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BIOLOGY FORM 4
CHAPTER 6
NUTRITION
(6.4 – 6.8)
PART 2
6.4 FOOD DIGESTION
Objectives
You will learn to:
• Define and explain the importance of physical and chemical digestion.
• Identify the main part of the human digestive system (mouth, salivary
glands, oesophagus, stomach, small intestine, liver, gall bladder,
pancreas, large intestine, rectum and anus).
• Describe the functions of the mouth, salivary glands, oesophagus and
stomach in relation to ingestion, movement of food along the gut,
physical and chemical digestion.
• Describe peristalsis in terms of rhythmic wave-like contractions of the
circular and longitudinal muscles to mix and propel food along the
alimentary canal.
Digestion is the process by
which
 insoluble food, consisting of large molecules is
broken down into soluble compounds
What are starch, proteins & fats
broken down into?
enzyme
enzyme
enzyme
STARCH
PROTEIN
FAT
Glucose
Amino acids
Fatty acids &
glycerol
Why must food be digested?
Blood Blood
Blood
Food in
intestine
Food in
intestine
Food in
intestine
1
3
2
Wall of
intestine
To be small enough
to be absorbed
through the wall of
intestine.
enzyme
Digestion
starts at the
mouth and
ends at the
……………….anus
Food is broken down by two actions:
1. PHYSICAL
/MECHANICAL
2. CHEMICAL
1. PHYSICAL DIGESTION by:
 teeth
 peristalsis of the alimentary
canal
Chewing (mastication)
Why is it important to break down
food physically?
To increase the surface area for enzyme action.
Question:
Give TWO reasons why food must be masticated
before swallowed. (4)
1. Increased surface area for enzymes to act
quickly.
2. Easier to manipulate by tongue to form a
bolus.
2. CHEMICAL DIGESTION by:
 enzymes
Digestive enzymes are the chemicals that break
large insoluble food molecules into smaller soluble
molecules.
Four stages in feeding & digestion:
1. Ingestion
2. Digestion
3. Absorption into
the bloodstream
4. Egestion
Digested food is absorbed & then
assimilated by the cells
Digestive
system
Circulatory
system
Body
cell
Absorption
Assimilation
Digestive tract is also
called:
 Alimentary canal / tract
 Gut
Mucus is produced
throughout the gut:
 For lubrication
 To protect gut wall
from digestive enzymes
Fig. 1
The human
digestive
system.
The 1st stage of nutrition:
2. Digestion
1. Ingestion
3. Absorption
4. Egestion
DIGESTION
IN THE
MOUTH
 salivary glands produce SALIVA
(pH = 7-8)
Salivation is a reflex action which
is triggered by:
 Sight
 Smell
 Thinking
of food
 mucus
 water
 sodium hydrogen
carbonate
 salivary amylase
(ptyalin [old term])
Saliva contains:
Functions of mucus in saliva:
1. lubricates the food
2. sticks the food particles together
bolus
Salivary
amylase
In swallowing, food is directed into
the gullet / oesophagus
A person cannot breathe while
swallowing. Why?
1. The soft palate closes
the nasal cavity .
2. The epiglottis closes the
trachea.
Swallowing
Peristalsis:
 wave-like motions of the alimentary
canal which move the food forwards
1
2
BolusDigestive tract
Wave of
contraction
Wave of
relaxation
Bolus
moves
2
Peristalsis:
Note:
Peristalsis occurs from the
Oesophagus to the rectum!
Longitudinal
muscle
Circular
muscle
Part of the gut wall
Peristalsis is possible as gut wall is
muscular
 contraction of circular & longitudinal
muscles alternate to push food
Food is pushed when:
What does the
longitudinal muscle
do at the same time?
Circular muscle
above bolus
CONTRACTS
Relaxes
Circular muscle contract,
Longitudinal muscle relax
Wall of the gut constricts –
It becomes narrower and
longer
Push the bolus forward
Circular muscle relax,
Longitudinal muscle
contact
Wall of the gut dilates – It
becomes wider and shorter
Lumen is widen for food to
enter
Mass of food
Antagonistic
action of the
muscles
Food reaches the
stomach
1. Describe the functions of the stomach, duodenum,
pancreas, gall bladder, liver, ileum, jejunum in relation
to physical digestion, chemical digestion, absorption of
nutrients and water.
2. State the function of proteases pepsin and rennin on
proteins and list the end products of protein digestion
in the stomach.
3. List the digestive enzymes produced by the intestinal
glands and pancreas.
4. Describe the function of bile in the emulsification of
fats.
Objectives
The stomach stores
food for some time &
releases it slowly
 Food stays for 2-6 hours in the
stomach
Chyme:
creamy liquid leaving
the stomach
Food remains inside stomach due to
contraction of two sphincters
Cardiac sphincter
Oesophagus
Duodenum
Pyloric sphincter
Layers of muscle
Churning due to:
Lining of
mucus
Churning due to:
Which sphincter is contracted?
Cardiac sphincter:
Pyloric sphincter: contracted
relaxes to let chyme
into the duodenum
Gastric glands
secrete
gastric juice
What happens to food inside the
stomach?
Gastric juice contains:
1. HYDROCHLORIC ACID
2. PEPSIN
3. RENNIN
What is the pH in
the stomach?
1-2
Functions of hydrochloric acid:
1. creates the optimum pH for pepsin
Pepsinogen
(inactive form)
Pepsin
(active enzyme)
3. kills bacteria taken in
with the food
2.
HCl
Excessive production of gastric
juice: burning sensation
Gastric juice enters oesophagus:
not enough mucus to protect wall
Remedy for burning sensation in
throat and chest:
1. Drink milk
2. Take antacids
Doctors can see the
stomach lining by using
an:
endoscope
oesophagus
Stomach ulcers due to:
little mucus in stomach
Stomach
(2 enzymes secreted)
Hydrochloric
acid
Pepsinogen Pepsin
(active enzyme)
Prorennin Rennin
(active enzyme)
Why is pepsinogen produced
instead of pepsin?
To prevent pepsin
from digesting the
stomach walls
Pepsin is a protease:
 breaks:
Polypeptides
Proteins
Which conditions are needed for a
piece of meat to be digested?
 Pepsin in acidic conditions
Question:
The following diagram represents the protein found
in egg white. Each circle represents an amino acid.
Complete the diagram below to show how pepsin
breaks down the protein found in egg white.
[Idea is that short chains representing polypeptides are
made.]
(Do NOT accept individual amino acids represented as single
circles or dipeptides represented as a pair of circles)
Question:
List TWO reasons why amylase does not act on
starch in the stomach. (2)
i. pH in stomach is not optimum for amylase
ii. there is no enzyme in the stomach to break
starch
Some substances that are absorbed
by the stomach:
 ethanol
 vitamins
 certain salts and drugs
 some water
 glucose
How did I
get drunk so
quickly?
Rennin
 is an enzyme found in the stomach of young
children
 Function:
Soluble protein
in milk
(caseinogen)
Changes into
insoluble protein
(casein)
Pepsin then acts
on the insoluble
protein
In cheese-making, rennet [contains
rennin] is added to milk
Protein Digestion In Stomach
Proteins Polypeptides
Pepsin
Soluble Insoluble
milk proteins milk proteins
(caseinogen) (casein)
Rennin
Casein Polypeptides
Pepsin
Due to cancer of the stomach, the
entire stomach of Patient A have
being surgically removed.
As the doctor of Patient A, you are to
provide information on the effect on
the lifestyle and digestive function
upon removing the stomach.
• Stomach is the site of initial protein digestion.
Removal of stomach will cause protein digestion
to be greatly affected;
• Patient A can rely only on the small intestine for
protein digestion, rate of protein digestion will be
lowered.
• No HCl, prone to food infection by bacteria.
• Need to reduce protein intake to avoid congesting
the small intestine.
THE INTESTINES:
Small intestine
Large intestine
1.5 m long
7 m long
The small
intestine is
composed of:
duodenum &
jejenum &
ileum
Two functions of the small
intestine:
1. digestion is completed
2. digested food is absorbed
Bloodstream
Products of
digestion
Duodenum
 U-shaped
 first part of small intestine (most digestion
occurs here)
 about 25 cm long
The duodenum receives secretions
from the:
Pancreas
[pancreatic juice via
the pancreatic duct]
Liver
[bile via the
bile duct]
DIGESTION IN THE
DUODENUM
Liver
Pancreas
Gall
bladder
Duodenum
of Small
intestine
Liver
Pancreas
Gall
bladder
Duodenum
of Small
intestine
Where is bile:
i) made? ii)stored?
