Session 2: Industrial Biotechnology
Title: Replacing Fossil Fuels – How Do We Scale Up Without Compromising On Food And Environment?
Dr Jim Flatt, Mascoma
Boost PC performance: How more available memory can improve productivity
09 CeoMeeting- Session2- Mascoma
1. Development and Commercialization of Consolidated
BioProcessing for Cellulosic Biofuels Production
MLSCF CEO Life Sciences Conference, 6 October 2009
Jim Flatt, Ph.D.
Mascoma Corporation
CONFIDENTIAL
2. Mascoma Background
Team
• Founded502 by Charlieyman & LeeLyndfrom DartmouthCollege,
W
world renownedleadersin cellulosicbiofuels research
• Experienced industryleadershipteam
• 70 + persontechnologyteam principallybasedin NH
Consolidated Bioprocessing (CBP) Technology
• Gamechanging
“widely consideredto be the ultimate lowrcostconfigurationfor cellulose
hydrolysisandfermentation” – DOE/SA JointResearch
U Agenda
• Enableslowrcostbiologicalconversionof cellulosicbiomassto a broadrangeof products
• Lowcostandabundantfeedstock(currentlytargetinghardwoods)
Facilities
• CorporateOffice& Lab
• Pilot & DemoPlant (Rome,NY)
• Commercial acilityPlanned(inross, Michigan)
F K
• $49.5M in stateandfederal grants
3. Track Record of Securing Significant
Private and Government Funding
• Raised 0
$1 Million of equity
• Strategicinvestmentsby
industryrleadingpartners
• Financial investmentsfrom
toprtier venturecapital funds
• Awardedover $60 million in
FederalandState
Confidential
governmentfunding
4. Why Consolidated Bioprocessing?
lower costs through enzyme reduction and process simplification
Conventional Approach Mascoma Approach
Feedstock
Supply
Steam & Power
Generation
Waste
Treatment Mascoma
Conditioning focus
Enzyme
Hydrolysis
Supply
Conditioning
Fermentation
Key
Developing Distillation
Technology & Storage
7. Enzyme Reductionon Hardwood
Equivalent
performance with
2.5 rfold less
added enzyme
Further reduction
anticipated
8. Proof of Concept: CBP Yeast Ferments Paper Sludge to
Ethanol with no added cellulase
Positive Control
50 85% Appearance at 120 hrs.
Yield
40
Ethanol Yield (g/L)
CBP
30
20
10 CBP strain
non-CBP
Negative Control strain M1179
0
0 20 40 60 80 100 120 140
Fermentation Time (hours)
18% solids, 1 mg/gTS β
9. CBP Scalerup – Rome Demonstration Facility
60
50
Milestones
Concentration (g/ l)
40
first E85 produced 11/08
30
CBP scale-up Q1.09
20
process engr. 2009 - 10
10
0
0 20 40 60 80 100
Age (h)
120 140 160 180 November 2008
Confidential
10. Promising Initial Results on Palm Residues
Screening Test on Palm Residue Types
• aqueous-based pretreatment
• stem has highest yield
• low lignin (17 – 18%)
Palm Residue Carbohydrate Yield Max Ethanol Yield
(% theoretical) (gal/mt)
Empty Fruit Bunch 73 62
Stem 80 76
Frond 71 62
11. Mascoma Business Model
• Diversify Feedstock
– form funded collaborations to tailor Mascoma technology to other
feedstocks e.g. paper sludge, palm residue and bagasse
– equity participation for both parties
• Diversify End products
– form funded collaborations to adapt Mascoma technology to
produce non-ethanol products
• Commercial Rollout with Regional Partners
– form JV with local partners
– value capture for JV partner and Mascoma via equity
– multiple plant focus
– non-ethanol products