Claim #1: Intramembranous Aβ behaves as chaperones of other membrane proteins An example of application of the nanopublications approach to represent AlzSWAN content.

1. AlzSWAN, HyQueand nanopublications An example: Claim #1: Intramembranous Aβ behaves as chaperones of other membrane proteins Paolo Ciccarese, PhD February 25, 2011 Contributors: Nigam Shah

2. A claim taken from AlzSWAN URL: http://tinyurl.com/4h2am3a

3. The claim by the author in SWAN rdf:type <http://tinyurl.com/4h2am3a> swande:Claim dct:title Intramembranous Aβ behaves as chaperones of other membrane proteins swan-de: http://purl.org/swan/2.0/discourse-elements/ dct: http://purl.org/dc/terms/

4. Claim in a graph with authorship rdf:type <http://tinyurl.com/4h2am3a> swande:Claim dct:title Intramembranous Aβ behaves as chaperones of other membrane proteins G1 pav:authoredBy <http://example.info/person/1> G2 rdf:type foaf:name Vincent Marchesi foaf:Person pav: http://purl.org/pav/provenance/2.0/ foaf: http://xmlns.com/foaf/0.1/

5. Adding provenance [1] rdf:type <http://tinyurl.com/4h2am3a> swande:Claim dct:title Intramembranous Aβ behaves as chaperones of other membrane proteins G1 pav:curatedBy <http://example.info/person/0> G3 rdf:type foaf:name Gwen Wong foaf:Person

6. Adding provenance [2] rdf:type <http://tinyurl.com/4h2am3a> swande:Claim dct:title Intramembranous Aβ behaves as chaperones of other membrane proteins G1 pav:authoredBy <http://example.info/person/1> G2 pav:curatedBy <http://example.info/person/0> G4 rdf:type foaf:name Gwen Wong foaf:Person

7. Author’s evidence rdf:type <http://tinyurl.com/4h2am3a> swande:Claim dct:title Intramembranous Aβ behaves as chaperones of other membrane proteins G1 swanrel:referencesAsSupportiveEvidence <http://example.info/citation/1> G5 pav:contributedBy <http://example.info/person/1> G6

8. Adding provenance G1 swanrel:referencesAsSupportiveEvidence <http://example.info/citation/1> G5 pav:contributedBy <http://example.info/person/1> G6 pav:curatedBy <http://example.info/person/0> G7

9. Translating the claim into HyQue-triples

10. Translating the claim into HyQue-triples

11. Depicting the HyQue-triples <http://example.info/alzswan:statement_f3556dcfc331d9b9af9d5c0cfc570ba6_event_1> Event of type GO "chaperone binding" rdfs:label rdf:type <http://bio2rdf.org/go:0051087> <prefix:actor_1> <http://bio2rdf.org/chebi:53002> rdf:type rdfs:label “Beta amyloid” <prefix:target_1> <http://bio2rdf.org/mesh:D008565> rdf:type rdfs:label “Membrane protein” <http://bio2rdf.org/go:0005886> <prefix:location_1> rdf:type rdfs:label “Plasma membrane” G8 Triples provided by Nigam Shah

12. Adding the provenance Hyque triples G8 pav:contributedBy <http://example.info/person/2> G9 rdf:type foaf:name Nigam Shah foaf:Person

13. Connecting SWAN Claim and Hyque triples rdf:type <http://tinyurl.com/4h2am3a> swande:Claim dct:title Intramembranous Aβ behaves as chaperones of other membrane proteins G1 swanrel:derivedFrom G8 Hyque triples