Made in
liver
Stored
in gall
bladder
Transported
through the
bile duct
Bile:
 has no enzymes
 consists of:
 water
 sodium chloride
 bile salts
 bile pigments
 pH = 8
Functions of Bile:
 dilutes contents from stomach
 creates optimum pH for pancreatic enzymes
to work in duodenum
 contains bile salts which emulsify fats
Bile salts
Bile salts emulsify fats i.e.:
 break large fat globules into smaller globules
Emulsification
of fats
What is the benefit of emulsification?
The surface area where lipase can act is increased.
Bile salts emulsify the fats by
reducing the attractive forces
between the fat molecules
Physically breaks-up the fat
molecules
Bile Salts
Tiny fat
droplets
Increase surface area to
volume ratio – speed up
digestion by lipase.
Bile salts
A person had his gall bladder removed.
Explain why the doctor told him to limit
fats in the diet.
Fats cannot be emulsified;
difficult to digest fats by lipase.
Three enzymes in
pancreatic juice:
Pancreatic amylase
Trypsin
Pancreas
Lipase
Action of
each
enzyme:
lipase +
fat molecule
glycerol fatty
acids
starch molecule
amylase
maltose
proteins &
polypeptides
trypsin
peptides
Secrete Pancreatic Juice:
• Pancreatic amylase,
• Pancreatic lipase
• Trypsinogen
trypsin
(active enzyme)
Pancreas
enterokinase
Question:
Bile and pancreatic juice are involved in
digestion of fats.
a) Describe the role of both secretions in this
process. (4)
b) Explain why bile must be released before
pancreatic juice for the efficient digestion of
fats. (2)
DIGESTION
IN THE
ILEUM
The wall of the ileum has
intestinal glands
that produce
intestinal juice
Secrete Intestinal juice
Maltase Sucrase
Lactase Erepsin
Intestinal
lipase
Intestinal Gland
Enzymes in intestinal juice
SUBSTRATE ENZYME END PRODUCT
Peptides Erepsin Amino acids
Lipids Lipase Fatty acids &
glycerol
Maltose Maltase Glucose + glucose
Sucrose Sucrase Glucose + fructose
Lactose Lactase Glucose + galactose
Remember:
Pepsin
Amino acids
Peptides
Polypeptides
Proteins
Trypsin
Erepsin
Remember: Digestion of starch
Starch
Maltose
Maltose
(in ileum)
Glucose
Pancreatic
Amylase
Salivary Amylase
(In Mouth)
No digestion of starch in
stomach (amylase is
denatured)
Maltase
Digestive
Juice
Remember:
Starch + water
Summary
6.4 FOOD DIGESTION
1. Digestion in the MOUTH
FOOD
Mouth
Salivary glands
Salivary amylase
bolus
aesophagus
maltose
secrete
chewing
triggers
rolled into
enters
(by peristalsis)# epiglottis
Digestion in Stomach
Gastric glands
Gastric juices
HCl Acid
Pepsin
Rennin
- pH 1.5 – 2.0
- Stops the activity of amylase
- Kill bacteria In food
Protein + water Polypeptides
Caseinogen + water Casein
Digestion in duodenum
Starch + water maltose
Polypeptide + water peptides
Lipid droplets + water glycerol + FA
Pancreatic amylase
trypsin
lipase
Digestion in small intestine
• Intestinal juice
• Digestive enzymes : digestion of peptides & dissaccharides
1) Protein digestion
• Peptides + water amino acids
2) Carbohydrates digestion ( Ma La S )
• Maltose + water glucose
• Sucrose + water glucose + fructose
• Lactose + water glucose + galactose
erepsin
maltase
sucrase
lactase
Region of
Digestion
Source Enzyme Action
MOUTH Salivary glands Salivary amylase Starch Maltose
STOMACH Gastric glands
Pepsin
Rennin
Protein Polypeptide
Soluble Insoluble
milk proteins milk proteins
SMALL
INTESTINE
Pancreas
Intestinal
glands
Pancreatic
Amylase
Trypsinogen
trypsin
Pancreatic Lipase
Maltase
Erepsin
Lipase
Starch Maltose
Protein Polypeptides
Fats Fatty acids+ glycerol
Maltose Glucose
Polypeptides Amino acids
Fats Fatty acids+ glycerol
Digestion is complete in the
ileum. What happens to the
digested food?
Objectives
1) Describe the structure of the inner wall of the small
intestine and explain it’s role in terms of increased
surface area for absorption of nutrients.
2) Explain the role of a lacteal and blood capillaries in the
transport and absorption of nutrients.
3) Describe the functions of the colon, rectum and anus in
relation to absorption of water and mineral salts,
temporary storage and egestion of faeces.
Model of the ileum showing numerous villi
Villus: a finger-like projection
Villi contain blood & lymph vessels
Villi – plural of villus
Structure of a villus
A villus is adapted for absorption
The ileum is adapted to absorb
digested food
 by providing a LARGE surface area:
 Folded walls
 Has villi
 Has microvilli
Inner wall of small intestine
Why is there a need for numerous folds, villi
and microvilli?
To increase surface area for absorption of digested
food substances – Increasing the absorption rate of
water and digested food products
Ileum is adapted for absorption:
1. Ileum is long:
 more time for digestion
 a greater surface area for absorption
2. Villi:
 increase surface area for absorption
3. Microvilli in epithelium:
 increase surface area for absorption
4. Epithelium is very thin:
 soluble products of digestion pass through quickly
5. Dense capillary network:
 removes the digested food
Glycerol and fatty acids
diffuse into the epithelium –
form fat globules – enter the
lacteals
Lacteal transport fats away
from the small intestine.
Blood
capillaries
Lacteal
Sugars, amino acids, are
absorbed by diffusion into
the blood capillaries
Blood capillaries transport
sugars and amino acids away
from the small intestine.
Epithelium
Villi
One cell
thick
Faster diffusion
of the digested
food products
What is the epithelium
one cell thick?
Would the absorption of
nutrients be affected if
digested food substances
cannot be transported
away by the blood
capillaries?
Explain your answer.
Yes. To a certain extent
The continual transport of
digested food substances
maintains a concentration
gradient for the absorption of
digested food substances by
diffusion
Lower concentration of digested
food substances in the lumen of the
small intestine, glucose and amino
acids are absorbed by active
transport
Mineral salts enter the blood
capillaries by active transport
Absorption of digested food
1) Glucose & Amino acids
- from lumen into the epithelial cells by facilitated
diffusion
- remaining nutrients – by active transport
- from epithelial cells – absorbed into the
bloodstream thru the blood capillaries in the villi
- converge into the hepartic portal vein
- Then transported to all parts of the body
Lumen
(glu & a.a)
facilitated
diffusion
Epithelial
cells
bloodstream
Hepartic portal vein
blood
capillaries
all parts of the body
2) Water
Lumen epithelial cells blood capillaries
3) Water-soluble vitamins
Epithelial cells blood capillaries
3) Fatty acids & glycerol
Epithelial cells (tiny droplets) lacteals lympatic system
Right lymphatic duct
Thoracic duct
Bloodstream
Subclavian
veins
Activity time!
I need a
doctor!
I need a doctor!
You are a doctor that specializes on
the ileum. As the doctor of a
patient who is overweight and has
the intentions to lose weight, what
procedures can be done to help
the patient lose weight? Explain
your answer.
THE
LARGE INTESTINE
The large intestine is composed of:
1.Caecum
Anus
2. Appendix
4. Colon
3. Rectum
Material in the large intestine
consists of:
 water
 mucus
 dead cells
 undigested matter
Most of the undigested matter is
cellulose. Why is this so?
Function of the:
Colon:
absorbs 90 % water
& mineral salts
Rectum:
stores FAECES before being
expelled through the ANUS
6.6 FORMATION OF
FAECES & DEFAECATION
The 4th stage of feeding &
digestion:
4. Egesting
Contents of Faeces:
1) undigested food
2) dead cells shed from the intestinal lining &
bile pigments & toxic subtances – eliminated
from the body
3) binds to the mucus that secreted by the
colon’s wall and lubricates the movement of
faeces along the colon
Defaecation
• How it works??
- elimination of faeces
- controlled by muscles around the anus, the
opening of the rectum
- When rectum is full, the muscles of the rectal
wall contract to eject the faeces via the anus
Egestion / Defaecation
 the process of removing
faeces
I really have
to go to the
bathroom!
Ingestion
(2 L) Salivary gland secretions
(1 L)
Gastric secretions
(2 L)
Pancreatic secretions
(1.2 L)
1% in
faeces
Small intestine
secretions
(2 L)
Bile
(0.7 L)
Although 8.9 L of
water are ingested
or secreted daily,
the faeces are dry.
Explain.
Ingestion
(2 L) Salivary gland secretions
(1 L)
Gastric secretions
(2 L)
Pancreatic secretions
(1.2 L)
Absorbed in the
small intestine &
colon.
