2. The Italian Brand for the skin
1. Quality
2. Pharmaceutical approuch and
experience
3. Italian brand power: Luxury
feeling and Technology for high
standing products
4. Effort and Support
3. Esthetic Line the products for
aging treatment that really work
without side effects
5. Cleanser
OP LIQUID SOAP
Fluid soap without irritating and allergenic detergents; it is
specifically formulated for intolerant and stressed skin especially
after dermatological and surgical treatments. It cleans gently the
skin, maintaining the epidermal surface lipids and reducing
irritation thanks to Jojoba Oil and Vitamin E.
Completely hypo-allergenic and physiological pH.
Indications: It is indicated for sensitive and intolerant skin,
suffering cleansing with common soap or detergents. You should
use the product in case of several skin diseases and after
dermatological or surgical practice such us chemical peelings or
other medical practice.
Apply a small amount of fluid soap on skin and massage. Rinse it
up with abundant water.
Size: 250 ml
6. Cleanser
Features: absolutely free from allergenic substances;
OP LIQUID SOAP
Physiological pH;
Advantages: you can use it for any kind of skin
problem, after surgery and also like make up remover to
avoid irritation;
Benefits: daily skin cleaning for any kind of skin;
Target: Pediatrists, General Prac., Aesthetic Doctors,
Dermatologists, Plastic Surgeons, Beauticians;
Main Competitor: Eucerin fluid Price: $15.00
Size: 200 ml
7. Cleanser
OP LIQUID SOAP
Graphs describing the improvement of the skin feeling after 4 weeks application twice per
day of OP liquid sensible skin soap after laser therapy. University of Pavia – Italy
100%
100% 91%
% of satisfied volunteers 82% 82% 81% 81%
80% 73%
60%
40%
20%
0%
8. Cleanser
OP GENTLE BODY CLEANSER
OP Gentle Body Cleanser is the latest answer from Mac Pharma research
in order to clean the sensitive and intollerant skins.
Sensible skin is very sensitive to the external aggressions both for the lack
of barrier skin lipids and for hypersensitivity to the normal external
stimulations. OP gentle Body Cleanser cleans sweetly even the more
sensible skin without sensitization favouring the replenish of important
fatty acids capable to restore the integrity and function of skin barrier.
Indications: Physiological cleaning of sensible and reactive skin in course
of irritative and allergic dermatitis such DAC, DIC Atopic dermatitis and in
case of aesthetic and dermatologic treatments. OP Gentle Body Clenaser
is indicated for all the skin type and also for children both for the face
and for the body
Size: 500 ml
9. Cleanser
OP GENTLE BODY CLEANSER
Characteristics: absolutely free from allergenic
substances;
Physiological pH;
Advantages: can be applied on any kind of
“untreatable” skin;
Benefits: effective cleanser, daily usage for any kind of
skin;
Target: Pediatrists, General Prac., Aesthetics Doctors,
Dermatologists, Plastic Surgeons, Beauticians.
Main Competitor: Aveeno Emulave Sensitive fluid
Price: $20.00 Size: 400 ml
10. Cleanser
OP GENTLE BODY CLEANSER
Graphs describing the improvement of the skin feeling after 4 weeks application twice per
day of OP liquid sensible skin soap after laser therapy. University of Pavia – Italy
100%
100% 91%
% of satisfied volunteers 90%
82% 81%
80% 72%
70%
60%
40%
20%
0%
11. Moisturizer and lenitive
OP LENITIVE CREAM
The product contains several molecules suitable to modulate the most important
signs of skin irritation and inflammation after dermatological and surgical
practices or photo-induced skin burning.
It works normalizing excessive vasodilatation, inhibiting inflammatory skin signs
and induce an anaesthetic effect against skin pain and burning.
Very high absorbing vehicle and hypo-allergenic.
Indications: This cream contains molecules suitable to reduce inflammation,
itching, burning in case of several skin conditions such excessive sun exposition,
dermatological or surgical skin practices such chemical peeling, laser therapy,
dermo-abrasion. Polidocanol induces a mild skin anaesthesia, glycyrrhetic acid
reduces inflammation signs and Rutin restores dermis vascular system
physiology.
Apply two or more time a day with a small massage.
Size: 50 ml
12. Moisturizer
OP LENITIVE CREAM
Features: Effective mix of polidocanol and liqorice
extract;
Advantages: Daily action to restore and protect the skin
from any kind of irritations and pollution with
moisturizing effect;
Benefits: protect sensitive skin, restore wellness after
dermatologic treatments, reduce discomfort of atopic
and allergic skin;
Target: Dermatologists, Plastic Surgeons, Pediatrists,
General Prac., Aesthetics Doctors, Beauticians;
Main Competitor: Lichtena, Giuliani Pharma
Size 50ml Price 25,00 Euro
13. Moisturizer
OP LENITIVE CREAM
Graphs describing the improvement of the skin feeling after 4 weeks application twice per
day of OP lenitive cream skin after laser therapy. University of Pavia – Italy
100% 92%
% of satisfied volunteers 89%
85%
80% 78%
75% 70%
60%
40%
20%
0%
14. Prevention Anti Aging
OP REBUILDING SERUM AGE
This is a new anti-age serum with a liposome based vehicle composed of the
most effective anti-age molecules available. This lipidic serum allows to
replace effectively the lost skin lipids, to induce the restoration of the
metabolic processes of the skin, to enhance the antioxidant activity within the
skin cells.
