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Repair : Regeneration of injured tissue by parenchymal cells of the same type or replacement by connective tissue. Chapter Three Repair Section A
Repair ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Cell population and cell cycle phases
 
Proliferative Potential ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],perichondrial cells chondrocytes with new cartilage matrix the quiescent cells and embed in the increased  matrix or the wall of lacunae.
 
 
[object Object],[object Object],[object Object],[object Object]
 
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Sarcolemma: a coating of BM-like material adhering to the plasma membrane.
[object Object],[object Object],[object Object]
Nerve fiber regeneration Normal nerve fiber Regeneration of Schwann cells and axon filaments at site of nerve lesion or section New axon extending into original channel.
1. Cell-cell interaction Conditioned medium Contact inhibition 2. Growth factors 3. Extracellular matrix Laminin:    Epithelia    Fibroblasts Fibronectin :    Epithelia  Fibroblasts Factors influencing regeneration
[object Object],[object Object],[object Object]
Cells anchor to dish surface and divide. When cells have formed a complete single layer, they stop dividing. If some cells are scraped away, the remaining cells divide to fill the dish with a single layer and then stop.
2. Growth factor s ,[object Object],[object Object],[object Object]
 
 
 
 
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
 
[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
 
Section B Fibrous Repair Granulation tissues: ,[object Object],[object Object],[object Object]
Repair by connective tissue ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
Granulation tissue : with numerous new blood vessels,  fibroblasts and inflammatory cells.
 
Granulation tissue
Components of the process of fibrosis ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Scar tissue: dense collagen, fibrocytes, scattered fibroblasts and sparse vessels.
[object Object],[object Object],[object Object]
 
[object Object]
[object Object],[object Object],[object Object],Section C Wound healing
Wound healing ,[object Object],[object Object],[object Object]
Wound healing (cont’d) ,[object Object],[object Object],[object Object]
Healing by First Intention Focal Disruption of Basement Membrane and loss of only a few epithelial cells e.g. Surgical Incision
Healing by  Second Intention Larger injury, abscess, infarction Process is similar but Results in much larger Scar and then CONTRACTION
Wound Strength ,[object Object],[object Object]
Healing  Skin wound
Healing - Skin Scar
Factors affecting Healing: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
Summary: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Tissue Repair

  • 1. Repair : Regeneration of injured tissue by parenchymal cells of the same type or replacement by connective tissue. Chapter Three Repair Section A
  • 2.
  • 3.  
  • 4. Cell population and cell cycle phases
  • 5.  
  • 6.
  • 7.  
  • 8.  
  • 9.  
  • 10.  
  • 11.  
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.  
  • 17.  
  • 18.
  • 19.  
  • 20.
  • 21.
  • 22.
  • 23. Nerve fiber regeneration Normal nerve fiber Regeneration of Schwann cells and axon filaments at site of nerve lesion or section New axon extending into original channel.
  • 24. 1. Cell-cell interaction Conditioned medium Contact inhibition 2. Growth factors 3. Extracellular matrix Laminin:  Epithelia  Fibroblasts Fibronectin :  Epithelia  Fibroblasts Factors influencing regeneration
  • 25.
  • 26. Cells anchor to dish surface and divide. When cells have formed a complete single layer, they stop dividing. If some cells are scraped away, the remaining cells divide to fill the dish with a single layer and then stop.
  • 27.
  • 28.  
  • 29.  
  • 30.  
  • 31.  
  • 32.
  • 33.
  • 34.
  • 35.  
  • 36.
  • 37.  
  • 38.
  • 39.
  • 40.  
  • 41.
  • 42.
  • 43.
  • 44.
  • 45. Granulation tissue : with numerous new blood vessels, fibroblasts and inflammatory cells.
  • 46.  
  • 48.
  • 49.
  • 50.
  • 51.
  • 52.
  • 53. Scar tissue: dense collagen, fibrocytes, scattered fibroblasts and sparse vessels.
  • 54.
  • 55.  
  • 56.
  • 57.
  • 58.
  • 59.
  • 60. Healing by First Intention Focal Disruption of Basement Membrane and loss of only a few epithelial cells e.g. Surgical Incision
  • 61. Healing by Second Intention Larger injury, abscess, infarction Process is similar but Results in much larger Scar and then CONTRACTION
  • 62.
  • 63. Healing Skin wound
  • 65.
  • 66.
  • 67.

Notes de l'éditeur

  1. 103