Scaling API-first – The story of a global engineering organization
Magnetic Drug Targeting, James Ritter, PhD
1. Magnetic Drug Targeting James A. Ritter, Armin D. Ebner and Jan Mangual Department of Chemical Engineering Swearingen Engineering Center University of South Carolina Columbia, SC 29208 Scientific Retreat on Bioengineering and Regenerative Medicine Charleston, SC March 24, 2010
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6. Magnetic Drug Carrier Particles for IA-MDT Size : 50 - 2000 nm Superparamagnetic Particles - FeCo, ferrites, etc. - largest magnetization - 80 wt% max (40-50 vol%) Polymer - biocompatible - non-immunogenic - biodegradable - porous for drug transport Drug - free or fixed (radioactive)
9. Comsol Simulations Simulation for 0.96 m MDCPs with 60 wt% magnetite at an applied field of 0.65 T and a velocity of 2.1 cm/s. Magnetic Field Gradients MDCP Streamlines Last captured particle Trajectory
10. In Vitro Particle Capture Images Effect of Fluid Velocity on Particle Capture A1) A2) B1) B2) Images at velocities of A) 2.1, and B) 21.2 cm/s 1) before and 2) after 10 ml of solution have passed through the collection area at an applied magnetic field of 0.17 T.
11. Experimental and Model Results Effect of Fluid Velocity D p = 0.87 m x fm = 25 wt% D w = 125 m Velocity negatively affects capture, but even at high velocities capture is still attainable. Capture seems to reach a steady value, where decrease in capture is greatly reduced. model
20. Artery Perfusion Experimental Setup Heart’s Right Ventricle Saline Solution (0.9% NaCl) Reservoir Peristaltic Pump ~ 40 mL/min Seed suspension 100 nm Fe 3 O 4 2.8 mg/mL 0.5 ml Injection Collection vessel Magnet
21. Right Coronary Artery Results Samples were analyzed using Atomic Absorption Spectroscopy for iron. The stent is a SS430 500 m coil, 3 mm in diameter and 3 cm long,
22. Particle Capture at Stent Area From visual inspection the particles could be seen accumulated in the area where the stent is located. While there are particles in other areas of the artery, it appears to be less compared to the stent area.
![Schematic of an MDT System ,[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)