1% in
faeces
Small intestine
secretions
(2 L)
Bile
(0.7 L)
Problems related to food
digestion
Incomplete
digestion
Lack of
digestive
enzymes
Gallstones
Causes:
• when people eat too much or too fast, or certain foods don't agree with them.
• smoke, drink alcohol, are stressed out, or don't get enough sleep.
• certain stomach problems, like gastritis (stomach inflammation) or an ulcer.
Indigestion or dyspepsia or upset stomach.
symptoms:
pain or burning in your upper belly
nausea
bloating
uncontrollable burping
heartburn
Prevention:
Avoid fatty, greasy foods, like fries ,
burgers.
Avoid too much chocolate or citrus fruits
Eat slowly.
Don't smoke.
relax.
Give your body a chance to digest food.
Gallstones
Gallstones are
hard deposits in
your gallbladder
Gallstones may
consist of
cholesterol, salt,
or bilirubin, which
are discarded red
blood cells.
Causes:
• Too much
cholesterol
• Too much
bilirubin
• Gallbladder
doesn’t empty
properly
Treatment:
• Surgery
• Medication
• Home remedy :
6.5 THE PROCESSES OF
ABSORPTION &
ASSIMILATION
OBJECTIVES
You will learn:
• 1) Define assimilation as the process where the products
of digestion are distributed and use as an energy source or
converted into protoplasm required for growth and repair
of worn-out parts.
• 2) State the role of the hepatic portal vein in transporting
sugars and amino acids to the liver.
• 3) Explain how sugars, amino acids and fats are utilised in
the body.
• 4) State that the hormone insulin is produced by islets of
Langerhans in the pancreas.
• 5) Explain the effect of insulin on glucose.
Assimilation
The distribution and use of
the digested food products
as an energy source or
converted into protoplasm
required for growth and
repair of worn-out parts -
Assimilation
Small
intestine
ASSIMILATION
• Definition
- the conversion of nutrient into the fluid
or solid substance of the body, by the
processes of digestion and absorption
- occurs in the LIVER and the CELLS
BLOOD SUPPLY OF THE LIVER
Oxygenated
blood from heart
Blood from
digestive system
HEPATIC
PORTAL VEIN
HEPATIC ARTERY
LIVER
HEART
HEPATIC VEIN
to heart
INTESTINES
Blood supply to and away from the liver
Transport of food substances
Hepatic
Portal vein
Small intestine
Liver
Blood capillaries
Gall
bladder
Bile
Duct
Absorbed food
substances (sugars
and amino acids) are
transported via the
hepatic portal vein to
the liver
Note: Fats are
transported through the
lacteal into the lymphatic
system
Assimilation in the LIVER
7 Functions of the LIVER
1) Regulation of blood glucose concentration
2) Production of bile
3) Protein synthesis
4) Iron storage
5) Deamination of amino acids
6) Detoxification
7) Heat production
Assimilation in the LIVER
synthesisconverts
glucose
excess
DEAMINATION
urea
kidney
- excess glucose
- enter heart
through subclavian
veins
Transport and utilization of
Glucose
Small
intestine
Function of glucose:
Glucose is used by all
cells as a source of
energy.
Hepatic vein
Some glucose is transported by the
blood leaving the liver to other parts
of the body
Excess glucose is
converted to glycogen
and stored in the liver.
Hepatic portal vein
Glycogen
Conversion of Glucose
Islets of Langerhan
cells in the pancreas –
secretes a hormone
Insulin
Insulin stimulate the
liver to convert excess
glucose to glycogen
and stored.
Transport and utilization of
Amino acids
Amino acids pass through
the liver before they are
transported to the rest of
the body.
Small
intestine
Hepatic vein
Function of amino acids:
• Make new cells for growth
• Replace worn-out cells
• Make useful substances
such as enzymes and
hormones
Excess amino
acids are
deaminated.
Hepatic
Portal
Vein
Deamination occurs in the liver
AMMONIA
AMINO ACID
is broken into two:
The rest is
used for
energy
Part with
nitrogen forms:
UREA
Question:
Write the correct term for each of the following
processes:
i) the breakdown of excess amino acids
Deamination
ii) rhythmical muscular contractions that push
food along the digestive system
Peristalsis
iii) the elimination of indigestible food from
the body
Egestion / Defaecation
iv) the passage of digested food through the
gut wall in the blood stream.
Absorption
Transport and utilization of
Fats
Fats is transported from
the Lacteal  Lymphatic
vessels  Bloodstream
 Rest of the body and
Liver
Lacteal
Transport and utilization of
Fats
Fate of Fats
• Use to form parts
of the cell such
as cell membrane
• Prevent excessive
heat loss.
Excess fats stored in
adipose tissues
When glucose supply is low,
fats are broken down in the
liver to provide energy
ASSIMILATION OF DIGESTED
FOOD
FOOD USE STORE
Glucose Respiration Glycogen or Fat
Fats Respiration,
to build cell structure,
as a store of energy
Fat
Amino
acids
Build proteins for cell
structures, enzymes
CANNOT BE STORED
– ARE DEAMINATED
& USED IN
RESPIRATION
Write an account of a controlled experiment
you would perform to show the action of the
enzyme amylase on starch. (6)
Two spotting tiles are
prepared with a drop of
iodine solution in each
hole.
An equal volume of starch
is placed into two separate
test tubes, labelled A and B.
1
2
An equal volume of amylase is placed
into two separate test tubes, labelled C
and D.
Test tube C is boiled for 5 minutes to
denature the enzyme and so act as a
control.
All four test tubes are
placed in a water bath at
37C for 5 minutes to
acclimatise.
3
4
Starch in test tube A is
poured into amylase in test
tube D, mixed and the stop
watch is started.
5
After 30 seconds, a drop of the
mixture is taken and added to one
of the drops of iodine solution on
the spotting tile. This is repeated
until a yellow colour appears.
6
Starch in test tube B is poured
into amylase in test tube C,
mixed and the same method is
repeated.
7
8
Contents in test tube:
i) D give a yellow colour with
iodine solution after a few
minutes
ii) C continues to give a blue-
black colour after 30 minutes.
9 The results show that amylase breaks down
starch.
10
If Benedict’s solution is added to
the contents of test tubes C and D
and heated for a few minutes, a
brick red colour is obtained only
in test tube D [unboiled amylase].
This shows that when starch
breaks down, reducing sugars are
formed.
C D
What processes take place in the same part of the
alimentary canal where ingestion of food takes
place?
1. Physical digestion only
2. Chemical digestion only
3. Physical and chemical digestion
4. Digestion and absorption
Which of the following statement(s) about the
Oesophagus is/are true?
I. There is no digestion occuring in the oesophagus
II. Food moves down the oesophagus via peristalsis
III. There is digestion of starch in the oesophagus
IV. The wall of the oesophagus secrete digestive
enzymes
1. II and III only
2. I and II only
3. II and IV only
4. II only
Complete the following equations
Starch _____________
Protein ______________
Fats _______________
amylase
proteases
lipase
Maltose
Amino acids
Fatty acids + glycerol
Why are bile salts not considered
enzymes?
Bile salts does not digest fats,
it only emulsify fats – Increase
surface area for digestion by
lipase.
TRUE / FALSE
Fat digestion will stop if the bile duct is
blocked by gallstones.
False .
Fat digestion will not stop
But will become very slow since
bile is absent to emulsify fats
At which part of the digestive system is
digestion of all food completed.
1. Stomach
2. Colon
3. Oesophagus
4. Ileum
Which of the following listed below is not a
feature of the ileum?
1. The inner surface is folded.
2. It releases gastric juice.
3. It is a very long tube.
4. Its main function is the absorption of
digested food.
The diagram below shows part of the human digestive
system and the associated blood vessels.
Blood vessel X would least likely contain _____________
1. Glycerol 2. Amino acids 3. Water 4. Glucose
X
The diagram below shows the percentage of proteins,
carbohydrates and fats digested as they pass through the
alimentary canal in man.
Which is PART C likely to be?
1. Ileum 2. Duodenum 3. Stomach 4. Oesophagus
Percentageofundigested
foodmolecules
How would the composition of the blood in the
hepatic vein change if there was a high intake
of protein-rich food? Explain.
The composition of the blood
would not change since excess
amino acids caused by the high
intake of protein-rich food will
be deaminated in the liver.
6.4 FOOD DIGESTION
(continuation)
DIGESTION IN
RUMINANTS
&
RODENTS
RUMINANTS
Digestive System of Ruminants
1.Rumen
2. Reticulum
4. Abomasum
3. Omasum
STOMACH
– 4 Chambers
Digestive System of Ruminants
How it works??