Particularly indicated for the treatment of eye contour skin marks, fine
wrinkles, atrophy and poor skin hydration and elasticity.
Indications: OP REBUILDING SERUM is indicated for a daily care of skin
face, to prevent aging signs, to enhance skin tone and pigmentation
uniformity.
Size: 75 ml
15. Prevention Anti Aging
OP REBUILDING SERUM AGE
Features: anti-age serum for face and neck with silky texture;
Advantages: it’s capable to induce a strong filling and smoothing
action;
Benefits: It’s easy to absorbe and ensures an immediate lifting
effect. Thanks to Trylagen-KGF active principle it boost up collagen
synthesis, uniformes skin pigmentation and inibits enzymatic
destruction.
Target: Pharmacists, customers.
Main Competitor: EC 30 - 5 senses system- 30 ml € 130,00
16. Prevention Anti Aging
OP REBUILDING SERUM AGE
Graphs of the results after 4 weeks application twice per day of OP rebuilding serum age.
University of Pavia – Italy
% of satisfied volunteers 100%
85%
78%
80%
69%
60%
60%
40%
20%
0%
17. Treatment Body
OP HYDRA SVELT
A new brand based on synergy of active ingredients such as
Panthenol, Hyaluronic Acid, Shea Butter, Olive leaf flavonoids
and PCA working closely with the skin to moisturize, rebuild and
restore the naturally protective hydro-lipidic film. The high
concentration of Jaluronic Acid ensures a constant moisturizing
level over a long period of time, whilst Shea Butter and Olive
leaf flavonoids help to induce a deep sensation of comfort and
suppleness.
Directions: Apply all over the body making sure the skin is
thoroughly cleaned and massage until fully absorbed.
Size: 250 ml
18. Treatment Body
OP HYDRA SVELT
Features: The high concentration of Jaluronic Acid ensures a constant
moisturizing level over a long period of time, whilst Shea Butter and Olive Oil
help induce a deep sensation of comfort and suppleness.
Advantages: Easily absorbed, OP Hydra Svelt is ideal after bath or shower
to smooth the skin stressed by sun, wind and pollutants or simply naturally dry;
Benefits:If used regularly, improve the firmness, hydration and elasticity of
your skin.
Target: Pharmacists, customers.
Main Competitor: HYDRA – FLASH Spécial Corps Formule Intensive - Sisley –
200 ml. – 98.00 Euro
19. Treatment Body
OP HYDRA SVELT
Graphs of the results of the skin after 4 weeks application twice per day of OP hydra
svelt. University of Pavia – Italy
100% 98%
% of satisfied volunteers
87% 90%
80%
60%
40%
20%
0%
20. Extra Care
OP LIGHTENING CREAM
The formulation contains innovative active compounds capable to inhibit the
melanic pigments biosynthesis and mainly to induce the production of clearest
pigments able to camouflage with the normal colour of the skin.
It furthermore contains Liquorice extract which shows reduction of melanic
pigmentation and anti-bruise and sun burns preventing actions;
Indications: This formulation is particularly indicated to treat melanic skin
spots thanks to its unique and innovative way of action capable to reduce
melanin skin synthesis and anyway to produce clearer melanins;
Apply this formulation twice a day with light massage.
Size: 50 ml
21. Extra Care
OP LIGHTENING CREAM
Characteristics: emulsion with association of Acethylcistein,
Sodium ascorbyl phosphate and Glabridin from Liquorice
capable to reduce melanic spots, melasma and eumelanic
synthesis;
Advantages: effective cosmetic treatment in case of melasma,
sun induced skin spots and chemical peeling;
Benefits: it reduces production of eumelanins, bleaches skin
spots physiologically and maintains uniform skin pigmentation;
Target: Dermatologists, Plastic Surgeons, Pediatrists, General
Prac., Aesthetics Doctors, Beauticians.
Main Competitor: NeoStrata Bionic Skin Lightening Cream. size
30 ml
22. Extra Care
Graphs of the results after 6 weeks application twice per day of OP Lightening cream.
University of Pavia – Italy
23. Extra Care
OP SOFT PEEL
New formulation for a soft daily exfoliation and skin surface
renewal. It contains mandelic acid, an a-hydroxyacid with good
cheratoplastic activity and safe skin behaviour. In combination
with allantoin, resveratrol and mild glucosidic surfactants it acts
as exfoliating and normalizing skin tissue even in case of
excessive sensibility and irritation. It has been formulated for the
preparation and maintenance of the professional chemical
peeling and to improve skin surface appearance and
homogenise skin pigmentation.
