Mitosis Presentation

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Cell Membrane Nucleus Chromosomes Parent Cell

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Multicellular organisms coordinate their functions for the proper survival of the individual. Cells send, receive and interpret an elaborate set of extracellular signals that serve as social controls. Resting, growing dividing, differentiating and dying all depend on these signals. Mutations tend to disrupt these social controls. Mutations give single cells a selective advantage of more prolific growth and division as compared to other cells. Cancer develops when an individual mutant clone of cells begins prospering at the expense of its neighbours. So, Cancer is a genetic disease characterized by uncontrolled division of abnormal cells leading to a malignant and invasive growth or tumor. TUMORS may be benign or malignant. BENIGN TUMORS: These, such as a common skin wart, remains confined to their original location, neither invade surrounding normal tissue nor spread to distant body sites. MALIGNANT TUMORS: These are capable of both invading surrounding normal tissue and spreading throughout the body via the circulatory or lymphatic systems (Metastasis).

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These are simplified slides discussing the regulation of cardiac output and venous return. Learning objectives: 1. Comprehend the determinants of cardiac output and factors affecting cardiac output 2. Comprehend the factors affecting stroke volume and heart rate and total peripheral resistance 3. Identify the factors regulating venous return 4. Discuss the causes of high and low output cardiac failure 5. Enlist the functions of veins and recognise the significance of venous reservoirs Study Resources: 1. Chapter 20, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 30 and 32, Ganong’s Review of Medical Physiology, 26th edition 3. Chapter 10, Human Physiology by Lauralee Sherwood, 9th edition 4. Physiology, Cardiac Output - StatPearls https://www.ncbi.nlm.nih.gov/books/NBK470455/

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