1.RUMEN
- Largest compartment
- Cellulose broken down by
cellulase (bacteria &
protozoa)
2.RETICULUM
- Further hydrolysis
- CUD – its content
- Regurgitated bit by bit
- Soften & break down
cellulose
mouth3.OMASUM
-Reswallowed cud
-Large  small
particles by
peristalsis
-Water is removed
4. ABOMASUM
-True stomach
- gastric juices secreted
– protein digested
Small intestine
Lembu Makan
R – Rumput
R – Redah
O – Onak dan
A – Air Busuk
Rodents
Cellulose digested by
cellulase-producing
bacteria in caecum
Rodents
Rodent Digestion
-Faeces 1st
batch
- soft & watery
-2nd batch faeces
– drier & harder
• Caecum & appendix =
enlarged to store
cellulase-producing
bacteria
• products pass through
alimentary canal =
TWICE
Rodent Digestion
Comparison of cellulose digestion
process in human, ruminant & rodent
Similarities
1)
2)
Differences
Aspect Human Ruminant Rodent
Stomach chambers
Cellulase producing bacteria
Food passes through
alimentary canal
Gastric juice is produced in
Size of caecum
Undigested cellulose
Caecum & Appendix are
 Large in herbivores Vestigial in humans:
[small & no function]
Caecum
Appendix
Question:
Humans are omnivores.
Do not depend only upon vegetation for
nutrients.
A large caecum is found in herbivores and is full
of bacteria that produce cellulase to digest
cellulose.
Explain why the caecum /
appendix in humans is small
and non-functional. (4)
Human Rabbit
THE END
Animal Nutrition
Oral Cavity
Carbohydrate
Digestion
Physical
Digestion
Salivary
Amylase
Starch
Maltose
Teeth Tongue
Food
Smaller
Pieces
Mix
Food
Bolus
Oesophagus
Peristalsis
Antagonistic
Muscles
Circular Longitudinal
Stomach
Protein
Digestion
Gastric
Juice
Enzymes
HCl
Acidic
MediumPepsin Rennin
Protein
Polypeptides
Soluble
Milk Proteins
Insoluble
Caesin
Small
Intestine
Carbohydrate
Digestion
Protein
Digestion
Fat
Digestion
Pancreatic
Amylase
Intestinal
Maltase
Pancreatic
Trypsin
Intestinal
Peptidase
BilePancreatic
Lipase
Intestinal
Lipase
Fats
Smaller
Globules
Polypeptides
Amino acids
Starch
Maltose Fatty
Acids
Glycerol
Liver
Large
Intestine
Colon Rectum
Faeces
Anus
DetoxificationDeamination Glycogen storage
involves
involved in
by
hydrolyses
into
involves
break
down
into into
helps
involved in
involves
that are
involved in
by
contains
provides
for
consist of
hydrolyses
into
into
coagulates
hydrolyses
hydrolyse
hydrolyse
into into
into
involved in
Consists of
involves
involves
involves
emulsifies
into
is involved in is for storing
is egested
via
Eventually lead to
has functions like
Blood glucose level
Breakdown of fatty acids
to regulate
EnergyAmino Acids
to provide
Breakdown of
haemoglobin
Recycle iron
of
Heat production
Body temperature
to regulate
hydrolyses
Maltose
Monosaccharides
Transported by
into
Blood capillaries
Transported by
Lacteals
to
Absorption of
H2O and
Mineral salts
6.7 EVALUATING GOOD
EATING HABITS
Problems related to food
digestion
Gastritis Obesity
Anorexia
nervosa
Bulimia
What is gastritis?
What is gastritis?
(
Gastritis is basically the condition where the mucosa
(which is the stomach lining) becomes inflamed.
• Causes:
• excessive alcohol consumption
• prolonged use of nonsteroidal
anti-inflammatory drugs.
• Sometimes after major surgery,
traumatic injury or burns
OBESITY
What happens to a person’s weight when:
Weight remains constant
What happens to a person’s weight when:
Weight increases
Obese person
What happens to a person’s weight when:
Weight decreases
• We can say that obesity is an increase in
bodyweight (>20% over BMI) because of
excess body fat.
What is obesity?
What is obesity?
• Obesity is a disease!
Obesity is a chronic disease caused by excess
weight.
• Affects men and women of all ages
• Predominates in
developed countries.
What is obesity?
• The World Health Organization considered
this disease as an epidemic of the 21st
century.
What is obesity?
Causes
Sedentary life
 Don’t do physical exercise;
 See a lot of television;…
Extreme consumption
Incorrect alimentary habits
 Eat fast food; poor foods…
Causes
Causes
Genetic cause (rare)
Consequences
Arteries
disease
Cancer
Obesity
Problems in
the biliary
vesicle
Renal
disease
Alterations in
the bones
Heart disease
&
Hypertension
Diabetes
Lung
diseases
Consequences
Arteries
disease
Cancer
Obesity
Problems in
the biliary vesicle
Renal
disease
Alterations in
the bones
Heart disease
&
Hypertension
Diabetes
Lung
diseases
It can cause death !
Consequences
And…
• Social isolation;
• Depression and loss of auto-esteem.
Consequences
And…
• Social and educative discrimination;
What to do to avoid?
• Eat healthy food;
 Physical exercice;
What to do to avoid?
• Medical help when obesity starts to be
serious.
What to do to avoid?
Look in the mirror. What do you see? Is it the real
you or just another "me"?
What is an Eating Disorder?
• mental illnesses
• cause serious disturbances in a
person’s everyday diet.
• eating extremely small amounts
of food or severely overeating.
Anorexia nervosa
• Individuals have a distorted body image that causes them to
perceive themselves as overweight even when they are
emaciated
• They often lose large amounts of weight because they refuse to
eat, exercise compulsively, or refuse to eat in front of others
• Females experience loss of menstrual cycles
• Males become impotent (erectile dysfunction)
Anorexia Nervosa: Warning Signs
 Dramatic weight loss
 Refusal to eat certain foods or food categories.
 Consistent excuses to avoid situations involving food
 Excessive and rigid exercise routine
 Withdrawal from usual friends/relatives
Health Risks with Anorexia
Heart failure
Kidney failure
Low protein stores
Digestive problems
Menstrual cycle
stops
Bulimia Nervosa
An eating disorder in
which one starts to
consume large amounts of
food at once and then is
followed by purging, using
laxatives, or
overexercising to rid
themselves of the food
they ate.
Bulimia Nervosa: Warning Signs
 Wrappers/containers indicating consumption of large
amounts of food
 Frequent trips to bathroom after meals
 Signs of vomiting e.g. staining of teeth, calluses on hands
 Excessive and rigid exercise routine
 Withdrawal from usual friends/relatives
Health Risks with Bulimia
• Dental problems
• Stomach rupture
• Menstruation
irregularities
deaths were caused
by eating disorders in the U.S.
in eating disorder deaths.
In 2009
The U.S. is ranked
• Low Self-esteem
• Feelings of inadequacy or
failure
• Feelings of being out of
control
• Response to change
(puberty)
• Response to stress (sports
or dance)
• Personal illness
• Troubled family and
personal relationships
• Difficult expressing
emotions and feelings
• History of being teased
or ridiculed based on
size or weight
• History of physical or
sexual abuse
• Cultural pressures that glorify thinness and
place value on obtaining the perfect body
• Narrow definitions of beauty that include
women and men of specific body weights and
shapes
• Cultural norms
that value
people on the
basis of physical
appearance and
not on inner
qualities and
strengths
• Seven feet tall
• 38 inch chest
• 21 inch waist
• 36 inch hips
• Virtually unattainable for an adult woman
http://www.youtube.com/watch?v=J_ax0h9F
Nag&feature=endscreen
WHAT IS THE THREATMENT FOR AN AND BN?
• Psychotherapy
• Support or self-help
groups
• Medical treatment
• Nutritional treatment
• Medication
• Hospitalization
6.8 IMPORTANCE OF A
HEALTHY DIGESTIVE
SYSTEM
TO PREVENT
DISEASES OF THE STOMACH
• Gastritis, Gastric Ulcer, Stomach Cancer,
Hemorrhage from the Stomach, Hyperacidity,
Dyspepsia
OTHER DIGESTIVE DISEASES
• Hepatitis, Diarrhea, Cirrhosis, Lactose
Intolerance, Short Bowel Syndrome,
Appendicitis, Constipation, Gallstones,
Flatulence and Abdominal Adhesions
nuts, beans,
grain, wheat,
rice,
vegetables
and fruits
1. Eat foods rich in fiber
 it helps the body eliminate waste, lowers cholesterol, feeds healthy bacteria
and reduces risks of irritable bowel syndrome and colon cancer
2. Eat good amounts of fish
 Fish contain omega-3 fatty acids which can improve certain digestive
problems because of their special anti-inflammatory properties.
