The document summarizes key information about rabies, including: 1. Rabies is a viral disease transmitted through bites or scratches from infected animals like dogs, foxes, and bats. 2. The virus travels from the site of infection to the central nervous system, where it causes acute inflammation and symptoms like fear of water, muscle spasms, and paralysis. 3. There is no cure for rabies, but post-exposure prophylaxis including wound cleaning and rabies vaccinations can prevent the disease if administered promptly after exposure.

2. BY: DR: NAJEEB MEMON Assist: Prof: Faculty of Community Medicine & Public Health Sciences Liaquat University of Medical & Health Sciences (LUMHS) Jamshoro Sind Pakistan

8. Agent Factors: Agent (LYSSAVIRUS type I) Rhabdoviridae type I

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20. 2) WILD LIFE RABIES : From jackals and foxes.

21. 3) BAT RABIES : Vampire bats which live on the blood of animals and men. These are one of the main causes of the death of bovine, around 0.5 to 1 million per year.

37. 2Tissue culture 2 nd G (Non-human) Potent, low cost WHO recommendatio Now purified DEV developed Improvement over adult animal nervous tissue V Not available in India & Pakistan Suckling mouse brain V Devoid of Neuroparalytic effect Used in Latin America Improvement over adult animal nervous tissue V 1, (HDC) safe, potent Pre & post expos:Immunization Used in UK,USA in past Exposed subjects Uses Fewer Allergic risks Severe & fatal reactions Side effects Fewer doses of small volume Large nos: are required Doses More potent more safer Eliminate Neuroparalytic factors Low or variable potency From fixed virus grown in brain of sheep or other animals preparation Cell culture vaccine Duck embryo vaccine Nervous Tissue vaccine

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