Development of a Viral Removal Device to Prevent HCV Recurrence Following Liver Transplantation, Michael Hughes, MD

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SCTR Institute

Santé & Médecine

Development of a Viral Removal Device to Prevent HCV Recurrence Following Liver Transplantation Michael G. Hughes, Jr., MD March 24, 2010 Medical University of South Carolina

Overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Impact of HCV Recurrence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Inoculum Size Contributes to Severity of Recurrent HCV Disease ,[object Object],[object Object],[object Object],[object Object]

HYPOTHESIS ,[object Object],[object Object],[object Object],[object Object],[object Object]

LIVER TRANSPLANT AS OPPORTUNITY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HOW TO REMOVE VIRUS? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HOW TO SELECTIVELY BIND AND REMOVE VIRUS? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MONOCLONAL ANTIBODIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

POLYCLONAL ANTIBODIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PEPTIDES IDENTIFIED BY PHAGE DISPLAY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

RECEPTORS FOR HCV ,[object Object],[object Object],[object Object],[object Object],[object Object]

HEPATOCYTES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HCV Biofilter ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Development of a Viral Removal Device to Prevent HCV Recurrence Following Liver Transplantation, Michael Hughes, MD

1. Development of a Viral Removal Device to Prevent HCV Recurrence Following Liver Transplantation Michael G. Hughes, Jr., MD March 24, 2010 Medical University of South Carolina

7. PROPOSED DEVICE: BIOFILTER FOR HCV

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