Indications: This formulation is particularly indicated for the
preparation and maintenance of chemical peeling. It can be
applied as detergent and to uniform skin surface and
pigmentation.
Size: 100 ml;
24. Extra Care
OP SOFT PEEL
Features: Film former and riepetilizing agent and sweet
tensioactive agent for a mild face cleansing;
Advantages: it improves capillaries resistance and
neutralize free oxigen radicals; help to uniform
cutaneous colour and to inhibit excessive melanic activity;
Benefits: It mantains peeling effect for a long time and
safety;
Target: Pharmacists, customers
Main Competitor: Perfectionist Peel
2-Step Enzyme Activating Treatment 50 ml - Estée
Lauder - € 94,00
25. Extra Care
OP SOFT PEEL
Graphs of the results after 4 weeks application twice per day of OP soft peeling.
University of Pavia – Italy
100% 93% 94%
% of satisfied volunteers
88%
80%
60%
40%
20%
0%
26. Sun Booster
OP BRONZ SVELT
This product, born from nanoemulsion technology, is capable to induce
a deep absorption of active ingredients (kinetic analisys with
Diclofenac sodium salt).
The active molecule is a liphophilic Tyrosine capable to stimulate
physiologic melanins synthesis;
Viscous gelified form with more than 65% of eudermal lipids.
The nano-structurated lipogel is completely vegetable based (Patent).
Paraben and IMU free.
Structure similar to the healthy horny layer (protein-lipids domains).
Indications:
Skin pigmentation modulator: without UV exposure, poor uniform skin
colour, localized acromie;
Tan sublimating: Natural or artificial UV exposure (UV-A and UV-B),
lenitive after-sun and melanic pigmentation mantainance
Size: 200 ml
27. Sun Booster
OP BRONZ SVELT
Features: Nano-structured lipogel completely vegetable
able to increase sun tanning physiologically;
Advantages: increasing sun tanning uniformity and lasting;
Benefits: More rapid and safe sun tanning;
Target: Pharmacists, customers
Competitors: Attiva-Bronz – ROUGJ – 125 ml - € 18,00
28. Sun Booster
OP BRONZ SVELT
Graphs results after 4 weeks application twice per day of OP bronz svelt. University of
Pavia – Italy
100% 93% 94%
% of satisfied volunteers
80%
72%
60%
40%
20%
0%
29. Nutraceutical
OP BIOREPAIR PLUS
Biorepair plus is a nutritional supplement indicated to prevent skin
aging and the most frequent phenomena such as wrinkles
formation, atrophy, melanic spots and sagging. It contains the most
powerful ingredients to sustain skin metabolism, improve skin
firmness and reduce oxidative damage. Thanks to its oro-soluble
form with good taste and flavour it results nice to take.
Contains:
Glutathion, an antioxidant enzyme to maintain cells healthy;
Glucosamine, the main brick of glucosaminoglycans such as Hyaluronic acid,
Lipoic Acid, an enzyme cofactor effective to prevent skin aging and reduce wrinkles depth;
B Vitamins, to improve cell metabolism;
Ascorbic Acid, to boost up collagen maturation and epithelia restoaration;
Betacaroten, to prevent sun damage and sustain skin trophism;
Directions: One sachet a day possibly far from meals, simply dissolved in the mouth or glass of
water.
30. Nutraceutical
OP BIOREPAIR PLUS
Features: thanks to the synergy of these substances, OP
BIOREPAIR PLUS is ideal as an anti-oxidant and trophic
nutritional support for the skin tissues during beauty medical and
surgery treatments;
Advantages: an effective nutritional answer to skin aging
problems, for successful and safe exposure to the sun and to
reduce cell aging according to the most recent biochemistry-
research breakthroughs;
Benefits: In this powder formulation, soluble in the mouth, it
offers high bio-availability of active ingredients (under-the-
tongue absorption) and has a pleasant taste.
Target: Pharmacists, customers.
Main Competitor: Inneov Re-Age Fermete (20 days) – 28.00 €
- each day: 1,40 €
31. Nutraceutical
OP BIOREPAIR PLUS
Graphs of the results after 4 weeks of OP Biorepair plus’ use University of Pavia – Italy
100% 95%
% of satisfied volunteers
80% 85%
80%
60%
40%
20%
0%
32. Biomedical
OP EMOLLIENT FOAM (14% Zinc Oxide)
Thanks to the Panthenol this new brand foam can improve epithelia restoration
in case of invasive skin treatment and bruise conditions.
