. (2001), and USDA (2002).

34. Butter – The Global PCB Marker Highest PCB levels in butter from Europe and North America. [i] Lowest levels were in Australia and New Zealand Levels of p,p-DDT, p,p-DDE and HCH were highest in butter from areas where those compounds are in regular use (DDT = India and south/central America; HCH = India, China, Spain). [i]Kalantzi OI, Environ SciTechnol 2001;35(6):1013-1018.

35. EPA List of Mercury in Fishwww.cfsan.fda.gov/%7Efrf/sea-mehg.htmlMost Toxic Least Toxic Tilefish (Gulf of Mexico) 1.45 ppm Shark 0.988 Swordfish 0.976 King Mackerel 0.730 Tuna (bigeye) 0.639 Orange Roughy 0.554 Marlin 0.485 Grouper 0.465 Mackerel Spanish 0.454 Tuna (fresh/frozen) 0.414 Chilean Bass 0.386 Bluefish 0.337 Lobster 0.310 Croaker, white (Pacific) 0.287 Scorpion fish 0.286 Weakfish (Sea trout) 0.256 Halibut 0.252 Sablefish 0.222 Bass (saltwater, black) 0.219 Snapper 0.189 Clam ND Ocean Perch ND Salmon (canned) ND Shrimp ND Whiting ND Tilapia 0.010 Oyster 0.013 Salmon (fresh/frozen) 0.014 Hake 0.014 Sardine 0.016 Haddock 0.031 Crawfish 0.033 Pollock 0.041 Anchovies 0.043 Herring 0.044 Flounder/Sole 0.045 Mullet 0.046 Catfish 0.049 Scallop 0.050 Atlantic Mackerel 0.050

36. What Do Patients and Clinicians Need?

37. A Current Dilemma(another inconvenient truth) Natural medicine is built upon finding the nutrient, supplement, or protocol the patient is deficient in which will bring a return to health All patients are toxic and will NOT get better until the obstacle to cure is identified and removed Photo by zedzap

38. What Patients Face Chronic health problems that current allopathic, naturopathic, and alternative methods are not working for Realization that this world is toxic Fear that their problems are caused by a toxic buildup and that no one can help Photo by DerrickT

39. What Clinicians Face Chronically ill patients in whom their sure-fire therapies are not working An influx of illnesses caused by toxicity (ie. Chemical sensitivity and chronic neurologic problems)that they cannot treat A knowledge (great or small) that toxins may be the culprit, but not sure how to proceed to confirm the diagnosis

40. For more information on toxicity testing contact Metametrix at 800.221.4640 or visit www.metametrix.com/toxicity