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Author:  R. Schumacher, 2009 License:  Unless otherwise noted, this material is made available under the terms of the  Creative Commons Attribution – Non-Commercial – Share Alike  3.0 License :  http://creativecommons.org/licenses/by-nc-sa/3.0/ We have reviewed this material  in accordance with U.S. Copyright Law  and have tried to maximize your ability to use, share, and adapt it.  The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact  open.michigan@umich.edu  with any questions, corrections, or clarification regarding the use of content. For more information about  how to cite  these materials visit http://open.umich.edu/education/about/terms-of-use. Any  medical information  in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised:  Some medical content is graphic and may not be suitable for all viewers.
Citation Key for more information see: http://open.umich.edu/wiki/CitationPolicy  Use + Share + Adapt Make Your Own Assessment Creative Commons – Attribution License  Creative Commons – Attribution Share Alike License Creative Commons – Attribution Noncommercial License Creative Commons – Attribution Noncommercial Share Alike License GNU – Free Documentation License Creative Commons – Zero Waiver Public Domain – Ineligible:  Works that are ineligible for copyright protection in the U.S. (USC 17 § 102(b)) *laws in your jurisdiction may differ Public Domain – Expired:  Works that are no longer protected due to an expired copyright term. Public Domain – Government:  Works that are produced by the U.S. Government. (USC 17 § 105) Public Domain – Self Dedicated:  Works that a copyright holder has dedicated to the public domain. Fair Use:  Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (USC 17 § 107) *laws in your jurisdiction may differ Our determination  DOES NOT  mean that all uses of this 3rd-party content are Fair Uses and we  DO NOT  guarantee that your use of the content is Fair. To use this content you should  do your own independent analysis  to determine whether or not your use will be Fair.  { Content the copyright holder, author, or law permits you to use, share and adapt. } { Content Open.Michigan believes can be used, shared, and adapted because it is ineligible for copyright. } { Content Open.Michigan has used under a Fair Use determination. }
The First Breath: M1 2009 R. Schumacher M1 Embryology Spring 2009 Source Undetermined
Beaker A
Pierre Simon Laplace ,[object Object],[object Object],[object Object],[object Object],Source Undetermined
Laplace Relationship ,[object Object],[object Object],Source Undetermined
Pulmonary Surfactant ,[object Object],[object Object],[object Object]
Source Undetermined
[object Object],Source Undetermined Source Undetermined
LAWS OF LUNG DEVELOPEMENT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Source Undetermined Source Undetermined
Jean L. Poiseuille Poiseuille, Jean Léonard Marie (1799-1869)  was a French physiologist who made a key contribution to our knowledge of the circulation of blood in the arteries.  Poiseuille's Law of The Flow of Liquids Through a Tube: Where: l = the length of the tube in cm r = the radius of the tube in cm p = the difference in pressure of the two ends of the tube in dynes per cm2 c = the coefficient of Viscosity in poises (dyne-seconds per cm2) v = volume in cm3 per second   Then:   v =  r  4  p/8cl   Source Undetermined
[object Object],[object Object],[object Object],[object Object],Source Undetermined
Pulmonary vascular resistance  “high” in the newborn because: ,[object Object],[object Object]
Pulmonary vascular resistance  low in the newborn because: ,[object Object],[object Object]
“ THE FIRST BREATH” ,[object Object],[object Object],[object Object],[object Object]
THE FIRST BREATH:  Goal #1:  Fluid out,  Air in. Source Undetermined
Fetal Pulmonary Fluid: Chloride Secreting Epithelium   ,[object Object],[object Object]
Fetal Pulmonary Fluid: Na “Reabsorption” ,[object Object],[object Object],[object Object],[object Object]
Fetal Pulmonary Fluid: Na “Reabsorption” ,[object Object],[object Object],[object Object],[object Object]
What About the Squeeze? ,[object Object],[object Object],[object Object]
Source Undetermined
[object Object],Source Undetermined
[object Object],Source Undetermined
Source Undetermined
[object Object],Source Undetermined
Source Undetermined
Source Undetermined
Source Undetermined
Goal  #2.  Blood In ,[object Object],[object Object],Source Undetermined
Pulmonary Vascular Resistance  Falls at Birth:  Why? ,[object Object],[object Object],[object Object],[object Object]
Source Undetermined
Source Undetermined
Source Undetermined
Source Undetermined
Source Undetermined (Both Images)
Additional Source Information   for more information see: http://open.umich.edu/wiki/CitationPolicy   Slide 3: Source Undetermined Slide 5: Source Undetermined Slide 6: Source Undetermined Slide 8: Source Undetermined Slide 9: Source Undetermined Slide 11: Source Undetermined; Source Undetermined Slide 12: Source Undetermined Slide 13: Source Undetermined Slide 17: Source Undetermined Slide 22: Source Undetermined Slide 23: Source Undetermined Slide 24: Source Undetermined Slide 25: Source Undetermined Slide 26: Source Undetermined Slide 27: Source Undetermined Slide 28: Source Undetermined Slide 29: Source Undetermined Slide 30: Source Undetermined Slide 32: Source Undetermined Slide 33: Source Undetermined Slide 34: Source Undetermined Slide 35: Source Undetermined Slide 36: Source Undetermined (Both Images)

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05.29.09: The Fetus at Birth

  • 1. Author: R. Schumacher, 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution – Non-Commercial – Share Alike 3.0 License : http://creativecommons.org/licenses/by-nc-sa/3.0/ We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact open.michigan@umich.edu with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.