The formulation is based, also, on high concentration (14%) micronized oxide
zinc and Vit. E in an innovative vehicle capable to transfer the microgranules of
active oxide zincum, deeply in the epidermal layer. The greatly enhanced
contact surface developed by micronization of oxide zinc allows to treat wide
skin areas with relatively small mousse amount.
Indications: This light and soft foam contains micronized zinc oxide and
Vitamine E and it is specifically formulated to treat sensitive, irritate and
bruised skin specially in paediatrics.
Its quick and complete penetration allows to induce an effective epithelia
restoration.
Apply several times a day with a mild massage on the skin involved.
Size: 30 ml
33. Biomedical
OP EMOLLIENT FOAM (14% Zinc Oxide)
Features: highest concentration of micronized zinc oxide;
Advantages: fast action for all Skin irritations without white
effect;
Benefits: rapid relief after any skin injury;
Target: Pediatrists, General Prac., Aesthetics Doctors,
Dermatologists, Plastic Surgeons, Beauticians.
Main Competitor: Obagi Derm Healthy Skin Protection 9%
Micronized Zinc Oxide SPF 35 3 oz Price: $32.00
34. Biomedical
OP EMOLLIENT FOAM (14% Zinc Oxide) Efficacy
Cosmetic
Graphs of the results after 1 week application twice per day of OP foam after laser
therapy. University of Pavia – Italy
100%
100% 91% 91%
% of satisfied volunteers
82% 82%
80% 73% 73%
60%
40%
20%
0%
35. Biomedical
OP HAND AND FEET CREAM 20% UREA
Op Hands and feet cream is a new A/O dermatologic formulation
specifically formulated for all the skin conditions characterizes by severe
dryness and scaling. This formulation is based on lanolin alcool 5% and
Urea 20% that in synergy with an W/O vehicle is capable to restore skin
lipids and physiologic skin moisture. By mean of an-effective emollient
proprieties Op Hands and Feet cream improves all the signs of altered skin
barrier in case of several dermatologic conditions such as xerosys, itching,
atopic dermatitis, psoriasis and severe scaling. This formulation is
particularly and especially indicated for the treatment of hand-feet
syndrome which can occur in case of oncological therapy such as 5FU.
Indications: sever scaling and dry skin conditions.
Size: 50 ml
36. Biomedical
OP HAND AND FEET CREAM 20% UREA
Characteristics: A/O emulsion with high percentage of Urea and lanolin
alcohol. It creates a barrier on the skin and improves skin dryness and
elasticity in case of severe skin impairments, hands-feet syndrome, xerosys.
Advantages: very fast skin signs improving (dryness, scaling) and long lasting
protection
Benefits: reduce discomfort and hands-feets impairment in case of
dermatosys induced by chemotherapic drugs. Very effective also in course of
exfoliative skin diseases such as psoryasis, ichthyosis, atopic dermatitis
Target: Dermatologists, Oncologist, General Prac..
Main Competitor: no products competitors with 20% of Urea
37. Biomedical
OP HAND AND FEET CREAM 20% UREA
Graphs of the results after 5 weeks application twice per day of OP Hand and feet cream.
University of Pavia – Italy
100% 93%
% of satisfied volunteers
88%
79%
80%
68%
60%
40%
20%
0%
38. Biomedical
OP SAFETY GEL
This innovative nano-structured formulation is realized with a patented nano-
emulsifier and contains natural oils, emollients and lenitive terpens. This
formulation is a nano-gel with up to 70% of oils and inside its water core
contains an effective concentration of hyaluronidase, an enzyme capable to
soften deep dermal tissue and solve the most common aesthetic side effects
concerned with sclerotherapy (extravasayion, inflammation) and with dermal
filler implantation (hyaluronic acid accumulation, inflammation and oedema).
Thanks to its specificity on hyaluronic acid breakage and to the high absorption
nano-sized structured vehicle, SAFETY GEL could be considered the elective topic
treatment for all the main aesthetic treatments side effects. It is completely safe,
not allergenic, and adapt for all skin type.
Indications: The product is indicated for sclerotherapy side effects, oedema
after hylauronic acid implants, skin inflammation;
Size: 20 ml
39. Biomedical
OP SAFETY GEL
Characteristics: New nanostructured lipogel containing high purification
hyaluronidase (350 UI). It acts promoting high absorption of enzyme into
the skin and favouring reabsorption of oedemas, dermal hyaluronic acid
accumulation and to improve signs and symptoms of irritations after
sclerotherapy extravasation.
Advantages: innovative and high performing nanogel; deep absorption
of hyaluronidase into dermo-epidermal tissue; preservants free; high skin
tollerability;
Benefits: dermatologic formulation to treat most frequent side effects in
dermatologic practice.
Target: Plastic Surgeons and Aesthetics Doctors.