3. AVOID PROCESSED FOODS!
 processed foods may contain ingredients which irritate the stomach
Avoid Junk food
- empty calories, minimum nutrients
- Artificial colourings, flavourings
Avoid food with high sugar /fat content
- Prevent diabetes, obesity, cardiovascular
disease
4. Take Good Bacteria –
THE GOOD BACTERIA
FOOD RICH IN PROBIOTICS
Probiotics are good bacteria that live in the gastrointestinal system. They maintain its health by
keeping bad bacteria at bay and creating a good harmony in your digestion's ecosystem. They
have been known to help ease conditions like gastroenteritis, irritable bowel syndrome and
inflammatory bowel disease.
DO DON’T
5. Develop good eating habits
6. Exercise regularly
 Exercise is great for boosting your body's natural functions and can improve
the natural rhythm of your digestive system, too. It is also great for helping
your food move through the digestive tract.
DO DON’T
7. Choose healthy hydration
THE END

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BIOLOGY FORM 4 CHAPTER 6 - NUTRITION PART 2

  • 1. BIOLOGY FORM 4 CHAPTER 6 NUTRITION (6.4 – 6.8) PART 2
  • 3. Objectives You will learn to: • Define and explain the importance of physical and chemical digestion. • Identify the main part of the human digestive system (mouth, salivary glands, oesophagus, stomach, small intestine, liver, gall bladder, pancreas, large intestine, rectum and anus). • Describe the functions of the mouth, salivary glands, oesophagus and stomach in relation to ingestion, movement of food along the gut, physical and chemical digestion. • Describe peristalsis in terms of rhythmic wave-like contractions of the circular and longitudinal muscles to mix and propel food along the alimentary canal.
  • 4. Digestion is the process by which  insoluble food, consisting of large molecules is broken down into soluble compounds
  • 5. What are starch, proteins & fats broken down into? enzyme enzyme enzyme STARCH PROTEIN FAT Glucose Amino acids Fatty acids & glycerol
  • 6. Why must food be digested? Blood Blood Blood Food in intestine Food in intestine Food in intestine 1 3 2 Wall of intestine To be small enough to be absorbed through the wall of intestine. enzyme
  • 7. Digestion starts at the mouth and ends at the ……………….anus
  • 8. Food is broken down by two actions: 1. PHYSICAL /MECHANICAL 2. CHEMICAL
  • 9. 1. PHYSICAL DIGESTION by:  teeth  peristalsis of the alimentary canal Chewing (mastication)
  • 10. Why is it important to break down food physically? To increase the surface area for enzyme action.
  • 11. Question: Give TWO reasons why food must be masticated before swallowed. (4) 1. Increased surface area for enzymes to act quickly. 2. Easier to manipulate by tongue to form a bolus.
  • 12. 2. CHEMICAL DIGESTION by:  enzymes Digestive enzymes are the chemicals that break large insoluble food molecules into smaller soluble molecules.
  • 13. Four stages in feeding & digestion: 1. Ingestion 2. Digestion 3. Absorption into the bloodstream 4. Egestion
  • 14. Digested food is absorbed & then assimilated by the cells Digestive system Circulatory system Body cell Absorption Assimilation
  • 15. Digestive tract is also called:  Alimentary canal / tract  Gut
  • 16. Mucus is produced throughout the gut:  For lubrication  To protect gut wall from digestive enzymes
  • 18. The 1st stage of nutrition: 2. Digestion 1. Ingestion 3. Absorption 4. Egestion
  • 20.  salivary glands produce SALIVA (pH = 7-8)
  • 21. Salivation is a reflex action which is triggered by:  Sight  Smell  Thinking of food
  • 22.  mucus  water  sodium hydrogen carbonate  salivary amylase (ptyalin [old term]) Saliva contains:
  • 23. Functions of mucus in saliva: 1. lubricates the food 2. sticks the food particles together bolus
  • 25. In swallowing, food is directed into the gullet / oesophagus
  • 26. A person cannot breathe while swallowing. Why? 1. The soft palate closes the nasal cavity . 2. The epiglottis closes the trachea.
  • 28. Peristalsis:  wave-like motions of the alimentary canal which move the food forwards 1 2 BolusDigestive tract Wave of contraction Wave of relaxation Bolus moves 2
  • 29. Peristalsis: Note: Peristalsis occurs from the Oesophagus to the rectum!
  • 31. Peristalsis is possible as gut wall is muscular  contraction of circular & longitudinal muscles alternate to push food
  • 32. Food is pushed when: What does the longitudinal muscle do at the same time? Circular muscle above bolus CONTRACTS Relaxes
  • 33. Circular muscle contract, Longitudinal muscle relax Wall of the gut constricts – It becomes narrower and longer Push the bolus forward Circular muscle relax, Longitudinal muscle contact Wall of the gut dilates – It becomes wider and shorter Lumen is widen for food to enter Mass of food Antagonistic action of the muscles
  • 35. 1. Describe the functions of the stomach, duodenum, pancreas, gall bladder, liver, ileum, jejunum in relation to physical digestion, chemical digestion, absorption of nutrients and water. 2. State the function of proteases pepsin and rennin on proteins and list the end products of protein digestion in the stomach. 3. List the digestive enzymes produced by the intestinal glands and pancreas. 4. Describe the function of bile in the emulsification of fats. Objectives
  • 36.
  • 37. The stomach stores food for some time & releases it slowly  Food stays for 2-6 hours in the stomach Chyme: creamy liquid leaving the stomach
  • 38. Food remains inside stomach due to contraction of two sphincters Cardiac sphincter Oesophagus Duodenum Pyloric sphincter Layers of muscle Churning due to: Lining of mucus
  • 40. Which sphincter is contracted? Cardiac sphincter: Pyloric sphincter: contracted relaxes to let chyme into the duodenum
  • 42. What happens to food inside the stomach?
  • 43. Gastric juice contains: 1. HYDROCHLORIC ACID 2. PEPSIN 3. RENNIN What is the pH in the stomach? 1-2
  • 44. Functions of hydrochloric acid: 1. creates the optimum pH for pepsin Pepsinogen (inactive form) Pepsin (active enzyme) 3. kills bacteria taken in with the food 2. HCl
  • 45. Excessive production of gastric juice: burning sensation
  • 46. Gastric juice enters oesophagus: not enough mucus to protect wall
  • 47. Remedy for burning sensation in throat and chest: 1. Drink milk 2. Take antacids
  • 48. Doctors can see the stomach lining by using an: endoscope oesophagus
  • 49. Stomach ulcers due to: little mucus in stomach
  • 50. Stomach (2 enzymes secreted) Hydrochloric acid Pepsinogen Pepsin (active enzyme) Prorennin Rennin (active enzyme)
  • 51. Why is pepsinogen produced instead of pepsin? To prevent pepsin from digesting the stomach walls
  • 52. Pepsin is a protease:  breaks: Polypeptides Proteins
  • 53. Which conditions are needed for a piece of meat to be digested?  Pepsin in acidic conditions
  • 54. Question: The following diagram represents the protein found in egg white. Each circle represents an amino acid. Complete the diagram below to show how pepsin breaks down the protein found in egg white. [Idea is that short chains representing polypeptides are made.] (Do NOT accept individual amino acids represented as single circles or dipeptides represented as a pair of circles)
  • 55. Question: List TWO reasons why amylase does not act on starch in the stomach. (2) i. pH in stomach is not optimum for amylase ii. there is no enzyme in the stomach to break starch
  • 56. Some substances that are absorbed by the stomach:  ethanol  vitamins  certain salts and drugs  some water  glucose How did I get drunk so quickly?
  • 57. Rennin  is an enzyme found in the stomach of young children  Function: Soluble protein in milk (caseinogen) Changes into insoluble protein (casein) Pepsin then acts on the insoluble protein
  • 58. In cheese-making, rennet [contains rennin] is added to milk
  • 59. Protein Digestion In Stomach Proteins Polypeptides Pepsin Soluble Insoluble milk proteins milk proteins (caseinogen) (casein) Rennin Casein Polypeptides Pepsin
  • 60. Due to cancer of the stomach, the entire stomach of Patient A have being surgically removed. As the doctor of Patient A, you are to provide information on the effect on the lifestyle and digestive function upon removing the stomach.
  • 61. • Stomach is the site of initial protein digestion. Removal of stomach will cause protein digestion to be greatly affected; • Patient A can rely only on the small intestine for protein digestion, rate of protein digestion will be lowered. • No HCl, prone to food infection by bacteria. • Need to reduce protein intake to avoid congesting the small intestine.
  • 62. THE INTESTINES: Small intestine Large intestine 1.5 m long 7 m long
  • 63. The small intestine is composed of: duodenum & jejenum & ileum
  • 64.
