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‫العباقرة‬ ‫بعقول‬ ‫فكر‬
‫طه‬ ‫محمد‬
Machinery
‫التخصصيه‬ ‫نحتاج‬
‫اإلشارة‬ ‫لنقل‬‫العصبيه‬
‫اإلنسولين‬ ‫هرمون‬ ‫إلرسال‬
‫معرفتنا‬ ‫مع‬‫بالحويصلة‬
‫وأن‬‫الخليه‬ ‫بداخل‬ ‫النقل‬ ‫عملية‬ ‫فى‬ ‫دور‬ ‫لها‬
‫األسرار‬ ‫أحد‬ ‫ذلك‬ ‫آلية‬ ‫ظلت‬
‫عام‬ ‫نوبل‬ ‫جائزة‬ ‫على‬ ‫الحاصلين‬ ‫عمل‬2013
‫كبيره‬ ‫بصوره‬ ‫فهمنا‬ ‫تغير‬
‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬
‫سكيكمان‬ ‫راندى‬‫وراثة‬ ‫إستخدم‬‫الخمائر‬
‫من‬ ‫عدد‬ ‫لتحديد‬‫الجينات‬
‫فى‬ ‫مهمة‬‫مسار‬ ‫تحديد‬‫الحويصلة‬
‫وتوجيه‬‫مسارالحويصله‬
‫ثالثة‬ ‫إلى‬ ‫تصنيفها‬ ‫ويمكن‬ ‫للحياه‬ ‫مهمه‬ ‫الجينات‬ ‫هذه‬ ‫أن‬ ‫أوضح‬
‫الحويصله‬ ‫لنقل‬ ‫المختلفه‬ ‫لألوجه‬ ‫تنظيمها‬ ‫حسب‬ ‫على‬ ‫أنواع‬
‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬
Randy W. Schekman
‫روسمان‬ ‫جيمس‬‫استخدم‬‫الكيمياء‬‫الحيويه‬
‫يحدث‬ ‫الذى‬ ‫البروتين‬‫االرتباط‬‫يتحكم‬
‫الخليه‬ ‫ارتباط‬ ‫فى‬
‫على‬ ‫البروتينات‬‫الحويصلة‬
‫وجوانب‬‫الغشاء‬‫المستهدف‬
‫محدده‬ ‫تخصصيه‬ ‫بصوره‬ ‫يرتبطان‬
‫يتحققان‬ ‫بحيث‬
‫من‬‫النهائى‬ ‫الهدف‬ ‫الى‬ ‫الوصول‬
‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬
James E. Rothman
‫سيدهوف‬ ‫توماس‬
‫الحويصله‬ ‫ارتباط‬ ‫آلية‬ ‫بدراسة‬ ‫اهتم‬
‫العصبيه‬ ‫النواقل‬ ‫إطالق‬ ‫تحفز‬ ‫الكالسيوم‬ ‫أيونات‬ ‫فيها‬ ‫والتى‬
‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬
Thomas C. Südhof
‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬
• ‫مان‬ ‫س‬ ‫راند‬ •‫سيدو‬ ‫تومس‬
‫بال‬ ‫جامعة‬
‫عام‬ ‫ولد‬1
‫ورنيا‬ ‫كالي‬ ‫جامعة‬
‫عام‬ ‫ولد‬1‫فى‬
‫ورد‬ ‫ستان‬ ‫جامعة‬
‫الحويصله‬ ‫حركة‬ ‫تن‬ ‫التى‬ ‫لية‬ ‫ا‬ ‫افه‬ ‫كت‬
‫يانا‬ ‫خ‬ ‫فى‬ ‫النقل‬ ‫مة‬ ‫أن‬ ‫أحد‬ ‫وهى‬
•‫يا‬ ‫الخ‬ ‫فسيولوجى‬ ‫ال‬ ‫الم‬