  • 2. Citation Key for more information see: http://open.umich.edu/wiki/CitationPolicy Use + Share + Adapt Make Your Own Assessment Creative Commons – Attribution License Creative Commons – Attribution Share Alike License Creative Commons – Attribution Noncommercial License Creative Commons – Attribution Noncommercial Share Alike License GNU – Free Documentation License Creative Commons – Zero Waiver Public Domain – Ineligible: Works that are ineligible for copyright protection in the U.S. (USC 17 § 102(b)) *laws in your jurisdiction may differ Public Domain – Expired: Works that are no longer protected due to an expired copyright term. Public Domain – Government: Works that are produced by the U.S. Government. (USC 17 § 105) Public Domain – Self Dedicated: Works that a copyright holder has dedicated to the public domain. Fair Use: Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (USC 17 § 107) *laws in your jurisdiction may differ Our determination DOES NOT mean that all uses of this 3rd-party content are Fair Uses and we DO NOT guarantee that your use of the content is Fair. To use this content you should do your own independent analysis  to determine whether or not your use will be Fair. { Content the copyright holder, author, or law permits you to use, share and adapt. } { Content Open.Michigan believes can be used, shared, and adapted because it is ineligible for copyright. } { Content Open.Michigan has used under a Fair Use determination. }
  • 3. The First Breath: M1 2009 R. Schumacher M1 Embryology Spring 2009 Source Undetermined
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  • 12. Jean L. Poiseuille Poiseuille, Jean Léonard Marie (1799-1869) was a French physiologist who made a key contribution to our knowledge of the circulation of blood in the arteries. Poiseuille's Law of The Flow of Liquids Through a Tube: Where: l = the length of the tube in cm r = the radius of the tube in cm p = the difference in pressure of the two ends of the tube in dynes per cm2 c = the coefficient of Viscosity in poises (dyne-seconds per cm2) v = volume in cm3 per second Then: v = r 4 p/8cl Source Undetermined
  • 13.
  • 14.
  • 15.
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  • 17. THE FIRST BREATH:  Goal #1: Fluid out, Air in. Source Undetermined
  • 18.
  • 19.
  • 20.
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  • 37. Additional Source Information for more information see: http://open.umich.edu/wiki/CitationPolicy Slide 3: Source Undetermined Slide 5: Source Undetermined Slide 6: Source Undetermined Slide 8: Source Undetermined Slide 9: Source Undetermined Slide 11: Source Undetermined; Source Undetermined Slide 12: Source Undetermined Slide 13: Source Undetermined Slide 17: Source Undetermined Slide 22: Source Undetermined Slide 23: Source Undetermined Slide 24: Source Undetermined Slide 25: Source Undetermined Slide 26: Source Undetermined Slide 27: Source Undetermined Slide 28: Source Undetermined Slide 29: Source Undetermined Slide 30: Source Undetermined Slide 32: Source Undetermined Slide 33: Source Undetermined Slide 34: Source Undetermined Slide 35: Source Undetermined Slide 36: Source Undetermined (Both Images)