2. Dementia
Dr nahed shehta

3. Definition:
AE
Clinical picture
Investigation
treatment

4. Definition
Progressive deterioration of memory
behavior
personality
AE:
Degenerative
Neurologic
systemic

5. Degenerative:
Alzheimer
Frontotemporal
Dementia with parkinsonism
Systemic
Endocrine thyroid
Heptic , renal
Nutritional B1, B6, B12, folate
alchoholic

6. Neurological causes
Vascular dementia
Tumers
Frontal
Temporal
Corpus callosum
NPHydrochephalus
Trauma SDH
Infection
AIDS
HSimplex

7. Speech motor Visuospatial
control Function
Reading
Speech

9. Alzheimer dementia
Risk factors
1.Age
2.Sex
3.Education
4.Alchol
5.Repeated trauma
6.Aluminum
7.Family history

10. Famous people with alzheimer

11. Vascular dementia
Risk factors
1.HPN
2. DM
3.Hyperlibidemia
4.Recurrent strokes

12. Frontotemporal dementia
 selective frontal , temporal atrophy
 memory loss
 personality changes
 biopsy: picks cells in frontal,
Temporal lobes

13. investigation
1.Lab
1. LFT, KFT , CBC (ANEMIA) , hormonal assay
2.Neuroimaging
1. CT, MRI
1. Cortical atrophy
2. Hippocampal atrophy
3. lacunar infarct
4. Frontotemporal atrophy
5. NPH

14. NORMAL CT BRAIN

15. AXIAL CT for Alzheimer

16. CT for Alzhiemer

17. treatment
Target: ↑ Ach
1. Cholinesterase inhibitors
2. NMDA antagonists
glutamate tocicity
3. Antidepressant
4. Cerebral dilators
5. Vitamins
6. Estrogen replacement