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تنظيم المرور بداخل الخليه

  • 2. ‫التخصصيه‬ ‫نحتاج‬ ‫اإلشارة‬ ‫لنقل‬‫العصبيه‬ ‫اإلنسولين‬ ‫هرمون‬ ‫إلرسال‬ ‫معرفتنا‬ ‫مع‬‫بالحويصلة‬ ‫وأن‬‫الخليه‬ ‫بداخل‬ ‫النقل‬ ‫عملية‬ ‫فى‬ ‫دور‬ ‫لها‬ ‫األسرار‬ ‫أحد‬ ‫ذلك‬ ‫آلية‬ ‫ظلت‬ ‫عام‬ ‫نوبل‬ ‫جائزة‬ ‫على‬ ‫الحاصلين‬ ‫عمل‬2013 ‫كبيره‬ ‫بصوره‬ ‫فهمنا‬ ‫تغير‬ ‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬
  • 3. ‫سكيكمان‬ ‫راندى‬‫وراثة‬ ‫إستخدم‬‫الخمائر‬ ‫من‬ ‫عدد‬ ‫لتحديد‬‫الجينات‬ ‫فى‬ ‫مهمة‬‫مسار‬ ‫تحديد‬‫الحويصلة‬ ‫وتوجيه‬‫مسارالحويصله‬ ‫ثالثة‬ ‫إلى‬ ‫تصنيفها‬ ‫ويمكن‬ ‫للحياه‬ ‫مهمه‬ ‫الجينات‬ ‫هذه‬ ‫أن‬ ‫أوضح‬ ‫الحويصله‬ ‫لنقل‬ ‫المختلفه‬ ‫لألوجه‬ ‫تنظيمها‬ ‫حسب‬ ‫على‬ ‫أنواع‬ ‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬ Randy W. Schekman
  • 4. ‫روسمان‬ ‫جيمس‬‫استخدم‬‫الكيمياء‬‫الحيويه‬ ‫يحدث‬ ‫الذى‬ ‫البروتين‬‫االرتباط‬‫يتحكم‬ ‫الخليه‬ ‫ارتباط‬ ‫فى‬ ‫على‬ ‫البروتينات‬‫الحويصلة‬ ‫وجوانب‬‫الغشاء‬‫المستهدف‬ ‫محدده‬ ‫تخصصيه‬ ‫بصوره‬ ‫يرتبطان‬ ‫يتحققان‬ ‫بحيث‬ ‫من‬‫النهائى‬ ‫الهدف‬ ‫الى‬ ‫الوصول‬ ‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬ James E. Rothman
  • 5. ‫سيدهوف‬ ‫توماس‬ ‫الحويصله‬ ‫ارتباط‬ ‫آلية‬ ‫بدراسة‬ ‫اهتم‬ ‫العصبيه‬ ‫النواقل‬ ‫إطالق‬ ‫تحفز‬ ‫الكالسيوم‬ ‫أيونات‬ ‫فيها‬ ‫والتى‬ ‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬ Thomas C. Südhof
  • 6. ‫طه‬ ‫محمد‬ ‫العباقرة‬ ‫بعقول‬ ‫فكر‬ • ‫مان‬ ‫س‬ ‫راند‬ •‫سيدو‬ ‫تومس‬ ‫بال‬ ‫جامعة‬ ‫عام‬ ‫ولد‬1 ‫ورنيا‬ ‫كالي‬ ‫جامعة‬ ‫عام‬ ‫ولد‬1‫فى‬ ‫ورد‬ ‫ستان‬ ‫جامعة‬ ‫الحويصله‬ ‫حركة‬ ‫تن‬ ‫التى‬ ‫لية‬ ‫ا‬ ‫افه‬ ‫كت‬ ‫يانا‬ ‫خ‬ ‫فى‬ ‫النقل‬ ‫مة‬ ‫أن‬ ‫أحد‬ ‫وهى‬ •‫يا‬ ‫الخ‬ ‫فسيولوجى‬ ‫ال‬ ‫الم‬