  • 65. Two functions of the small intestine: 1. digestion is completed 2. digested food is absorbed Bloodstream Products of digestion
  • 66. Duodenum  U-shaped  first part of small intestine (most digestion occurs here)  about 25 cm long
  • 67. The duodenum receives secretions from the: Pancreas [pancreatic juice via the pancreatic duct] Liver [bile via the bile duct]
  • 71. Where is bile: i) made? ii)stored?
  • 73. Bile:  has no enzymes  consists of:  water  sodium chloride  bile salts  bile pigments  pH = 8
  • 74. Functions of Bile:  dilutes contents from stomach  creates optimum pH for pancreatic enzymes to work in duodenum  contains bile salts which emulsify fats Bile salts
  • 75. Bile salts emulsify fats i.e.:  break large fat globules into smaller globules Emulsification of fats What is the benefit of emulsification? The surface area where lipase can act is increased.
  • 76. Bile salts emulsify the fats by reducing the attractive forces between the fat molecules Physically breaks-up the fat molecules Bile Salts Tiny fat droplets Increase surface area to volume ratio – speed up digestion by lipase. Bile salts
  • 77. A person had his gall bladder removed. Explain why the doctor told him to limit fats in the diet. Fats cannot be emulsified; difficult to digest fats by lipase.
  • 78. Three enzymes in pancreatic juice: Pancreatic amylase Trypsin Pancreas Lipase Action of each enzyme:
  • 79. lipase + fat molecule glycerol fatty acids starch molecule amylase maltose proteins & polypeptides trypsin peptides
  • 80. Secrete Pancreatic Juice: • Pancreatic amylase, • Pancreatic lipase • Trypsinogen trypsin (active enzyme) Pancreas enterokinase
  • 81. Question: Bile and pancreatic juice are involved in digestion of fats. a) Describe the role of both secretions in this process. (4) b) Explain why bile must be released before pancreatic juice for the efficient digestion of fats. (2)
  • 83. The wall of the ileum has intestinal glands that produce intestinal juice
  • 84. Secrete Intestinal juice Maltase Sucrase Lactase Erepsin Intestinal lipase Intestinal Gland
  • 85. Enzymes in intestinal juice SUBSTRATE ENZYME END PRODUCT Peptides Erepsin Amino acids Lipids Lipase Fatty acids & glycerol Maltose Maltase Glucose + glucose Sucrose Sucrase Glucose + fructose Lactose Lactase Glucose + galactose
  • 87. Remember: Digestion of starch Starch Maltose Maltose (in ileum) Glucose Pancreatic Amylase Salivary Amylase (In Mouth) No digestion of starch in stomach (amylase is denatured) Maltase
  • 89. Starch + water Summary 6.4 FOOD DIGESTION 1. Digestion in the MOUTH FOOD Mouth Salivary glands Salivary amylase bolus aesophagus maltose secrete chewing triggers rolled into enters (by peristalsis)# epiglottis
  • 90. Digestion in Stomach Gastric glands Gastric juices HCl Acid Pepsin Rennin - pH 1.5 – 2.0 - Stops the activity of amylase - Kill bacteria In food Protein + water Polypeptides Caseinogen + water Casein
  • 91. Digestion in duodenum Starch + water maltose Polypeptide + water peptides Lipid droplets + water glycerol + FA Pancreatic amylase trypsin lipase
  • 92. Digestion in small intestine • Intestinal juice • Digestive enzymes : digestion of peptides & dissaccharides 1) Protein digestion • Peptides + water amino acids 2) Carbohydrates digestion ( Ma La S ) • Maltose + water glucose • Sucrose + water glucose + fructose • Lactose + water glucose + galactose erepsin maltase sucrase lactase
  • 93. Region of Digestion Source Enzyme Action MOUTH Salivary glands Salivary amylase Starch Maltose STOMACH Gastric glands Pepsin Rennin Protein Polypeptide Soluble Insoluble milk proteins milk proteins SMALL INTESTINE Pancreas Intestinal glands Pancreatic Amylase Trypsinogen trypsin Pancreatic Lipase Maltase Erepsin Lipase Starch Maltose Protein Polypeptides Fats Fatty acids+ glycerol Maltose Glucose Polypeptides Amino acids Fats Fatty acids+ glycerol
  • 94. Digestion is complete in the ileum. What happens to the digested food?
  • 95. Objectives 1) Describe the structure of the inner wall of the small intestine and explain it’s role in terms of increased surface area for absorption of nutrients. 2) Explain the role of a lacteal and blood capillaries in the transport and absorption of nutrients. 3) Describe the functions of the colon, rectum and anus in relation to absorption of water and mineral salts, temporary storage and egestion of faeces.
  • 96. Model of the ileum showing numerous villi Villus: a finger-like projection
  • 97. Villi contain blood & lymph vessels Villi – plural of villus
  • 98. Structure of a villus
  • 99. A villus is adapted for absorption
  • 100. The ileum is adapted to absorb digested food  by providing a LARGE surface area:  Folded walls  Has villi  Has microvilli
  • 101. Inner wall of small intestine Why is there a need for numerous folds, villi and microvilli? To increase surface area for absorption of digested food substances – Increasing the absorption rate of water and digested food products
  • 102. Ileum is adapted for absorption: 1. Ileum is long:  more time for digestion  a greater surface area for absorption 2. Villi:  increase surface area for absorption 3. Microvilli in epithelium:  increase surface area for absorption 4. Epithelium is very thin:  soluble products of digestion pass through quickly 5. Dense capillary network:  removes the digested food
  • 103. Glycerol and fatty acids diffuse into the epithelium – form fat globules – enter the lacteals Lacteal transport fats away from the small intestine. Blood capillaries Lacteal Sugars, amino acids, are absorbed by diffusion into the blood capillaries Blood capillaries transport sugars and amino acids away from the small intestine. Epithelium Villi One cell thick Faster diffusion of the digested food products What is the epithelium one cell thick?
  • 104. Would the absorption of nutrients be affected if digested food substances cannot be transported away by the blood capillaries? Explain your answer. Yes. To a certain extent
  • 105. The continual transport of digested food substances maintains a concentration gradient for the absorption of digested food substances by diffusion Lower concentration of digested food substances in the lumen of the small intestine, glucose and amino acids are absorbed by active transport Mineral salts enter the blood capillaries by active transport
  • 106. Absorption of digested food 1) Glucose & Amino acids - from lumen into the epithelial cells by facilitated diffusion - remaining nutrients – by active transport - from epithelial cells – absorbed into the bloodstream thru the blood capillaries in the villi - converge into the hepartic portal vein - Then transported to all parts of the body Lumen (glu & a.a) facilitated diffusion Epithelial cells bloodstream Hepartic portal vein blood capillaries all parts of the body
  • 107. 2) Water Lumen epithelial cells blood capillaries 3) Water-soluble vitamins Epithelial cells blood capillaries 3) Fatty acids & glycerol Epithelial cells (tiny droplets) lacteals lympatic system Right lymphatic duct Thoracic duct Bloodstream Subclavian veins
  • 108. Activity time! I need a doctor!
  • 109. I need a doctor! You are a doctor that specializes on the ileum. As the doctor of a patient who is overweight and has the intentions to lose weight, what procedures can be done to help the patient lose weight? Explain your answer.
  • 111. The large intestine is composed of: 1.Caecum Anus 2. Appendix 4. Colon 3. Rectum
  • 112. Material in the large intestine consists of:  water  mucus  dead cells  undigested matter Most of the undigested matter is cellulose. Why is this so?
  • 113.
  • 114. Function of the: Colon: absorbs 90 % water & mineral salts Rectum: stores FAECES before being expelled through the ANUS
  • 115.
  • 116. 6.6 FORMATION OF FAECES & DEFAECATION
  • 117. The 4th stage of feeding & digestion: 4. Egesting
  • 118. Contents of Faeces: 1) undigested food 2) dead cells shed from the intestinal lining & bile pigments & toxic subtances – eliminated from the body 3) binds to the mucus that secreted by the colon’s wall and lubricates the movement of faeces along the colon
  • 119. Defaecation • How it works?? - elimination of faeces - controlled by muscles around the anus, the opening of the rectum - When rectum is full, the muscles of the rectal wall contract to eject the faeces via the anus
  • 120. Egestion / Defaecation  the process of removing faeces I really have to go to the bathroom!
  • 121. Ingestion (2 L) Salivary gland secretions (1 L) Gastric secretions (2 L) Pancreatic secretions (1.2 L) 1% in faeces Small intestine secretions (2 L) Bile (0.7 L) Although 8.9 L of water are ingested or secreted daily, the faeces are dry. Explain.