Main Competitor: no products competitors
40. Biomedical
OP SAFETY GEL
Graphs of the results after 4 weeks application twice per day of Safety gel. University of
Pavia – Italy
94%
100% 93% 94%
% of satisfied volunteers
88%
80%
79%
60%
40%
20%
0%
41. Biomedical
OP C-KADERM
Silicon based lipogel specifically formulated to prevent and manage
hypertrofic scars and Keloids. It acts as film forming onto the skin
surface, reducing scar extension, hydrating scar tissue, reducing scar
redness and discomfort. Musqueta oil improves skin tissue normalization,
reduces inflammation and favours skin epithelia restoration.
Indications: cosmetic manage of hypertrophyc scars in
case of surgical treatment, aesthetic treatment and small dermatologic
surgery;
Size: 20 ml
42. Biomedical
OP C-KADERM
Features: New lipogel containing high purification silicon polymers
acting as film-folmer. Elective formulation to manage hyperthrophic
scars and keloids. Thanks to Rosa Mosqueta Oil it acts as a skin
epithelia restoring and moisturizer.
Advantages: innovative and high performing silicon based lipogel;
high hydrating properties, emollient, scar tissue emollient and
depigmenting;
Benefits: dermatologic formulation to treat most frequent
abnormalities of scarring.
Target: Plastic Surgeons and Aesthetics Doctors
Main Competitor: Dermatix gel 15 g - Valeant - € 40,00
43. Biomedical
OP C-KADERM
Study of the citotoxicity and evaluation on wound healing of C-kaderm - EVIC HISPANIA -
February 2004 - Barcelona
200%
Dermal human fibroblast
200%
160%
160%
migration
120%
100%
80%
40%
0%
49. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION
•Innovative features
•Indications
•Marketing strategies
MY CLI
Direzione scientifica-R&S
Andrea Fratter
2
50. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION
• Liquid cristals technology;
• Centella asiatica staminale cells;
• Innovative association between Nicotinamide
and Glucosamine for the structural
restoration of dermal layer and bleaching of
melanic spots;
3
51. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION
LIQUID CRISTALS
• Technology capable to promote high stability to the formulations,
high skin feeling and boost up penetration of active compounds;
• Liquid cristals overcome the concept of classic emulsion in which a
water phase and an oily one are mixed together;
• Liquid cristals are “small islands” in which water and oil mix
together thanks to particular emulsifiers: as like in a cream box
there are milions of microscopic droplets of active principles;
4
52. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION
CENTELLA ASIATICA
(vegetal stem cells)
• Glucosides extracted from this plant show a vigorous action in the inhibiting of
jaluronidase, enzyme involved in jaluronic acid destruction;
• Association with Glucosamine is particularly inteersting because represents the
brick of jaluronic acid and promote its biosynthesys; it is possible to reduce
physiologic jaluronic acid degradation and so inducing an “endo-filler” effect;
• Centella asiatica is widely employed in dermatology as epithelia restoration
agent, scar promoting and blood vessels protector;
• An innovative biotechnological technique is capable to isolate Centella asiatica
stem cells highly enriched in active molecules. This technique allows to maintain
plant phyto-complex with an high active principles content (up to 50% of
glucosides on the plant weight) (Patent, IRB);
5
55. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION
GLUCOSAMINE
• Main brick of GAG (jaluronic acid, condroitin
sulphate);
• An adequate introduction of Glucosamine (at less 100
mg/die) permits a correct turn-over of dermal matrix
(water embedded in dermal matrix);
• Glucosamine promotes sinovial liquid rigeneration
(cartilages protection);
• Particularly indicated the assumption for at least one
month before a dermal filler injection or chemical peeling
to improve esthetic result;
• It works as melanic bleaching in sinergy with
nicotinamide;
8
56. • Glucosamine: an ingredient with skin and other benefits.
• Bissett DL.
• Procter & Gamble Co., Miami Valley Laboratories, Cincinnati, OH 45252, USA.
bissett.dl@pg.com
• Both glucosamine and its derivative N-acetyl glucosamine are amino-monosaccharides that
serve key biochemical functions on their own and as substrate precursors for the biosynthesis
of polymers such as glycosaminoglycans (e.g., hyaluronic acid) and for the production of
proteoglycans. Glucosamine has an excellent safety profile and has been shown to provide
benefits in several clinical disorders. Glucosamine compounds have been reported to have
several beneficial effects on the skin or skin cells. Because of its stimulation of hyaluronic acid
synthesis, glucosamine has been shown to accelerate wound healing, improve skin hydration, and
decrease wrinkles. In addition, as an inhibitor of tyrosinase activation, it inhibits melanin
production and is useful in treatment of disorders of hyperpigmentation. Mechanistically,
glucosamine also has both anti-inflammatory and chondroprotective effects. Clinical trials have
shown benefit in using oral glucosamine supplementation to improve symptoms and slow the
progression of osteoarthritis in humans. Glucosamine has also been used to prevent and
treat osteoarthritis in animals. Based on other observations, glucosamine has been suggested
for additional clinical uses, including treatment of inflammatory bowel disease, migraine
headaches, and viral infections. The current clinical uses for topical and oral glucosamine
compounds and the mechanistic rationale for these uses are reviewed here.
