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OWN THE
        OXYGEN!
Preoxygenation and apneic oxygenation
     during emergency intubation


            Chris Nickson
          Emergency Registrar
         SCGH, November 2011
A talk that pays homage to
        the brilliant work of
Richard Levitan and Scott Weingart
http://lifeinthefastlane.com/2011/11/rr-in-the-fastlane-001/
3 Steps to Own the Oxygen!
① Preoxygenation
       • Why, how, and for how long?

② Apneic oxygenation
       • Why and how?
       • Positioning, ventilations and maneuvers
       • Paralytic agents

③ Putting it into practice
   •    Risk stratification and logistics
Why preoxygenate before you
        intubate?
Preoxygenation
extends safe apnea time
   during intubation
From Weingart and Levitan 2011
Goals of preoxygenation
① SaO2 100%

② Denitrogenate the lungs
  (big O2 reservoir)

③ Oxygenate the blood
  (less important)
What is the best source of high
 FiO2 for preoxygenation?
Use a face mask with a reservoir
and oxygen flow as high as possible

  e.g. NRB mask with 15+ L/min
How long should you
  preoxygenate for
 before intubation?
If adequate respiratory drive:

            3 minutes
                or
8 breaths with maximal inspiration
          and expiration
Is there a role for positive
pressure in preoxygenation?
Yes!

Use CPAP or NIV or BVM with PEEP
  valve in patients with baseline
         SpO2 95% or less
How should you position the
patient during preoxygenation?
Whenever possible,
 elevate the head
How long will it take a
preoxygenated patient to
      desaturate?
Somewhere between 8 minutes
     and immediately!
From Walls RM, Murphy MF. Manual of Emergency Airway Management (2008), 3rd edition
What is the role of apneic
     oxygenation?
15 L/min via nasal cannulae
extends the safe apnea time
Are ventilations during the
 apneic period an option?
Yes…
if benefits > risks

   consider if
  SpO2 90-95%

  ‘essential’ if
   SpO2 <90%
How should the patient
      be positioned,
  and what maneuvers
     should be used,
during the apneic period?
Ear-to-sternal notch
      positioning

Consider nasal airway

Jaw thrust when apneic

   (Forget cricoid!)
Position is everything!
Ear hole at
the same
height as the
neck hole!

(aka sternal
notch)
                Scott Weingart - http://emcrit.org/
How does choice of paralytic
 agent affect oxygenation?
Suxamethonium
              leads to
     shorter safe apnea times
        than rocuronium

http://lifeinthefastlane.com/2011/05/ruling-the-resus-room-004/
In Summary…
Oxygenate according to risk




   Know the logistics…
Preoxygenation period
• Head up positioning
• Ear-to-sternal notch position
• Place nasal cannula
• High flow oxygen: 15 L/min via NRB
• Preoxygenate for 3 minutes with tidal breaths, or
  8 maximal inspirations/ expirations
• If hypoxic, consider:
    – CPAP (e.g. 5-15 cmH20 to achieve SO2 >98%)
    – BVM with PEEP valve
Apneic period
•   Push sedative and roc
•   Commence 15 L/min oxygen via nasal cannula
•   Remove face mask
•   Maintain airway with jaw thrust
•   If hypoxic, consider:
    – CPAP
    – BVM (6 breaths/ min) with PEEP valve
Intubation period
• Leave the nasal cannula on at 15 L/min while
  you….




 OWN THE AIRWAY!
Low risk
High risk
Hypoxic
http://lifeinthefastlane.com/2011/02/own-the-airway/
Remember to check out:
http://emcrit.org/preoxygenation/
THE END