  • 122. Ingestion (2 L) Salivary gland secretions (1 L) Gastric secretions (2 L) Pancreatic secretions (1.2 L) Absorbed in the small intestine & colon. 1% in faeces Small intestine secretions (2 L) Bile (0.7 L)
  • 123. Problems related to food digestion Incomplete digestion Lack of digestive enzymes Gallstones
  • 124. Causes: • when people eat too much or too fast, or certain foods don't agree with them. • smoke, drink alcohol, are stressed out, or don't get enough sleep. • certain stomach problems, like gastritis (stomach inflammation) or an ulcer. Indigestion or dyspepsia or upset stomach. symptoms: pain or burning in your upper belly nausea bloating uncontrollable burping heartburn Prevention: Avoid fatty, greasy foods, like fries , burgers. Avoid too much chocolate or citrus fruits Eat slowly. Don't smoke. relax. Give your body a chance to digest food.
  • 125. Gallstones Gallstones are hard deposits in your gallbladder Gallstones may consist of cholesterol, salt, or bilirubin, which are discarded red blood cells. Causes: • Too much cholesterol • Too much bilirubin • Gallbladder doesn’t empty properly Treatment: • Surgery • Medication • Home remedy :
  • 126. 6.5 THE PROCESSES OF ABSORPTION & ASSIMILATION
  • 127. OBJECTIVES You will learn: • 1) Define assimilation as the process where the products of digestion are distributed and use as an energy source or converted into protoplasm required for growth and repair of worn-out parts. • 2) State the role of the hepatic portal vein in transporting sugars and amino acids to the liver. • 3) Explain how sugars, amino acids and fats are utilised in the body. • 4) State that the hormone insulin is produced by islets of Langerhans in the pancreas. • 5) Explain the effect of insulin on glucose.
  • 128. Assimilation The distribution and use of the digested food products as an energy source or converted into protoplasm required for growth and repair of worn-out parts - Assimilation Small intestine
  • 129. ASSIMILATION • Definition - the conversion of nutrient into the fluid or solid substance of the body, by the processes of digestion and absorption - occurs in the LIVER and the CELLS
  • 130. BLOOD SUPPLY OF THE LIVER
  • 131. Oxygenated blood from heart Blood from digestive system HEPATIC PORTAL VEIN HEPATIC ARTERY LIVER HEART HEPATIC VEIN to heart INTESTINES Blood supply to and away from the liver
  • 132. Transport of food substances Hepatic Portal vein Small intestine Liver Blood capillaries Gall bladder Bile Duct Absorbed food substances (sugars and amino acids) are transported via the hepatic portal vein to the liver Note: Fats are transported through the lacteal into the lymphatic system
  • 133. Assimilation in the LIVER 7 Functions of the LIVER 1) Regulation of blood glucose concentration 2) Production of bile 3) Protein synthesis 4) Iron storage 5) Deamination of amino acids 6) Detoxification 7) Heat production
  • 134. Assimilation in the LIVER synthesisconverts glucose excess DEAMINATION urea kidney - excess glucose - enter heart through subclavian veins
  • 135. Transport and utilization of Glucose Small intestine Function of glucose: Glucose is used by all cells as a source of energy. Hepatic vein Some glucose is transported by the blood leaving the liver to other parts of the body Excess glucose is converted to glycogen and stored in the liver. Hepatic portal vein Glycogen
  • 136. Conversion of Glucose Islets of Langerhan cells in the pancreas – secretes a hormone Insulin Insulin stimulate the liver to convert excess glucose to glycogen and stored.
  • 137.
  • 138. Transport and utilization of Amino acids Amino acids pass through the liver before they are transported to the rest of the body. Small intestine Hepatic vein Function of amino acids: • Make new cells for growth • Replace worn-out cells • Make useful substances such as enzymes and hormones Excess amino acids are deaminated. Hepatic Portal Vein
  • 139. Deamination occurs in the liver AMMONIA AMINO ACID is broken into two: The rest is used for energy Part with nitrogen forms: UREA
  • 140. Question: Write the correct term for each of the following processes: i) the breakdown of excess amino acids Deamination ii) rhythmical muscular contractions that push food along the digestive system Peristalsis
  • 141. iii) the elimination of indigestible food from the body Egestion / Defaecation iv) the passage of digested food through the gut wall in the blood stream. Absorption
  • 142. Transport and utilization of Fats Fats is transported from the Lacteal  Lymphatic vessels  Bloodstream  Rest of the body and Liver Lacteal
  • 143. Transport and utilization of Fats Fate of Fats • Use to form parts of the cell such as cell membrane • Prevent excessive heat loss. Excess fats stored in adipose tissues When glucose supply is low, fats are broken down in the liver to provide energy
  • 144. ASSIMILATION OF DIGESTED FOOD FOOD USE STORE Glucose Respiration Glycogen or Fat Fats Respiration, to build cell structure, as a store of energy Fat Amino acids Build proteins for cell structures, enzymes CANNOT BE STORED – ARE DEAMINATED & USED IN RESPIRATION
  • 145. Write an account of a controlled experiment you would perform to show the action of the enzyme amylase on starch. (6) Two spotting tiles are prepared with a drop of iodine solution in each hole. An equal volume of starch is placed into two separate test tubes, labelled A and B. 1 2
  • 146. An equal volume of amylase is placed into two separate test tubes, labelled C and D. Test tube C is boiled for 5 minutes to denature the enzyme and so act as a control. All four test tubes are placed in a water bath at 37C for 5 minutes to acclimatise. 3 4
  • 147. Starch in test tube A is poured into amylase in test tube D, mixed and the stop watch is started. 5 After 30 seconds, a drop of the mixture is taken and added to one of the drops of iodine solution on the spotting tile. This is repeated until a yellow colour appears. 6
  • 148. Starch in test tube B is poured into amylase in test tube C, mixed and the same method is repeated. 7 8 Contents in test tube: i) D give a yellow colour with iodine solution after a few minutes ii) C continues to give a blue- black colour after 30 minutes.
  • 149. 9 The results show that amylase breaks down starch. 10 If Benedict’s solution is added to the contents of test tubes C and D and heated for a few minutes, a brick red colour is obtained only in test tube D [unboiled amylase]. This shows that when starch breaks down, reducing sugars are formed. C D
  • 150.
  • 151. What processes take place in the same part of the alimentary canal where ingestion of food takes place? 1. Physical digestion only 2. Chemical digestion only 3. Physical and chemical digestion 4. Digestion and absorption
  • 152. Which of the following statement(s) about the Oesophagus is/are true? I. There is no digestion occuring in the oesophagus II. Food moves down the oesophagus via peristalsis III. There is digestion of starch in the oesophagus IV. The wall of the oesophagus secrete digestive enzymes 1. II and III only 2. I and II only 3. II and IV only 4. II only
  • 153. Complete the following equations Starch _____________ Protein ______________ Fats _______________ amylase proteases lipase Maltose Amino acids Fatty acids + glycerol
  • 154. Why are bile salts not considered enzymes? Bile salts does not digest fats, it only emulsify fats – Increase surface area for digestion by lipase.
  • 155. TRUE / FALSE Fat digestion will stop if the bile duct is blocked by gallstones. False . Fat digestion will not stop But will become very slow since bile is absent to emulsify fats
  • 156. At which part of the digestive system is digestion of all food completed. 1. Stomach 2. Colon 3. Oesophagus 4. Ileum
  • 157. Which of the following listed below is not a feature of the ileum? 1. The inner surface is folded. 2. It releases gastric juice. 3. It is a very long tube. 4. Its main function is the absorption of digested food.
  • 158. The diagram below shows part of the human digestive system and the associated blood vessels. Blood vessel X would least likely contain _____________ 1. Glycerol 2. Amino acids 3. Water 4. Glucose X
  • 159. The diagram below shows the percentage of proteins, carbohydrates and fats digested as they pass through the alimentary canal in man. Which is PART C likely to be? 1. Ileum 2. Duodenum 3. Stomach 4. Oesophagus Percentageofundigested foodmolecules
  • 160. How would the composition of the blood in the hepatic vein change if there was a high intake of protein-rich food? Explain. The composition of the blood would not change since excess amino acids caused by the high intake of protein-rich food will be deaminated in the liver.
  • 164. Digestive System of Ruminants
  • 165. 1.Rumen 2. Reticulum 4. Abomasum 3. Omasum STOMACH – 4 Chambers
  • 166. Digestive System of Ruminants
  • 167. How it works?? 1.RUMEN - Largest compartment - Cellulose broken down by cellulase (bacteria & protozoa) 2.RETICULUM - Further hydrolysis - CUD – its content - Regurgitated bit by bit - Soften & break down cellulose mouth3.OMASUM -Reswallowed cud -Large  small particles by peristalsis -Water is removed 4. ABOMASUM -True stomach - gastric juices secreted – protein digested Small intestine Lembu Makan R – Rumput R – Redah O – Onak dan A – Air Busuk
  • 170. Rodent Digestion -Faeces 1st batch - soft & watery -2nd batch faeces – drier & harder • Caecum & appendix = enlarged to store cellulase-producing bacteria • products pass through alimentary canal = TWICE
  • 172. Comparison of cellulose digestion process in human, ruminant & rodent Similarities 1) 2) Differences Aspect Human Ruminant Rodent Stomach chambers Cellulase producing bacteria Food passes through alimentary canal Gastric juice is produced in Size of caecum Undigested cellulose
  • 173.