9
57. Br J Dermatol. 2010 Feb 1;162(2):435-41. Epub 2009 Aug 28.
Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of
topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled
trial.
Kimball AB, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL.
Harvard Medical School, Boston, MA 02114, USA. harvardskinstudies@partners.org
Abstract
BACKGROUND: Topical niacinamide and N-acetyl glucosamine (NAG) each individually inhibit epidermal
pigmentation in cell culture. In small clinical studies, niacinamide-containing and NAG-containing formulations
reduced the appearance of hyperpigmentation. OBJECTIVES: To assess the effect of a combination of
niacinamide and NAG in a topical moisturizing formulation on irregular facial pigmentation, including specific
detection of changes in colour features associated with melanin. METHODS: This was a 10-week, double-blind,
vehicle-controlled, full-face, parallel-group clinical study conducted in women aged 40-60 years. After a 2-
week washout period, subjects used a daily regimen of either a morning sun protection factor (SPF) 15
sunscreen moisturizing lotion and evening moisturizing cream each containing 4% niacinamide + 2% NAG (test
formulation; n = 101) or the SPF 15 lotion and cream vehicles (vehicle control; n = 101). Product-induced
changes in apparent pigmentation were assessed by capturing digital photographic images of the women
after 0, 4, 6 and 8 weeks of product use and evaluating the images by algorithm-based computer image
analysis for coloured spot area fraction, by expert visual grading, and by chromophore-specific image
analysis based on noncontact SIAscopy for melanin spot area fraction and melanin chromophore evenness.
RESULTS: By all four measures, the niacinamide + NAG formulation regimen was significantly (P < 0.05) more
effective than the vehicle control formulation regimen in reducing the detectable area of facial spots and the
appearance of pigmentation. CONCLUSIONS: A formulation containing the combination of niacinamide +
NAG reduced the appearance of irregular pigmentation including hypermelaninization, providing an effect
beyond that achieved with SPF 15 sunscreen.
10
58. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION
• Treatment of atrophic, aplastic and oxidized skin; highly photo-damaged skin
(pigmentations, poor hydration, wrinkles);
• Neck and decolletè (main districts of application);
• Rich and nourishing formulation, very nice sensoriality and good misturizing
properties;
• This formulation is to be considered effectively a filler boosting formulation
capable to enhance dermal filler duration and reduce its degradation (very
important to associate BIOREPAIR PLUS);
11
59. OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION
• Protocol for face and neck aging;
• Association with CELAZOME;
• Association with ULTRA ANTIOXIDANT FORMULA (face)
• Association with BIOREPAIR PLUS;
12
61. OP PLURIATTIVO 3 CORPO
BODY CREAM
Antiage revolution for body care
MY Cli, Scientific Affairs and Formulation
Manager
Andrea Fratter
Pharm. D, PhD Cosmetic Sciences
1
63. Innovative features
• Liquid crystals technology;
• Silky and vanishing sensoriality;
• Very fast absorption (body lotion with high “spreading
value” lipids):
Average “spreading value”: 1500 mm2/10 min;
• Association of ElastocellTM (Inci: Lysine Carboxymethyl
Cysteinate) and Reboescin-salTM (Patent pending),
active blend of pure trans-Resveratrol, Escin, Salicylyc
Acid, Retinol and Centella Asiatica Stem Cells ;
3
64. Innovative features
Liquid cristals
• Technology capable to ensure high stability of
the emulsions, very good sensoriality feeling
and improve active compounds skin
penetration;
• Liquid cristals are “small islands” in which water
and oil create a unique continous phase thanks
to peculiar emulsifying agents: in a cream box
there are bilions of microscopic emulsion
droplets entrapping active compounds;
4
65. Innovative features
ELASTOCELLTM (5% w/w)
• Synthetic molecule produced starting from
L-Cysteine (Inci: Lysine Carboxymethyl
Cysteinate) capable to induce a complete
renovation of epidermal layer and
improve skin elasticity up to 30% after 3
weeks of application);
• Patented molecule capable to improve
skin distensibility, surface smoothness and
rejuvenate epidermis;
• Very useful and effective to improve skin
quality of the body in course of aging,
cellulitis and poor elasticity;
5
66.
67. Innovative features
RESVERATROL (1% w/w)
• Phytoextrogen extracted from Vitis Vinifera seeds and
skin and from Poligonum Cuspidatum roots;
• One of the most investigated natural substances;
• Scientifically and clinically clarified its phytoextrogenic,
cardiovascular protective and onco-preventive activities;
• Highly effective to improve structure and health of
mature skin (menopausa) and in the management of
severe aging skin conditions, especially if photo-
damaged;
• Very good skin penetration at the contrary of the
sistemic absorption;
7
68.