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Own the Oxygen

Notes de l'éditeur

  1. Aim is to intubate avoid desats and aspirationSO2 &lt;70% -&gt; dysrhytmia, hemodynamic compromise, brain injury, deathSafe apnea time is time to 90% sats…Why do we have an apnoea time?RSI is modification of the anesthetic RS induction approach to patients presumed to be at risk of aspiration… same in ED: full stomachs, body habitus, SICK
  2. Once sats drop into the low 90s you’re on the slippery slide.. And its steep!Critical desats can occur witihin moments&lt;1 minute in a well patient breathing room air!
  3. 450 mL O2 in lungs at room air, 3L at FiO2 100% - + about 1L in the bloodstreamOxygen consumption 3mL/min or 250-300 mL/imn in an adult
  4. Anesthesia circuit delivering 100% oxygen would be ideal!
  5. Standard NRBs are loose fitting face masks without 1-way valves covering all of the ports – Fi)2 60-70% max at 15 L/minNot sufficient for complete denitrogenationIncrease to ~90% with 30+L – keep opening the valve (only calibrated to 15)BVM only useful if giving +ve pressure ventilations or good inspirations with tight seal (use 2 hands) to open the 1-way valvesMost are close to room air only if lacking ideal 1-way valves
  6. Ideal is 90% end tidal oxygen level (rarely performed in ED, widely performed in OT)Ask patient to exhale fully first!8 breaths = 60 seconds in cooperative patientsMost critically ill patients cannot take vital capacity breathsTimes assume FiO2 &gt;90%
  7. Use CPAP or BVM with PEEP valve if unable to adequately preoxygenate without PPVIf unable to preox &gt;95% then shunt physiology exists = alveoli perfused but not ventilated e.g. collapse, pneumona, APOMay be overcome by postive pressure -&gt;recruits alveoliEvidence from 6 small RCTsNo gastric distention or CV compromise – likely negligible effects &lt;25 cmH2O)
  8. Supine is not ideal – posterior lungs more prone to collapse, difficult to take full breaths
  9. Repeated studies show that head up prolongs safe apnea times by about 90 seconds – about 50 seconds in the obeseUse reverse Trendelenbergifcan’t bend at the waist e.g. spinal immobilisation(head elevation also gives a betterr view of the cords duriglaryngoscopy)
  10. 1 min at room air vs 8 mni if high fio220 seconds to 85% if critically ill – metabolic demand, anemia, low CO, volume depletion
  11. Benumof et al – physiological modellingAssumes completedenitrogenation and 80% o2 content of lungsIgnores pulse ox lag – petip 30-60 sec behind centralSudy by Mort et al – preox less effective in the critically ill – less than 20% have &gt;50 mmHg rise
  12. 250 mL/min O2 uptake - &lt;20 mL/min CO2 released (buffering + solubility + Hb affinityNet flow of gas from nasopharynx to alveoliIn optimal conditon PaO2 100 can be maintained for 100 mintues! (hypercapnia leads to acidosis and death eventually)Used routinely for brain death exams in ICUNASAL PRONGSNear FiO2 100% achieved when apneic – 15L/min, air not entrained, nasoharynx acts as a reservoirMain limitiation of high flow is discomfort and dessication – not so impt in apneicpatietns!Mouth opening does seem to matter experiemntallyFacemaks tend to vent air and get in the way – BVM only useful if PPV providedNasal prongs can be applied in advance and left on during intubation attemptsIn practice extends safe apnea time by about 1-2 minCan continue CPAP until moment of intubation – improves apneic oxygenation, prevents absorption atelectasis and prevents recurrence of factors that lead to shunt physiologySome people like to insert an LMA (Braude)
  13. Need to avoid laryngoscopy until adequate realtion - good views and obtunded gag reflexBenefits – ventilation + oxygenationApnea PCO@ increases 8-16 mmHg in first min then 3/min – only impt if metabolic acidosis, tox (NCB, salicylate) or raised ICPAvoid &gt;25 cmH20 – slow 6-8/min or &gt;&gt;&gt; gastric distention and dynamic hyperinflation
  14. Apneic oxygenation requires airway patency to be maintainedUse adjuncts – esp if OSA etcEAM at same level as sternal notch = best view of cords for DLMay need to build rampCan’t do it if c-spine precuationsCP – shown in some studies to decrease gas entry into stomach but…No reall evidence of efficacy in preventing meaningful harmMRI shows oftn pushes esophagus to side, laryngotracheal compression results, worsens DL view, people get in the way, impairs BVM and increase pressuresAlways performed incorrectly
  15. Rocuronium appears to have longer safe apnoea times than suxamethonium. For instance, in ASA grade 1 or 2 patients with BMIs of 25 to 30 receiving general anesthetic, patients who were given rocuronium took 40 seconds longer to fall to an SO2 of 93% when apneic than those who received suxamethonium. This might be a result of increased oxygen consumption from the fasciculations caused by depolarising neuromuscular blockade.