  • 174. Caecum & Appendix are  Large in herbivores Vestigial in humans: [small & no function] Caecum Appendix
  • 175. Question: Humans are omnivores. Do not depend only upon vegetation for nutrients. A large caecum is found in herbivores and is full of bacteria that produce cellulase to digest cellulose. Explain why the caecum / appendix in humans is small and non-functional. (4) Human Rabbit
  • 177. Animal Nutrition Oral Cavity Carbohydrate Digestion Physical Digestion Salivary Amylase Starch Maltose Teeth Tongue Food Smaller Pieces Mix Food Bolus Oesophagus Peristalsis Antagonistic Muscles Circular Longitudinal Stomach Protein Digestion Gastric Juice Enzymes HCl Acidic MediumPepsin Rennin Protein Polypeptides Soluble Milk Proteins Insoluble Caesin Small Intestine Carbohydrate Digestion Protein Digestion Fat Digestion Pancreatic Amylase Intestinal Maltase Pancreatic Trypsin Intestinal Peptidase BilePancreatic Lipase Intestinal Lipase Fats Smaller Globules Polypeptides Amino acids Starch Maltose Fatty Acids Glycerol Liver Large Intestine Colon Rectum Faeces Anus DetoxificationDeamination Glycogen storage involves involved in by hydrolyses into involves break down into into helps involved in involves that are involved in by contains provides for consist of hydrolyses into into coagulates hydrolyses hydrolyse hydrolyse into into into involved in Consists of involves involves involves emulsifies into is involved in is for storing is egested via Eventually lead to has functions like Blood glucose level Breakdown of fatty acids to regulate EnergyAmino Acids to provide Breakdown of haemoglobin Recycle iron of Heat production Body temperature to regulate hydrolyses Maltose Monosaccharides Transported by into Blood capillaries Transported by Lacteals to Absorption of H2O and Mineral salts
  • 179. Problems related to food digestion Gastritis Obesity Anorexia nervosa Bulimia
  • 181. What is gastritis? ( Gastritis is basically the condition where the mucosa (which is the stomach lining) becomes inflamed.
  • 182. • Causes: • excessive alcohol consumption • prolonged use of nonsteroidal anti-inflammatory drugs. • Sometimes after major surgery, traumatic injury or burns
  • 183.
  • 184.
  • 185.
  • 187. What happens to a person’s weight when: Weight remains constant
  • 188. What happens to a person’s weight when: Weight increases Obese person
  • 189. What happens to a person’s weight when: Weight decreases
  • 190. • We can say that obesity is an increase in bodyweight (>20% over BMI) because of excess body fat. What is obesity?
  • 191. What is obesity? • Obesity is a disease! Obesity is a chronic disease caused by excess weight.
  • 192. • Affects men and women of all ages • Predominates in developed countries. What is obesity?
  • 193. • The World Health Organization considered this disease as an epidemic of the 21st century. What is obesity?
  • 194. Causes Sedentary life  Don’t do physical exercise;  See a lot of television;…
  • 195. Extreme consumption Incorrect alimentary habits  Eat fast food; poor foods… Causes
  • 196.
  • 198. Consequences Arteries disease Cancer Obesity Problems in the biliary vesicle Renal disease Alterations in the bones Heart disease & Hypertension Diabetes Lung diseases
  • 199. Consequences Arteries disease Cancer Obesity Problems in the biliary vesicle Renal disease Alterations in the bones Heart disease & Hypertension Diabetes Lung diseases It can cause death !
  • 200. Consequences And… • Social isolation; • Depression and loss of auto-esteem.
  • 201. Consequences And… • Social and educative discrimination;
  • 202. What to do to avoid? • Eat healthy food;
  • 203.  Physical exercice; What to do to avoid?
  • 204. • Medical help when obesity starts to be serious. What to do to avoid?
  • 205.
  • 206. Look in the mirror. What do you see? Is it the real you or just another "me"?
  • 207. What is an Eating Disorder? • mental illnesses • cause serious disturbances in a person’s everyday diet. • eating extremely small amounts of food or severely overeating.
  • 209. • Individuals have a distorted body image that causes them to perceive themselves as overweight even when they are emaciated • They often lose large amounts of weight because they refuse to eat, exercise compulsively, or refuse to eat in front of others • Females experience loss of menstrual cycles • Males become impotent (erectile dysfunction)
  • 210. Anorexia Nervosa: Warning Signs  Dramatic weight loss  Refusal to eat certain foods or food categories.  Consistent excuses to avoid situations involving food  Excessive and rigid exercise routine  Withdrawal from usual friends/relatives
  • 211. Health Risks with Anorexia Heart failure Kidney failure Low protein stores Digestive problems Menstrual cycle stops
  • 212.
  • 213. Bulimia Nervosa An eating disorder in which one starts to consume large amounts of food at once and then is followed by purging, using laxatives, or overexercising to rid themselves of the food they ate.
  • 214.
  • 215. Bulimia Nervosa: Warning Signs  Wrappers/containers indicating consumption of large amounts of food  Frequent trips to bathroom after meals  Signs of vomiting e.g. staining of teeth, calluses on hands  Excessive and rigid exercise routine  Withdrawal from usual friends/relatives
  • 216. Health Risks with Bulimia • Dental problems • Stomach rupture • Menstruation irregularities
  • 217.
  • 218. deaths were caused by eating disorders in the U.S. in eating disorder deaths. In 2009 The U.S. is ranked
  • 219. • Low Self-esteem • Feelings of inadequacy or failure • Feelings of being out of control • Response to change (puberty) • Response to stress (sports or dance) • Personal illness
  • 220. • Troubled family and personal relationships • Difficult expressing emotions and feelings • History of being teased or ridiculed based on size or weight • History of physical or sexual abuse
  • 221. • Cultural pressures that glorify thinness and place value on obtaining the perfect body • Narrow definitions of beauty that include women and men of specific body weights and shapes • Cultural norms that value people on the basis of physical appearance and not on inner qualities and strengths
  • 222. • Seven feet tall • 38 inch chest • 21 inch waist • 36 inch hips • Virtually unattainable for an adult woman
  • 224. WHAT IS THE THREATMENT FOR AN AND BN?
  • 225. • Psychotherapy • Support or self-help groups • Medical treatment • Nutritional treatment • Medication • Hospitalization
  • 226. 6.8 IMPORTANCE OF A HEALTHY DIGESTIVE SYSTEM
  • 227. TO PREVENT DISEASES OF THE STOMACH • Gastritis, Gastric Ulcer, Stomach Cancer, Hemorrhage from the Stomach, Hyperacidity, Dyspepsia OTHER DIGESTIVE DISEASES • Hepatitis, Diarrhea, Cirrhosis, Lactose Intolerance, Short Bowel Syndrome, Appendicitis, Constipation, Gallstones, Flatulence and Abdominal Adhesions
  • 228. nuts, beans, grain, wheat, rice, vegetables and fruits 1. Eat foods rich in fiber  it helps the body eliminate waste, lowers cholesterol, feeds healthy bacteria and reduces risks of irritable bowel syndrome and colon cancer
  • 229. 2. Eat good amounts of fish  Fish contain omega-3 fatty acids which can improve certain digestive problems because of their special anti-inflammatory properties.
  • 230. 3. AVOID PROCESSED FOODS!  processed foods may contain ingredients which irritate the stomach
  • 231. Avoid Junk food - empty calories, minimum nutrients - Artificial colourings, flavourings
  • 232. Avoid food with high sugar /fat content - Prevent diabetes, obesity, cardiovascular disease
  • 233. 4. Take Good Bacteria – THE GOOD BACTERIA
  • 234. FOOD RICH IN PROBIOTICS Probiotics are good bacteria that live in the gastrointestinal system. They maintain its health by keeping bad bacteria at bay and creating a good harmony in your digestion's ecosystem. They have been known to help ease conditions like gastroenteritis, irritable bowel syndrome and inflammatory bowel disease.
  • 235. DO DON’T 5. Develop good eating habits
  • 236. 6. Exercise regularly  Exercise is great for boosting your body's natural functions and can improve the natural rhythm of your digestive system, too. It is also great for helping your food move through the digestive tract.
  • 237. DO DON’T 7. Choose healthy hydration
  • 238.
  • 239.