Insulin Actions and Receptors
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Insulin Actions and Receptors
- 2. Main site of action of insulin Liver Also Muscle Adipose tissue
- 16. Insulin actions Stimulates Glycogenesis Lipogenesis Protein synthesis Inhibits Glycogenolysis Lipolysis Protein breakdown www.medicinemcq.com
- 17. Liver - insulin actions Decreases glucose output Decreased gluconeogenesis Increased glycogen synthesis Decreases ketogenesis
- 18. Muscle Cells And Adipose Cells insulin actions Markedly increase uptake of glucose
- 19. Insulin receptors Present on virtually all cells High concentration Liver Muscle Adipose tissue www.medicinemcq.com
- 20. Insulin Receptor Belongs to tyrosine kinase class
- 28. GLUT 4 Glucose transporter Stimulated by insulin Muscle Adipose tissue
- 30. Half Life Insulin receptor 7 to 12 hours Insulin 5 minutes
- 31. GLUT 4 Two major insulin target tissues Skeletal muscle Adipose tissue www.medicinemcq.com
- 33. GLUT 4 Sequestered mainly within an intracellular compartment Does not function as a glucose transporter until insulin signaling causes translocation of GLUT 4 to the cell membrane www.medicinemcq.com
- 34. Glucose disposal after a meal Important sites of glucose disposal Skeletal muscle and adipose tissue www.medicinemcq.com
- 35. Glucose disposal after a meal Important sites of glucose disposal Skeletal muscle and adipose tissue GLUT4 Insulin-responsive www.medicinemcq.com
- 36. Exercise Muscle Drives GLUT 4 translocation to the cell surface By activating MAPK. www.medicinemcq.com
- 37. Exercise increase insulin sensitivity of muscle Persists for several hours after exercise Regular exercise Prolonged increase in insulin sensitivity
- 38. Decrease Insulin Receptors Per Cell Exposure to increased levels of insulin. Diabetes type 2 Obesity. Acromegaly.
- 39. Insulin Secreted only by pancreas www.medicinemcq.com
- 40. Glucose > 70 mg/dL Stimulate insulin synthesis and insulin secretion Food intake Insulin secretion stimulated
- 43. Insulin Anabolic Insulin helps in the storage of Carbohydrate Fats Proteins
- 44. Insulin Promotes Energy Storage Conversion of substrates into Glycogen Triglycerides Proteins
- 45. Excess carbohydrates Stored as glycogen Liver and muscles. Excess carbohydrates that cannot be stored as glycogen Converted into fats Stored in the adipose tissue.