69. Arch Biochem Biophys. 2011 Apr 15;508(2):164-70. Epub 2011 Jan 4.
The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges.
Ndiaye M, Philippe C, Mukhtar H, Ahmad N.
Source
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA.
Abstract
Resveratrol, a phytoalexin antioxidant found in red grapes, has been shown to have both
chemopreventive and therapeutic effects against many diseases and disorders, including those
of the skin. Studies have shown protective effects of resveratrol against ultraviolet radiation-
mediated oxidative stress and cutaneous damages including skin cancer. Because many of the
skin conditions stem from ultraviolet radiation and oxidative stress, this antioxidant appears to
have promise and prospects against a wide range of cutaneous disorders including skin aging
and skin cancers. However, there are a few roadblocks in the way of this promising agent
regarding its translation from the bench to the bedside. This review discusses the promise and
prospects of resveratrol in the management of skin disorders and the associated challenges.
70. Arch Dermatol Res. 2010 Mar;302(2):71-83. Epub 2009 Nov 7.
Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair
mechanisms.
Nichols JA, Katiyar SK.
Source
Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard,
Volker Hall 557, PO Box 202, Birmingham, AL 35294, USA.
Abstract
Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation
in various skin diseases including, premature aging of the skin and melanoma and non-
melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders
are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc.
The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-
exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit,
reverse or retard the process of these harmful events in the UV-exposed skin. A wide variety of
polyphenols or phytochemicals, most of which are dietary supplements, have been reported to
possess substantial skin photoprotective effects. This review article summarizes the
photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape
seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation,
oxidative stress and DNA damage, etc., with a focus on mechanisms underlying the
photoprotective effects of these polyphenols. The laboratory studies conducted in animal
models suggest that these polyphenols have the ability to protect the skin from the adverse
effects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols may
favorably supplement sunscreens protection, and may be useful for skin diseases associated
with solar UV radiation-induced inflammation, oxidative stress and DNA damage.
71. J Drugs Dermatol. 2010 Dec;9(12):1523-6.
Dose-dependent antioxidant function of resveratrol demonstrated via modulation of reactive oxygen
species in normal human skin fibroblasts in vitro.
Jagdeo J, Adams L, Lev-Tov H, Sieminska J, Michl J, Brody N.
Source
Department of Dermatology, SUNY Downstate, Brooklyn, NY 11203, USA. Derm_Research@yahoo.com
Abstract
The study of free radicals is particularly relevant in the context of human skin carcinogenesis and photoaging
because of their ability to induce DNA mutations and damaging lipid peroxidation byproducts. Therefore, it
is important to identify and evaluate agents with the ability to modulate intracellular free radicals.
Significant interest exists in evaluating the chemotherapeutic and anti-oxidant properties of resveratrol
(trans-3,4',5-trihydroxystilbene). Resveratrol is a phytoalexin, a naturally occurring compound derived from
the skin of grapes and other plants. Resveratrol was selected for evaluation because of demonstrated
chemopreventive and chemotherapeutic properties in a murine skin cancer model and other human cancer
models through a variety of mechanisms. However, the intracellular anti-oxidant properties of resveratrol
on free radicals in human skin cells in vitro is not well characterized. The purpose of this research is to
investigate the ability of resveratrol to modulate the hydrogen peroxide-induced upregulation of reactive
oxygen species (ROS) free radicals in normal human skin fibroblast cells in vitro. Hydrogen peroxide is a well
known generator of free radicals that occurs during endogenous and UV-induced oxidation processes in the
human skin and was used to upregulate ROS in normal human skin fibroblast cells. Using a flow cytometry-
based assay, the results demonstrate highly significant (P<0.001) dose-dependent reduction of intracellular
hydrogen peroxide-upregulated ROS by resveratrol at 0.01%, 0.001% and 0.0001% concentrations in human
skin fibroblasts in vitro.
72. Biofactors. 2010 Sep;36(5):342-9.
Effect of resveratrol on endothelial cell function: Molecular mechanisms.
Schmitt CA, Heiss EH, Dirsch VM.
Source
Wolfson Institute for Biomedical Research, University College London, United Kingdom.
Abstract
The polyphenolic natural product resveratrol (RV), best known for its occurrence in grape skin
and red wine, is considered a candidate drug for prevention and treatment of cardiovascular
diseases. This review aims to summarize the molecular effects of RV on endothelial cells,
which line the inner walls of blood vessels and play a key role in the development of those
diseases. We describe how RV enhances endothelial nitric oxide production, improves
endothelial redox balance and inhibits endothelial activation in response to pro-inflammatory
and metabolic insults. Furthermore, we summarize effects of RV on endothelial senescence,
apoptosis, endothelin-1 release, and endothelial progenitor cell function. As many of RV's
actions seem to be mediated by SIRT₁, different mechanistic possibilities how RV may lead to
SIRT₁ activation are discussed.
73. Innovative features
ESCIN (0,6% w/w)
• Steroidic Saponine extracted from Horse chestnut seeds
and cortex;
• Very effective molecule in the protection and trophism
of veno-linfatic vessels, to reduce and absorb oedema,
soft tissue congestion and imbibition and to prevent
connective fibrosis (cellulitis);
• In form of hydrogel at percentage of 1 and 2% is
considered drug (REPARIL GEL);
• Very effective and quick to reduce dermal and adipose
soft tissue infiltration in course of cellulitis;
• The most effective molecule in the topical treatment of
cellulitis;
13
74.
75. Innovative features
RETINIL PALMITATE (0,6% w/w)
• Esterified Retinol with palmitic acid (simmetry with Ascorbyl
Palmitate);
• One of the tree biological active form of Vitamina A
(Retinol, Retinaldheyde, Retinoic acid);
• It is converted in the skin to Retinoic acid acting as dermal
renoving agent (boosting up of hyaluronic acid, collagen,
amorphous substance synthesys);
• Very high percentage (0,6% w/w) equivalent to Retinoic
acid at 0,05% w/w (Retin-A); usually it is employed at no
more than 0,2% w/w;
• Very good skin penetration and rapid onset of esthetic and
dermo-plastic effect;
15
76. Br J Dermatol. 2008 Mar;158(3):472-7. Epub 2007 Dec 6.
Repair of photoaged dermal matrix by topical application of a cosmetic 'antiageing' product.
Watson RE, Long SP, Bowden JJ, Bastrilles JY, Barton SP, Griffiths CE.
Source
Dermatological Sciences Research Group, The University of Manchester, Manchester M13 9PT, UK.
rachel.watson@manchester.ac.uk
Abstract
BACKGROUND:
Photoaged skin is characterized by coarse and fine wrinkles. The mechanism of wrinkle formation appears to involve
changes to components of the dermal extracellular matrix. Topical treatment with all-trans retinoic acid (RA) can repair
photoaged dermal matrix; this is regarded as the 'gold standard' against which repair agents are judged. To date, little is
known regarding the ability of over-the-counter 'antiageing' products to repair photoaged skin.
OBJECTIVES:
We used a modified occluded patch test to ascertain whether topical applications of cosmetic 'antiageing' products are able
to repair photoaged human skin.
METHODS:
Commercially available test products [basic moisturizer, 'antiageing' cream containing different active complex levels (6%
active: lipopentapeptide, white lupin peptides, antioxidants, retinyl palmitate; 2% active: lipopentapeptide, white lupin
peptides, antioxidants)] were applied under occlusion for 12 days prior to biopsy and histological assessment in photoaged
volunteers (n=9). RA was used as a positive control.
RESULTS:
In agreement with previous studies, the patch-test study revealed that RA produced significant fibrillin-1 deposition in the
papillary dermis (P<0.01) but had little effect on procollagen I or matrix metalloproteinase-1 expression. The 6% total active
complex formulation, however, increased the deposition of fibrillin-1 and procollagen I (P<0.01, P<0.05, respectively).
CONCLUSIONS:
This study indicates that in an in vivo 12-day patch test an over-the-counter cosmetic product can induce changes in
photoaged dermal extracellular matrix, which are indicative of repair.
77. Innovative features
CENTELLA ASIATICA (0,5% w/w)
(Vegetal stem cells)
• Glucosydes extracted from this plant show a vigorous action of
inhibition of the enzymes involved in the degradation of hyaluronic
acid (hyaluronidase);
• It is possible to induce a lower hyaluronic acid degradation so
promoting an “endo-filler effect”;
• Centella asiatica is widely employed in dermatology as epithelium
restoration agent, scarring promoting agent and phlebotonic
(Madecassoside, Roche Posai);
• This innovative biotechnological technique is capable to select and
reproduce meristem vegetal cells of Centella asiatica;
• This technology allows to maintain phytocomplex of the plant so
improving its properties and promoting the production of an high
percentage of active molecules (up to 50% in weight, Patented
technology by IRB);
17
80. Innovative features
SALICYLYC ACID (0,5% w/w)
• b-hydroxyacid with keratolytic and dermo-
purifying activity;
• It works reducing horny layer cells cohesion
and promoting their physiological detachment;
• Works as skin penetration/absorption
enhancer;
• Favours skin surface uniformity;
20
81. Indications
• The most effective body lotion in the Italian market for the concentration and
activity of the active molecules introduced;
• Treatment of body skin aging, aplastic skin and severe dermal structure lost, elasticity
and firmness;
• Very effective for the mature skin during and after menopausa;
• Very good sensoriality features, very quick absorption; it can be applied few minutes
before dress (not greasy, not sticky);
• It is advisable to apply the product at least one time per day (the best is 2
applications per day for the first week), after shower or bath to improve
penetration;
21
